Clot Retraction & Fibrinolysis

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Video Summary:
Clot retraction occurs by interaction of actin and myosin filaments in platelets. During the process clot oozes serum. Serum is basically plasma without clotting factors. It lacks clotting factors as they are used up in clot formation. So, it cannot coagulate. Eventually the break in vessel is repaired, so clot starts to dissolve. The process starts with tissue plasminogen activator(t-PA) which activates plasminogen that was trapped in clot when clot was being formed. Thus, the inactive plasminogen is converted to active plasmin. Plasmin degrades fibrin meshwork into fibrin degradation products. This leads to dissolution of clot. Fragments of clot are cleared by phagocytes. Plasmin also prevents unnecessary clot formation as healthy sites. Its non-specific and can also degrade other clotting factors. So, its activity at healthy sites is kept under control by plasminogen activator inhibitor which inhibit plasminogen activator and α2 antiplasmin which inhibits plasmin. At clot, fibrin potentiates activity of plasminogen activator as well as prevents active plasmin from inhibitory effect of α2-antiplasmin by occupying its active site. So, at clot, plasmin activity is higher.
● Hemostasis Physiology:
• Platelet Plug Formation: • Platelet Plug Formatio...
• Blood Coagulation Cascade: • You Will FALL IN LOVE ...
• Clot Retraction & Fibrinolysis: (Current video)
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• Warfarin (Vitamin K Antagonists): • I Will LEAVE TH-cam I...
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• Antiplatelet Drugs: • Antiplatelet Drugs: As...
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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

[@radicalarachnid475]

Wasn't able to imagine clot retraction via the diagrams in the book. Excellent animation with wonderful explanation. Thank You

[@alhaddi]

I don't know how to thank you.
I haven't seen a channel like this.

[@MurtazaMazher-st2uz]

احسنت بارك الله فيك 🤍

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I have seen multiple video, but this one is best!
Best wishes Sir!

[@s.m.zahidhasan6251]

Just awesome explanation. Thank you so much. Love from Bangladesh 🥰

[@Simplensweett]

Very clearly explained which is making easy to understand.

[@shamimaeasmin8205]

The video was so helpful... thank you sir🙏

[@richarddekoa7657]

sir this is very helpful, thank you

[@dhritikana410]

Wonderful explanation sir...This 7 min video saves my 1 hour in understanding these topic
Keep uploading videos sir 🙏🙏🙏🙏

[@NonstopNeuron]

Yes I am regularly uploading videos 😊

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so goood,thankyou so much for the simplest presentation.

[@NonstopNeuron]

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wonderful

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[@NonstopNeuron]

Glad to hear that

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So beautifully explained 🤩🧡

[@NonstopNeuron]

Thanks. Keep watching.!

[@ndmshah]

Thank you sir.
Very well explained

[@NonstopNeuron]

You are most welcome

[@Shady.Moustafa]

Very good so injection with Human Plasmin Purified will break down old blood clots ? and help heart condition ?

[@malavik]

Thank you❤🙏

[@NonstopNeuron]

Welcome!

[@bandavedasri5816]

Soo good explanation bro
Tq very much 😊

[@NonstopNeuron]

Welcome 😊

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Nice sir

[@navyaroy2324]

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[@NonstopNeuron]

Glad you like it. Keep watching.😊

[@103ksmsoreichon9]

So helpful ....thank you

[@NonstopNeuron]

Glad it was helpful!

[@shaiklathifmunnisha1426]

Very well explained

[@NonstopNeuron]

Keep watching

[@rollno.47kesharwanipratik81]

Fabulous explanation

[@NonstopNeuron]

Thanks a lot 😊

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Well explained 👏

[@NonstopNeuron]

Thank you 😊

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Excellent 😘

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Super

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Thanks

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👌🏻

[@sh8494]

Nice

[@NonstopNeuron]

Thank you

[@sh8494]

@@NonstopNeuron I am a PG student of (medical physiology). I have some doubts will you plz help me??

[@NonstopNeuron]

Sure. Whats the doubt?

[@sh8494]

@@NonstopNeuron in tissue type plasminogen activator (t-PA) or urokinase type or streptokinase type plasminogem activator what is the meaning of tissue type or urokinase or streptokinase type???

[@NonstopNeuron]

tissue-Plasminogen activator is physiological plasminogen activator. Alteplase, reteplase and tenecteplase are produced externally by recombinant DNA technology with slight variation in structure of t-PA. Thus, they are like t-PA. Urokinase and streptokinase are all different. For them, there is nothing like category as of now. Hope it clears the doubt.

[@usmansheikh4628]

First like first view

[@NonstopNeuron]

Thank you Abbubakar.!