Class (03) = Shikimic Acid Pathway (Part 02) | Shikimic Acid Pathway Steps with Chemical Reaction
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- เผยแพร่เมื่อ 14 ต.ค. 2024
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The shikimic acid pathway is a metabolic pathway for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine and tryptophan).The shikmic acid is a key intermediate from carbohydrate for the biosynthesis of C6-C3 units (phenyl propane derivative).
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
1. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
3. The fifth enzyme involved is the shikimate kinase, an enzyme that catalyzes the ATP-dependent phosphorylation of shikimate to form shikimate 3-phosphate (shown in the figure below).
4. Shikimate 3-phosphate is then coupled with phosphoenol pyruvate to give 5-enolpyruvylshikimate-3-phosphate via the enzyme 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase.
Then 5-enolpyruvylshikimate-3-phosphate is transformed into chorismate by a chorismate synthase. Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismate mutase.
Prephenate is oxidatively decarboxylated with retention of the hydroxyl group to give p-hydroxyphenylpyruvate, which is transaminated using glutamate as the nitrogen source to give tyrosine and α-ketoglutarate. The prephanic acid undergo aromatization to synthesize Phenylpyruvic acid followed by reductive amination to form Phenylalanine.
The anthranilic acid from chorismic acid extended to form phosphoribosylanthranilic aicd. Later in conjugation with serine in presence of tryptophan synthase it converts to aromatic acid tryptophan.
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My goodness!!!! I always postpone learning Pharmacognosy and especially these pathways, but I got so glued to this video and found it so easy and interesting as well!!!! I wish my professor would have taught this way. Completely loved it!!!!!! Genuinely appreciate your effort ma'am! Not only do you discuss the topic but also give important information related to it!!!!!
Thank you so much for your valuable feedback
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Very very nice explained mak i understood very clearly ech and every point than my teacher thought me in clss tq
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Thanks but I don't get the language, please help
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Detail study for competitive exam..
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We need cognosy sessions regularly like cology...please upload regularly..thanks to both of you..
She is trying her best and more than me but she has several other responsibilities. So she is not able to make videos as often as me.
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Mam paper mae introduction or ye synthesis dono likhna padega
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Mam please acetate pathway and amino acid pathway ki bhi video dalo
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in 6th step phosphoric acid is leaving so how it is written -h20 there ?
Mam plz upload videos on each day like pharmacology
Mam structure bna kr likha important h Kya exam me sidha name likh kr pura circle n bta skte
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Ma'am does prephenic acid contain chiral center's?
Structures are compulsory to draw in exam ?
Yes
Thank you..please upload regularly
Mam HMP is there?
Drive link is empty kindly check it..... When we try to download from Fb grup it waste time...
Reply by admin- we never said that you will get all cognosy nites in drive. We made drive so that we will automatically upload and that may be available to all in future. We have just started and you even cant wait for few time. Searching is time wast for you them making notes is not time waste for us ? Our priority is video not notes and we have cleared it already. Think about it
Mam i have question
Question: write a note on shikinic acid pathway . To kya isme introduction aur synthesis structure k sath dono likna padega
Agar dono likhte hai to bhot lamba bhi ho jayega
To Mam iss queston me kitna likhe
Mem d pharma Ke subjects ke topic ki video banaye
Mam extraction ke ware mein pls video banaye..n Happy teachers day mam....🙏🙏🙏🙏
Thank you. We have already uploaded 02 videos on extraction process and its apparatus. Pleaae find in our channel.
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Yes
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There is no Step 2 in the description box between step 1 and 3, please provide if it is left by mistake.
Ok i will ask madam to correct it.
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grandhi eswar Pharmacognosy materials are less availavle. Kokate and BN shah are good
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This video can't be played in my mobile .....
. How is it......
Their is no notes in drive
Mam, kyu kewal C-6 ka oxidation ho rha hai??
Aur agar ho bhi rha hai to kyu??
Because the enzyme oxidises the 6th carbon of the compound
Okay mam thanku 😊
Please upload acetate pathway..its been two weeks..no 5th semester video..please help..we can't complete our syllabus
She is doing her best. She is not professional not she is institute. She is making videos if solution thats a big thing for me and us.
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6 step m po3H2k Kiya hua mam
hello thank you for this lecture do you have hand written notes on this pathway ?
Sir maim ko 5th unite ka video ke liye time nikale le kisi tarah "i request plzzz sir"
Lloyd wale agye 👍
Mam can you provide notes?
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Mam unit 2,3,4,5se bhi questions de do
mam shikimic acid pathway ke part 3 kaha hai
انتِ جيدة
اشرحي لنا باللغة العربية
Ye aayega exam me?
Yes
Mam apke pass eske notes hai kay
CK kokate m chorismic acid ka structure galat bnah......
Refer Trease and Evans for this pathway..
Video seems normal at x1.25
Mam i need your help ..
Aap kaise cognocy pdhate h hm smjhte h pr kuch smjh nhi aata
Mam app Pharmaceutics ka lecture nhi hai
abhishek sharma She has not said anywhere about pharmaceutics. She is uploading cognosy only.
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(All replies are made by admin of the channel not by madam) What do you want to know ?
H
Very good explanation
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Structures are compulsory to draw in exam?
It will give you good marks
Thanks