Neuropathology in Focus: Shaping Our Understanding of Dementia

In this podcast we venture into the complex world of neuropathology. Our guests talk about their research, and uncover why neuropathology is so important to understanding dementias. During the discussion they also share a behind scenes glimpse into the workings of a brain bank, explore how brain tissue is used and how it can inform drug trials and personalised care, and provide a shock revelation about the difference between diagnosis in life, and what the brain shows after death.
From groundbreaking discoveries to the cutting-edge techniques transforming how we understand and approach brain health, this episode is an essential listen for anyone intrigued by the science of the brain and the fight against dementia.
Dr Kamar Ameen-Ali, Senior Lecturer at Teesside University hosts our expert guests, Tammaryn Lashley, Professor of Neuroscience from University College London, Dr Daniel Erskine, Senior Lecturer in Neurodegenerative Pathology and Newcastle University and Dr Laura Palmer, Manager of the South West Dementia Brain Bank at University of Bristol.
For more information on our guests work visit:
• South West Brain Bank - bit.ly/49VRVUD
• Queen Square Brain Bank - bit.ly/3SEskbH
• Brains for Dementia Research - bit.ly/3SICEiX
• Newcastle Neuro Lab - bit.ly/3SIb45d
00:00 Introductions
03:50 What is neuropathology
06:00 Tammaryn's Research
09:19 Daniel's Research
13:25 Laura's Research
17:41 What do we learn from brain tissue
19:21 Inside the South West Brain Bank
25:19 Translating neuropathology into biomarkers for dementias
28:22 Surprising discoveries
32:43 Diagnosis in life vs diagnosis from brain tissue
36:12 Brain for Dementia Research
36:57 How could we learn more
43:37 Slide scanning & AI / Digital Tools
46:50 Lessons for ECRs
52:33 Roundup and Goodbyes
Full biographies on all our guests and a transcript can be found on our website www.dementiaresearcher.nihr.a...
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This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.
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[@DementiaResearcher]

Does it surprise you to find that around 40% of the brains reviewed postmortem after donation resulted in discovering that the diagnosis the person recieved in life was probably inaccurate? And increasingly the Brain Banks are not finding one simple pathology, but complex mixed pathologies?

[@annburge291]

This backs up Dr Dale Bredesen take on Alzheimer's. He argues we need to look at approximately 40 factors. I'd like more research done particularly on diet over a long period, mould exposure and history of head injuries