An absolute boon to us med students. My professor taught this once and took an hour for this. I can revise the same pathway in less than 15 mins, with diagrams, mnemonics, concepts and clinical correlations as well. Thank you, good sir!!!
Time will come when education will b like this....its actually interesting, its simple, very logical, fun to watch, keeps attention and without noticing u just learned everything till the ending of the video!! Great stuff, Thanks man, You are really awesome!!.... hitting something that 99,9% of the professors r unable to do....
After 2 days of digging in the COX mode of action, none of the article was easy to read....found this video that made my life easy...Amazing job done boy
@@MedicosisPerfectionalis I have only one question if you please. In 5:39 you said, now you know why inhaled steroids are used to treat asthmatics. This is because they block the pathway leading to production of Thromboxane A2 and so no vasoconstriction?
No, it’s because inhaled steroids block the PLA2 and therefore decrease the level of arachidonic acid. This will, subsequently, decrease the level of leukotriens which make the life of an asthma patient hell!
When you linked it to real clinical scenarios, it felt like it clicked! Thank you! Also, I am from Australia and I am worried there are differences in the naming of certain things. Should I be worried about any differences that you know of?
Hey 👋 Emily...Thank you so much for your kind words...Brand names differ between countries, but what really helps is knowing the generic name by heart.
I never comment on TH-cam videos, but your channel is one of the best things I've ever found on the Internet. Everything is so well explained and you're so damn funny. A huuuge thank you ❤️
great video...just curious about how does the NSAID drug inhibits the cyclocygenase? like the functional groups present within the binding site etc....
Got curious about cox 1 and cox 2 because celebrex only inhibits the latter and I'm wondering why I'm still in pain compared from when I took ibuprofen before getting prescribed celebrex. I have otitis externa. From what I understood, I shouldn't be in pain. This is coming from a non-pharmacy student. Thank you very much by the way for having this lecture free for everyone to learn. :)
One might have tought: maybe if you inhibit COX1, since COX2 still works and can't make TXA2, it can make more PGI2 when not racing against COX1 for PGH2 thus decreasing the risk of clotting more than non-selective COX inhibitors?
You are great! I am beside myself angry with uneducated nurses shaming me for managing pain after a surgery without NSAID’s (asthmatic). I don’t know why in the hell I have to do all of this research myself as a patient. I have learned a lot but this is aggravating. Anesthesiologist understands it. What do I tell these people? Please help
Thank you 🙏 I appreciate your comment! I really admire your perseverance and the fact that you are doing all of this research even though you’re not a doctor! Hats off to you!
@@MedicosisPerfectionalis well my friend, I’ve always had interest in the medical field…. being a seasoned IT veteran, many of those whom which I’ve helped have called me a doctor anyway, lol. Being an analytical thinker to begin with, they have some alignment. Anyway if anybody would be kind enough to provide their two cents I would love to hear it. Obviously it’s not going to be taken as any sort of medical advice I promise! More or less,, direction,, would be nice or references to material that I can study. Just trying to feel better as all. And I’m in such a small group of people apparently. Asthma exacerbation caused by classical NSAID’s with persistent nasal polyps and contact dermatologist. I’ve been called lucky in the past by several people. Evidently as my life continues I realize I am always gaining on that forefront LOL…
You are absolutely the best at explaining things in a way I understand! And you're so funny, my 14 year old watches you with me just to hear you're jokes
Hello! I love this video, thank you! I would like to ask about the PGI2 - prostacyclin, its COX-1 and COX-2? At your "game" COX 2 OR COX 1 you left PGI2 out :)
Hi, I love your videos. However I don't think the vignettes at the end are accurate and may confuse medical students here as the pain management suggested is only viable in a utopic world. Experience teaches us that this is not viable. 1) COX-2 inhibitors are frequently used for arthritic pain. But we must remember that patients with arthritis tend to have cardiovascular issues so these should be used with extreme caution. COX2 inhibitors may be more viable in younger athletes with joint pain. 2) COX-2 inhibitors are to be avoided in the post-operative phase because they may augment the stress response to surgery, possible even putting the patient in DIC. 3) I honestly have no idea what this is (I'm just a stupid surgeon) and will not dwell on this. Apart from that, keep up the really good videos!
how is PGI2 decreasing in COX 2 inhibition? It should be promoted with TXA2 right? and there can be balance. Isnt PGI2 coming under COX1 control? please help thanks :)))
Hi, very informative video thanks for it. I have a question for you, my diet was high ( now realized) in Salicylates & histamine for few months. After all I am now suffering from Chronic Sinusitis & hypersensitivity to salicylates in food. As COX is blocked. My question is how you unblock COX. Even a tiny amount in food gives me bloating. Can salicylates free diet for long term will help? Or reducing omega 6 & boosting? omega 3 will help. Thanks
So does this pathway, work differently in different cells. So the membrane phospholipids of platelets dont produce leukotrines do they. So its not really at multiple choice pathway but a single choice depending on what cell you are?
hello, have an pharmacology text book "pharmacology for health professionals 5th ed, by B, Byrant & K, Knights, and it says that it is PGI2 with COX1 inhibition that causes gastric ulcers, not Thromboxane A2 and now im confused to know which is right. Could you please be able to explain why the text book may be saying this and why you have said otherwise? Thank you :)
@@MedicosisPerfectionalisoops my bad, then what causes gastric ulcers more specifically other than just saying COX 1? I just want to learn thank you :)
There are some prostaglandins that protect the stomach...These prostaglandins are produced thanks to COX-1...When a drug inhibits COX-1 and COX-2, the protective mechanism is destroyed. However, when a drug selectively inhibits COX-2 only, the stomach is in good shape because COX-1 is uninhibited...Hope it helps!
What happens if you combine classical (COX-1 + COX-2) and new NSAIDs (COX-2 only)? Could you mix these in a way which balances out the bleeding vs clotting risks to make the medicine not impact this aspect at all?
Don't miss my 50 hematology 💉 cases, limited availability, go to www.patreon.com/medicosis/
where is microbiology.cardio-diseases,respiratory disease
On their way
Medicosis Perfectionalis
Where can I get COX2? I’m going to have a surgery in October. Don’t want to take NSAIDS .
Thank you you !
i guess Im kind of off topic but do anybody know of a good place to watch newly released movies online?
@Alexis Ernesto Lately I have been using FlixZone. Just google for it =)
An absolute boon to us med students. My professor taught this once and took an hour for this. I can revise the same pathway in less than 15 mins, with diagrams, mnemonics, concepts and clinical correlations as well. Thank you, good sir!!!
I am honored!
Kindly help me by sharing my videos with others!
Time will come when education will b like this....its actually interesting, its simple, very logical, fun to watch, keeps attention and without noticing u just learned everything till the ending of the video!!
Great stuff, Thanks man, You are really awesome!!.... hitting something that 99,9% of the professors r unable to do....
Thank you ☺️
i didn't know that i can laugh so hard watching a pharmacology video....
😂😂
Learning should be fun!
Me neither!!!!!! 🥰🥰🥰🥰🤣🤣🤣🤣🤣🤣🤣
You made pharmacology fun to me !! Thanks
I'm so glad!
I'll never understand how you can teach complex things, that even professors find difficult, so easily. Thank you so much sirrr❤
💊 Pharmacology Playlist: th-cam.com/play/PLYcLrRDaR8_d5RzuEJprW-NWXTK22ByVC.html&si=MGlX4_a2LlLOo6Ed
Thank u for saving those of us struggling in biochem
My pleasure!
Damn, this video is funnier than most of the stand up comedies🤣
Thank you so much 😊
You're definitely the best 😩😩how can one ever forget the concept 🥰🥰
Thanks a million! I am honored!
if the cell membrane is 55% protein and 42% lipid.. why isn't it called lipoprotein bilayer?
These are the best videos! Man, I am just a regular person with no medical education just an interest. You make it understandable and entertaining.
Thank you 😊
You make it a point to respond to every comment. You’re a great teacher❤
I am honored!
spent hours looking up this stuff online, this video couldnt have been more helpful !!!
the BEST teacher ever, I wish you could teach all of my lectures.... these videos are pure gold.
Thanks a million, dear!
I am speechless.
Can you please help me by sharing?
@@MedicosisPerfectionalis shared with my classmates!!
Hi sir 🥰 you are saving me every time I have an exam..
Sending gratitude and love for you 🥰🥰🥰
You are a great human being
Thank you so much 😊
I appreciate you!
This video is pure gold. Funny and informative!! Concepts well explained
Bro love the video, the sarcasm is great. It's funny, the way you talk is the same way I talk to myself when I'm studying. Thanks for making this!
You're very welcome 😊
After 2 days of digging in the COX mode of action, none of the article was easy to read....found this video that made my life easy...Amazing job done boy
Thank you so much 😊
@@MedicosisPerfectionalis I have only one question if you please. In 5:39 you said, now you know why inhaled steroids are used to treat asthmatics. This is because they block the pathway leading to production of Thromboxane A2 and so no vasoconstriction?
No, it’s because inhaled steroids block the PLA2 and therefore decrease the level of arachidonic acid. This will, subsequently, decrease the level of leukotriens which make the life of an asthma patient hell!
Medicosis Perfectionalis u r awesome..thanks a lot
Thank u thank u thank u. Honestly love people who are make sure to help others by education and other things they can offer the society with
Thank you 🙏
When you linked it to real clinical scenarios, it felt like it clicked! Thank you! Also, I am from Australia and I am worried there are differences in the naming of certain things. Should I be worried about any differences that you know of?
Hey 👋 Emily...Thank you so much for your kind words...Brand names differ between countries, but what really helps is knowing the generic name by heart.
El mejor video de quimica que he visto sobre la ciclooxigenasa :D
🙏🙏🙏
Sometimes I think you know me better than I do, because as soon as I have a question, you immediately answer it!
Haha 😂
i really love your sarcasm and funny jokes, this is my first video and i cant help but to subscribe. thank you very much !!
Thank you so much 😊
Informative and humorous.... as always... a winning combo.
Thank you so much 😊
Can you please help me by sharing?
great presentation thank you from a non academic studying herbs!
Thank you!
oh how I wish you were my pharmacology professor. This makes so much more sense now!
Awesome 👏
I never comment on TH-cam videos, but your channel is one of the best things I've ever found on the Internet. Everything is so well explained and you're so damn funny. A huuuge thank you ❤️
Thank you so much 😊
I am honored!
iv never heard an into this insanely cooooll
Thank you so much!
great video...just curious about how does the NSAID drug inhibits the cyclocygenase? like the functional groups present within the binding site etc....
This video is great! Thank you! I understood everything! 🎉
My pleasure!
I found you just before our exam! I feel so lucky. Sending love! Thank you for the fun-niest learning💚
Thanks a million, dear :)
I truly appreciate it.
If you have time, can you please help me by sharing?
U got a nice way of teaching...keep it up...good job man...i like ur style
Thanks a million!
I love the prostacyclins keep the blood "cyclin" that helps me actually recall PGI2 function!
Thank you 😊
Awesome video. I am currently writing an article about this subject, and it was really informative and entertaining. Keep it up.
Thank you 🙏
first video i saw, you already earned my loyal subscription
Thank you so much 😊
Got curious about cox 1 and cox 2 because celebrex only inhibits the latter and I'm wondering why I'm still in pain compared from when I took ibuprofen before getting prescribed celebrex. I have otitis externa. From what I understood, I shouldn't be in pain. This is coming from a non-pharmacy student.
Thank you very much by the way for having this lecture free for everyone to learn. :)
My pleasure 😇
I am sorry for your pain, but I really don’t know...Please talk to your doctor.
Sir u have great sense of humor
Thank you ☺️
I'm subscribing purely for your laugh. The personality in this video makes me actually enjoy pharmacology
I am honored! Thank you 🙏
Very creative ways of nomenclature,doctors are geniuses...🤣🤣🤣
Haha 😂
One might have tought: maybe if you inhibit COX1, since COX2 still works and can't make TXA2, it can make more PGI2 when not racing against COX1 for PGH2 thus decreasing the risk of clotting more than non-selective COX inhibitors?
you are better than my uni teacher
Thank you so much ☺️
thank you u got a new follower , im pharmacy student and this is way better thanhow my professor explain
Thanks 😊
Can you please help me by sharing it with your colleagues?
man, I fucking love you and your sense of humor
Thank you so much!
what an explanation man😍😍😍.....thank you for making it easier and funny👍🏻👍🏻
My pleasure 😇
You are great! I am beside myself angry with uneducated nurses shaming me for managing pain after a surgery without NSAID’s (asthmatic). I don’t know why in the hell I have to do all of this research myself as a patient. I have learned a lot but this is aggravating. Anesthesiologist understands it. What do I tell these people? Please help
Thank you 🙏
I appreciate your comment! I really admire your perseverance and the fact that you are doing all of this research even though you’re not a doctor! Hats off to you!
@@MedicosisPerfectionalis well my friend, I’ve always had interest in the medical field…. being a seasoned IT veteran, many of those whom which I’ve helped have called me a doctor anyway, lol. Being an analytical thinker to begin with, they have some alignment.
Anyway if anybody would be kind enough to provide their two cents I would love to hear it. Obviously it’s not going to be taken as any sort of medical advice I promise! More or less,, direction,, would be nice or references to material that I can study. Just trying to feel better as all. And I’m in such a small group of people apparently. Asthma exacerbation caused by classical NSAID’s with persistent nasal polyps and contact dermatologist. I’ve been called lucky in the past by several people. Evidently as my life continues I realize I am always gaining on that forefront LOL…
2:31 in the name of God The most merciful
بسم الله الرحمن الرحيم
💜
Thanks for this, I'm working on a article. This gave me a great insight.
Yay 😃
You are absolutely the best at explaining things in a way I understand! And you're so funny, my 14 year old watches you with me just to hear you're jokes
I didn't know when clicking on this video I'd laugh, let alone how much I did. Amazing work ahahhaa
Thank you so much 😊
should be called sassy science. loved it tho
😂
Thank you very much
I always love watching your video
Your video help me alot ❤
I am honored, Mary!
THIS HELPED ME SO MUCH!
Awesome 👏
It was great. So simple and easy to remember way of teaching
Thank you so much 😊
@@MedicosisPerfectionalis may you make a lecture about antipsychotics?
Amazing but i have one question so cox-1 is responsible for stomach protection by which prostaglandins is it PGE2 but its also responsible for pain
thank you! you just saved my LIFE
My pleasure 😇
Hello! I love this video, thank you! I would like to ask about the PGI2 - prostacyclin, its COX-1 and COX-2? At your "game" COX 2 OR COX 1 you left PGI2 out :)
I was not bored for a single miN lol thanku! really helpful
Wow 🤩
Thank you so much 😊
Thanks alot for your easy simple entertaining Explanation 💜💜.. really appreciate it !! You are awesome
Thank you 😊
The best lectures!
Thank you so much 😊
You are amazing , I’m in love with your lectures
Thank you so much 😊
I am honored!
Hi, I love your videos. However I don't think the vignettes at the end are accurate and may confuse medical students here as the pain management suggested is only viable in a utopic world. Experience teaches us that this is not viable.
1) COX-2 inhibitors are frequently used for arthritic pain. But we must remember that patients with arthritis tend to have cardiovascular issues so these should be used with extreme caution. COX2 inhibitors may be more viable in younger athletes with joint pain.
2) COX-2 inhibitors are to be avoided in the post-operative phase because they may augment the stress response to surgery, possible even putting the patient in DIC.
3) I honestly have no idea what this is (I'm just a stupid surgeon) and will not dwell on this.
Apart from that, keep up the really good videos!
Hello sir, can you please do a general pharmacology videos
I have an entire series of videos (course) about general pharmacology here: www.medicosisperfectionalis.com/products/p/general-pharmacology-course/
how is PGI2 decreasing in COX 2 inhibition? It should be promoted with TXA2 right? and there can be balance. Isnt PGI2 coming under COX1 control? please help thanks :)))
PGI2 is via COX-2
I assumed PGI2 comes under COX 1 coz COX2 selective inhibition allows COX1 function to occur unopposed..
Everithing looks clear now! Awesome vid, thanks...
You’re very welcome, bro!
YOU ARE FREAKIN FUNNY. I love it. Learned so much.
Thank you so much 😊
This was really helpful
I am glad 😃
Can't thank you enough for this content.
My pleasure 😇
Awesome video!
Do steroids as well increase the risk of peptic ulcer ?
Thank you for the video! Which one makes PGI - COX1 or COX2?
PGI2 is by COX-2...Mnemonic: 2 by 2
Cyclooxygenase 1 and 2 begins at 6:15 for those that only need that information.
I wish i could shake my hand with you..just awesome man., 💜💜💜💜
🤝🤝🤝
@@MedicosisPerfectionalis 😂😂 handshake in online is like this
😁😁
@@MedicosisPerfectionalis 💚💙💚💙
👍😍😍
Amazing Video, Thank You for sharing your Knowledge with us.
Hi, very informative video thanks for it. I have a question for you, my diet was high ( now realized) in Salicylates & histamine for few months. After all I am now suffering from Chronic Sinusitis & hypersensitivity to salicylates in food. As COX is blocked.
My question is how you unblock COX. Even a tiny amount in food gives me bloating. Can salicylates free diet for long term will help?
Or reducing omega 6 & boosting? omega 3 will help. Thanks
Why was only Rofecoxib removed and not other COX 2 selective NSAIDs? Don't they all increase the risk of blood clotting because like you said at 9:44?
Theoretically you are correct, but in the real world, there seem to be a difference.
Great teaching..... Bless up
Thanks 🙏
Can you please help me by sharing?
So does this pathway, work differently in different cells. So the membrane phospholipids of platelets dont produce leukotrines do they. So its not really at multiple choice pathway but a single choice depending on what cell you are?
Brilliant video!!
Thank you so much 😊
Can you please help me by sharing?
THANK YOU VERY MUCH! YOU ARE JUST AMAZING!!
Thanks a million 😎
This is amazing, thank you so much!
My pleasure 😇
I really love this teaching yo perfect 👍🏼
Thanks a million!
YOU ARE AMAAAAAAAAAZING...THANK YOOOOOU
My pleasure 😇
Very helpful and fun in learning.
Thanks a ton!
I couldn't thank you enough !
Can u plz answer why diclofenac sodium is enteric coated while potassium is not?
It’s just the manufacturing process.
They simply succeeded in coating the diclofenac sodium.
You are amazing. Thank you for your videos♡♡♡
My pleasure 😇
hello, have an pharmacology text book "pharmacology for health professionals 5th ed, by B, Byrant & K, Knights, and it says that it is PGI2 with COX1 inhibition that causes gastric ulcers, not Thromboxane A2 and now im confused to know which is right. Could you please be able to explain why the text book may be saying this and why you have said otherwise?
Thank you :)
I never said that inhibition of thromboxane A2 causes gastric ulcers.
@@MedicosisPerfectionalisoops my bad, then what causes gastric ulcers more specifically other than just saying COX 1? I just want to learn thank you :)
There are some prostaglandins that protect the stomach...These prostaglandins are produced thanks to COX-1...When a drug inhibits COX-1 and COX-2, the protective mechanism is destroyed. However, when a drug selectively inhibits COX-2 only, the stomach is in good shape because COX-1 is uninhibited...Hope it helps!
@@MedicosisPerfectionalis thank you very much :)
My pleasure 😇
WOW... Just WOW :)
Thank you so much 😊
My GOAT🐐
Thank you so much!
Stupid stuff you learnt in physiology 😂 you made my day , i enjoyed this lesson , thank you
What happens if you combine classical (COX-1 + COX-2) and new NSAIDs (COX-2 only)? Could you mix these in a way which balances out the bleeding vs clotting risks to make the medicine not impact this aspect at all?
I think... i can use it for AUB for peptic ulcer girls instead of tranexamic acid... Can't I?
Thank you ❤😘
My pleasure 😇
awesome video .got solid concepts!
Great 👍
Ahahha never enjoyed studying before thank you
My pleasure 😇
Thank you soo much sir ❤
Most welcome!
How I’m get this paper of lecture??
Thankyou so much🙌
My pleasure!
Hi whose voice are in these vids? He’s pretty hilarious. 🎉🎉What’s his name?
Its fun to watch these videos on 1.5X Speed. The Jokes land very well
Haha 😂