I reached my plateau 5 months ago. I had to face that continued use of Mounjaro and the calorie deficit I was sustaining was not healthy. I had hoped to achieve a BMI of 24, and I was at 27. I decided that I needed to get off Mounjaro and continue to maintain reasonable dietary and exercise habits, and work on regaining lost muscle mass. In the 5 month that followed I got a trainer for a month and strengthened my resistance and cardio training program. I put on a few pounds and my BMI is up to 28. But I am so proud of my new found body, and feel like I am the best me I can be. I weigh less and have a smaller waist than when I graduated high school. I have respectable arms, shoulders and legs, and I am proud of my body for the first time in many decades. I hope my new lifestyle affords me a bit more muscles in my butt, as sitting on a flat a__ is not comfortable. Life is pretty good at 73 years old. 🎉
Same here! I've not lost anything in 6 months. I'm on Ozempic the highest dosage. I went from a size 20 to a size 12. I'm 64 yrs old. I'm happy with my weightless, however, I'd love to lose another 15-20 lbs. I'm thankful for this video too, it's helped me understand what's going on! 🤩
I started in March ‘23 and hit a stall around the end of November. I never had full food suppression but Mounjaro stopped my snacking. I maintained my 71lbs weight loss up until this month and I started getting back to basics and did a “stall” series. I got back to what I found success…increased protein and veggies, daily walks, strength training, hydration and sleep. Lost 9.2lbs in 3 weeks. Now I am close to 80lbs down and not once did I starve myself or stay under 1300-1400 cals. Plateaus happen with or without injectables, you need to be patient and make simple changes and the weight loss will pick up.
Thank you so much for making this video, because I really thought something was horribly WRONG with me, and that's why I wasn't losing weight these last few weeks. Now I can feel better, going forward.
I barely ate and lost 25 lbs in four months. I have plateaued for few months on Ozempic. If I cut back calories I will have nothing to eat. I also workout on weight training three times a week on heavy weights.
Thank you, Dr. Dan. Definite plateau of 8 months on Ozempic .50 mostly. Not diabetic. Changed to Mounjaro last week 2.5. Do you think this will help? I only have 10 or 15 pounds to lose.
Thank you for the amazing video. I reached the plateau for almost 3 months, talked to my dr and now I increased my dose to1 g of ozempic. I guess I need to exercise to start loosing weight again.
This is very useful information. Yes it is a lot to do with self perception and weight loss goal. I know why I have reached a plateau, a long hard look at my diet 😢 changes are needed. Healthy ones.
I enjoy your breakdowns whenever I come across them. I've encountered something that strikes me as counterintuitive and I'm trying to figure out the science behind it. I'm not sure if you've covered it, or know anything about experiences similar to mine, so I'll summarize real quick. I was on Ozempic for a while and it worked great, was off it for a while and maintained the lost weight until food prices went mad and I had to change eating habits in order to avoid going without food. I've now regained all the weight in terms what the scale reads, but unlike other times I've lost and regained, my measurements have stayed what they were at the lowest weight on Ozempic. I expected a couple of clothing items to not fit around my hips properly (as they had before ozempic) but since ozempic, the clothing fits around my hips still despite regaining the weight, the measuring tape reads the same. This surprised me, as I don't think I've put on muscle or something like that. I'm not sure if ti's a matter of the fat distribution going to different parts of the body or what. The thing that really sticks out to me as counterintuitive is that I have more loose skin after regaining the weight than I did when I was on Ozempic or the 6 months off of ozempic when my weight was maintained. This is counter to all previous experiences of weight regaining, so I'm wondering if the ozempic had something to do with it? Also, I never had experienced dumping syndrome until I was on ozempic, figured out quickly how to avoid it. But now, even though about a year has passed since I was last on Ozempic, I'll occasionally have episodes of dumping syndrome sneak up on me. Most of the episodes I can figure out what set it off, but others have me absolutely befuddled. I'm wondering if I'll have occasional bouts of dumping syndrome for the rest of my life (if I'm not careful) because I was on Ozempic? I've not found much when looking for similar experiences, but I may just not be looking in the right places. If you happen upon any cases similar to mine or studies that cover similar experiences, I would love to see a video on it, but no pressure or worries if it's not feasible.
There are a lot of factors to consider here. There is no data to say the meds can lead to fat redistribution - resistance training can. But if your measurements are all the same and your diet had to change to what I am assuming is more processed/higher salt foods, I suspect you've taken on a lot of water weight vs. fat. Alternatively, your scale is potentially inaccurate now and is giving you incorrect readings. As for dumping syndrome unless you've had surgery that shouldn't be occurring even with the medication. In fact the glp1 meds are sometimes used to treat dumping syndrome. I'd recommend more investigations with your doctor and looking at other potential GI conditions ie. IBS.
Are most people taking Ozempic/Wagovy/Mounjaro at the beginning of their weight loss journey? I only added the medication after failing with only diet and exercise (dietician, gym trainer). I was able to keep the weight off for 15 months, but eventually started slowly gaining the weight back. I am taking the medication to hopefully allow me to maintain my weight with a healthy lifestyle. (I may be an unusual case since type-1 and type-2 diabetes runs in my family. Willpower/lifestyle do not make the beta cells in your pancreas regenerate)
Depends on the individual, many people who come through the door have an extensive history of diet and lifestyle attempts. Albeit some are fad diets etc. So it is often the case we will pair a better approach to diet and lifestyle while also utilizing medication to help someone lose weight and like you said keep weight off.
Somehow I doubt it... people don’t usually start with medication. I ended up asking for the GLP-1 after years of failed attempts at losing the weight I put on when I became hypothyroid 🫤 I definitely had metabolic issues in addition to the hypothyroidism. Prior to that I was roughly the same weight my whole adult life. Mounjaro got the scale moving in the right direction after years of frustration, it’s been life changing.
Should be a very interesting topic. 👌 Dan, hope that one aspect of it you address is the ‘stalls vs brick walls’ part… IOW, when is it a *’stall’* , meaning further lifestyle changes or an increase in dose can get you unstuck (if you’re not maxxed already), OR, is it a *‘brick* *wall’* , meaning, you’ve likely gotten all there is to get from the drug regarding weight-loss, and maybe it’s time to consider either supplementing the medication with an add-on med (metformin? etc), or switch to an entirely new med altogether (ex: Ozempic/Wegovy-to-Mounjaro switchers, and vice-versa). Obviously a common thing, ‘cuz, if you’ve got say 100+ lbs to lose/40+ percent of your body weight, typical results with any current weight-loss med will not get you all the way there. Even with significant lifestyle changes alongside it. 💪🏻 🚴 🥗 And even with you not trying for a ‘supermodel or male model’ BMI. 😑
@Clark Or, a simple meds switch, perhaps. Kim over at Plus SideZ lost a lot of weight on Wegovy, then stalled for several months (‘brick-walled’) on it. She then switched to Monjauro, and resumed losing weight. 👍 I assume one could hopefully also get the same result starting on Monjauro, and then switching to Wegovy. 🤔 Bariatric surgery yields great results, but I tend to think of major surgery as a last resort (and suspect many ppl feel similarly).
@@cloaksterMounjaro is shown to be much more efficient than Wegovy for weight loss in comparative studies, it makes sense that she started losing again when she switched.
Taken my 2shot of 1mg and in total im on ozempic for 4 weeks- weight has stayed same was 83.4 kg before starting and ive been 80kg for the last few weeks. Due for my 3rd 1mg shot today.
I didn’t have a “plateau” but Ozempic did stop working for me. Lost 70 lbs kept It off for two years then all the sudden then weight started to creep back On and food thoughts came Back. Tried upping the dose but did nothing :(( not sure what the solution is but I’m having trouble again and don’t want to go fully back to my high weight
I’m not on ozempic and on metformin but sustaining lifestyle changes is essential for long term change and seeing that with my own experience. I have lost a lot of weight but it has slowed some so this video was really helpful.
It never fails, with my plateaus, there is always one little bad habit I can think of (iced coffee at the moment) that would help & if generally does even if it’s a little bit. But that’s really how healthy weight loss (mentally and physically) should be - small steady, consistent steps - practice & 1 iced coffee instead of 2 😂
@Dr.Dan Isn’t that one of those things that’s ‘technically true, but doesn’t quite tell the whole story’? I mean yes, the Ozempic’s still in your system, and yes, if you’re plateauing that means you’re not in a calorie deficit… but WHY are you not in a calorie deficit anymore? 🤔 There’s a couple of usual suspects, but a major one is that your calorie intake has increased. Could that be because the Ozempic (or other WL drug) isn’t working as well anymore (at hunger-suppression & other things), because you’ve built up a tolerance to your current dosage? And if tolerance somehow isn’t a thing, then wouldn’t only *one* dosage be offered, aka the starter dose? 🤷♀️ After all, in most all of the clinical trials for Ozempic/Wegovy, Mounjaro, etc, the weight loss slowed after a certain amount of time and eventually nearly stopped… even at the maximum dosage. I think a lot of this is the body ‘fighting back’ after you’ve lost a lot of weight by turning down your metabolism and turning up the hunger response… but this still speaks to WL drug tolerance, since any drug help in fighting this increased hunger response would be *very* welcome, and maybe even required for most ppl in order to get back to being in a calorie deficit. Just sayin’. ✌️
@cloakster You are almost there. So I think you are confusing a couple of ideas. Tolerance is your body is used to the current dosage and requires a higher dose to get the same effect as a previous lower dose - this sounds like what might be happening with these drugs but not quite. Instead Opioid medications are a great example of this. In the case of opioid meds, the body downregulates receptors and responses, thus needing higher doses for the same effect. In the case of glp1 meds, a tolerance doesn't develop. Receptors don't downregulate, and the meds are having the same effect over time - see STEP5 trial. People also maintained weight successfully over a 2 year period with minimal regain. A single dosage isn't offered largely because everyone has different responses and requirements. Some do great on 0.25mg, and others need 2.4mg. You are correct about biology, and that is what most people are fighting with. You see the same response when someone goes on a low cal diet or is too restrictive. They can white knuckle it to a point, then something happens, and biology bites back and they binge, overeat, etc. Same thing with these drugs. We need to understand and respect biology. If it is biting back, it's a good indication that what one is doing is too restrictive and ultimately will not be sustainable. Sure, we could pump more drugs in, but to what avail? You might get temporary benefits, but if you aren't working on all the other aspects of your lifestyle. Biology will rear its head again. Hence why these meds are just a tool. To successfully lose weight and keep the weight off long term with or without drug is about striking a balance. A balance between sustainable behaviors and your biology. Drugs just make engaging in the behaviors you want a little easier and can certainly allow you to achieve a lower weight to a certain point. The reason I spend so much time asking why? Why do you need to lose another 10 lbs? What will it actually do for you? Is because if losing thar weight leads you to not having the above balance again even with the drug. It's only going to be a temporary loss. You can switch drugs, you can get surgery, or what have you, but every single situation will end with the same result if everything else isn't taken care of. So it's not a tolerance. It's biology, but more importantly, it's what kind of life you want to live?! Too often, people hyperfocus on a number and will go to any extremes to achieve it but ultimately miss what is actually important in life.
Wow finally found real talk on this subject. I would like to ask you a lot of questions. First off im 58 6'4" and have weighed around 220lbs most of my life. had bad reaction to covid in march 2020. after that weight sky roketed. few weeks ago went to DR was 380lbs blood sugar was 121. The dr put me on Ozempic. Well that not only took appetite away but also the bad cravings. Other videos I have watched say's to maxamise weight loss keep your calorie's below 1200. After two weeks I have lost 16lbs and sugar droped 5 points. but am I going about this wrong?
My God. Who is making these videos?! No 1200 cals is not the answer. You need a much higher and sustainable amount of cals with a focus on protein. Check out my other videos for more details.
I've lost 64 lbs since February, and after I lost the first 30 lbs, I decided to get on semaglutide to keep my progress going and I lost the other 34 lbs, and now my body just stopped at this weight. I've been at the same exact weight for a month now... I haven't changed my diet at all, and I even started walking on the treadmill and I'm still not losing, and I have like 45 lbs left to get to my goal weight but I don't know how to get get the process going again. 😒
"with Ozempic" should not be in the title of this video. (It is super fascinating that you are pharmacist, but don't mention medication changes) One obvious answer from my perspective is to switch to Wagovy that allows higher doses than Ozempic since they are identical medications. Rebelsus (same medication as Ozempic) might be the answer when 25 mg/50mg get approved. Rebelsus is a daily pill so better uniformity of impact over the week than a weekly injection. Or you could switch to Mounjaro which showed better weight loss than Wagovy in clinical trials.
@Clark I also was hoping that Dan would’ve addressed medication changes/switches in the vid. But in retrospect, probably that wasn’t realistic of me, as Dan’s in Canada, and there’s still a dearth of powerful weight-loss med options there. 🇨🇦 Mounjaro? Approved, but not yet available. Wegovy? Approved, but not yet available. High-dose Rybelsus? Still in trials, so not approved *anywhere* yet (as you said). 🤨 So right now, in ‘top-tier’, best-in-class WL meds, Dan has… off-label Ozempic to work with, pretty much. That’s it. 🤷♂️ So yeah, I guess he can’t really speak much to meds-switching as a technique, since probably all he sees of that so far are switches between weaker older drugs (like Saxenda or Trulicity), and Ozempic.
@@cloakster Excellent points about Canada. I guess that this video assumes you are already on the top on-label dose for Ozempic (2 mg), and have reached a plateau?
@@kateburns1023it’s not yet approved for weight loss; I’ve read that the FDA is currently fast-tracking it and they’re expecting to have it approved by the end of the year. Very exciting. 😅
I’m trying to switch to see if mournjorno helps me get boosted back after regaining some weight and Ozempic no longer working as it did, but finding it hard with dose shortages and prices in Canada :(
Any. Weight loss journey you will have the body asking you want me to do what?! It is a survival mechanism. Are you drinking pure water? Are you getting electrolytes? Are you eating cleanly or are you taking an injection and still eating carb laden meals without changing thing? Do you eat sugar or flower? I had to do without. Any corn derivative in artificial sweeteners. I was stalled. Have you measured? That helps when the scale is not moving.
This podcast is just psychobabble about calorie deficit to lose weight. He completely ignores the role of Ozempic and the plateau which comes after use and why it happens. He says to just reduce the overall calories consumed. That is hardly helpful at all. Ozempic works by increasing insulin secretion from the pancreas which, in turn, allows for the sugar/carbs to enter the cells through the receptors. The real question - which he completely ignores - is why does that hormonal process stop working after taking Ozempic for some time.
The point of the drug is to control the food cravings. If I can control the food cravings without the drug, then why would I need the drug? And why would anyone be overweight in the first place if they can just control their diet????
Yes, but as I stated in the video biology is a powerful force and cravings will increase beyond what any drug can suppress. To manage biology in conjunction with the drug you need to ensure you are achieving adequate nutrition as you should for general health. Perhaps watch the video again?
I reached my plateau 5 months ago. I had to face that continued use of Mounjaro and the calorie deficit I was sustaining was not healthy. I had hoped to achieve a BMI of 24, and I was at 27. I decided that I needed to get off Mounjaro and continue to maintain reasonable dietary and exercise habits, and work on regaining lost muscle mass. In the 5 month that followed I got a trainer for a month and strengthened my resistance and cardio training program. I put on a few pounds and my BMI is up to 28. But I am so proud of my new found body, and feel like I am the best me I can be. I weigh less and have a smaller waist than when I graduated high school. I have respectable arms, shoulders and legs, and I am proud of my body for the first time in many decades. I hope my new lifestyle affords me a bit more muscles in my butt, as sitting on a flat a__ is not comfortable. Life is pretty good at 73 years old. 🎉
That is effing amazing Gregg! I'm so happy for you.
Congratulations
Same here! I've not lost anything in 6 months. I'm on Ozempic the highest dosage. I went from a size 20 to a size 12. I'm 64 yrs old. I'm happy with my weightless, however, I'd love to lose another 15-20 lbs. I'm thankful for this video too, it's helped me understand what's going on! 🤩
I started in March ‘23 and hit a stall around the end of November. I never had full food suppression but Mounjaro stopped my snacking. I maintained my 71lbs weight loss up until this month and I started getting back to basics and did a “stall” series. I got back to what I found success…increased protein and veggies, daily walks, strength training, hydration and sleep. Lost 9.2lbs in 3 weeks. Now I am close to 80lbs down and not once did I starve myself or stay under 1300-1400 cals. Plateaus happen with or without injectables, you need to be patient and make simple changes and the weight loss will pick up.
Thank you so much for making this video, because I really thought something was horribly WRONG with me, and that's why I wasn't losing weight these last few weeks. Now I can feel better, going forward.
I barely ate and lost 25 lbs in four months. I have plateaued for few months on Ozempic. If I cut back calories I will have nothing to eat. I also workout on weight training three times a week on heavy weights.
You are consuming too few calories!!!
Very informative. Thank you for the advice.
🥰🥰
Thank you, Dr. Dan. Definite plateau of 8 months on Ozempic .50 mostly. Not diabetic. Changed to Mounjaro last week 2.5. Do you think this will help? I only have 10 or 15 pounds to lose.
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Thank you for the amazing video. I reached the plateau for almost 3 months, talked to my dr and now I increased my dose to1 g of ozempic.
I guess I need to exercise to start loosing weight again.
That's where I'm at... I gotta add in exercise to get past this plateau
This is very useful information. Yes it is a lot to do with self perception and weight loss goal. I know why I have reached a plateau, a long hard look at my diet 😢 changes are needed. Healthy ones.
I enjoy your breakdowns whenever I come across them. I've encountered something that strikes me as counterintuitive and I'm trying to figure out the science behind it. I'm not sure if you've covered it, or know anything about experiences similar to mine, so I'll summarize real quick.
I was on Ozempic for a while and it worked great, was off it for a while and maintained the lost weight until food prices went mad and I had to change eating habits in order to avoid going without food. I've now regained all the weight in terms what the scale reads, but unlike other times I've lost and regained, my measurements have stayed what they were at the lowest weight on Ozempic. I expected a couple of clothing items to not fit around my hips properly (as they had before ozempic) but since ozempic, the clothing fits around my hips still despite regaining the weight, the measuring tape reads the same. This surprised me, as I don't think I've put on muscle or something like that. I'm not sure if ti's a matter of the fat distribution going to different parts of the body or what.
The thing that really sticks out to me as counterintuitive is that I have more loose skin after regaining the weight than I did when I was on Ozempic or the 6 months off of ozempic when my weight was maintained. This is counter to all previous experiences of weight regaining, so I'm wondering if the ozempic had something to do with it?
Also, I never had experienced dumping syndrome until I was on ozempic, figured out quickly how to avoid it. But now, even though about a year has passed since I was last on Ozempic, I'll occasionally have episodes of dumping syndrome sneak up on me. Most of the episodes I can figure out what set it off, but others have me absolutely befuddled. I'm wondering if I'll have occasional bouts of dumping syndrome for the rest of my life (if I'm not careful) because I was on Ozempic? I've not found much when looking for similar experiences, but I may just not be looking in the right places.
If you happen upon any cases similar to mine or studies that cover similar experiences, I would love to see a video on it, but no pressure or worries if it's not feasible.
There are a lot of factors to consider here. There is no data to say the meds can lead to fat redistribution - resistance training can. But if your measurements are all the same and your diet had to change to what I am assuming is more processed/higher salt foods, I suspect you've taken on a lot of water weight vs. fat.
Alternatively, your scale is potentially inaccurate now and is giving you incorrect readings.
As for dumping syndrome unless you've had surgery that shouldn't be occurring even with the medication. In fact the glp1 meds are sometimes used to treat dumping syndrome. I'd recommend more investigations with your doctor and looking at other potential GI conditions ie. IBS.
Are most people taking Ozempic/Wagovy/Mounjaro at the beginning of their weight loss journey? I only added the medication after failing with only diet and exercise (dietician, gym trainer). I was able to keep the weight off for 15 months, but eventually started slowly gaining the weight back. I am taking the medication to hopefully allow me to maintain my weight with a healthy lifestyle. (I may be an unusual case since type-1 and type-2 diabetes runs in my family. Willpower/lifestyle do not make the beta cells in your pancreas regenerate)
Depends on the individual, many people who come through the door have an extensive history of diet and lifestyle attempts. Albeit some are fad diets etc. So it is often the case we will pair a better approach to diet and lifestyle while also utilizing medication to help someone lose weight and like you said keep weight off.
Somehow I doubt it... people don’t usually start with medication. I ended up asking for the GLP-1 after years of failed attempts at losing the weight I put on when I became hypothyroid 🫤 I definitely had metabolic issues in addition to the hypothyroidism. Prior to that I was roughly the same weight my whole adult life. Mounjaro got the scale moving in the right direction after years of frustration, it’s been life changing.
5 months on plateau😢
Should be a very interesting topic. 👌
Dan, hope that one aspect of it you address is the ‘stalls vs brick walls’ part… IOW, when is it a *’stall’* , meaning further lifestyle changes or an increase in dose can get you unstuck (if you’re not maxxed already), OR, is it a *‘brick* *wall’* , meaning, you’ve likely gotten all there is to get from the drug regarding weight-loss, and maybe it’s time to consider either supplementing the medication with an add-on med (metformin? etc), or switch to an entirely new med altogether (ex: Ozempic/Wegovy-to-Mounjaro switchers, and vice-versa).
Obviously a common thing, ‘cuz, if you’ve got say 100+ lbs to lose/40+ percent of your body weight, typical results with any current weight-loss med will not get you all the way there. Even with significant lifestyle changes alongside it. 💪🏻 🚴 🥗
And even with you not trying for a ‘supermodel or male model’ BMI. 😑
Bariatric surgery?
@Clark Or, a simple meds switch, perhaps.
Kim over at Plus SideZ lost a lot of weight on Wegovy, then stalled for several months (‘brick-walled’) on it.
She then switched to Monjauro, and resumed losing weight. 👍
I assume one could hopefully also get the same result starting on Monjauro, and then switching to Wegovy. 🤔
Bariatric surgery yields great results, but I tend to think of major surgery as a last resort (and suspect many ppl feel similarly).
@@cloaksterMounjaro is shown to be much more efficient than Wegovy for weight loss in comparative studies, it makes sense that she started losing again when she switched.
I am in your definition of plateau since four months now.
What some people call “plateau” a lot of the population understand as “weight maintenance”, so congrats on maintaining your weight!
This is some tough but accurate advice. I appreciate it Dr. Dan.
Taken my 2shot of 1mg and in total im on ozempic for 4 weeks- weight has stayed same was 83.4 kg before starting and ive been 80kg for the last few weeks. Due for my 3rd 1mg shot today.
Progress is progress - you got this! 🩵🩵
Excellent video. Thank you
I didn’t have a “plateau” but Ozempic did stop working for me. Lost 70 lbs kept
It off for two years then all the sudden then weight started to creep back
On and food thoughts came
Back. Tried upping the dose but did nothing :(( not sure what the solution is but I’m having trouble again and don’t want to go fully back to my high weight
I’m not on ozempic and on metformin but sustaining lifestyle changes is essential for long term change and seeing that with my own experience. I have lost a lot of weight but it has slowed some so this video was really helpful.
Thank you ❤❤❤❤
🥰🥰🥰
Thx
It never fails, with my plateaus, there is always one little bad habit I can think of (iced coffee at the moment) that would help & if generally does even if it’s a little bit. But that’s really how healthy weight loss (mentally and physically) should be - small steady, consistent steps - practice & 1 iced coffee instead of 2 😂
So this has nothing to do with ozempic ?
Nope. It's that you aren't in a calorie deficit. Drug is working but need that cal deficit to lose
@@theofficialdrdan ah ok, I read the title “weight loss plateau with ozempic” assumed ozempic lol
@lizzyg1114 exactly lol. Having 'ozempic' helps searchability. And it can apply to it as well as all other drugs or any weight loss journey
@Dr.Dan Isn’t that one of those things that’s ‘technically true, but doesn’t quite tell the whole story’?
I mean yes, the Ozempic’s still in your system, and yes, if you’re plateauing that means you’re not in a calorie deficit… but WHY are you not in a calorie deficit anymore? 🤔
There’s a couple of usual suspects, but a major one is that your calorie intake has increased.
Could that be because the Ozempic (or other WL drug) isn’t working as well anymore (at hunger-suppression & other things), because you’ve built up a tolerance to your current dosage?
And if tolerance somehow isn’t a thing, then wouldn’t only *one* dosage be offered, aka the starter dose? 🤷♀️
After all, in most all of the clinical trials for Ozempic/Wegovy, Mounjaro, etc, the weight loss slowed after a certain amount of time and eventually nearly stopped… even at the maximum dosage.
I think a lot of this is the body ‘fighting back’ after you’ve lost a lot of weight by turning down your metabolism and turning up the hunger response… but this still speaks to WL drug tolerance, since any drug help in fighting this increased hunger response would be *very* welcome, and maybe even required for most ppl in order to get back to being in a calorie deficit.
Just sayin’. ✌️
@cloakster You are almost there.
So I think you are confusing a couple of ideas.
Tolerance is your body is used to the current dosage and requires a higher dose to get the same effect as a previous lower dose - this sounds like what might be happening with these drugs but not quite. Instead Opioid medications are a great example of this. In the case of opioid meds, the body downregulates receptors and responses, thus needing higher doses for the same effect. In the case of glp1 meds, a tolerance doesn't develop. Receptors don't downregulate, and the meds are having the same effect over time - see STEP5 trial. People also maintained weight successfully over a 2 year period with minimal regain.
A single dosage isn't offered largely because everyone has different responses and requirements. Some do great on 0.25mg, and others need 2.4mg.
You are correct about biology, and that is what most people are fighting with. You see the same response when someone goes on a low cal diet or is too restrictive. They can white knuckle it to a point, then something happens, and biology bites back and they binge, overeat, etc. Same thing with these drugs. We need to understand and respect biology. If it is biting back, it's a good indication that what one is doing is too restrictive and ultimately will not be sustainable. Sure, we could pump more drugs in, but to what avail? You might get temporary benefits, but if you aren't working on all the other aspects of your lifestyle. Biology will rear its head again. Hence why these meds are just a tool.
To successfully lose weight and keep the weight off long term with or without drug is about striking a balance. A balance between sustainable behaviors and your biology. Drugs just make engaging in the behaviors you want a little easier and can certainly allow you to achieve a lower weight to a certain point.
The reason I spend so much time asking why? Why do you need to lose another 10 lbs? What will it actually do for you? Is because if losing thar weight leads you to not having the above balance again even with the drug. It's only going to be a temporary loss. You can switch drugs, you can get surgery, or what have you, but every single situation will end with the same result if everything else isn't taken care of.
So it's not a tolerance. It's biology, but more importantly, it's what kind of life you want to live?! Too often, people hyperfocus on a number and will go to any extremes to achieve it but ultimately miss what is actually important in life.
My doctor suggested semaglutide for my fatty liver ( non drinker)...What's your opinion on that please.
I did a video on that a couple weeks ago. It can ve helpful more so it helps with weight loss and leads to reduction in liver fat
@theofficialdrdan I found the video.
Thank you for replying..
Super ❤❤❤
Wow finally found real talk on this subject. I would like to ask you a lot of questions. First off im 58 6'4" and have weighed around 220lbs most of my life. had bad reaction to covid in march 2020. after that weight sky roketed. few weeks ago went to DR was 380lbs blood sugar was 121. The dr put me on Ozempic. Well that not only took appetite away but also the bad cravings. Other videos I have watched say's to maxamise weight loss keep your calorie's below 1200. After two weeks I have lost 16lbs and sugar droped 5 points. but am I going about this wrong?
My God. Who is making these videos?! No 1200 cals is not the answer. You need a much higher and sustainable amount of cals with a focus on protein. Check out my other videos for more details.
I've lost 64 lbs since February, and after I lost the first 30 lbs, I decided to get on semaglutide to keep my progress going and I lost the other 34 lbs, and now my body just stopped at this weight. I've been at the same exact weight for a month now... I haven't changed my diet at all, and I even started walking on the treadmill and I'm still not losing, and I have like 45 lbs left to get to my goal weight but I don't know how to get get the process going again. 😒
Edit: I understand better after watching this video. Lol
Awesome! Thank you for watching! And keep going, don't give up!
There's no such word as bestest!
Its the mostest bestest word!
@@theofficialdrdan If you sayest soist.. Appreciate the video x
"with Ozempic" should not be in the title of this video. (It is super fascinating that you are pharmacist, but don't mention medication changes) One obvious answer from my perspective is to switch to Wagovy that allows higher doses than Ozempic since they are identical medications. Rebelsus (same medication as Ozempic) might be the answer when 25 mg/50mg get approved. Rebelsus is a daily pill so better uniformity of impact over the week than a weekly injection. Or you could switch to Mounjaro which showed better weight loss than Wagovy in clinical trials.
@Clark I also was hoping that Dan would’ve addressed medication changes/switches in the vid.
But in retrospect, probably that wasn’t realistic of me, as Dan’s in Canada, and there’s still a dearth of powerful weight-loss med options there. 🇨🇦
Mounjaro? Approved, but not yet available. Wegovy? Approved, but not yet available. High-dose Rybelsus? Still in trials, so not approved *anywhere* yet (as you said). 🤨
So right now, in ‘top-tier’, best-in-class WL meds, Dan has… off-label Ozempic to work with, pretty much. That’s it. 🤷♂️
So yeah, I guess he can’t really speak much to meds-switching as a technique, since probably all he sees of that so far are switches between weaker older drugs (like Saxenda or Trulicity), and Ozempic.
@@cloakster Excellent points about Canada. I guess that this video assumes you are already on the top on-label dose for Ozempic (2 mg), and have reached a plateau?
Is mounjaro approved?
@@kateburns1023it’s not yet approved for weight loss; I’ve read that the FDA is currently fast-tracking it and they’re expecting to have it approved by the end of the year. Very exciting. 😅
I’m trying to switch to see if mournjorno helps me get boosted back after regaining some weight and Ozempic no longer working as it did, but finding it hard with dose shortages and prices in Canada :(
Any. Weight loss journey you will have the body asking you want me to do what?! It is a survival mechanism. Are you drinking pure water? Are you getting electrolytes? Are you eating cleanly or are you taking an injection and still eating carb laden meals without changing thing? Do you eat sugar or flower?
I had to do without. Any corn derivative in artificial sweeteners. I was stalled.
Have you measured? That helps when the scale is not moving.
I don't eat any flowers. is this a common thing for you?
Hi, now I remember where I’ve heard your name on another podcasters chat this past week- I am carnivorous ! :)
Supplement are SO important to prevent starvation hormones
This podcast is just psychobabble about calorie deficit to lose weight. He completely ignores the role of Ozempic and the plateau which comes after use and why it happens. He says to just reduce the overall calories consumed. That is hardly helpful at all. Ozempic works by increasing insulin secretion from the pancreas which, in turn, allows for the sugar/carbs to enter the cells through the receptors. The real question - which he completely ignores - is why does that hormonal process stop working after taking Ozempic for some time.
The point of the drug is to control the food cravings. If I can control the food cravings without the drug, then why would I need the drug? And why would anyone be overweight in the first place if they can just control their diet????
Yes, but as I stated in the video biology is a powerful force and cravings will increase beyond what any drug can suppress. To manage biology in conjunction with the drug you need to ensure you are achieving adequate nutrition as you should for general health. Perhaps watch the video again?
I CAN walk 15 miles to my job each day but I'm still gonna take the car