KREBS CYCLE MADE SIMPLE - TCA Cycle Carbohydrate Metabolism Made Easy
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- เผยแพร่เมื่อ 26 มิ.ย. 2016
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The citric acid cycle - also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats and proteins into carbon dioxide and chemical energy in the form of guanosine triphosphate (GTP).
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In addition, the cycle provides precursors of certain amino acids as well as the reducing agent NADH that is used in numerous other biochemical reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically.
The name of this metabolic pathway is derived from citric acid (a type of tricarboxylic acid) that is consumed and then regenerated by this sequence of reactions to complete the cycle. In addition, the cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, and produces carbon dioxide as a waste byproduct. The NADH generated by the TCA cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.
In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria which lack mitochondria, the TCA reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion.
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Hi "MED simplified " ..Your videos are excellent and of great help !thank you so much they helped me a lot for my exams ☺😊
yes
Recent created by a brilliant mbbs student.
yes... It really helped my friend and I.
Plzz make a video on fomation And utilisation of ketone bodies ;ketoacidosis
acetylco a is a two carbon compoIJnd in
b©i
Who has exams tomorrow? Hahahaha
Today ½hour left 😂
Tomorrow
Legends are present.tomorrow is my exam 😂
Today I have internals 😂
Neet ha bhai kal 🥲👍🏻
you did a good job. Still gonna fail my test tho
Edit: thanks for the support. I did in fact fail. Goodnight.
Update: now I'm in my doctoral program. Don't give up!
How did the test go
Same
Ryan G I have a test tmmr and I have to label the whole process of cellular respiration and photosynthesis... school is honestly bullshit and a waste of my time cause who tf needs to know this stupid shit unless you’re gonna major in something with biology
loooool i feel that
Hope you guys passed your tests
when ever i look up a certain video about a topic for my exams , i'm so happy when i see this channel on top result , u know the video will be short and sweet and straight to the point . thank you , u're really making a difference
Me: I need help in college
Some Indian guy on TH-cam: I got you, fam
Relatable
All these Indians teaching me biology and physics ,chemistry even cuz my college is bullshit
Exam tomorrow for me :(
@@garymarkow7005 How did it go?
@@shishirmaharana4022 It actually helped; I got a B!!!
I'm inlove with the way you drop words from your mouth.
I loved this video so much! You made all the different intermediates and enzymes so easy to understand and remember, my professor didn't spend sufficient time explaining this concept and your video was extremely helpful.
Thank you. I have watched several tutorials on the the Krebs Cycle (cellular respiration) and this is the most clarifying one. Thank you for keeping it simple yet informative. I was able to keep my focus on the main aspects of the Krebs cycle and have a much better understanding. Keep posting!
Considering how complex this is, i'm pretty sure i took a lot of information on-board. Thank you so much for your awesome video!
there should be some corrections
1. its succinyl-CoA synthetase not synthase
2. during above reaction occurs the produced GTP is turned into GDP and using that energy release one ADP molecule is converted into ATP
Synthase hi hai
This video is incredibly helpful. It's a detailed explanation of all the processes involved in the Krebs cycle, yet it doesn't get caught up in the minutiae and is simple enough to commit to memory. Thanks!
After two weeks, i finally found a video that explained the cycle clearly and simply. Thank you so much, great video.
+Summaya M. U are welcome summaya
+Summaya M. U are welcome summaya
U are write since last two months I am going to tusion and when I study the Krebs cycle in tusion I dot under stand anything so then I can search on u tube and seriously I understand every concept
after 4 years youtube recomended this...
Today was my assessment test and I scored highest marks in class . All credit goes to you sir . You did a great job . Thanks 💕😊
Oooo
Noiccee
nice visuals make it even easier to understand. thankyou!
hello!!
med simplified.
your videos are just amazing .💟 and had saved my time a lot !!!
thank you for such a great service . please keep it up and looking forward for more amazing stuff like this👍😄❤
Wow, I really feel like I learned something here. This helped me so much in understand the flow of the kreb cycle. Thank you
U r explaining great and this’s helping me to understand the cycles even more better .. thanks a lot 😇
This video is so good. But he forgot to mention one thing. Like he said Qh2 becomes FADH2 same ways that GTP gets converted to ATP, hence kerb cycle produces 2 GTP meaning it produces 2 ATP. thank me later. Keep studying, peace out
correct, the conversion of GTP to GDP will facilitate the formation of ATP from ADP
Thanks for the information.. I was thinking about the same...does GTP enters ETC or directly get converted... Then I thought of its a substrate level phosphorylation so obviously it won't enter ETC..
You r a keen observer like me
😃
Yeah
thank you! this saved me. :)
Thank you
Of all videos I have watched, yours is the one that finally helped my idiot mind understand this stuff. Thanks.
😂
Hi! As a medical student myself, I very much appreciate your videos! They were very beneficial for my biochemistry exam. Can you please make more videos?
th-cam.com/video/8hLWmvxwmpI/w-d-xo.html
Are you a doctor now?!
@@anurimakarmakar2525 Yes! I graduated this July thankfully!
@@lanjarashid5308 Congratulations!!! I am in second year of MBBS 😅
@@anurimakarmakar2525 you have biochem in second year of MBBS?
i usually don't comment on videos, but your videos are really well made and i think you are really underrated. thanks for the video
Simple, to the point, efficient. Thanks a lot mate!
arrest situation - SO GLAD I remembered KREBS CYCLE. It helped me so much... said no one - ever.
Thank you so much MED Simplified!
Keep uploading these videos
you deserve everything sir!
Just what i was looking for short, simple, clear and straight to the point
thank you for simplifying complicated concept.
This is so far so good. Keep it up , am enjoying your videos. Continue making more videos because your videos are well simplified and easy to understand. Wow wow wow.... May God continue Blessing you....🙏🏾🔥🙏🏾.
That was just perfect. Please keep doing this... You have a gift for clarity and concision. Thank you.
Bless you. I have a quiz today and nothing helped until your mnemonic. Your channel has saved me so many times.
Like howwww do you do this .... I was just watching and now I’m ready for my finals ❤️😍 man you are amazing
That was made super easy , after surfing TH-cam for hours I could finally understand it Alhamdllah , thanks 💖
+Asmaa Fathy Glad it helped you
Thank you so much! Loved being able to pause and draw step by step! Best video yet.
This format of presenting the information is fantastic! Thanks for all the detail, clarity, and quickness!
I am very glad to hear that you liked the video.
I missed 2 weeks of university because of my visa issues and I was worried about catching up with biochemistry work. I'm no longer worried now because I found your videos. Thanks a lot!
Same thing is happening to me
you have no idea how helpful your videos are! truly saved me for my bio exam
This is too good. Explained it with great ease. Thank you.
You actually made it look so easy to memorize and the drawing is also comfortable for the eyes hahahah thank you for your wonderful work
woooooooooooow was worried about this cycle.......yeah surely it is made easier here.....................THANK YOU SO MUCH
Wonderful, short specific and straight to the point. I was looking for help with a tutorial and this helped a lot.
Your videos are SO clear!
My exams in 20 minutes 🤧 will update y’all
Pass hua bhai ?
What happened?
Lagta h fail ho gaya AUR MUMMY NE PHONE LE LIYA😂🎉😅
Zinda hai??
????
Awesome I was reading Harpers and must say you smoothen it out :) thanks
Thanks for the appreciation 🙏
i love how you explain and compound about krebs cycle :) thank you so much
Thank you for getting right to the point! Clear and concise.
This video is really helpful.thanks alot
+Buland Iqbal You are most welcome iqbal
+Buland Iqbal You are most welcome iqbal
+Buland Iqbal thank you so much your appreciation
I have a biochemistry exam in 2 days and I'm so glad I found your videos, only wish I found them sooner! ✨💕
how was ur exam?
@@tulipa5171 I passed the practical part of the exam😌✨ however we went into another lock down and I'm doing the second theoretical part this April 😊🤞 hopefully it goes well! 🍀✨😭😅
Really informative and a brief description of each and every point.
Thank you for making this man! Be blessed
DUDE!!! I FREAKING LOVE YOU MAN!!!! SUBSCRIBED!!!! YOU ARE THE BEST!!!!
+Omer Khan thanksssssss soo much. Btw my name is omer too! 😇😇but its spelled umar. Thanks so much for all the appreciation. Much love
thanks bro you just made my life easier
+Yousef Murad u r welcome sir
do you have video for electron transportation chain ?
Thank you. You made it easy for me to understand this.
ive been trying to understand this for two weeks thank you so much
hi bro you did my exam tomorrow
thank you so much for this video! I've been having a lot of trouble understanding this on my own, but after watching your video i feel better! keep it up :)
+Aileen Flores i am glad it helped
R u a doctor now??
Short and to the point. Very well done.
This really helped me big time. Thank you!
hey! thanks! please keep it up!!!
Thanks a million, you have made it easy for me.
Most!!! EASY
; SIMPLIFIED AND AMAZING EXPLANATION
I just loved it ... the way you explain simple short and crisp
Hey "med simplified" we are appreciating your work ...kindly upload videos on rest of the metabolic pathways (glycogen synthesis , its regulation ,degradation ,) as well please.
Yes surely. The work on these topics is in progress 👍
Thank you for this video. However, I would just like to correct fumrase into fumarase and the succinyl CoA synthase into succinyl CoA synthetase. Nevertheless, this video is excellent.
Thankkk you
Yes, I am going to subscribe because it helps me alot, thanks MEDSIMPLIFIED
You explain it very well thank you so much
you are the best
I study in Maharashtra state of India. In the biology textbook, the krebs cycle is not shown at all, yet we have been given this question in the textbook. This is extremely weird. This video helped me a lot and understood the Krebs cycle. I am studying in grade 10th and this video helps a lot. Thank you medsimplified!
oh I feel like I'm released from so much pain and street cause I was super worried about how Iam going to remember and understand Krebs cycle. thank u so much!
God bless u
Thank you so much. The krebs cycle was really simplified.
I didn’t expect to learn this in high school lol.
wow.. this calligraphy makes me stare at the screen
Thank you so much! Excellent video. Very straight forward. Much easier to remember and understand
This is amazing. Keep up the good work bro.
brother please give a video glycolysis cycle please please please please please
+Munna Munna Glyu can find the video on Glycolysis on our channel
brother give a video of about our eye please please please please please please please please please please
Munna Munna
L
Wth we have to learn this in our second month of IB Biology...
I feel ya. And to make it worse, our teacher doesn't teach a thing!
Tresia Lol GG.
Rip us all D:
Also, John Green's crash course on this helps too
Zetsuke4 same... im not even in ib tho. Plus my teacher told us to do this to do this on our own and made the unit final open book but... no one is prepared for the final exam now
This is so awesome!! thank you so much for such a simple explanation
Best lecture listened so far. Thanks
4:12 "So this forms the SHORT description of the Krebs cycle".... bro
🤣🤣🤣
*sips tea* Do I spot an ARMY? taste👌🏽
Yes, he skipped some rxn to make it little easy.
succinyl coA converted to succinate. The enzyme is succinyl coA SYNTHETASE not SYNTHASE. SYNTHASES and SYNTHETASES are different 1st one is class 4 & 2nd one is class 6.
Dark master yes you are right... synthetases require ATP or GTP but synthases do not.
Yeah you are right
In my book the enzyme given is succinate thiokinase. Is it the same ?
also it is fumarase instead of fumrase
These videos are awesome. Thank you.
this is the most easiest way to break down Krebs cycle. Thank you so much for the video !
dont understand =(
#Pathophysiology
watch this video several times.. I am sure You'll understand understand =)
what Jo IU you so very usurious I have a great day and I will be more HP hi Jo hi Jo Jo
you know its unsimplified when a brown guy is teaching
+Sami Al-Asady . i don't think thousand of other viewers on this channel have the same thoughts as u.
MEDSimplified lol I'm just saying it unsimplified my understanding of the Krebs cycle
MEDSimplified I'm an 8th grader finding a quick video on Krebs but this like a college video
+Sami Al-Asady U can only learn the names of the products formed in this cycle. Forget about the enzymes. Nd best of luck for ur school
MEDSimplified ya thanks sorry for the racist joke
So much thanks for saving my academic life
This is so clearly explained... thanks a lot!
Thank you..!! Simple and to the point.
Thank you. This was a beautiful explanation
awesome and very simplified ... thanks too much
So helpful! Thank you so much!
Thank you! This really helped!
Thank you so much, much aprreciated explanation.
THIS IS THE BEST VIDEO I HAVE EVER SEEN ON THE KREBS CYCLE
OUT STANDING
I REALLY UNDERSTAND THE PROCESS OF GLYCOLYSYS
This was very helpful! thank you so much, very much appreciated :)!
Amazingly simple when you explained it. Thanks
thank you for helping us!! I am a visual learner, so this is amazing
God bless you. This is fantastically explained. Even the way it eventually links to the Electron Transport Chain. I finally understand.
I love it. thank you!
Finally after so much of research i finally found a good video
Great job with the videos, simple, fast, and clear :D
Excellent video
I just loved it