Hal Cranmer in an interview with Dr. Shawn Baker (This is Scary) put care home residents on a carnivore diet, made a deal with the kids, no donuts, no candy, no cake. Some regained their memories/cognitive function, some went home to live a normal life again. How much more does one need to know.
Is there even a case series on this? I love inspiring patient stories, but if this is legitimate would he not want to write it up at least as a case series to inspire a clinical trial?
@nicknorwitzPhD I don't think so Nick, however, if you started reviewing the miracles and I'm not mincing words, that have been reported on No Carb Life with Dave Mac you will be there for awhile. He is so respectful, so Polite, he is a rare individual with his own tale of recovery. "No Carb Life" see also Dr. Paul Mason from DoctorstoTrust.
@@nicknorwitzPhD Hal Cranmer is not a scientist, he is probably not even aware of that type of scientific literature. I think I saw that interview, but that was some months ago. Maybe Dr Baker asked him about this and hopefully they are working on it now. But I have no clue. "This is Scary" is actually the words on the video thumbnail, if you want to google for the interview. (I'm actually using Duck Duck Go search engine (no advertisement tracking...) and searched for "Hal Cranmer in an interview with Dr. Shawn Baker")
@nicknorwitzPhD Looks like increased "processed meats" are associated with dementia, most likely it's the cabs that are the villain, Dr. Feldman claims that as little as 4g fry your organs. I like to think of it a singe as I am not off the stuff..... Yet.
As a neurologist treating Alzheimer’s patients for 30 years, I can say the tablets and now IV infusions we have do little to nothing to help these pitiful patients and their families. Something new is desperately needed. Thank you again Dr. Nick for this info.
It was only said forever ago.. food is medicine. Which most have heard this. Most don’t know the full quote. The part is, to eat when you are sick is to feed your sickness. And what happen when you fast OR do keto? Exactly. “Studies” for the most part have been lousy. They don’t quite encourage but always say “may” and people will be people. Many studies have been tampered with as Linus Pauling saw first handedly.
Well this explains a lot!! I was injured with pyrolized hydrocarbons that included toxic solvents and neurotoxic tricresyl phosphate... an organophosphate. I was severely compromised both in the CNS and PNS. I literally shut down .... until a friend introduced me, first to butter coffee then the ketogenic diet. 20 minutes after the first butter coffee it was like the lights went on for the first time in years. Then enter the Johns Hopkins dietary protocol for epilepsy... then enter a dialogue I had with Dominic D'Agostino where he led me further into ketogenic protocols (this was in 2011 WAY before most even heard of keto).... not only did I recover but I got my career back as an airline captain.... flying the Boeing 777... an occupation you will agree whereby mental acuity is paramount. I think (anecdotal) ketones do a LOT more than remove garbage from the brain... I had precancerous lesions on my DNA that was reversed as well! SO much to learn!! That was found through the use of Raman spectroscopy Thanks Nick!
😊 I had in my 4 pragnancy diabetis, becouse it was verry sevire i discover keto diet and did theat befor i know what is was. Now with long covid ... is become so dificut to still do it...
@@1TieDye1 I stand corrected, it was not on the mitochondria but lesions or adducts on my DNA. I have edited my note above and took the info out of the researchers report written in 2012... I also had a completely dysfunctional krebs cycle. ATP utilization was extremely low.
Nick, the amount of high quality content you release is insane for someone who still have other hobbies such as professional scientific research. Congrats
Thanks for using the verbiage "suggest" when describing the paper findings. Wish "suggest" was used more often in all nutritional study findings especially when studies have not been replicated. Good job.......again.
What I'm seeing in this is that it means that ketones heal... I think. While ketones will bind to and help destroy mal-formed/folded proteins, does the body rebuild the protein that was removed? I have to believe so. This is amazing news. Absolutely wonderful. Thanks, Nick!!
63yo man here, I've been taking MCT oil daily now for over 2 years and follow an IF/low carb lifestyle ( an occasional 'dalliance' here and there): I feel great and doing such keeps my mild arthritis at bay. MCT Oil helps the body to produce ketone bodies ( as you as a researcher well know ), also, ketones are 'energy without ( the aide of ) insulin!'
One of my closest and oldest friends died of demenchia two years ago. When he started having symptoms we begged him to do hflc...He refused. Anyway,this is amazing!
@@dacisky Same here, I am at the age where many friends are experiencing cognitive decline but who am I to suggest keto, I’m not a doctor. But because people know my position, they will come up to me with success stories.
I have a muscle wasting disease that also involves misfolded proteins. The duo of DNAJB6 and HSP70 are responsible for muscle protein quality control, and I have a mutation of the B allele of DNAJB6. One of the hallmarks is aggregated misfolded proteins. I have been in ketosis for 3yr and had hoped elevated ketones would equal upregulated autophagy and it would influence muscle strength, but no joy at this point. It might look better under the microscope but from a practical, boots on the ground point, it's not helping. I have recently added BHB ester, and I am supplementing with a cocktail to support mitochondrial health and will see what happens!
Great video on a really interesting new research paper Nick. You break up the studies so clearly in digestible nuggets for us laypersons. I see that your textbook chapter: "Norwitz N.G. et al. Ketotherapeutics for Neurodegenerative Diseases. International Review of Neurobiology (2020)" from your Ph.D. days at Oxford, also dealt with the basic subject from this new research paper by Madhavan et al. It must have been a really enjoyale paper for you. BTW, can you please, if it's not too much trouble for you since you're super busy, to also post the Pubmed references or the DOIs of the studies so we can more easily find the studies. Thank you for sharing your knowledge and a happy new year to you and your loved ones.
Nice Nick. I saw something that really threw into question whether plaques and tangles were the problem we assume them to be. Leslie Stahl on a 60 Minutes(TV Show). Researchers followed a retirement community over time and tested the older residents for mental function. Some showed decline, others not so much. The participants upon dying, left their bodies to science for follow up research. What they found (through dissection) was counter intuitive, some with plenty of tangles and plaque still functioned well. Others with clear brain tissue showed signs of cognitive impairment. I think Dom D’Agostino shared the first study and it and the follow up should be readily available.
Plaques and tangles play a role but there are other factors, including susceptibility and "resilience" factors. But you can't have AD without plaques and tangles, by definition.
The debate I have heard here is that one school of thought is the tangles are the source of disease. The other camp purposes that the tangles are produced to slow down the progress of the disease. Is that what you are referring too?
@@nicknorwitzPhD so, the people with apparent free of plaques and tangles brains, that behaved like they had Alzheimer’s disease, what did they in fact, have?
Haaaa same here 😂🎉🎉🎉 ketosis for 18 month (TBI almost 10 years ago) and my brain is clearing up. Nerves stronger. Agility in thinking and imagining and curiosity return! All the best, @Greglemon57!
@@greglemon57 If you aren't already doing red/NIR light therapy that is also good for TBI. One of the best therapies for TBI is hyperbaric oxygen therapy. But that one is hard to do at home. And very expensive to get in clinics. But some who really need it get at home units.
I really enjoy some of these videos. It's nice to hear about research that looks very promising to impact large numbers of people in a beneficial manner in the near future.
But so many of the patients at the Alzheimer’s care facility where I worked only ate carbs/sweets. So many older people eat toast with jam and a half sandwich or soup then some store baked goods. My Mom is keto and is 76. She will break the mold. Perhaps we will be the generation that changes the dietary structure and see if it makes a difference. Any type of dementia is awful. Any type of prevention is worthy.
I think they crave the carbs because glucose metabolism has been shown to be impaired in brains with Alzheimer's. So, their neurons are starving for energy despite their blood glucose probably being sky-high. And since their glucose is chronically high, keeping their insulin chronically elevated, they never switch into fat-burning and produce ketones their neurons could actually utilize. So, the neurons are screaming "Feed us! We're starving to death!", and the person jams down another bagel or other high-carb meal, which would provide them with instant fuel, if only their neurons could use it.
I love the open questions at the end! and it's so fascinating how ketones meet misfolding proteins, as they are lovely attracted for healthy functioning!! it's also interesting how ketones clear up instead of high blood glucose and polyunsaturated oxidized fats build up misfolding proteins
@@nicknorwitzPhDfew months ago I was reading a study about highly reactive PUFA (I think about from industrial refined oils) can damage protein folding... as chronic high blood glucose ... I have to look for it again and post here. I suppose due to high vhronic inflammation impairing chaperons
fantastic video once again Nick. Best in the game right now 100%. I would love to see what your general 'day on a plate' and supplementation looks like with all of the research considerations you have accumulated over the years. Especially considering you're APOE4 and a LMHR.
Appreciate that Chris. I try to resist sharing exactly what I eat both because it changes and because what I do is based on many person factors. But I eat a lot of fish and EVOO!
@@singamajigy supplementing b12 and copper can lower ldl. Although it may be useful to have a cholesterol test done that analyzes the types of ldl you have - and the ratio of hdl to ldl is really what matters most. Learn more about ldl. It isn’t the problem you think it is.
There is a channel called Metabolic Mind that is about treating mental issues with the keto diet. Another channel Lauren Kennedy West is about how she used keto to heal her Schizophrenia
Wonderful, thank you. One tiny comment, apologies. When you say at start, "this is science" surely that should be "this is evolution" / some variant ? I've fasted for 4 decades and ketoed for 3 decades. Magical to hear all the nuanced science. You've a delightful way of presenting.
Great video. My dad died from Altziemers at 82. I was always so scared that I might have the "Altziemers" gene. I am 62 and thank god I have been keto/carnivore for the past few years and usually only eat OMAD.
Thank you Nick for bringing this info to our attention. My paternal grandmother and father both died from Alzheimer's. I have been on a quest for all related info. BTW I have been keto for 15 years and feel great!
This was a reply, but i wanted to put it in the main thread. Dr. Adkins put keto diets(ketosis for health and weight loss)on the map for average people in the 70's. Not the first to study ketosis, but i believe the first to write a book promoting low carb diets. He was vilified by the medical committee for his position. They did everything they could to destroy him. And he was right. To me, he is the father of the dietary keto enlightenment. And he gets no credit.
I agree.. in the 90s I met a girl who lost a lot of weight on Atkins diet.. I was a vegetarian and thought she was creating a heart attack problem for herself… I was a vegetarian for over 35 years.. totally brainwashed.. I developed pre diabetes and low energy… I just finished reading Dr Atkins book and I’m now on a Ketogenic diet and my energy so much better and blood 🩸 sugar normal
I think he gets a decent amount of credit. And if was still living, we'd be seeing him all over TH-cam being interviewed by the keto and carnivore influences. Dr. Eric Westman gives him credit all the time.
Yes, great questioning, with far more to come! And, are other mis-folded proteins, ones associated with toxic contamination by lead or glyphosate, also mechanistically helped to be 'cleaned up' by ketones? I have become very concerned by these two toxicants potentially adding to the mis-folded protein body burdens in brain cells, either in glia or neurons, as they are so persistent in contamination across society currently. We have all accumulated lead in bone, perhaps 100 to 1000 x's those found in bone from 10KA. When the body come under stress, and needs quick additional calcium to deal with the stresses (old age, illness, pregnancy etc.) bone pool lead comes out into soft tissue again along with the calcium, at the most physiologically vulnerable times. If lead frequently substitutes for zinc during protein synthesis, yielding mis-folding (eg. zinc finger enzyme production), building up trash in the cells can be fairly difficult to phagocytose out again? And, subsequent mitochondrial function decreases, having to be disrupted by the debris, is metabolically pathogenic. Glymphatic cleanup during paralysis of quality depth of sleep, is essential yet perhaps hampered by 'blue light' toxic LED and fluorescent lighting life styles now dominating the premature switch away from incandescent light beneficial wavelengths otherwise left outdoors by current lighting? Turns out that physics actually does affect biology, and light quality IS deadly serious for maintaining deep enough sleep quality to support 'clean up mechanisms?!? This paper is a great hope toward clarification IMHO.
Google’s ad service, using the principles of surveillance capitalism, decide what ads to serve up to viewers. Google, based on what they know about me, showed me an ad for Paleo Valley’s keto products. Google decided to show you a pizza ad.
At 3:36 minutes I had to pause to process your info - it’s so simple yet so hard for the addicted carb person. I always have to bring food with me in a small cooler otherwise I might be doomed to what other people are indulging in
Many of us are carb addicted. I had to make healthy choices convenient because unhealthy foods are absolutely everywhere. All my meals for a long time were made ahead of time.
Dear Barbara, I find as a 60 yo woman if I eat a 8 oz 80/20 hamburger or a can of sardines before an event, I am feeling full and satisfied at a function. Best wishes!
Another piece to the puzzle is SLEEP/ this is when the waste is removed. Apparently the reduction in blood pressure allows the vessels to be more permeable.
Audio engineer recommendation here, Your music volume is a bit heavier than the dialogue volume. I think your dialogue volume is good. You could use a plugin to remove his for example on the end type of clips. End just do some low end cut on the music about 80hz or turn down by maybe -1.5db or both And feel free to message me with any questions
@@nicknorwitzPhDfor sure. And as a medical side note. I healed major CPTSD & schizophrenia symptoms and created a protocol by which to do so if you are interested in that info, it’s not a protocol I’ve seen anywhere else at the specificity I’ve put together, and I’ve studied medicine since I was a child. Also, amazing videos, you’re killing it 🎉
@@nicknorwitzPhDIf I could add, make sure to normalise the audio (all audio tracks combined aka the master) to -14LUFS for the long term or very close to it for the best and consistent audio level for youtube
To be honest, I have not felt better since I started doing KETO (Clean) and OMAD 8 years ago, it’s like I took some smart drugs that woke up my brain! I just hope morse people would try it out.
Drop nuts and greens (high oxylate) foods for an even clearer brain. My brain fog disappeared and only returns when I stray like last week. Bad food feeds brain fog for sure. But accepted “good” food also causes it. Only meat is free from blame in my diet.
A lot of my friends’ parents who are bedridden full time are on MTC, but seems a bit too late for that. Why can’t doctors start advising ketones therapy much earlier before it’s too late??? Beats me! 🙄
@@DanzeMusicCan they also try supplementing with Ketones? Audacious Nutrition makes a good coffee and hot chocolate. Their Ketostart can cause diarrhea, I think because of the Magnesium citrate. Dr. Boz also makes ketones. The cucumber lemon is tasty without being too sour. I’m going to try these on my relative.
Janitors or Angels! Reminds me of The Wisdom of our Cells where biologist Dr Bruce Lipton, shows how even our thoughts as energy signals, binds to proteins and affects how poor or how well they fold.
Not sure what the direct tie is to methylation vis-a-vis this mechanism; however, if we're talking post-translational modifications... keep in mind BHB is a PTM too: "beta-hydroxybutyrlation"
It's like the presence of ketones is used as a signal that the body could use some extra energy, so the body looks for things that it can burn. You might not want to do this when you already have plenty of glucose in the body, as that could lead to a spike in blood sugar, but when you have low blood glucose that is the ideal timing to burn some stored proteins. So the body not only stores glucose as glycogen and triglycerides, but also protein. We know that the body recycles proteins when blood glucose levels are low (and/or when ketone levels are up), but this may be a mechanism for triggering this. I would not be surprised if it worked similarly with other proteins in other parts of the body as well. That could have major implications. We know that ketogenic diets are beneficial for people with cancer. Cancer cells use glucose to grow, so that made sense, but this may be another mechanism. Similarly for fighting infections. When the body creates a fever in response to an infection it burns more energy to raise the body temperature, while at the same time reducing hunger. This combination increases the likelihood of reaching ketosis.
Some cases of glaucoma are from the tribecular mesh being clogged up with faulty proteins - could ketones helps clear this to restore normal eye pressure
Very good question. But regardless of whether or not exogenous ketones ketones perform this cleanup process, they do improve cognitive function - especially in insulin resistant brain cells and/or bodies whose ability to produce ketones is compromised.
I wonder if drinkable exogenous ketones are molecularly the same as ketones produced by the body. If so would they be beneficial for cleaning out miss-folded proteins even if the person isn’t in Ketosis or would they not perform this function if the person isn’t in Ketosis, in itself answering this question would be valuable.
Of course caprylic acid C8 is a great option to get more ketones. I really like it and i will never stop using that stuff. Try in on the skin also any kind of skin seem to love the stuff
Amazing! Makes me wonder if ketones (and other metabolites) could have the same effect on misfolded protein aggregates in pancreas cells that are associated with type 2 diabetes.
Nick, love your videos! Would I be wrong to conclude that a high glucose SAD is at least a factor in AD if not directly causative? Conversely, ketosis at any level short of acidosis is not only not harmful but even protective? Keep bringing the rain!
You would not be wrong. That is why Alz is alternatively called type 3 diabetes. Ketoacidosis is a completely different phenomenon. Not really a worry for those who are not diabetic (especially type 1). Yes. Ketosis is beneficial. In many many ways.
Wow, so many questions. I wonder myself what kind of reaction is causing the bonding of the ketone to these specific proteins. Is there some special catalyst in this environment to cause the reaction to occur. Where is the ketone binding to on the protein.
Nick I’m 56 5’11 weight 280 pre diabetic. Right on the verge of 6.5 A1C. Last LDL was around 110. Never had APO B tested. Trigs are about 170. Hesitant about low carb and too much saturated fat and red meat. Should I try a carnivorous diet?
@ A while ago, there was a recommendation to consume coconut oil, based on a story from an MD who fed it to her husband who had MCI. It was popular for a while as an idea. Not much of a rational basis for it: just based on an N=1. I was just reflecting how there was so much more evidence supporting this idea that Nick pointed to
Would exogenous sources of ketones benefit here? -- I'm thinking MCT oil as a good commercial option. Particularly for those unwilling to achieve nutritional ketosis. Also, was there a limit to the benefits after a particular blood ketone level? Where do the diminishing returns occur? I get the sense from the author that mechanisms are not known, and so it could be difficult to answer best 'dosage' of blood ketones.
OMG you are so right. I went to the keto/carni lifestyle since sept 23 and my journey has been on of suffering and findings alike. Since then I see the issues that people fight all around me, which are correlated to bad food and habits a lot. It almost feels like a superpower to be able to see what makes them sick while being able to avoid it at the isle in the super market at the same time. I read food lables all the time and when I stand at the cashier waiting and looking at the carts of others its pure cancer, what they are buying. I picture it more like, overweight mid 30' ish people gasping for air while pushing their carts to the car. Cart filled with a myriad of things that brought them to this state. Yet they still go to the super market to prolong their suffering and/ or start it even earlier (even for their kids) Its like paying for staying sick and getting sicker evne. And the industry even makes you buy your own poison every other week and carry it home by yourself to feed you or your relatives. Isnt that sad?
❤ love this ! My doctor is at her wits end . Except for my cholesterol, my labs are awesome . She's freaking out becuse I'm not on her bucket of pills . When you are a post menopausal woman the drug cascade begins .
I'm a 78 year old male, and keeping the doctor and his druggest pals at bay is an ongoing challenge. I recently went to urgent care for a sprained ankle and had to endure a 10 minute lecture on how I was going to die imminently of a MI unless I started taking a, statin.
@@stubloom4870 - I’m guessing the statin push was due to your high ldl? I gave up with dealing with the docs and I’m self monitoring my blood work. I’m lmhr and my ldl peaked at 623 and has started slowly coming down. I’m 366 days carnivore and zero meds at 66.
Yes, I'm a LMHR and my LDL is >350. But my triglycerides are in the 70s and my HDL is >100. My A1C is 5.4, my BP 105/65, and my BMI is about 21. All due to a slightly "dirty" carnivore WOE. But all the docs want to talk about is LDL, LDL, and LDL.
@@stubloom4870If you haven't high blood pressure high ldl isn't dangerous is my conclusion and as far as I understand these things. It has to be an over stress of the tissue from the high blood pressure for the high ldl to be an factor. If anyone knows for a fact this is not the case. Please correct me though.
Would these same theories apply for folks who are being diagnosed with ATTR-CM which is a condition where a protein called transthyretin misfolds and builds up in the heart muscle? I understand this was a video about the Brain and we fought this battle with my father so I know first hand the cruel reality of Alzheimer's. Also fought the battle of getting my dad and mother to eat differently. But I circle back to ATTR-CM because my brother got this diagnoses early 2024 and of course there's not a lot of options. I would assume a folded protein is a folded protein to ketone bodies. Thanks for being a resource, I've followed your channel for while and a lot of the info is confirmation we're doing the right things at the dinner table.
Hal Cranmer in an interview with Dr. Shawn Baker (This is Scary) put care home residents on a carnivore diet, made a deal with the kids, no donuts, no candy, no cake. Some regained their memories/cognitive function, some went home to live a normal life again. How much more does one need to know.
Is there even a case series on this? I love inspiring patient stories, but if this is legitimate would he not want to write it up at least as a case series to inspire a clinical trial?
@nicknorwitzPhD I don't think so Nick, however, if you started reviewing the miracles and I'm not mincing words, that have been reported on No Carb Life with Dave Mac you will be there for awhile. He is so respectful, so Polite, he is a rare individual with his own tale of recovery. "No Carb Life" see also Dr. Paul Mason from DoctorstoTrust.
@@nicknorwitzPhD Hal Cranmer is not a scientist, he is probably not even aware of that type of scientific literature. I think I saw that interview, but that was some months ago. Maybe Dr Baker asked him about this and hopefully they are working on it now. But I have no clue. "This is Scary" is actually the words on the video thumbnail, if you want to google for the interview. (I'm actually using Duck Duck Go search engine (no advertisement tracking...) and searched for "Hal Cranmer in an interview with Dr. Shawn Baker")
@nicknorwitzPhD Looks like increased "processed meats" are associated with dementia, most likely it's the cabs that are the villain, Dr. Feldman claims that as little as 4g fry your organs. I like to think of it a singe as I am not off the stuff..... Yet.
I think Dr Chaffee also interviewed him
As a neurologist treating Alzheimer’s patients for 30 years, I can say the tablets and now IV infusions we have do little to nothing to help these pitiful patients and their families.
Something new is desperately needed. Thank you again Dr. Nick for this info.
Thank you for your service and sharing - and of course listening and commenting ;)
So true. My mother died of Alz - if only i had known about ketones in time.
It was only said forever ago.. food is medicine. Which most have heard this. Most don’t know the full quote. The part is, to eat when you are sick is to feed your sickness. And what happen when you fast OR do keto? Exactly. “Studies” for the most part have been lousy. They don’t quite encourage but always say “may” and people will be people. Many studies have been tampered with as Linus Pauling saw first handedly.
Well this explains a lot!! I was injured with pyrolized hydrocarbons that included toxic solvents and neurotoxic tricresyl phosphate... an organophosphate. I was severely compromised both in the CNS and PNS. I literally shut down .... until a friend introduced me, first to butter coffee then the ketogenic diet. 20 minutes after the first butter coffee it was like the lights went on for the first time in years. Then enter the Johns Hopkins dietary protocol for epilepsy... then enter a dialogue I had with Dominic D'Agostino where he led me further into ketogenic protocols (this was in 2011 WAY before most even heard of keto).... not only did I recover but I got my career back as an airline captain.... flying the Boeing 777... an occupation you will agree whereby mental acuity is paramount. I think (anecdotal) ketones do a LOT more than remove garbage from the brain... I had precancerous lesions on my DNA that was reversed as well! SO much to learn!! That was found through the use of Raman spectroscopy Thanks Nick!
Dominic owes me $20. Do you know where that swindler's at?
WOW! Amazing event!
😊 I had in my 4 pragnancy diabetis, becouse it was verry sevire i discover keto diet and did theat befor i know what is was. Now with long covid ... is become so dificut to still do it...
Precancerous lesions on mitochondria? A subcellular organelle with precancerous lesions? How does that work?
@@1TieDye1 I stand corrected, it was not on the mitochondria but lesions or adducts on my DNA. I have edited my note above and took the info out of the researchers report written in 2012... I also had a completely dysfunctional krebs cycle. ATP utilization was extremely low.
You what I love about his videos? It's less than 30 mins. But packed with information that even I -a non medical informed person would understand.
Thanks 😊
*Concerning Medical Science, this is one of the best channels I have ever found. Your scholarship in this field is indeed matchless* 👍
Thank you :). So kind Abdar
WOW ! Fascinating info. 83 year old f here. My friends think I'm 'odd' as I endevour to stay in Ketosis while they munch away at their carbs.😊
That is awesome! Thanks for sharing! StayOdd!
Thanks for so many great videos!
Your channel is blowing up. So well deserved. More power to ya.
Yes! Thank you!
Working as a practitioner in neurology, I thank you for your videos !! Keep up the good work.
Thank you for engaging! Have a great new year!
Nick, the amount of high quality content you release is insane for someone who still have other hobbies such as professional scientific research. Congrats
Hobbies? He is in medical school, Harvard no less.
@cynthiagilbreth1352 it was a joke
@ well it sure went over my head! 🥹 Thanks for the response.
Stay informative!! I know you will!! Forwarding this amazing info to my mom. Have a wonderful Monday.
Thank you! You too!
Thanks for using the verbiage "suggest" when describing the paper findings. Wish "suggest" was used more often in all nutritional study findings especially when studies have not been replicated. Good job.......again.
What I'm seeing in this is that it means that ketones heal... I think. While ketones will bind to and help destroy mal-formed/folded proteins, does the body rebuild the protein that was removed? I have to believe so. This is amazing news. Absolutely wonderful. Thanks, Nick!!
63yo man here, I've been taking MCT oil daily now for over 2 years and follow an IF/low carb lifestyle ( an occasional 'dalliance' here and there): I feel great and doing such keeps my mild arthritis at bay. MCT Oil helps the body to produce ketone bodies ( as you as a researcher well know ), also, ketones are 'energy without ( the aide of ) insulin!'
One of my closest and oldest friends died of demenchia two years ago. When he started having symptoms we begged him to do hflc...He refused. Anyway,this is amazing!
I’m sorry to hear about your friend
@@dacisky Same here, I am at the age where many friends are experiencing cognitive decline but who am I to suggest keto, I’m not a doctor. But because people know my position, they will come up to me with success stories.
@@robertlaveyra9940 invite them over and serve them butter coffee and different types of high fat food then don't say anything, until they ask :)
Thank you Nick. He is definately missed.@@nicknorwitzPhD
I have a muscle wasting disease that also involves misfolded proteins. The duo of DNAJB6 and HSP70 are responsible for muscle protein quality control, and I have a mutation of the B allele of DNAJB6. One of the hallmarks is aggregated misfolded proteins. I have been in ketosis for 3yr and had hoped elevated ketones would equal upregulated autophagy and it would influence muscle strength, but no joy at this point. It might look better under the microscope but from a practical, boots on the ground point, it's not helping. I have recently added BHB ester, and I am supplementing with a cocktail to support mitochondrial health and will see what happens!
Interesting. So if you work out to failure, your failure point goes down?
I hope you will find the key toward improvement. Longer fasting? Higher fat? Beef only? 🙏🙏🙏
Just curious if you’ve tried carnivore? Beef only (with the fat) would be worth a shot. Cleanest, most healing food on earth.
I'm sorry to hear that, but thank you for sharing. Wishing you the best!
Would you share which ester product you are using?
I've been saying this since 2017 when my Dad was suffering from Alzheimer's and I started learning about ketogenic diets.
This is my new second best channel after Pottenger's Human. Doesn't stop delivering gems of knowledge.
so many channels I like... too many now I think...
Love PH
This. So many gems of info.
I'll take it :)
bots
Great video on a really interesting new research paper Nick. You break up the studies so clearly in digestible nuggets for us laypersons. I see that your textbook chapter: "Norwitz N.G. et al. Ketotherapeutics for
Neurodegenerative Diseases. International Review of Neurobiology (2020)" from your Ph.D. days at Oxford, also dealt with the basic subject from this new research paper by Madhavan et al. It must have been a really enjoyale paper for you. BTW, can you please, if it's not too much trouble for you since you're super busy, to also post the Pubmed references or the DOIs of the studies so we can more easily find the studies. Thank you for sharing your knowledge and a happy new year to you and your loved ones.
Nice Nick. I saw something that really threw into question whether plaques and tangles were the problem we assume them to be. Leslie Stahl on a 60 Minutes(TV Show). Researchers followed a retirement community over time and tested the older residents for mental function. Some showed decline, others not so much. The participants upon dying, left their bodies to science for follow up research. What they found (through dissection) was counter intuitive, some with plenty of tangles and plaque still functioned well. Others with clear brain tissue showed signs of cognitive impairment. I think Dom D’Agostino shared the first study and it and the follow up should be readily available.
Plaques and tangles play a role but there are other factors, including susceptibility and "resilience" factors. But you can't have AD without plaques and tangles, by definition.
The debate I have heard here is that one school of thought is the tangles are the source of disease. The other camp purposes that the tangles are produced to slow down the progress of the disease. Is that what you are referring too?
@@jamesasimmons no, they showed brains that appeared clear of either but the behavior prior to death was that of an Alzheimer’s patient.
@@nicknorwitzPhD so, the people with apparent free of plaques and tangles brains, that behaved like they had Alzheimer’s disease, what did they in fact, have?
There are multiple forms of dementia. It may be that it was not AD but another kind.
Great stuff! I understand we all have to go, I just want my brain to last as long as my body! Thanks Dr Nick! Love your videos!
Thanks Joe!
Absolutely Fascinating!!! Please keep following this topic and providing updates as new data becomes available. Great Job!! Happy New Year!!
Thanks Nick! I’m apoe4 with a TBI(I’m screwed lol!) Been IN nutritional ketosis for 18 months now I’ll keep you posted lol!!
Haaaa same here 😂🎉🎉🎉 ketosis for 18 month (TBI almost 10 years ago) and my brain is clearing up. Nerves stronger. Agility in thinking and imagining and curiosity return!
All the best, @Greglemon57!
I hope you are adding some molecular distilled Omega 3 to that because omega 3's EPA and DHA is great for TBI.
@@cajampathank you!!!
@@greglemon57 If you aren't already doing red/NIR light therapy that is also good for TBI.
One of the best therapies for TBI is hyperbaric oxygen therapy. But that one is hard to do at home. And very expensive to get in clinics. But some who really need it get at home units.
I really enjoy some of these videos. It's nice to hear about research that looks very promising to impact large numbers of people in a beneficial manner in the near future.
Cheers! Hopeful!
This brings so much HOPE! Please keep this content coming Nick! Really appreciate your work!
Thank you! Will do!
But so many of the patients at the Alzheimer’s care facility where I worked only ate carbs/sweets. So many older people eat toast with jam and a half sandwich or soup then some store baked goods. My Mom is keto and is 76. She will break the mold. Perhaps we will be the generation that changes the dietary structure and see if it makes a difference. Any type of dementia is awful. Any type of prevention is worthy.
I think they crave the carbs because glucose metabolism has been shown to be impaired in brains with Alzheimer's. So, their neurons are starving for energy despite their blood glucose probably being sky-high. And since their glucose is chronically high, keeping their insulin chronically elevated, they never switch into fat-burning and produce ketones their neurons could actually utilize. So, the neurons are screaming "Feed us! We're starving to death!", and the person jams down another bagel or other high-carb meal, which would provide them with instant fuel, if only their neurons could use it.
Awesome video Nick!
I’ve seen a few case reports on exogenous ketones helping with dementia symptoms. This new research helps me understand why!
I love the open questions at the end! and it's so fascinating how ketones meet misfolding proteins, as they are lovely attracted for healthy functioning!! it's also interesting how ketones clear up instead of high blood glucose and polyunsaturated oxidized fats build up misfolding proteins
Thanks for the kind words. What do you mean by PUFA building up misfolded proteins?
@@nicknorwitzPhDfew months ago I was reading a study about highly reactive PUFA (I think about from industrial refined oils) can damage protein folding... as chronic high blood glucose ... I have to look for it again and post here. I suppose due to high vhronic inflammation impairing chaperons
@@nicknorwitzPhD pmc.ncbi.nlm.nih.gov/articles/PMC7666899/ HSP 70 is foundamental in protein folding
Yes, I thought Dr. Adkins was on to something many years ago!🎉
Thank you for sharing the new information and evidence about Ketones ❤
fantastic video once again Nick. Best in the game right now 100%. I would love to see what your general 'day on a plate' and supplementation looks like with all of the research considerations you have accumulated over the years. Especially considering you're APOE4 and a LMHR.
Appreciate that Chris. I try to resist sharing exactly what I eat both because it changes and because what I do is based on many person factors. But I eat a lot of fish and EVOO!
@ totally appreciate that brother! Don’t forget the Macadamia nuts 😉
@@chrisbrowning3313 True true ;) - you get me
@@nicknorwitzPhD I’ve recently lost a lot of weight on keto and IF but my LDL has gone up. Would more fish and olive oil help lower LDL cholesterol?
@@singamajigy supplementing b12 and copper can lower ldl. Although it may be useful to have a cholesterol test done that analyzes the types of ldl you have - and the ratio of hdl to ldl is really what matters most. Learn more about ldl. It isn’t the problem you think it is.
Thank you. I really love this channel!
So very welcome!
There is a channel called Metabolic Mind that is about treating mental issues with the keto diet.
Another channel Lauren Kennedy West is about how she used keto to heal her Schizophrenia
I know both :).
Fantastic presentation…thank you
You're welcome :)
Just found this channel. Saw only 2 videos. They are on point 👍🏼👍🏼
Wonderful, thank you.
One tiny comment, apologies.
When you say at start, "this is science" surely that should be "this is evolution" / some variant ?
I've fasted for 4 decades and ketoed for 3 decades.
Magical to hear all the nuanced science.
You've a delightful way of presenting.
Eating a ketogenic diet is absolutely the way forward!! ❤❤
And it’s yummy 😋
You are an easily understood teacher, due to your superb presentation skills.
Thanks a lot
Great video. My dad died from Altziemers at 82. I was always so scared that I might have the "Altziemers" gene. I am 62 and thank god I have been keto/carnivore for the past few years and usually only eat OMAD.
Thank you Nick for bringing this info to our attention. My paternal grandmother and father both died from Alzheimer's. I have been on a quest for all related info. BTW I have been keto for 15 years and feel great!
Just curious your age if you can provide a related insight - below 44, between that and 60 or 60+? Thanks
OUTSTANDING talk Nick! Thank you!!
Thanks!
Thanks so much!
As always, excellent presentation and research. Thanks!
This was a reply, but i wanted to put it in the main thread. Dr. Adkins put keto diets(ketosis for health and weight loss)on the map for average people in the 70's. Not the first to study ketosis, but i believe the first to write a book promoting low carb diets. He was vilified by the medical committee for his position. They did everything they could to destroy him. And he was right. To me, he is the father of the dietary keto enlightenment. And he gets no credit.
I agree.. in the 90s I met a girl who lost a lot of weight on Atkins diet.. I was a vegetarian and thought she was creating a heart attack problem for herself… I was a vegetarian for over 35 years.. totally brainwashed.. I developed pre diabetes and low energy… I just finished reading Dr Atkins book and I’m now on a Ketogenic diet and my energy so much better and blood 🩸 sugar normal
I think he gets a decent amount of credit. And if was still living, we'd be seeing him all over TH-cam being interviewed by the keto and carnivore influences. Dr. Eric Westman gives him credit all the time.
utterly fascinating.
Glad you think so!
Yes, great questioning, with far more to come! And, are other mis-folded proteins, ones associated with toxic contamination by lead or glyphosate, also mechanistically helped to be 'cleaned up' by ketones? I have become very concerned by these two toxicants potentially adding to the mis-folded protein body burdens in brain cells, either in glia or neurons, as they are so persistent in contamination across society currently. We have all accumulated lead in bone, perhaps 100 to 1000 x's those found in bone from 10KA. When the body come under stress, and needs quick additional calcium to deal with the stresses (old age, illness, pregnancy etc.) bone pool lead comes out into soft tissue again along with the calcium, at the most physiologically vulnerable times. If lead frequently substitutes for zinc during protein synthesis, yielding mis-folding (eg. zinc finger enzyme production), building up trash in the cells can be fairly difficult to phagocytose out again? And, subsequent mitochondrial function decreases, having to be disrupted by the debris, is metabolically pathogenic. Glymphatic cleanup during paralysis of quality depth of sleep, is essential yet perhaps hampered by 'blue light' toxic LED and fluorescent lighting life styles now dominating the premature switch away from incandescent light beneficial wavelengths otherwise left outdoors by current lighting? Turns out that physics actually does affect biology, and light quality IS deadly serious for maintaining deep enough sleep quality to support 'clean up mechanisms?!? This paper is a great hope toward clarification IMHO.
Very informative
Thanks Nick. Your doing good work.
Cheers :).
Fabulous video.... thank you 🙏❤
You are so welcome
An add for Mr. Jim's Detroit style pizza showed up in the middle of watching this. Wrong advertisement for this video there, Jimbo.
Google’s ad service, using the principles of surveillance capitalism, decide what ads to serve up to viewers. Google, based on what they know about me, showed me an ad for Paleo Valley’s keto products. Google decided to show you a pizza ad.
TH-cam choses according to your location and popularity of the advertiser.
The content creators have no say.
At 3:36 minutes I had to pause to process your info - it’s so simple yet so hard for the addicted carb person. I always have to bring food with me in a small cooler otherwise I might be doomed to what other people are indulging in
Many of us are carb addicted. I had to make healthy choices convenient because unhealthy foods are absolutely everywhere. All my meals for a long time were made ahead of time.
Know thyself and prepare for obstacles you can anticipate. Good work :)
Dear Barbara, I find as a 60 yo woman if I eat a 8 oz 80/20 hamburger or a can of sardines before an event, I am feeling full and satisfied at a function. Best wishes!
I am recent subscriber. Love your workd. Thanks for paper reference!
Thanks 🙏🏻… you’re very welcome
Great information, Nick!
Thanks :).
Good! Thanks Professor❤
You’re welcome Debbie!
Is there any connection of this and the use of a keto diet to help epilepsy patients?
Yes there is. Fat helps , I read it many times here and there. Please research it
Ok Nick! I need to know! How did you manage to just hit 2 homeruns with 1 at bat? Amazing! Thank You!
Thank you… I guess I’m compensating for being possibly the worst little league player of all time when I was a kid.
Another piece to the puzzle is SLEEP/ this is when the waste is removed. Apparently the reduction in blood pressure allows the vessels to be more permeable.
Google “glymphatic system”
Such a great video thank you
Please show this to dr Saladino and thomas delauer that have different views sometimes these days
Audio engineer recommendation here,
Your music volume is a bit heavier than the dialogue volume. I think your dialogue volume is good.
You could use a plugin to remove his for example on the end type of clips.
End just do some low end cut on the music about 80hz or turn down by maybe -1.5db or both
And feel free to message me with any questions
Thanks. I'll pass this on to my editor. I'm currently working on my audio game. Appreciate the feedback.
@@nicknorwitzPhDfor sure. And as a medical side note. I healed major CPTSD & schizophrenia symptoms and created a protocol by which to do so if you are interested in that info, it’s not a protocol I’ve seen anywhere else at the specificity I’ve put together, and I’ve studied medicine since I was a child.
Also, amazing videos, you’re killing it 🎉
@@nicknorwitzPhDIf I could add, make sure to normalise the audio (all audio tracks combined aka the master) to -14LUFS for the long term or very close to it for the best and consistent audio level for youtube
😮 thanks Nick.
To be honest, I have not felt better since I started doing KETO (Clean) and OMAD 8 years ago, it’s like I took some smart drugs that woke up my brain! I just hope morse people would try it out.
Drop nuts and greens (high oxylate) foods for an even clearer brain. My brain fog disappeared and only returns when I stray like last week. Bad food feeds brain fog for sure. But accepted “good” food also causes it. Only meat is free from blame in my diet.
Happy for you!
A lot of my friends’ parents who are bedridden full time are on MTC, but seems a bit too late for that. Why can’t doctors start advising ketones therapy much earlier before it’s too late??? Beats me! 🙄
@@DanzeMusicCan they also try supplementing with Ketones? Audacious Nutrition makes a good coffee and hot chocolate. Their Ketostart can cause diarrhea, I think because of the Magnesium citrate. Dr. Boz also makes ketones. The cucumber lemon is tasty without being too sour. I’m going to try these on my relative.
@@DanzeMusicmaybe science like this will change that!
I'm eat 16:8 and keeping carbs under 20%. So far, so good.
I've been eating 16:8 for forty years, I don't think it's harmful.
Currently on Day 6 of a ten day water fast. (With electrolytes)
Feeling good.
Janitors or Angels! Reminds me of The Wisdom of our Cells where biologist Dr Bruce Lipton, shows how even our thoughts as energy signals, binds to proteins and affects how poor or how well they fold.
Ooh, loved hearing from the author!
Thank you from Germany (MD).
Thank you for this share. Now really curious how this ketogenic-associated process unfolds in an α-syn/Parkinsonian condition.
Thanks Nick. Good talk.
Curious how methylation ties into this...
Not sure what the direct tie is to methylation vis-a-vis this mechanism; however, if we're talking post-translational modifications... keep in mind BHB is a PTM too: "beta-hydroxybutyrlation"
I'm curious if this could have an application in treating pryon diseases.
Authors draw analogy to prions in the paper. And, yes, it could have relevance. But I still wouldn't recommend getting Mad Cow Disease.
Amazing work!
Thanks!
Very interesting, Thanks Nick for sharing.
Very welcome
It's like the presence of ketones is used as a signal that the body could use some extra energy, so the body looks for things that it can burn. You might not want to do this when you already have plenty of glucose in the body, as that could lead to a spike in blood sugar, but when you have low blood glucose that is the ideal timing to burn some stored proteins. So the body not only stores glucose as glycogen and triglycerides, but also protein.
We know that the body recycles proteins when blood glucose levels are low (and/or when ketone levels are up), but this may be a mechanism for triggering this. I would not be surprised if it worked similarly with other proteins in other parts of the body as well.
That could have major implications. We know that ketogenic diets are beneficial for people with cancer. Cancer cells use glucose to grow, so that made sense, but this may be another mechanism. Similarly for fighting infections. When the body creates a fever in response to an infection it burns more energy to raise the body temperature, while at the same time reducing hunger. This combination increases the likelihood of reaching ketosis.
Thank you Greben!
Fascinating, and hopeful
I think so!
Some cases of glaucoma are from the tribecular mesh being clogged up with faulty proteins - could ketones helps clear this to restore normal eye pressure
Let's ask an ophthalmologist
There are testimonies of people on ketogenic carnivore that have normalized their eye pressure.
Is it the Autophagy associated with being ketogenic... Or does taking Exogenous Ketones provide this same or a similar benefit?
Very good question. But regardless of whether or not exogenous ketones ketones perform this cleanup process, they do improve cognitive function - especially in insulin resistant brain cells and/or bodies whose ability to produce ketones is compromised.
I really took this video as a proof for me doing the right thing! I am 72 so this is for me!
I wonder if drinkable exogenous ketones are molecularly the same as ketones produced by the body. If so would they be beneficial for cleaning out miss-folded proteins even if the person isn’t in Ketosis or would they not perform this function if the person isn’t in Ketosis, in itself answering this question would be valuable.
Hi! I have a question about Inuits: They have a gene that prevents them from making ketones. How is that evolutionary advantageous?
Great info. How long do you have to be in ketosis to start seeing benefits? And what level of ketosis (as per GKI) is needed for the benefits to show?
I assume we don't even need to be in ketosis but can also supplement with things that provide ketones to get the same benefits.
Im sure this is pretty individual. Why not do hour own n of 1?
Thank you Nick for every new Information 😀😀😀 Is C8 a good option ? Tahnks a lot
Of course caprylic acid C8 is a great option to get more ketones. I really like it and i will never stop using that stuff.
Try in on the skin also any kind of skin seem to love the stuff
Keep it up Nick! Love ya
Thanks! Will do! Very kind
@nicknorwitzPhD Im the one that should be thanking you!
This is some awesome science! Ty!
Glad you liked it!
Amazing! Makes me wonder if ketones (and other metabolites) could have the same effect on misfolded protein aggregates in pancreas cells that are associated with type 2 diabetes.
Well, being in ketosis reverses type 2 diabetes.
Best channel on TH-cam
Nick, love your videos! Would I be wrong to conclude that a high glucose SAD is at least a factor in AD if not directly causative? Conversely, ketosis at any level short of acidosis is not only not harmful but even protective?
Keep bringing the rain!
You would not be wrong. That is why Alz is alternatively called type 3 diabetes.
Ketoacidosis is a completely different phenomenon. Not really a worry for those who are not diabetic (especially type 1).
Yes. Ketosis is beneficial. In many many ways.
Wow, so many questions. I wonder myself what kind of reaction is causing the bonding of the ketone to these specific proteins. Is there some special catalyst in this environment to cause the reaction to occur. Where is the ketone binding to on the protein.
Got it. Would be awesome if you did a video on diet and hyperhidrosis sir
What type of fatty acids were used?
Thank you
Welcome!
Can we order the enzymatic chart behind you in the video?
+1 I would also like to purchase
My dad hand drew that while doing his PhD at Oxford in the late 80s. One of a kind!
@@nicknorwitzPhD Amazing! Transcribe to digital format and sell it 😁
@@nicknorwitzPhDcan you laminate, scan, and sell them?
Excellent!
Thank you! Cheers!
Nick I’m 56 5’11 weight 280 pre diabetic. Right on the verge of 6.5 A1C. Last LDL was around 110. Never had APO B tested. Trigs are about 170. Hesitant about low carb and too much saturated fat and red meat. Should I try a carnivorous diet?
That mechanism is amazing……… It is a BIG move beyond “eat coconut oil to slow down cognitive impairment”
Coconut oil is good to consume?
Agreed... I don't think coconut oil is going to do all the much alone in preventing AD
@ A while ago, there was a recommendation to consume coconut oil, based on a story from an MD who fed it to her husband who had MCI. It was popular for a while as an idea. Not much of a rational basis for it: just based on an N=1. I was just reflecting how there was so much more evidence supporting this idea that Nick pointed to
@@nicknorwitzPhD True. But is it true that MCTs help accelerate the metabolism to shift into fat-burning/ketogenesis?
Dr. Mary Newport was a big advocate of that.
Very interesting keep it up love your perspective 🥩🥩
Would giving c8 c10 or ketone ester help?
Really cool video and fascinating findings. I wonder how do they know a mice has Alzheimer’s 😃
Great news. Thx.
You bet!
Would exogenous sources of ketones benefit here? -- I'm thinking MCT oil as a good commercial option. Particularly for those unwilling to achieve nutritional ketosis. Also, was there a limit to the benefits after a particular blood ketone level? Where do the diminishing returns occur? I get the sense from the author that mechanisms are not known, and so it could be difficult to answer best 'dosage' of blood ketones.
A Keto/Carnivore diet for the elderly is assisted living. A high carb diet is assisted dying.
Definitely assisted suffering for sure
OMG you are so right. I went to the keto/carni lifestyle since sept 23 and my journey has been on of suffering and findings alike.
Since then I see the issues that people fight all around me, which are correlated to bad food and habits a lot.
It almost feels like a superpower to be able to see what makes them sick while being able to avoid it at the isle in the super market at the same time.
I read food lables all the time and when I stand at the cashier waiting and looking at the carts of others its pure cancer, what they are buying.
I picture it more like, overweight mid 30' ish people gasping for air while pushing their carts to the car. Cart filled with a myriad of things that brought them to this state.
Yet they still go to the super market to prolong their suffering and/ or start it even earlier (even for their kids)
Its like paying for staying sick and getting sicker evne. And the industry even makes you buy your own poison every other week and carry it home by yourself to feed you or your relatives.
Isnt that sad?
❤ love this !
My doctor is at her wits end . Except for my cholesterol, my labs are awesome . She's freaking out becuse I'm not on her bucket of pills .
When you are a post menopausal woman the drug cascade begins .
I'm a PM woman in London. No drugs. No belly pouch. I practice fasting and meat heavy keto. Yay!
I'm a 78 year old male, and keeping the doctor and his druggest pals at bay is an ongoing challenge. I recently went to urgent care for a sprained ankle and had to endure a 10 minute lecture on how I was going to die imminently of a MI unless I started taking a, statin.
@@stubloom4870 - I’m guessing the statin push was due to your high ldl? I gave up with dealing with the docs and I’m self monitoring my blood work. I’m lmhr and my ldl peaked at 623 and has started slowly coming down. I’m 366 days carnivore and zero meds at 66.
Yes, I'm a LMHR and my LDL is >350. But my triglycerides are in the 70s and my HDL is >100. My A1C is 5.4, my BP 105/65, and my BMI is about 21. All due to a slightly "dirty" carnivore WOE. But all the docs want to talk about is LDL, LDL, and LDL.
@@stubloom4870If you haven't high blood pressure high ldl isn't dangerous is my conclusion and as far as I understand these things. It has to be an over stress of the tissue from the high blood pressure for the high ldl to be an factor.
If anyone knows for a fact this is not the case. Please correct me though.
Faat for how long to benefit?
Would these same theories apply for folks who are being diagnosed with ATTR-CM which is a condition where a protein called transthyretin misfolds and builds up in the heart muscle? I understand this was a video about the Brain and we fought this battle with my father so I know first hand the cruel reality of Alzheimer's. Also fought the battle of getting my dad and mother to eat differently. But I circle back to ATTR-CM because my brother got this diagnoses early 2024 and of course there's not a lot of options. I would assume a folded protein is a folded protein to ketone bodies. Thanks for being a resource, I've followed your channel for while and a lot of the info is confirmation we're doing the right things at the dinner table.