Making and Tasting the COLDEST Substance Known - Icilin
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- เผยแพร่เมื่อ 27 ก.ย. 2024
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In this video I am making one of the coldest/iciest/mintiest substances known, Icilin. It is a super-agonist of the TRMP8 ion-channel which is a receptor on our mucous membranes that gives us the cold feeling from temperature and food such as mint. The compound is not found in nature and is fully synthetic, there are no other known natural compounds that induce a colder feeling. Supposedly the compound WS-12 should feel colder but is less potent, which I will make later to compare.
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Pretty chill molecule.
Oh how does it feel to be the funniest person on earth
pretty cool too
Man, thats just cold@jakelancaster5889
tasting your own chemicals just like the good ol days
Always remember the quote: "If it don't contain nitrogen, I'm snaccin"
After 9/11
He casually mentions that the researchers did too. It's hard to resist with something like that
@@y33t23 uranium: am i a joke to you?
@@multiarray2320 the context there was organic molecules, I can very well live without heavy metal poisoning
Mix it with Capsaicin, Bromelain & Malic acid and apply to tongue.
Why malic acid? Anyway sound kinda irritating!
Are you trying to make the tongue implode, open a portal, or what
@@user255it’s what candy companies use to make stuff sour
Instant death
@@chemistryofquestionablequa6252 They use many other organic acids as well. I thought you have something more specific in mind.
OUR BOY BEAT THE LIT YIELD % EVERYONE!!! CLEANEST CHEMIST ON TH-cam #1!!!!!
Lmao
I mean if you get everything from Sigma obviously you’re gonna get a purer synthesis
you mean ligma baldrich
Can't wait to try this on my mucous membranes!
All of it
chilly foreskin
I'd rub it on my D before a good F.
11:40 I like the fact that you use gloves to handle the product, but at the same time you spread it on your skin 🤣
I wonder if the high cost of certain chemicals (like Icilin) is due to lack of economy of scale. That is, you're essentially paying some other chemist to make your specific order just for you, rather than paying some amount from a much larger batch (possibly made by the same chemist).
Very likely. There is not really a market for it so vendors can also get away with charging ridiculous prices.
To some degree, yes. But also, it's a useless chemical to a chemist, who could easily make it themselves anyway. So the only ones who would be interested in the molecule are molecular biologists, and those people generally don't need more than a few mg to do an experiment, so suppliers are more than happy to charge the same price for 10 mg that one would for 10 g if they were selling to a chemist.
@@adrianpip2000 I suppose, given its properties and uses, one might also be paying for USP-quality chemicals as well (as opposed to non-USP-quality ones, which I assume are cheaper to make).
Would think that makers of things like icy hot or bengay and other topical analgesics would be interested in that chemical
I'm surprised you experienced such a mild taste from the DMSO. I got a tiny drop of it (lab grade) on my skin and a minute later there was a disgusting onion/garlic taste in my mouth.
I also visited a veterinary barn where one of the equine patients with septicemia/toxic shock had been given 20cc IV DMSO and the whole place stank to high heaven for the rest of the day.
DMSO itself shouldn't have much of a direct taste when pure, it just contains sulfide impurities that make it taste a bit like dirty vegetables. I didn't have an aftereffect of garlic taste, I think that could be genetic
@@Chemiolis This was DMSO from Sigma-Aldrich which they claim is ≥99.9%. Yeah, it could be genetic as you say. I remember someone telling me that sensitivity to HCN is genetic. I can always tell immediately if someone in the lab has been using it, even when they can't smell it themselves. Mind you, the smell receptors also quickly desensitize to (or are killed off by?!) cyanide.
we should do a genetic test based only on the compounds you can smell and taste, then we could elect the genetically-best chemist in the world xD
Apparently "Part of the DMSO is transformed to the volatile metabolite dimethyl sulfide, which gives a characteristic garlic- or oyster-like smell when excreted through the lungs", according to Adverse reactions of dimethyl sulfoxide in humans: a systematic review (10.12688/f1000research.16642.2).
@@Kenionatus Interesting, thanks!
Your explanations of chemical transformations sound like some strategy war game steps.
I've got an exercise in awful for you to try. Isolate whatever is in a green persimmon, the small variety, that instantly dries the mouth and even the teeth, and taste that. I've never experienced something else that could make my teeth dry.
Probably immature tannins
First time I tried a persimmon I thought I was having an allergic reaction from how bitter it was and how it made my mouth dry. I only found out after googling that the it was because I ate a unripe one. I still haven't tried to eat a ripe one out of fear of getting that bitter taste again.
Khat (Catha edulis) does this too.
@@KyleJones734 Persimmons are bitter to you guys? I’ve always found them super sweet
@@eliasdraper1143 if they are not ripe, they are super bitter
0:50 example of Sigma Aldritch being Ligma-Baldritch
Sigma-Eldritch, of ELDRITCH HORROR PRICES 😂
I was eyeballing this chemical for a while now, cool to see a video about it
Random but I really hope someday a talented chemist will be able to discover a pain killer that DOESN'T cause negative physical reactions once someone stops using it. If someone can discover that it could genuinely change the world and improve so many peoples lifes. People that have never experienced physical withdrawals don't fully understand. Someone can fully be mentally ready but no matter what you do, physical withdrawals are completely unavoidable and it makes you feel like an utter failure and our society has a very misunderstood negative perspective on physical withdrawals and physical dependency. I truly believe if some scientist could discover something that doesn't cause physical dependency but helps with pain relief, then I really think it could positively impact the world.
If you actually have debilitating chronic pain then why are you trying to get off? You should be on long-term maintenance therapy, and therefore withdrawals shouldn't be an issue unless you are taking your medication improperly and are running out. All your language of "someone being mentally ready" makes it pretty clear that you are an opioid addict who can't stay clean and want a wonder drug that lets you get lit without the consequences, which hell, that sounds pretty sick, if that existed I'd want some too. 🤷
Also, physical withdrawals are definitely NOT "unavoidable" if your are actually trying to get clean. Buprenorphine is an EXTREMELY effective medication and a slow buprenorphine taper will give you essentially zero withdrawal systems.
That stock footage of the lab guys is hilarious
Surely ill buy chemicals from a stranger online to taste! ;)
Your tasting is well documented, great stuff
i'm surprised this isn't used more, given how easy and cheap it is to make
damn i didn't know u were chill like that 😳🥶
I'm glad I found this channel because nilered was getting boring with barely any uploads except shorts. Bye nilered, hello Chemiolis 😊
Don't forget Extractions&Ire.... if you don't mind chaos energy.
Nile blue too
@@andersjjensengarage chemistry will always have a special place in my heart
@@b3dubbs72 Everything Nile, I'm done with. Nowadays he's living off old vids I guess. As soon as he moved out of his parents garage, he went south.
@@BoyKhongklai his vids take a long time to produce because is projects have grown in scope. He’s put some banger long format vids in the past few months.
Is it really chemistry if u don’t taste the products?? 🤷♂️😉🍻
Sounds like a good ingredient to use in my limonada.
How is „potent“ vs „strong“ defined? How can something be stronger but less potent?
This is the difference between receptor affinity vs efficacy - think of affinity as how well a key fits in a lock, and efficacy as how far the lock turns
It's interesting that making double bond at @10:00 does not go towards the creation of the long conjugated system of double bonds.
That would be awesome to add to drinks just so they taste cold even if they arent
This is like the fentanyl of spearmint
A little suggestion: using your Eppendorf pipette for highly corrosive and volatile liquids like conc. HCl will dramatically decrease its lifetime because it can corrode the mechanical parts inside. At least that's what's been told during my undergrad.
Fantastic. Always enjoyable and well explained
i wonder if 'chewing gum' companies like extra/wrigleys/orbit etc would love this stuff to be encapulated in some kind of nanoparticle to make a chewing gum that would last forever or at least much longer than anything out there right now.the cold peppermind and wintergreen sensation is what everyone loves and associates with the flavor lasting a long time. so interesting!
bro skill issued literature OMEGALUL
Man I really love this Kind of videos
Taking "got ice in my veins" to a whole other level
@NileRed should do this too
Is it not lipophilic? I was a bit surprised when you said “this leaves me with one option” and it wasn’t an oil.
danm i wish i had a lab so i could make it and sell it at half or quarter price. how much would it cost to setup making it on average since its easier than most other things?
I think a really cool project for you to consider is making ferrari pigment red
Okay but how do you predict the way molecules will rearrange themselves within the right conditions with the right reagents? How do you ensure the chemical bonds as intended? Is it simply chance, followed by a gleaning of the intended chemical?
Good old DMSO - always enjoyed how quickly the taste of oysters appears when it touches skin.
Usually advised to use 85% aqueous since it's hard on your skin if it's pure....(some people use it as a topical analgesic, but the readily available MSM (methylsulfonylmethane) apparently does the same thing....did you know that MSM was briefly a controlled substance in California?
I was stoked to see this and immediately wondered "what about the WS- compounds?"
Interesting historical note, the WS in WS-5, WS-12, and WS-23 alludes to "Wilkinson Sword", a shaving products brand that evolved from a gun manufacturer in Great Britain started around 1775. Apparently they wanted better cooling sensation compounds for things like shaving creams and discovered some that are now in chewing gum and pretty much everything else. Which brings me to the question: Why doesn't Japan approve amides as food additives?
I think the problem with a lot of amides is that they can enzymatically hydrolyse in the body to give back the amine that is usually toxic.
I mean, it reminded me of the toffees I used to make at home, with Chili and Menthol Flavor... I called them the Hot and Cold. Very strange feeling eating them.
Cool chemistry you got here 😂 🥶
This is straight up alchemy
Need to put this in my pre workout…
if menthol is used on drinks to make them fresh, would it be viable to make an icilin soft drink?
Well that was a good peek into the world of chemistry, My probably (at least to the best of my own perception, grades aside) least understood school subject, that I've never further build upon after end of High School. Considering how most of what is going on inside humans is affected by exactly stuffs like that... Imagine what the people that understand, understand this science do... and can do... Like that was a week long process by a single person to make an bubble gum compound on steroids, now multiply that by 100ths of staff members of well funded government orgs operated for years upon years, having all the previous research and know how available. Well ~or private.
Do you take suggestions? I think it would be cool to have a video detailing the differences between food grade/lab grade/industrial/military etc chemical preparation.
Best vid ever
Hi Chemiolis, great vid. I was wondering, where do you get your reaction mechanisms from? Do you draw them yourself?
Thanks!
I draw them myself and usually let someone else check them. If I don't know it I ask someone. Often it is not readily found online and we draw the most reasonable/likely explanation.
I usually draw reaction mechanisms with ChemDraw, which I licensed with my uni account.
@@Chemiolis What software do you use to draw structures?
@@adamorylski8195 Can almost guarantee he's using ChemDraw with the ACS 1996 template
@@adamorylski8195 Chemdraw 21
Would you be willing to cover RB-64 at some point (salvinorin derivative compound)?
I want an Icilin vape!
is it safe to randomly taste a chemical without doing some tests before? i dont know anyzhing about chemistry but to me it seems unsafe/dangerous. wasnt one of the chemical something with cyanide?
No, you have to analyze it or know for sure that it is fine. In this case I did a simple but effective test and found it only contains the desired product. It is also important to take into account tasting vs ingesting, I always spit it out afterward. Besides, the amount is extremely small, even if my product was 95% pure, it is unlikely to cause harm. There aren't many compounds that are toxic enough to case harm with several milligram exposure. Experience and understanding the reaction and product is also ideal. With that, you can tell that there is no reason to suspect anything dangerous. There are more factors to take into account, such as literature precedent (the discovers tasted and ingested it too) etc.
@@Chemiolis thanks for the reply. what test have you done to make sure its just the desired product? (or have i missed it in the video)
I did TLC but I will probably also do NMR later
What happens when you mix capsaicin with icilin?
this guy spills less without a funnel than chemdelic with one
How this substance creates cold feeling?
Can anybody give me the source of the recipe he used?
Heat? Very interesting. I have some menthyl methyl lactate, I wonder how this compares. I'm guessing the heat is because both propylene glycol and DMSO are causing a heating sensation when they pull moisture from your mouth, or are actually heating up from exotherm.
How many weeks until somebody tries to vape this stuff
I want to taste this molecule!
Where can I buy Icilin? Thank you
you should try drinking cold water after tasting it to get the full experience
Could it be that the reaction of acetophenol is driven by anchimeric assistance (aka neighbouring group participation) of the carbonyl oxygen? This would form an oxocarbenium intermediate, which is very sensitive towards nucleophilic substitution and would definitely allow this specific substitution to occur at mild conditions.
Quick question, how do I learn analytical techniques and literature like this?
ICEEE 🥶
Can you involve the papers that you used?
DMSO is tastable???
I assume at some point soon, one of the chewing gum companies will use this in their mint gum.
Canada is watching....
The longevity community would be very interested in: Nicotinamide Riboside (NR) created from precursors.
Propylene glycol. Interesting. Could it be used in vapes?
WS-12 is used in vapes. This might be able to be used too, but with a nitro group being present it might not be very heat stable? Just at a glance, WS-12 looks like a more stable molecule that won’t polymerise or decompose readily under heating, unlike this Icilin
imagine an Icilin vape juice lmao
You really should've at least recrystallized the product before tasting tho
Yeah I was expecting to see a recrystallization too, not just a solvent wash.
WHAT IF YOU TASTE THIS MIXED WITH RESINIFERATOXIN?
Or capsaicin. (because it's safer)
Bro shulgin'd it😭
what if you put it on…
So you basically made 240.000$ worth of icilin 😎
should of drank water after tasting it and see how that feels
-If that stuff is so expensive, and you just made a ton, why not put it up for sale for a significant discount?-
Edit: Just got to that part. 👍
But can you vape it?
now make a chewing gum with it
Да, хорошие синтезы автор проводит.!
Pretty sure that's the crap they put in Burt's Bees
This was great. But I would consider the end of the video being biology experiment. No dissing of biology!
Must be pretty acidic looking at how much the charge of the OH group can distributed if deprotonated.
It's cool 'n all, but it's not 0K 😬
Where can I buy this in powder form this is perfect for a prank.
🥶🥶🥶
if i pour it on a pen does it gain antibiotic properties?
Huh.. I keep getting unsubscribed from. The channel.. TH-cam being weird as heck.
Well good in it for suggesting the channel again, but man I'd appreciate it if it didn't unsub me.
"skill issue" 💀
My dude, I would be doing some extra purification steps before tasting your product, especially considering how poorly mixed in that potassium cyanide was.
Are you dutch? youve got like a dutch accent
Don't expose me
you missed out on calling it the coolest molecule...
also, can you sell me some?
Watching this while high is distributing
I want this in a cigarette
theres NO WAY the chems are going to be easy to sell and ship from a website. Particularly overseas. Chems shipments are tightly regulated, and you can bet everything you do will be checked for illicit drugs. "hey bro, i ordered the icilin, ps. don't forget the fentanyl i paid extra for" . This is going to be an interesting project to witness as it develops.
did he died
Cool.
Bro why the procces really confuesing?
I must taste it i absolutly adiccted to that feeling i cant live with out that and chillis
Yellow chemistry. Lol..
Where do u sell your stuff atx
Store will go live in future video!
@@Chemiolis thanks! I'll have to make sure I'm subscribed!
I think we will see it on sexual lubricants...