Making Tryptamines for Enlightenment
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- เผยแพร่เมื่อ 28 มี.ค. 2024
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In this video I make the common medication scaffold tryptamine from the essential amino-acid L-Tryptophan, found in all foods and available OTC as a supplement. I then use it to make a Tryptoline derivative, which are interesting for their wide variety of applications in medicine.
Intro largely written by Damian (Discord: tangramexcerpt)
No literature was used for Tryptamine synthesis
Tryptoline synthesis
www.nature.com/articles/s4159...
Animation of Psilocybin/Psilocin receptor binding from:
• Psilocybin/Psilocin Bi...
Glowing scorpion footage from Veritasium:
• Why Scorpions Glow in ...
Harmala extract Fluorescence footage from:
• peganum harmala extrac... - วิทยาศาสตร์และเทคโนโลยี
If it wasn't so illegal, "Making DMT from a Turkey" would be such a NileRed video
Bro should still do it for educational purposes only (and he should add some uranium in it since why not)
@@hotenyIn PIHKAL, Shulgin discusses the possibility of an astatine-incorporating phenylethylamine, 2C-A, a recreational dose of which would probably be around 10-20 mg.
However, he concedes that acquiring the necessary ~10 mg of astatine might be a bit challenging (since you need a nuclear reactor to produce it, and its half-life is just 8 hours), and that even if you managed to synthesize your dose of 2C-A, the screaming radiation would be enough to send you to the afterlife.
I’m pretty sure 5-methoxy-N,N-dimethyltryptamine is perfectly legal in Mexico. Hamilton Morris did an entire video about it. All Nile has to do is go on a vacation…
Broooo😂@@hoteny
@@Sniperboy5551 cartel wouldn’t let go of nilered (their superior chemistry guy)
It truly is a golden age of chemistry youtube.
We're taking back the 50s baby, yeah
ah yes, alchemist, havent heard of that since the renaissance era
Yes, and from today even weed is legal in Germany at least partly. meaning now you can make videos about weed and chemicals in it legally on youtube without trying to hide something.
No way. Do you not remember ChemPlayer?
The god fatger is
Nile red/blue
"No literature was used for Tryptamine synthesis."
Shulgin would be proud :)
May he rest in peace.
I've known and loved
@@robertchampeau6867 phenethylamines and tryptamines both
Ruflux tryptophan in KOH?
Information should never be suppressed
But always is.
i have like 10 yt profiles just for commenting
@@dannacollins2520It is is it?
never ? escaped or intentionally released gain of function modified pathogens ? nerve agent synthesis ? Perhaps you would be correct in the absence of the mentally ill, psychopathic or Islamic Jihadist death cults.
It's only as suppressed as you let it be.
Salute
Its a crime that tryptamines are illegal! Incredible potential in therapy.
hopefully that will start changing soon
@sem9799 not the good ones tho, imo. Maybe some pro-drugs
@@Basieeeepsilocybin is a pro drug
You could also go insane you shouldn't use them like an afternoon joint
@@S.aTan-._.- Yeah insanely enlightened! I took LSD maybe 100 times
We making it to the 4th dimension 🗣🔥
Higher!
We live in time we are already there in a sense, I'm not sure why ppl say we only live in 3 since we live in 4 but yeah I digress... I wonder how many we could go trough before the brain just get scrambled maybe 3 more or so
pffft.
i'm in the 2nd dimension hurry
Can't wait for the next video: synthesis of (2S)-N-methyl-1-phenylpropan-2-amine!
Uncle Fester did that one with Hamilton's Pharmacopeia, minus the very last step.
There are some full syntheses via P2P on youtube. Well a couple of routes to P2P and one to racemic N-methyl-1-phenylpropan-2-amine from one of the P2P routes. I can't remember the channel name though. It is a horrid drug though. Makes you feel good for a few hours and then shit for days.
@chrisbrent7487 Propylhexedrine is still sold over-the-counter
@@Sniperboy5551 Not in most places. The US is an oddity there and it is restricted in a bunch of states. It is an S4 prescription only medication where I live.
meh that's barely a step above baking soda volcano for a guy like chemiolis
This may as well have been in a foreign language for me but i stayed till the end anyway. "That was it. See you." 😂
hell yeah tryptamine time
I've been thinking about this synthesis for years. Thank you for making a detailed video on it!
Hamilton interviews a “chromium carbene chemist” who talks about it quite a lot
Yeah...me too
Shoutout all you chemists making chemistry interesting and keeping me learning and changing perspectives of this world
better than my organic chem lectures
This video came out right as I was partaking in some tryptamine-based compounds! Great timing!
😅
Pfp checks out ✅
@@DruggiePlays best part is that’s not at all what I was going for with this pfp lmao
@@TagetesAlkesta It looks like a grapefruit to me.
@@TagetesAlkesta kinda looks like a peyote lol
7:35 why is this filtration so satisfying to watch? Everytime the pump is switched on you can watch the filter get sucked down.
The outro cracked me up. "That was it. See you 😒"
i'm glad I stumbled upon this channel. I love all science channels, and glad to see 15 years later people from Nilered/blue, thought emporium, ex&fire ex&ire, ect, all commenting on Periodic Table Videos, univeristy from nottinham, chemist, with Neil and professor. It's finally gone full circle, and glad to see the channels i followed for many many years, finally be recognized.
"It makes snappy bubbly sounds that are very satisfying"... You had me on that. But the whole of the video just got me curious into your other videos. And got me to sub/bell.
JUST in case this gets taken down... One should download/store it somewhere.
You can increase the yield above 90% by using catalytic amounts of PhAc in refluxing cyclohexanol as a solvent. Gradually add the Trp powder in increments of 10 g / 100 mL until the previous addition is completely consumed (clear liquid). Boiling cHexOH can take almost it’s own mass in TNH2. Work up: Add equal volume of toluene, 1.1 eq. of 5% HCl , separate the aqueous layer and extract the organic phase 4 times with 5% aq. HCl. Wash 3 times with some DCM. Alkalise the combined aq. phases with aq. NaOH, extract product with DCM and evap. RC from MeCN. Although tryptamines are sensitive to strong acids, it’s totally fine for as long as it’s cooled, dilute and you work fast. And use a protective atmosphere throughout the reaction and work up as they oxidize readily, which causes the brown/red discolouration
Hey
Few questions,
What is PhAc?
What is TNH2?
What you mean by RC from MeCN?
@@sorenschleifenbaum9013 phAc - acetophenone, TNH2 - tryptamine, MeCN - acetonitrile, RC - re-crystallization
My point is that the procedure used by chemiolis is designed to avoid exposing the product to strong acids as this catalyses it’s decomposition, but if you do this nonetheless in a controlled manner, the yield increases actually. An excess of ketone catalyst may actually lead to the formation the corresponding aldehyde instead of the amine of my memory serves me right. I did tryptamine chemistry a couple of years ago and found that if you keep it always cooled and under protective atmosphere (pretty basic organic synthesis stuff), it’s not as difficult to handle as is commonly believed
@@sorenschleifenbaum9013 PhAc = acetophenone; TNH2 = tryptamine (as the NH2 represents the amino group); RC from MeCN = recrystallise from acetonitrile.
Better benzyl alcohol because good smell and yeld 75-88%
And workup possible without HCl, just fraction vacuum distillation RM after deccarboxylation
Hey man, really nice video. I'm pretty sure that most of your yield disappeared into the oil layer. Why not just hydrolyze the acetone imine with acetic acid for some time with strong stirring in aqueous solution, basify the solution with NaOH, filter it and carry on with the next step?
You're mechanistic pathways are getting solid! 1 little thing I would look out for is the pka of (de)protonated species depicted. For instance, I doubt that the acetophenone is protonated upon nucleophilic attack from the amine, since its pka with the neutral form is less than 0 whereas the amine's pka is around 9 and so is a much stronger base than the carbonyl. That being said, tryptophan is a most likely in neutral form rather than zwitterion in this organic medium so you can think of this step as being assisted by H-bonding from the carboxylic acid with either concerted or stepwise deprotonation by the generated alkoxide.
Same goes for the anions on aliphatic nitrogens, the pka of those with the neutral amine is around 35, so I would expect a proton assisted formation and scission of the hemi-aminal
anime amine anime proton
Tell me more about the zwitterion
Is homie even speaking English???
ON GANG 🗣🗣🗣🔥🔥🔥
In 2002 i smoked dmt and it was an orange crystal. Similar to orange in beginning
We’re gonna be meeting with the gods with this one
Useful and really interesting video mate - iv tried a ketone catalysed rxn with cyclohexanone and again with peppermint oil - TOTALLY unsuccessful…it was however my first synthesis so I’m not too surprised. May try again one day using your method tbf….I even tried salting it out the way you did but don’t THINK I ever managed it successfully…ended up buying some lol
You hear any loud knocks and or see bright lights shinning through your windows, greet them with a smile xD
Nice work on the decarboxylation, didn't know iminium salts could be isolated like that. Depends heavily on the imine I imagine. Letting reactions stand is usually fine (though more of a 1950s and before thing), but the mixture should be homogenous at that point.
phenylhydrazine dissolved in water + hs204 stirred for 30 mins + 4,4-Diethoxybutylamine dissolved in acetonitrile (equal volume as the water). let it run 40c for 8 hours (tryptamine synthesis 90%= yields at large scale) you can add another charge of hs204 and raise temps to 80c for a few hours and cyclize the newly made tryptamine to carboline. fischer indole rxn with no side products. grad school was fun.
Ive always been interested in chemistry. Glad i found your channel. Very cool my friend
RIP Alexander Shulgin
Couldn't you just start with acetone as the solvent for the decarboxylation if you displace the acetophenone with acetone anyway or ist the bp too low?
hey man, I was just wondering if you made that psilocybin model in chimera... and if you did, what computer specs are you using?
Enlightenment is like jumping out of an airplane without a parachute.
So the bad news is that you don't have parachute, but the good news is that you discover there is no ground. And then you're just endlessly falling and you never reach the ground.
So in a sense, what i'm asking you to do is to jump. And you don't want to jump. You're saying, I'm scared. I'm too scared to jump. And I'm saying, jump. God is telling you, jump, jump into infinite love and it's going to be great. But you're like, what if I kill myself and what if something else happens? I don't know. You just jump into infinite love. Take the leap of faith and you'll discover infinite love. And you're too scared to do it. But then eventually when you do it, then you're just going to discover that there's no ground. You're endlessly falling forever and it's great. But yeah, taking that leap is really difficult. It requires you to face your death. So of course, everybody is too afraid to do it. People are just to scared.
:)
You can look at a wall and you can think of an elephant and you will see an elephant in the wall because as it turns out that's the actual mechanism by which all of reality is created. It's not really that you're hallucinating or something is wrong with you. You're not going crazy if you see an elephant in the wall. What's happening is Law of Attraction is happening. You are materializing the things that you are thinking.
From this super fluid state you are able to imagine entirely new worlds and realities and it feels so surreal and unbelievable because it's too good to be true.
Reality is pure imagination. TADA!
I'm talking about a robust deeply sophisticated notion of hallucination. Hallucinations that are so real you cannot distinguish them from reality. Hallucinations that are so mesmerizing that... Imagine that you started imagining that you were a kangaroo and you just sat there day after day after day imagining that you were a kangaroo and you imagined it so much that you literally became a kangaroo and you could not remember anymore that you were ever a human. That's the kind of power of imagination that I'm talking about.
Jump into infinite love. Sky diving... Talk about feeling! You WILL feel something far, far more than the fear of falling. I L is real
I'll face my death when its my time, life is short as it is. no sense in cutting it short. I'll enjoy the ride while I'm on it 👍
How do you measure the yield? And also, how do you remove the impurities? Seems like very important safety steps. Would much appreciate some insight into this.
It would be such a shame if you methylated the amine
No you're so sexy haha don't methylate the amine
Nah, it would be a waste of time and resources to synthesize such a common naturally occurring compound. It’s done occasionally but…😏
I personally think it wouldn't align with my moral standards.
4-HO-MiPT is one of the magical ones.
Beautiful chemical
Shoutout to squarespace 🙌🏽😅
Nice video. I also like how you always explain the reaction mechanisms. Missing o-chem!
- from a p-chemist
An elf told me that the reaction also works well with spearmint oil as a catalyst 🤓
very cool video thank you for the time much appreciated.
i understand EWG EDG & SN1 VS SN2. but where would i find resources describing condition's where the aliphatic chain is added to as opposed to the phenol ring? is this just anti markovnikov using peroxides as well as SN2 with strong nucleophiles so there is no carbocation intermediate for methyl or hydride shifts? ? EAS & NAS dont seem to cover this.
I had not considered the idea the chemistry of Tyrosine kinase inhibitors being distantly related to hallucinogenic drugs. Been designing cisplatin-Tki prodrugs with them for my thesis.
Alright you’ve got my attention.
My boy is a gift to the enlightened world. Bless you child.
I extracted DMT from elder berry using acetone with a base of benzoic acid and threw in salt with apple cider vinegar to isolate the isotopes. What was left was a sticky substance which gave a high like 5-meo malt Hnicro!! Hnicro is similar to 5-meo DMT without the nitrogen beta Ring!!
4-HO-MET is a tryptamine I found quite enlightening. But I’m not sure if you’re allowed to synthesise it in your state
I love how not ok this is but TH-cam still hasn't seen it yet. 🤣
You're the goat.
Keep up the awesome work dude.
Fist bump. 👊😎
how is it not okay? tryptamine isnt psychoactive or illegal. i didn see any methyl groups on that alkyl chain.
How is this not OK you can literally write the federal government and ask them for the information to create LSD bombs etc. it’s called the freedom of information act. It’s what you do with that information that gets you into trouble.
@@Mp-jw1qg it's still technically manufacturing.
@@williamcunningham1669 manufacturing something legal. whats the problem?
Ahhh! Magnificent splendor!!!
You can legally produce 5meo-dmt using melatonin and a few other non restricted off the shelf chemicals (since all the precursor aren't controlled, how will they know u got 5meo?)
You can go in a Forest or swamp and find the right tree, flowers, or specific grasses and 40bucks at a Lowe's and you can easily extract your own DMT
You wouldn’t mind elaborating?🤔
Good job boys, well done!!
If I was taught chemistry and biology this way in school, I would have given a shit.
CRUSHER: No. Usually a temporal shift would leave some kind of triptamine residue in the cerebral cortex, but the scan didn't show any. Personally, I think you just enjoy waking everybody up in the middle of the night.
Dr. Bones McCoy: In this timeline, Jim, they are going to tell EVERYONE how to synthesize Cordrazine from rubber bands and pineapple.
I really enjoyed Chemistry in College. I am super good at Math and studied Agricultural Ecology. I almost went into Soil Science. I have this crazy dream of getting Math, Chem and Physics Degrees to discover new things! I've been practicing Silat and Escrima since 1993. I have these really far out ideas all the time. I grew up in Hollywood!
I love learning new stuff
Fuck yeah 👍
Me too
I recently ran out of 4-HO-MET so this could be useful.
some are saviours for those with cluster headaches.
I‘m waiting for someone to use D2O in a synthesis, I find it interesting how it can be used to shift the yield of a specific isomer.
very interesting.
I always thought sumatriptan was a fascinating compound. It’s a DMT derivative with no psychoactive effects that stops cluster headaches right in their tracks.
eyy a dutch brother, keep up the amazing content
what is the name of that beta carboline derivative at 2:58?
Did it glow tho? You said beta carbolines usually glow.
Sad that you didnt show us its luminescence, I’m a little bit dissapointed 😔
It is unsaturated in the extra cyclic component, so it would not have a nice glow. It would only be as fluorescent as the unsub tryptamine realistically
@@Wcwcwcwc570but tryptoline is unsaturated and is luminescent…
💀 ?
Tetrahydroharmine glows despite it being unsaturated
Just a heads up, I've taken MAOIs for a long time and have the degrees to back up my own experience. Tyramine reactions are rarely that severe, they're often similar to a prolonged panic attack with a headache... in fact much of the damage done by them in years gone by was when doctors attempted to tank blood pressure and starved either the heart or brain of sufficient blood flow.
It's also variable, often causing no reaction at all. I got away with eating many tyramine rich foods when I was prescribed them. My shrink warned me that this didn't mean I had immunity or tolerance, and any at any future occasion I might get a severe reaction. It's a crapshoot Also, it's been found that processed commercial pizza cheese (in the US, anyways) has no mozzarella, so doesn't pose the danger once thought. True for a lot of other "aged", but highly processed foods.
Did you get inspired by TiKHAL? ;D
Nice
Is there any tutorial or explanation on how to create such animations of substance docking into a protein receptor like the one at 1:11???
Autodocking
now i want you to replace the hydrogens with methyl groups
👇👇
Assuming you really wanted to make a betacarboline and not an camouflaged intermediate for a different type of drug, why didn't you use anisaldehyde as stochiometric decarboxylation catalyst and use the resulting imine directly for the Pictet-Spengler reaction?
You are being great and detailed but saying 4-hydroxy-tryptamine during the mushroom binding part would of been nice but then you see psilocybin being mentioned instead in the animation, am I missing the phosphate group somewhere or did they just label it wrong?
Idk if he even labeled it himself, but you're right, it'd be 4-hydroxy-tryptamine or psilocin, which is the pharmacologically active metabolite of psilocybin, which is doing the binding, afaik.
@@user-yw9mw9hv8o What does afaik mean? I'm Dyslexic and almost 33.
How about that! Perhaps you can proceed, and show us how to make the DM* stuffs?
I hope he synthesized a get out of jail free card first 🤔
I have experimented with 5Meo amyl triptamine
Science on TH-cam = balls of cosmic steel ❤❤
Make a list of the ones you know and love!
DMT is SOOO easy to extract. It's insane.
how to make DMT from tryptophan ?
@@Anuisgod why make it so hard, just look up mimosa hostilis root bark or acacia (anything really) confusa root bark and you're good to extract easy.
Anyone know where I can get some methoxphenidine?
Am I sitting in a tin can
Far above the world
Planet Earth is blue
And there's nothing I can do
Ya i have study these molecule's since i first started chemistry way back when before info was widely available its a good bus ride.
If i could get 5 dimensional molecular tag of this i would be happy 9:37
make amyl nitrite for relaxation next
6:29 wait i thought imines were base stable, wouldn't it be hydrolyzed in acid? (I know I could totally be wrong here, haven't worked with imines much, may be thinking of something else.)
Also, congrats/good choice on avoiding the use of volatile indoles for this. Having a project that started with skatole for four years, I can tell you that smell don't come out easy.
Is it pretty harsh on the lungs, or?
Hell's yes, I love tryptamines.
Trip to where?
Omg I love dis! "That was it.. see you!" 😅
5:15 sounds like a big chip fryer!
I didn’t know it begun with Tetrahydro
Is THC considered a tryptamine?
No
In before take down
5-meo-MIPT is STILL legal in canada
How hard is it to access all of these ingredients as a non chemist citizen🤔
Apparently converting tryptamines is pretty easy
The interview I’d Hamilton with the “chromium carbene chemist” talks about it a lot.
Isn't adding hcl in last step destroyed some product because of local concentration and ph went off a lot? Shouldn't it been added last, after water?
Good video
I've wondered if RU 28306 can be made from Tryptophan
Yes, via a fiedel krafts acylation of the chloro with AlCl3. Then bromination and displacement with dimethylamine :)
Love you dude 😘
2:25
This effect is pretty overblown. It doesn't apply at all to reversible inhibitors like beta-carbolines because as concentrations of other amines (e.g. tyramine) rise, they displace the inhibitor. (This is also why reversibles are poor antidepressants.)
With respect to irreversible inhibitors (e.g. tranylcypromine, phenelzine), which react covalently to destroy the enzyme, the human body still retains (diminished) capacity to metabolize dietary monoamines, both from residual MAO as well as other enzymes (e.g. hepatic cytochrome oxidases). As a result, there is a threshold dose for tyramine-induced hypertension, which varies by person and food source, but in the absolute worst case is still approximately a quarter pound (0.1 kg) of cheese. Probably not the best dietary practice in any case. Like anything else, the effect beyond that point scales with dosage.
The symptoms can be uncomfortable but are very rarely medically problematic, as it is very difficult for tyramine alone to raise blood pressure above the levels seen during intense exercise, and the body is capable of clearing systemic tyramine in 1-2 hours. Ironically, fear of this effect has led to inappropriate overtreatment, where powerful antihypertensives are used and cause dangerously low blood pressure since the tyramine is shortly cleared.
For context, millions of people were prescribed irreversible MAOIs during the early 60s (when tyramine levels in food were much higher), with no knowledge or warning of this possibility, and there were only a handful of cases of death occurring, which were due to cerebral hemorrhage. Any time your blood pressure rises a lot, even during intense exercise, there is a risk of this happening, but fundamentally it is because of a pre-existing weakness in the cerebral vasculature.
This is something that people on MAOIs have to be aware of, but with a little knowledge and common sense, it just isn't a problem. Unfortunately, misperceptions of risk have led to MAOIs being mostly shelved, even though they are highly effective antidepressants and anxiolytics that often work when everything else, even shock therapy, has failed. Candidly, once you've seen the effect a drug like tranylcypromine can have on someone, people who once looked like walking corpses now restored to life, suddenly filled with joy and passion, you will wonder why anyone would accept "I'm not sure if it's placebo" SSRIs.
Sponsored by squarespace, wow 🎉
is pure tryptamine as psychoactive as it's psychedelic indole cousins?
Not at all. There has been experiments done with IV tryptamine and it was only vaguely hypertensive and psychedelic, mostly gave a rise in temperature
Spice must flow.
SUBSCRIBED!
5-MeO when🗣️🗣️🗣️
actually making it from melatonin would be fun
yummy yummy, downloaded and notes taken
Great
Acetophenone is unreliable for me and is a roll of a dice but cyclohexanone gives consistent 40% to 60% and isophorone is way better. spearmint oil is nice but it must be purified to carvone.
Is this the same thing as amitriptyline?
No