Go to ground.news/Labcoatz to see how any news story is being framed by news outlets around the world and across the political spectrum. Use my link to get 50% off unlimited access with the Vantage Subscription. Also, it has come to my attention that one of the chemical diagrams was wrong: it's a small thing, but the double bond on the imine intermediate (produced from the norpropylhexedrine and formaldehyde) should be on the nitrogen's other bond...it's a METHYLimine
Making meth is stupid easy. Making _clean_ meth that isn't poisoned with toxic impurities, and without blowing anything up is the hard part (doubly so if you consume any of the product while making more). Most of the work in designing commercial viable synthetic pathways for drugs is finding ways to avoid _creating_ those toxic byproducts. Since they cannot be reasonably removed at-scale, the only solution is to carefully control conditions to not generate them in the first place. (Or if you are selling illegal drugs on the black market, just don't worry about your clients' future health).
Make pseudoephedrine next to tell DEA (and FDA) it's dumb to restrict it. EDIT: Nice that google's first autocomplete result is propylhexedrine abuse...
@@norbert.kiszka it *has the potential* to be converted into MDMA or meth. But so do the rest of the chemical elements in meth. Our DEA likes to make chemicals illegal without trying to help the people struggling with addiction. So yeah they just keep making more and more basic level chemicals illegal.
@@norbert.kiszka It's legal here too, can buy it at any pharmacy. You're just limited in the amount you can buy per month and you have to give your ID, which gets run through a centralized database to make sure you're not just running from pharmacy to buy more than you're supposed to
It's a fully scheduled drug in my state, meaning you need a doctor's prescription for it no matter what and can't get it OTC or from the pharmacist. And yet, meth is still a huge problem here and has actually gotten worse since the pseudo-ban (pun intended). Shocker 🙄
I remember when ChemPlayer got banned for making _precursors._ I know that drug chem (and energetics) gets the views, but I really hate seeing quality chem channel after quality chem channel go the way of the dodo.
True, but ChemPlayer was also dabbling with more extreme precursors, like phenylacetone. TH-cam chemistry is always a bit of a gamble, but as long as things stay legal (and far enough away from illegal drugs), things tend to go alright!
@@BackYardScience2000 It amazes me sometimes that you can find video after video of people playing with microwave transformers but videos about white phos don't fly. The only logic I can come up with is that there haven't (yet) been any, err... "conflict crimes" committed with microwave transformers. And that makes them more "ad-friendly"?
@@BackYardScience2000 They deleted a video of you gently heating the scrapings of a match box? That's crazy - why would they not want people to see someone collecting the red powder on matchboxes and gently heating it over a hotplate?
LabCoats is speed running ruining his life. not even exaggerating. This is like the 8th in a long string of very bad choices that he has made lately. Dude is screaming for help, but he won't accept help, so he'll continue to spiral until he changes his mind or... well, you know how the story goes...
I tried this, pharma made, one time and my goodness was it an amazing ride. I’ve wanted to do it again. I can see how some people end up in bad places with this type of thing.
I believe the biggest issue was the impurities produced via the Henry reaction (it is well-known to be one of the dirtiest synthetic pathways, with enough unique impurities carrying through to the final product to allow for forensic fingerprinting), as well as the side-products formed from the uncontrolled LiAlH4 reduction. As an alternative route, you should really try doing a Grignand reaction with acetonitrile and the (bromomethyl)cyclohexane, which would allow you to directly reduce the formed imine to the primary amine in one pot. If you manage to exclude water, oxygen and CO2 (which excess Grignard reagent will also help to scavenge down to PPM levels if you seal the apparatus with something like a balloon), then this pathway will produce much a cleaner and easily crystallizeable primary amine: After the Grignand reaction is finished, cool down the resultant ether solution to around 0°C in an ice bath. Then, while still minimizing exposure to the atmosphere, you just need to slowly add some LiAlH4 or borohydride, with stirring and cooling.
Those of us who have been particularly desperate when having issues getting ADHD meds have long been familiar with the Benzedrex last resort...nothing like those lavender burps to remind you you're having a horrible/great day!
Bruh really? Having issues getting amphetamine and going to Benzedrex sounds like addiction. When I couldn't get opioids I would get like 2lbs of poppy seeds and wash them to get the latex off.
@bok.. both in the case of Benzedrex instead of amphetamine, and poppy seed tea instead of pharmaceutical opes, whether or not it reads like addict behavior depends mainly on the presence of a medical condition (or lack thereof) which the substance in question provides effective relief for, and also on the specifics around use habits -- not merely the decision to take a less popular/traditional substance
@jackass6257 Pro-tip: your comment doesn't really make sense and is difficult to take seriously, considering that dopamine is THE primary neuroreceptor involved in ADHD...
I appreciate the technical legality of this synthesis, but with that collective list of unique ingredients, the DEA may still be very interested based on numerous popular precursors for MDxx compounds.
You didn't get a precipitate in the first step because of impurities and unreacted reagents. You can obtain a precipitate in the first step by washing with metabisulfite (or dumping the whole mixture into a solution of metabisulfite). This removes unreacted aldehyde that becomes water-soluble as bisulfite adduct. The material will then be much more likely to crystallize.
@@rocketlauncher6207 I think it depends on the kind and size of group that is attached to the carbonyl. In a more general sense, the solubility of aldehydes and ketones is only mediated by the carbonyl oxygen acting as H-bond acceptor. In the case of adducts, there are way more oxygens that can participate in hydrogen bonds and there is the ionic charge of the salt. Whether or not the adduct will be very soluble in water, it will certainly be more soluble than the original aldehyde, and conversely it will be less soluble in the oil that we see in the video. It's a good way to separate the two
Mate congrats on the 100k subs! Your little self-aware text remarks had rolling. The troll face on the drug lab test results was *chefs kiss* very enjoyable watching your borderline legal videos
Nice work, even after getting such disappointing oil. Actually you can do TLC but on paper, ordinary filtering paper. Sure it'll be uncomparable with any external reference but you can put witness drops with source substances on same paper to get some references. And you can buy this pills or whatever OTC and extract taget substance from there for reference,if possible. Amines can stay oily because of presence of solvents and water. Try to dry in vacuum this oil to remove traces of anything volatile and then recrystallize.
Propylhexedrine HCl has a melting point of 123°C. When melted, it looks like a clear to slightly brown liquid. To solidify Propylhexedrine HCl, you need to cool it in the freezer and then refrigerator for a few hours. Also, using a Bovado Borosilicate Glass cooking dish to have more surface area can help with Propylhexedrine HCl. Propylhexedrine HCl should be hard crystals, but sometimes it's soft and pasty due to moisture or impurities from Petroleum Distillates based solvents. I think I need Pentane and Hexane. I also made Hydrogen using Aluminum Galinstan amalgam.
Avoid Al/Hg. Make an Al melt and make some pirate Raney nickel. It's not near as flammable as you might believe. I usually add some Zn as a promoter. Get a crucible and propane furnace and melt some beer cans. Thank me later.
Before you make fluorine, checkout the video on Ty of some crazy German/Austrian guy making a HUGE ampule of pure caesium. Can’t remember the final weight, but it’s way more than enough to burn a large building down 😂 he distilled it really well, and the final product was completely free of any oxidation. Absolutely stunningly beautiful to look at.
Normally when you do RA, you add the aluminium and all of your reagents to the reaction vessel first. Then you proceed to add the mercury solution. This way, everything comes together in the same place and at the same time. Also it’s better (usually) (depending on your catalyst) to grind the aluminium up almost to a powder, but not all the way. This will prevent the reaction from occurring super slow by increasing surface area, and also prevent it from going to fast and foaming up, AND getting too hot.
If you ever get around to doing an Amalgam reduction again, I'd love to see you do a Galinstan/Al alloy one. There's a post on science madness about it, it seems to work great and it's non toxic.
Everything should be legal....its none of the governments business to tell us what we can and can't do...as long what you do don't infringe on others rights and libertys then it should be completely legal
A lot of your reagents are on watch lists. Still ok to buy since your not doing anything naughty, but defo expect a knock at the door at some point from some angry guys with a big stick up their asses, who are convinced you are the devil, and are paid a LOT of money to cause the problems that they are paid to also fix. Great, GREAT video!!
Lol. There were two statements in here that will take this video down in a flash *when u say then that refuses or converts to anfetamine [purposefully spelled that wrong] Great video!
I'm a PhD level chemist, and I have had years of both academic and home chemistry experience. This synthesis scared me, in all honesty. Not because of the product being formed but the methods. You seem to have an undergraduate-level understanding of some of these reactions, which is incredible and I deeply admire, but you need to be far more careful with some of these reagents and make a safety plan lest something goes horribly wrong. Very close friends of mine have had their home labs burn down or nearly burn down, and they have graduate degrees in chemistry. ThatChemist is a great guy, and I hope you both have not only discussed synthesis but also safety. That Hg(II) is no joke also, and I hope it was properly disposed of. Love the channel, but I would hate to see you get hurt.
The thing that boggled my mind recently was that levomethamphetamine is an OTC drug in nasal sprays in the US and has been for decades. 🤣 Not gonna suggest you try THAT OG decongestant, but I did find learning out that levomethamphetamine is OTC bizarre to a serious degree. I get it *mostly* impacts the rest of the body vs the brain, unlike dextromethamphetamine, similar to how levoamphetamine works in comparison to the dextroamphetamine that I take as spansules for my severe ADHD, and for which the morons at the DEA + Greedy Mofos in the pharmaceutical monopolies have caused a massive shortage, bad enough that it ALMOST makes me wonder if the CIA is afraid of dextroamphetamine cutting into their cocaine sales to prop up and pay for all of their Black ops operations, as they have since my Dad was in special forces in Vietnam. 🤣 Cuz, wouldn't they WANT druggies to stick with dextroamphetamine as opposed to using cocaine or dexteomethamphetamine? 🤔 Like, from a harm reduction standpoint, dextroamphetamine is a fuckton less problematic than dextromethamphetamine. (Still crazy that dextromethamphetamine is only scheduled 2 or that cocaine is still legal for dental and eye surgery. 🤣 Yeah, the dental and opthomopogy students are VERY familiar with this. 🤣 I had one retired dental prof openly admit that he could get as much cocaine as he wanted. Though, the side effects make cocaine rather undesirable. 🤔 Though, it works amazing to stop bleeding and as a contact anesthetic (why it was used to begin with). Still, crazy. And, no. I don't recommend ADHD chemists who are sick of dealing with the med shortage to go out and make their own homebrew dextromethamphetamine or dextroamphetamine if they have a prescription and a license to produce hazardous chemicals, or even a lab with explosion proof fume hoods. It ain't worth it. Leave that to your professors to do while you hide behind a concrete wall. 🤣 Seriously, though, chem regulation in this country is sus as fuck. Meth is schedule 2, benzos are schedule like 4 (absolutely nuts, they should be schedule 2 just based upon side effects and severity of chemical dependency alone! If we are going to schedule drugs), and yet THC is schedule 1 with no acceptable medical usage… 😑 And MDMA, LSD, psilocybin, and other psychedelics that can MASSIVELY help thise of us with treatment resistant C-PTSD were recently yet again told to "fuck off" by the FDA, because #reasons. Drugs that are generally safe when used responsiby = disproportionate/illogical scheduling. Hence, how utterly bizarre it is that levomethamphetamine is OTC. 🤣
As someone with both an absolute need for ADHD prescriptions, and in very very high doses due to some genetic tomfoolery thats decided to play a trick on me by giving be both utterly debilitating ADHD along with an absolutely obscene response dose to medications. Im in a situation where should my prescriber quit (its happened unnervingly often with no warning) i can end up having to explain to a walk in walk out insurance physician ive never met in 10 or so min why i need a prescription dose and quantity that looks utterly indefensible by current standards on paper (thanks war on drugs for pushing the FDA to limit the on label doses for stimulants at a number thats under an estimated 5th of peoples required doses by the FDAs own admission) I can confidently tell you 3 things 1. Levomethamphetamine is utterly useless as a stimulant, in very thorough searching to see if any OTC substitutes can function in the event of a supply interruption i can tell you it just doesent work. It might seem like it should, and heck, even if you read some papers on it it *seems* like it should at high enough doses. It doesn't, waste of time. 2. The fear of prescription stimulants combined with the utter lack of caution in prescribing benzos in massive doses for near every on and off label use you can think off is black comedy, Its not uncommon now to walk in with a clear, documented, long term ADHD diagnosis and be offered xanax or valium "to see if that works before trying stimulants which are addictive" (thats a quote by the way), or be told "Id like you to quit ADHD meds and try an SSRI, i dont belive in adderall because the side effects" (also a quote) heck i got offered clonidine or xanax for an episode of acute muscle tension when i dident even ask for meds, i just wanted to check everything was fine after a novel and unusually severe pain out of caution. The fact they hand out something that can show a marked withdrawal syndrome in as little as a weeks use at any dose as a "non addictive" alternative to a medication im both *Already taking* and doing so at a minimum of twice the currently on label amount which i can, and regularly do, skip for multiple days without ill effect is something out of a monty python skit. If they had reason to think a patient is unreasonably dependent on a substance is their modus operandi to send them right into withdrawal and call it a day? 3. Yours where in the 2-3 hour peak range when your wrote that lmao. mallinckrodt or activas? Side note, dextroamphetamine and dextromethampetamine are not *that* different until midway through the dose curve useing the same ROA. At MG equivalent doses, 5-10 MG MA is equivalent to 30-40 dex pretty evenly, probably reliably indistinguishable if you A-B'ed it. The difference comes at more moderate doses in two ways, MA has an exponentially higher tolerance ceiling, which is where most of its medical use emerges, theres a point dex, adderall, or amp sulf simply wont do more, MA will keep going, which makes it vital particularly for treating narcolepsy, or as an alternative for high dose response ADHD patience, its also where the much higher abuse potental emerges. Secondly at a certan point it starts takeing up a more adderall esq feeling of importance in what your doing which scales with the higher potency and dose ceiling, which can in some patience be hugely helpful, and in most people, lead to locking on to useless BS. just saying that because while its not optimal for *me* i do have a friend with narcolepsy who with a moderate dose is able to live a normal life who wouldn't be able to otherwise, so it is a legal med for a reason. and on that note, i see why i shouldn't eyeball comments while waiting for the gears to start turning before writeing the next finals paper, JFC,
I can tell you from dissecting benzedrex inhalers that your product will be oily and that color at room temperature. It appears as a stain on a cotton rod of approximately that color. Not saying you should test it, but it likely is PPX.
This is so much more difficult than anything Walter White did, all he ever did could easily be done in a kitchen sink. Search up catalytic dehydrogenization.
when i interned for my BsC, i had to carry out the Friedel-Crafts acylation of thiophene with a nahphtyl-substituted chloride. It polymerized almost immediately in contact with the chloride and AlCl3. So i had to use an heavily diluted, on ice mixture of those, and dropwise added heavily diluted thiophene. It worked.
Cyclohexyl Bromide can react with Ethyl Acetoacetate Enolate made using Sodium Ethoxide NaOEt in refluxing Ethanol EtOH. Then it can react with HCl and heat and decarboxylate to Cyclohexyl-2-Propanone (Cyclohexylacetone).
It's a great pass-time, and the "entry cost" isn't too bad either (a few hundred for the glassware and a hotplate, plus a bit more if you're committed and build a fume hood)
there's actually a closer legal molecule. levmetamfetamine is just meth's enantiomer and it's also a legal nasal decongestant. it's just one methyl is a wedge instead of dash
Interestingly, both are Schedule I substances in Canada so you can buy a decongestant in Detroit, board a bus, and accidentally commit international drug smuggling
We used to eat the brown bits of benzedrex inhaler cotton back in the day. Plenty of ravers parties off the cotton while hating ourselves for the terrible camphor taste bubbling up from our stomachs
I thought this was going to be about Levo-Methamphetamine. Which is also used in decongestants and is more adrenergic than dopaminergic. I would argue that's closer to D-meth than even this. Although, I did not realize how close propylhexedrine was to meth, structurally. Very interesting.
I think that would be impossible not to get deleted instantly. Most routes to L-meth yield 50/50 of the L and D types, and the L type is separated from the mixture later on. That's why L-meth is also being regulated -- you can chemically modify it a little bit, then modify it back, voila, you now have a 50/50 mix of meth.
eh, L-meth is pretty useless, PPX is *something* the primary problem is its violently vasoconstrictive compared to its piers, doesent work quite as well and crashes like a plane into the second tower only a couple hours later at even responsible doses
I love how a bunch of straight lines can be either random lines to most people, or the blueprints of chemicals from benign to crazy toxic/deadly with just a line or two difference lol
In the nitropropene reduction you could add LiAlH4 in thf to the nitropropene solution diluted in the same solvent, this would avoid the degradation of your starting compound
I remember reading brightstar's synthesis on seedy forums 20 years ago. I knew where you got it from when I saw the mercury-aluminun amalgam. That's the part that scared younger, dumber me away from making happy sugars.
I wonder if there’s a way to make an analogue of the OG ice “4-MAR” (4-methylaminorex but spelling may be off) I know analogues exist that are legal, but it’s barely been properly documented, so it might be worth looking into
There was an old thread on (i think) sciencemadness that did reductive amination with formaldehyde and metallic zinc powder. I'd love to see a video on that. Or alternative hydrogen catalysts like Raney or Urushibara nickel, or pyrophoric nickel produced by thermal (anoxic) decomposition of nickel oxalate.
He didn't get stupid...he just went more in the materials science direction lol. I do like his recent synths, like thioacetone and all of his glove/soda synths!
A Grieco elimination would have been a better choice of reaction type to make the alkene in your first route. Also, I would have hydrated the alkene and oxidized to the ketone so you could do a reductive amination rather than an alkylation to install the amine.
Even if someone did try to modify this pathway to produce some less legal analogues, my man would that be prohibitively expensive and comparatively difficult... Especially for something that can be made via a one pot method in like 15 minutes of which there are videos on TH-cam of people doing said shake and bake methods.
@@Imaboss8ball You don't know what your saying. The only thing you need that is regulated is pseudoephedrine. Some states you can buy it over the counter then you can get everything else at walmart, tractor supply stores, and dollar stores.
@@Imaboss8ball some places have banned pseudoephedrine however there are so many ways to get around this... Like you can directly substitute ephedrine over pseudoephedrine and it will work (and you can buy ephedrine in bulk easily). Everything else required for it can be obtained from things like fertilizer and batteries. I genuinely mean it when I say everything else as it's your precursor+ammonia+alkali metal and that's it. It's dirty and dangerous but the people doing this don't care
@@Brendakye2468few people are doing it anymore in the US as there is huge amounts of extremely cheap pharma grade mass produced cartel methampehetamine carried across the border from Mexico.
@lagrangiankid378 people never did shake and bake because it's cheap (it isn't, it's one of the most expensive production methods), they do shake and bake because their dealer won't supply to them anymore and it is so dead simple. People are still doing it and I've literally watched people do it in parking lots outside of Walmart this year.
@@Chiberia It means that over regulation of the legal market leads to the formation of a completely unregulated black market. It's the soap bar effect: the stronger you hold it, the more it flows out of your hands.
16:09 I'm by no means a chemist but I get the feeling whenever you see that orange vapour it's always something scary, bromine being a key example of scary orange vapour.
why you all want fluorine? I mean, are you trying to start a semiconductor fab in the backyard? I did chlorine synthesis and it was hell! like utter hell! hell has no brimstone or sulfur, it has chlorine, I'm sure of it!
Mostly to show that it can be done safely in a home lab. Fluorine is twice as toxic as chlorine, but overall, they are VERY similar. And when a reactor can only produce 30mL of gas per minute, the risk of inhaling a dangerous amount is very low (especially in a fume hood like I have).
@@fishingfan1500 It's a name I made up based on the fact that both "dick" and "johnson" are euphemisms for penis. I am not sure what you're thinking about, but probably not that.
It's made from fine zinc powder reducing a nickel salt, very similar to Raney nickel. It CAN be made from aluminum, but when I tried with shredded foil (since I didn't have zinc), it didn't react very well at all.
Go to ground.news/Labcoatz to see how any news story is being framed by news outlets around the world and across the political spectrum. Use my link to get 50% off unlimited access with the Vantage Subscription.
Also, it has come to my attention that one of the chemical diagrams was wrong: it's a small thing, but the double bond on the imine intermediate (produced from the norpropylhexedrine and formaldehyde) should be on the nitrogen's other bond...it's a METHYLimine
Bro, can you do a course of oxytocin? And LSD,
6:30 As a fellow organic chemist.....
"So you decided on madness and then eventual suicide the long way around."
You should try Raney nickel as a reductant, it’s very cheap and a very good reducing agent.
I think youtube probably unsubscribed me. So i reload app to check, then subscribe again.
Just for you know. Not gaslighting, but first comment.🤡🤏
I edited in adding formic acid and the like from the comment disappeared.
we're so back (on the watchlist)
yessir
Lol
Oh you're back
you left it 😂
True but these times you would have to delete all fun science channels- so at least I am on that list anyways..
It’s funny that it would have been easier to *actually* make meth.
I feel like you could accidentally make meth with this process. Also it requires the same restricted precursor to meth.
Making meth is stupid easy. Making _clean_ meth that isn't poisoned with toxic impurities, and without blowing anything up is the hard part (doubly so if you consume any of the product while making more). Most of the work in designing commercial viable synthetic pathways for drugs is finding ways to avoid _creating_ those toxic byproducts. Since they cannot be reasonably removed at-scale, the only solution is to carefully control conditions to not generate them in the first place. (Or if you are selling illegal drugs on the black market, just don't worry about your clients' future health).
LabCoatz: “TH-cam, this is completely legal you have no recourse to age restrict or demonetize”
TH-cam: “and I took that personally”
It pays to remember that TH-cam is a global platform, and what is "technically legal" in one country can be very much an illegal analogue in others.
@@theKashConnoisseur TH-cam is an American platform, actually. California, to be specific.
@@PhysicsGamer American company, global platform.
@@PhysicsGamer Just because it has a US headquarters doesn't restrict the platform's use to California lmao.
@@theKashConnoisseur Sure, but they operate under California (and therefore American) law.
12:12 "As with most of life's problems, this was readily overcome with a healthy dose of acid" lmfao
fax 💯
Amen brother 🌈🌻
Oh now I get it. 😂
😱😱😭🤩🕺
"I have a sore throat"
****school nurse give you a thumbprint of orange sunshine****
Make pseudoephedrine next to tell DEA (and FDA) it's dumb to restrict it.
EDIT: Nice that google's first autocomplete result is propylhexedrine abuse...
IDK how it's in USA, but in Poland pseudoephedrine is 100% legal and You can buy it everywhere.
@@norbert.kiszka it *has the potential* to be converted into MDMA or meth. But so do the rest of the chemical elements in meth. Our DEA likes to make chemicals illegal without trying to help the people struggling with addiction. So yeah they just keep making more and more basic level chemicals illegal.
@@norbert.kiszkaIts very restricted, due to people using to to make meth. You can get it OTC, but its a pain
@@norbert.kiszka It's legal here too, can buy it at any pharmacy. You're just limited in the amount you can buy per month and you have to give your ID, which gets run through a centralized database to make sure you're not just running from pharmacy to buy more than you're supposed to
It's a fully scheduled drug in my state, meaning you need a doctor's prescription for it no matter what and can't get it OTC or from the pharmacist. And yet, meth is still a huge problem here and has actually gotten worse since the pseudo-ban (pun intended). Shocker 🙄
THE GOVERNMENT HATES HIM FIND OUT THIS MAN STAYS AWAKE FOR 7 DAYS STRAIGHT
and also half an hour gay
@@quint3ssent1a +2
@@quint3ssent1a does that mean if you are already gay you will stay awake for 7 days gay and a half hour straight?
This is a known side effect of stimulant abuse.
Many such cases
Careful, That Manchild might contact your family and their associates on you...
😂
Definitely an IYKYK moment
I'm not scared of the boogie man...I mean That Chemist...
@@LabCoatz_Science He may be That Chemist, but he's not Dank Chemist. 😎
such a disappointing situation with that one. 😞
People can be really stupid sometimes.
I remember when ChemPlayer got banned for making _precursors._ I know that drug chem (and energetics) gets the views, but I really hate seeing quality chem channel after quality chem channel go the way of the dodo.
True, but ChemPlayer was also dabbling with more extreme precursors, like phenylacetone. TH-cam chemistry is always a bit of a gamble, but as long as things stay legal (and far enough away from illegal drugs), things tend to go alright!
My white phosphorus videos keep getting deleted. TH-cam really hates when you show how to make that...
@@BackYardScience2000 It amazes me sometimes that you can find video after video of people playing with microwave transformers but videos about white phos don't fly. The only logic I can come up with is that there haven't (yet) been any, err... "conflict crimes" committed with microwave transformers. And that makes them more "ad-friendly"?
@@BackYardScience2000
They deleted a video of you gently heating the scrapings of a match box?
That's crazy - why would they not want people to see someone collecting the red powder on matchboxes and gently heating it over a hotplate?
LabCoats is speed running ruining his life. not even exaggerating. This is like the 8th in a long string of very bad choices that he has made lately. Dude is screaming for help, but he won't accept help, so he'll continue to spiral until he changes his mind or... well, you know how the story goes...
I love this structure!
You two should do a collab, it'd be sick af
@@deangilburry8216agreed
I tried this, pharma made, one time and my goodness was it an amazing ride. I’ve wanted to do it again. I can see how some people end up in bad places with this type of thing.
I believe the biggest issue was the impurities produced via the Henry reaction (it is well-known to be one of the dirtiest synthetic pathways, with enough unique impurities carrying through to the final product to allow for forensic fingerprinting), as well as the side-products formed from the uncontrolled LiAlH4 reduction.
As an alternative route, you should really try doing a Grignand reaction with acetonitrile and the (bromomethyl)cyclohexane, which would allow you to directly reduce the formed imine to the primary amine in one pot.
If you manage to exclude water, oxygen and CO2 (which excess Grignard reagent will also help to scavenge down to PPM levels if you seal the apparatus with something like a balloon), then this pathway will produce much a cleaner and easily crystallizeable primary amine: After the Grignand reaction is finished, cool down the resultant ether solution to around 0°C in an ice bath. Then, while still minimizing exposure to the atmosphere, you just need to slowly add some LiAlH4 or borohydride, with stirring and cooling.
Those of us who have been particularly desperate when having issues getting ADHD meds have long been familiar with the Benzedrex last resort...nothing like those lavender burps to remind you you're having a horrible/great day!
Bruh really? Having issues getting amphetamine and going to Benzedrex sounds like addiction. When I couldn't get opioids I would get like 2lbs of poppy seeds and wash them to get the latex off.
@bok.. both in the case of Benzedrex instead of amphetamine, and poppy seed tea instead of pharmaceutical opes, whether or not it reads like addict behavior depends mainly on the presence of a medical condition (or lack thereof) which the substance in question provides effective relief for, and also on the specifics around use habits -- not merely the decision to take a less popular/traditional substance
Pro tip : pseudo is way better and literally meth without the dopamine but works wonders for adhd
@jackass6257 Pro-tip: your comment doesn't really make sense and is difficult to take seriously, considering that dopamine is THE primary neuroreceptor involved in ADHD...
I love benzedrex, PPX is beautifully fun drug
I appreciate the technical legality of this synthesis, but with that collective list of unique ingredients, the DEA may still be very interested based on numerous popular precursors for MDxx compounds.
that plus lab glassware is a door kicker
That sulfuric and hydrobromic acid route is a nasty, dirty process that is very difficult to control without a professional lab.
You didn't get a precipitate in the first step because of impurities and unreacted reagents. You can obtain a precipitate in the first step by washing with metabisulfite (or dumping the whole mixture into a solution of metabisulfite). This removes unreacted aldehyde that becomes water-soluble as bisulfite adduct. The material will then be much more likely to crystallize.
That's a decent idea!
Aren't carbonyl bisulfite adducts famous for being....water insoluble?
@@rocketlauncher6207 I think it depends on the kind and size of group that is attached to the carbonyl. In a more general sense, the solubility of aldehydes and ketones is only mediated by the carbonyl oxygen acting as H-bond acceptor. In the case of adducts, there are way more oxygens that can participate in hydrogen bonds and there is the ionic charge of the salt. Whether or not the adduct will be very soluble in water, it will certainly be more soluble than the original aldehyde, and conversely it will be less soluble in the oil that we see in the video. It's a good way to separate the two
Mate congrats on the 100k subs! Your little self-aware text remarks had rolling. The troll face on the drug lab test results was *chefs kiss* very enjoyable watching your borderline legal videos
I appreciate the irony of making fake urine to induce a fake failure of a fake drug test of a fake drug.
Nice work, even after getting such disappointing oil.
Actually you can do TLC but on paper, ordinary filtering paper. Sure it'll be uncomparable with any external reference but you can put witness drops with source substances on same paper to get some references. And you can buy this pills or whatever OTC and extract taget substance from there for reference,if possible.
Amines can stay oily because of presence of solvents and water. Try to dry in vacuum this oil to remove traces of anything volatile and then recrystallize.
Propylhexedrine HCl has a melting point of 123°C. When melted, it looks like a clear to slightly brown liquid. To solidify Propylhexedrine HCl, you need to cool it in the freezer and then refrigerator for a few hours. Also, using a Bovado Borosilicate Glass cooking dish to have more surface area can help with Propylhexedrine HCl. Propylhexedrine HCl should be hard crystals, but sometimes it's soft and pasty due to moisture or impurities from Petroleum Distillates based solvents. I think I need Pentane and Hexane. I also made Hydrogen using Aluminum Galinstan amalgam.
this
Avoid Al/Hg. Make an Al melt and make some pirate Raney nickel. It's not near as flammable as you might believe. I usually add some Zn as a promoter.
Get a crucible and propane furnace and melt some beer cans. Thank me later.
Before you make fluorine, checkout the video on Ty of some crazy German/Austrian guy making a HUGE ampule of pure caesium. Can’t remember the final weight, but it’s way more than enough to burn a large building down 😂 he distilled it really well, and the final product was completely free of any oxidation. Absolutely stunningly beautiful to look at.
Advanced tinkeringis thr name of the channel if anyone curious
I would have just put a label on the specimen jar, peed in it, and added a drop haha.
That wouldn't have given a definitive result due to all the drugs he's been doing.
@@1BergerVongSchlauigkeitHer 🤣
He didn't because he's actually a meth addict so it would have contaminated the results😢
Normally when you do RA, you add the aluminium and all of your reagents to the reaction vessel first. Then you proceed to add the mercury solution.
This way, everything comes together in the same place and at the same time.
Also it’s better (usually) (depending on your catalyst) to grind the aluminium up almost to a powder, but not all the way. This will prevent the reaction from occurring super slow by increasing surface area, and also prevent it from going to fast and foaming up, AND getting too hot.
If you ever get around to doing an Amalgam reduction again, I'd love to see you do a Galinstan/Al alloy one. There's a post on science madness about it, it seems to work great and it's non toxic.
this is my domicile and i will not be harassed
I rarely let ad reads play, but you’re on my cool people list.
Benzedrex inhalers always seem to mysteriously sell out around midterms and finals week. If you know what to do with the cotton inside, you know...
weird!
I got lemon juice on hand at all times, I know what to do, I know what I must go do again.
Oh boy we made it to the list now!
TH-cam hate this guy for absolutely no reason
Because TH-cam is evil.
The HCl gas needed to be dried with calcium chloride and xylene dried prior.
Everything should be legal....its none of the governments business to tell us what we can and can't do...as long what you do don't infringe on others rights and libertys then it should be completely legal
Haha that is how these kind of synthesis usually go :D I completly feel your frustration.
Study for chem test: no
Watch someone do random synthesis: yes
That's literally what I'm doing right now...I should get back to studying...
A lot of your reagents are on watch lists. Still ok to buy since your not doing anything naughty, but defo expect a knock at the door at some point from some angry guys with a big stick up their asses, who are convinced you are the devil, and are paid a LOT of money to cause the problems that they are paid to also fix.
Great, GREAT video!!
Watching this before it goes down 😂
I downloaded it just in case lmao
Dido lmao
Lol. There were two statements in here that will take this video down in a flash
*when u say then that refuses or converts to anfetamine [purposefully spelled that wrong]
Great video!
@@thengspjo4716same
Watching this currently after taking a 25mg bronkaid for my usual winter congestion. Ephedrine should really get back to pre-2004 legality
So much relief when I saw you using a testing kit instead of taste testing it this time Lol
I'm a PhD level chemist, and I have had years of both academic and home chemistry experience. This synthesis scared me, in all honesty. Not because of the product being formed but the methods. You seem to have an undergraduate-level understanding of some of these reactions, which is incredible and I deeply admire, but you need to be far more careful with some of these reagents and make a safety plan lest something goes horribly wrong. Very close friends of mine have had their home labs burn down or nearly burn down, and they have graduate degrees in chemistry. ThatChemist is a great guy, and I hope you both have not only discussed synthesis but also safety. That Hg(II) is no joke also, and I hope it was properly disposed of. Love the channel, but I would hate to see you get hurt.
Mercuric salts were all safely given disguised as food to the children of a nearby orphanage, in full accordance with federal law and EPA protocols.
The thing that boggled my mind recently was that levomethamphetamine is an OTC drug in nasal sprays in the US and has been for decades. 🤣 Not gonna suggest you try THAT OG decongestant, but I did find learning out that levomethamphetamine is OTC bizarre to a serious degree. I get it *mostly* impacts the rest of the body vs the brain, unlike dextromethamphetamine, similar to how levoamphetamine works in comparison to the dextroamphetamine that I take as spansules for my severe ADHD, and for which the morons at the DEA + Greedy Mofos in the pharmaceutical monopolies have caused a massive shortage, bad enough that it ALMOST makes me wonder if the CIA is afraid of dextroamphetamine cutting into their cocaine sales to prop up and pay for all of their Black ops operations, as they have since my Dad was in special forces in Vietnam.
🤣
Cuz, wouldn't they WANT druggies to stick with dextroamphetamine as opposed to using cocaine or dexteomethamphetamine? 🤔
Like, from a harm reduction standpoint, dextroamphetamine is a fuckton less problematic than dextromethamphetamine. (Still crazy that dextromethamphetamine is only scheduled 2 or that cocaine is still legal for dental and eye surgery. 🤣 Yeah, the dental and opthomopogy students are VERY familiar with this. 🤣 I had one retired dental prof openly admit that he could get as much cocaine as he wanted. Though, the side effects make cocaine rather undesirable. 🤔 Though, it works amazing to stop bleeding and as a contact anesthetic (why it was used to begin with).
Still, crazy.
And, no. I don't recommend ADHD chemists who are sick of dealing with the med shortage to go out and make their own homebrew dextromethamphetamine or dextroamphetamine if they have a prescription and a license to produce hazardous chemicals, or even a lab with explosion proof fume hoods. It ain't worth it. Leave that to your professors to do while you hide behind a concrete wall. 🤣
Seriously, though, chem regulation in this country is sus as fuck. Meth is schedule 2, benzos are schedule like 4 (absolutely nuts, they should be schedule 2 just based upon side effects and severity of chemical dependency alone! If we are going to schedule drugs), and yet THC is schedule 1 with no acceptable medical usage… 😑
And MDMA, LSD, psilocybin, and other psychedelics that can MASSIVELY help thise of us with treatment resistant C-PTSD were recently yet again told to "fuck off" by the FDA, because #reasons. Drugs that are generally safe when used responsiby = disproportionate/illogical scheduling.
Hence, how utterly bizarre it is that levomethamphetamine is OTC. 🤣
As someone with both an absolute need for ADHD prescriptions, and in very very high doses due to some genetic tomfoolery thats decided to play a trick on me by giving be both utterly debilitating ADHD along with an absolutely obscene response dose to medications. Im in a situation where should my prescriber quit (its happened unnervingly often with no warning) i can end up having to explain to a walk in walk out insurance physician ive never met in 10 or so min why i need a prescription dose and quantity that looks utterly indefensible by current standards on paper (thanks war on drugs for pushing the FDA to limit the on label doses for stimulants at a number thats under an estimated 5th of peoples required doses by the FDAs own admission) I can confidently tell you 3 things
1. Levomethamphetamine is utterly useless as a stimulant, in very thorough searching to see if any OTC substitutes can function in the event of a supply interruption i can tell you it just doesent work. It might seem like it should, and heck, even if you read some papers on it it *seems* like it should at high enough doses. It doesn't, waste of time.
2. The fear of prescription stimulants combined with the utter lack of caution in prescribing benzos in massive doses for near every on and off label use you can think off is black comedy,
Its not uncommon now to walk in with a clear, documented, long term ADHD diagnosis and be offered xanax or valium "to see if that works before trying stimulants which are addictive" (thats a quote by the way), or be told "Id like you to quit ADHD meds and try an SSRI, i dont belive in adderall because the side effects" (also a quote)
heck i got offered clonidine or xanax for an episode of acute muscle tension when i dident even ask for meds, i just wanted to check everything was fine after a novel and unusually severe pain out of caution. The fact they hand out something that can show a marked withdrawal syndrome in as little as a weeks use at any dose as a "non addictive" alternative to a medication im both *Already taking* and doing so at a minimum of twice the currently on label amount which i can, and regularly do, skip for multiple days without ill effect is something out of a monty python skit. If they had reason to think a patient is unreasonably dependent on a substance is their modus operandi to send them right into withdrawal and call it a day?
3. Yours where in the 2-3 hour peak range when your wrote that lmao. mallinckrodt or activas?
Side note, dextroamphetamine and dextromethampetamine are not *that* different until midway through the dose curve useing the same ROA. At MG equivalent doses, 5-10 MG MA is equivalent to 30-40 dex pretty evenly, probably reliably indistinguishable if you A-B'ed it. The difference comes at more moderate doses in two ways, MA has an exponentially higher tolerance ceiling, which is where most of its medical use emerges, theres a point dex, adderall, or amp sulf simply wont do more, MA will keep going, which makes it vital particularly for treating narcolepsy, or as an alternative for high dose response ADHD patience, its also where the much higher abuse potental emerges. Secondly at a certan point it starts takeing up a more adderall esq feeling of importance in what your doing which scales with the higher potency and dose ceiling, which can in some patience be hugely helpful, and in most people, lead to locking on to useless BS.
just saying that because while its not optimal for *me* i do have a friend with narcolepsy who with a moderate dose is able to live a normal life who wouldn't be able to otherwise, so it is a legal med for a reason.
and on that note, i see why i shouldn't eyeball comments while waiting for the gears to start turning before writeing the next finals paper, JFC,
I can tell you from dissecting benzedrex inhalers that your product will be oily and that color at room temperature. It appears as a stain on a cotton rod of approximately that color. Not saying you should test it, but it likely is PPX.
yea but the cottons also have that nasty lavender n stuff, so who knows what pure stuff should be like (even oil extracts won't be pure)
That spongebob scene is hilarious
If taken internally (not as directed), propylhexedrine is a CNS stimulant and does have high abuse potential.
I'm assuming he knew that but chose to omit it in hopes of not giving anyone any ideas lol
Congrats on 100k!
Excellent video. Failure videos are great because we still get to see the process of experimentation.
Cyclohexyl-2-Nitropropene can be reduced using Tin Chloride and HCl to Cyclohexyl-2-Propanone Oxime. Then Zinc dust reduces it to Norpropylhexedrine.
This is so much more difficult than anything Walter White did, all he ever did could easily be done in a kitchen sink. Search up catalytic dehydrogenization.
Not on the scale he did though.
bro what 😂😂 nobody is making 99.1% pure ANYTHING outside of a pharmaceutical lab
when i interned for my BsC, i had to carry out the Friedel-Crafts acylation of thiophene with a nahphtyl-substituted chloride. It polymerized almost immediately in contact with the chloride and AlCl3. So i had to use an heavily diluted, on ice mixture of those, and dropwise added heavily diluted thiophene. It worked.
You could also try an iron reduction to a propanone from the nitro propane. Or a 2 step NaBH4 + H2O2/K2CO3
been waiting for this for a while looks great!
Cyclohexyl Bromide can react with Ethyl Acetoacetate Enolate made using Sodium Ethoxide NaOEt in refluxing Ethanol EtOH. Then it can react with HCl and heat and decarboxylate to Cyclohexyl-2-Propanone (Cyclohexylacetone).
1:28 I don't remember that episode of SpongeBob 😂
I've wanted to get into hobby level chemistry. I think what you're doing is interesting and cool.
It's a great pass-time, and the "entry cost" isn't too bad either (a few hundred for the glassware and a hotplate, plus a bit more if you're committed and build a fume hood)
those hyperlab screengrabs are gonna get you on a list labcoatz...
It definitely has abused potential. The only thing really stopping people from that is the lavender oil in it which can be easily extracted
If you have a less...expensive imine available, I would be curious if the reduction could be done with Al/Ga instead of Al/Hg.
I was thinking about that yesterday, lol
now that's a... rewarding... synthesis ;)
0:25 nearly😁😁😁😁
Super cool seeing your channel grow.
there's actually a closer legal molecule. levmetamfetamine is just meth's enantiomer and it's also a legal nasal decongestant. it's just one methyl is a wedge instead of dash
Interestingly, both are Schedule I substances in Canada so you can buy a decongestant in Detroit, board a bus, and accidentally commit international drug smuggling
We used to eat the brown bits of benzedrex inhaler cotton back in the day. Plenty of ravers parties off the cotton while hating ourselves for the terrible camphor taste bubbling up from our stomachs
I thought this was going to be about Levo-Methamphetamine. Which is also used in decongestants and is more adrenergic than dopaminergic. I would argue that's closer to D-meth than even this. Although, I did not realize how close propylhexedrine was to meth, structurally. Very interesting.
I think that would be impossible not to get deleted instantly. Most routes to L-meth yield 50/50 of the L and D types, and the L type is separated from the mixture later on. That's why L-meth is also being regulated -- you can chemically modify it a little bit, then modify it back, voila, you now have a 50/50 mix of meth.
eh, L-meth is pretty useless, PPX is *something* the primary problem is its violently vasoconstrictive compared to its piers, doesent work quite as well and crashes like a plane into the second tower only a couple hours later at even responsible doses
I love how a bunch of straight lines can be either random lines to most people, or the blueprints of chemicals from benign to crazy toxic/deadly with just a line or two difference lol
***has sore throat***
"As with most of life's problems, this was readily overcome with a healthy dose of acid"
***takes 1000ug, see's god***
In the nitropropene reduction you could add LiAlH4 in thf to the nitropropene solution diluted in the same solvent, this would avoid the degradation of your starting compound
ARE WE TALKING ABOUT LEFT METH?!?!
Nevermind, I thought you were talking about levometh.
@@TheChrisLeone ah yes, those sweet Vick's sticks...or "minty breath in your eyes" for my fellow ravers 🤪
I thought so too at first lol
I remember reading brightstar's synthesis on seedy forums 20 years ago. I knew where you got it from when I saw the mercury-aluminun amalgam. That's the part that scared younger, dumber me away from making happy sugars.
I wonder if there’s a way to make an analogue of the OG ice “4-MAR” (4-methylaminorex but spelling may be off)
I know analogues exist that are legal, but it’s barely been properly documented, so it might be worth looking into
There was an old thread on (i think) sciencemadness that did reductive amination with formaldehyde and metallic zinc powder. I'd love to see a video on that. Or alternative hydrogen catalysts like Raney or Urushibara nickel, or pyrophoric nickel produced by thermal (anoxic) decomposition of nickel oxalate.
Alternatively, I'd be very curious about making the methyl ether of ephedrine (and pseudoephedrine), and whether it has any interesting activity.
Saturated meth synthesis, complete with similar synthetic intermediates, formaldehyde and mercury(II) solutions.
1:02 Someone stole the double bonds in your phenyl, now it stinks benzene :(
I think this is a first time someone was happy to get positive results on that kind of drug test
8:43 looks like an orange soda with an icecube made of cola, which honestly sounds pretty good
First time watching this channel. It's like watching Nile before he got stupid.
He didn't get stupid...he just went more in the materials science direction lol. I do like his recent synths, like thioacetone and all of his glove/soda synths!
Legalize it!!
Bless you for telling the DEA exactly your dreams :)
"Fortunately, as with most of life's problems, this was readily overcome with a healthy dose of acid..."
Nice brother👍
That SpongeBob bit had me riling in painful laughter and confusion! I spit my coffee out!
Super intresting.glad you put this video on.🙂
I have all the tools and ingredients readily available; now I have the knowledge
A Grieco elimination would have been a better choice of reaction type to make the alkene in your first route. Also, I would have hydrated the alkene and oxidized to the ketone so you could do a reductive amination rather than an alkylation to install the amine.
i'm the average person and i agree with mr coatz.
PPX is indeed the most fun legal decongestant! Can't wait to see this one!
This guy is a legit chemist folks. Much like NileRed, he has done things with chemicals that would give an ophthalmologist night terrors.
Doesn't regular table salt contain iodine. And is it in large enough quantities to even make a difference.
It won't make a difference. If anything, there might be a few milligrams of propylhexedrine hydroiodide with the hydrochloride.
but does this fill the lab with that nostalgic m-lab smell that send us back to our childhood days?
i love writing lists, to do list, grocery list, watch list, I love making lists
Even if someone did try to modify this pathway to produce some less legal analogues, my man would that be prohibitively expensive and comparatively difficult... Especially for something that can be made via a one pot method in like 15 minutes of which there are videos on TH-cam of people doing said shake and bake methods.
I thought shake and bake is obsolete due to all the precursor bans.
@@Imaboss8ball You don't know what your saying. The only thing you need that is regulated is pseudoephedrine. Some states you can buy it over the counter then you can get everything else at walmart, tractor supply stores, and dollar stores.
@@Imaboss8ball some places have banned pseudoephedrine however there are so many ways to get around this... Like you can directly substitute ephedrine over pseudoephedrine and it will work (and you can buy ephedrine in bulk easily).
Everything else required for it can be obtained from things like fertilizer and batteries. I genuinely mean it when I say everything else as it's your precursor+ammonia+alkali metal and that's it. It's dirty and dangerous but the people doing this don't care
@@Brendakye2468few people are doing it anymore in the US as there is huge amounts of extremely cheap pharma grade mass produced cartel methampehetamine carried across the border from Mexico.
@lagrangiankid378 people never did shake and bake because it's cheap (it isn't, it's one of the most expensive production methods), they do shake and bake because their dealer won't supply to them anymore and it is so dead simple.
People are still doing it and I've literally watched people do it in parking lots outside of Walmart this year.
Legalize, regulate, and tax ALL DRUGS!!!
tax => black market
"regulate" - you realize that's what's done, currently, right? the schedules are literally regulation.
@@Chiberiaif you regulate everything you regulate nothing.
@@lagrangiankid378 what does that even mean
@@Chiberia It means that over regulation of the legal market leads to the formation of a completely unregulated black market. It's the soap bar effect: the stronger you hold it, the more it flows out of your hands.
Nice. Can't wait to synthesize this.
16:09 I'm by no means a chemist but I get the feeling whenever you see that orange vapour it's always something scary, bromine being a key example of scary orange vapour.
"All colored gases are toxic, but not all toxic gases are colored" my HS chem teacher used to say.
That was a great video I like to see the failures and successes.
Onto 'the widomaker', as it was called.
why you all want fluorine? I mean, are you trying to start a semiconductor fab in the backyard? I did chlorine synthesis and it was hell! like utter hell! hell has no brimstone or sulfur, it has chlorine, I'm sure of it!
Mostly to show that it can be done safely in a home lab. Fluorine is twice as toxic as chlorine, but overall, they are VERY similar. And when a reactor can only produce 30mL of gas per minute, the risk of inhaling a dangerous amount is very low (especially in a fume hood like I have).
Say my name
Thy lab's...
your god dam right
My name
Dick Johnson
@@bytefuis that the same DJ as what I'm thinking?
@@fishingfan1500 It's a name I made up based on the fact that both "dick" and "johnson" are euphemisms for penis. I am not sure what you're thinking about, but probably not that.
the AI spongebob and patrick talking about benzedrex was wild lmao
Damn, we had to learn all this in high school without the fun part of actually trying the synthesis in a lab.
I love everything about this.
What problems arose with the Urushibara Nickel? I'm not too familiar with it as a catalyst. Just hard to get? Dangerous to make?
It's made from fine zinc powder reducing a nickel salt, very similar to Raney nickel. It CAN be made from aluminum, but when I tried with shredded foil (since I didn't have zinc), it didn't react very well at all.
In the breaking bad scene, he uses mercury fulminate to explode everything in the building that taco was in