NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4
ฝัง
- เผยแพร่เมื่อ 4 มิ.ย. 2024
- In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion.
#DavidSinclair #Longevity #Lifespan
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Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support
Links:
The Sinclair Lab website: sinclair.hms.harvard.edu/
Nicotinamide riboside is well-tolerated in humans: go.nature.com/3G1blbb
Nicotinamide riboside is a sirtuin-activator: bit.ly/3FUWWxa
Mice treated with nicotinamide riboside are longer-lived: bit.ly/3KD5L2h
Nicotinamide riboside protects mice against obesity: bit.ly/345E4hF
An inflammatory signature is attenuated by nicotinamide riboside: bit.ly/3Aum78I
Nicotinamide riboside, pterostilbene, and ALS: bit.ly/3nYdxK6
Nicotinamide mononucleotide combats diabetes in mice: bit.ly/3AwakXx
Aging is slowed by nicotinamide mononucleotide: bit.ly/344jGgW
Nicotinamide mononucleotide in prediabetic women: bit.ly/3H1vv6b
NAD and cancer in mice: go.nature.com/32xl1wp
Resveratrol protects mice against a high-calorie diet: go.nature.com/3G2pZyE
Resveratrol in patients with type 2 diabetes: rsc.li/3Aupk8h
Supplementing resveratrol in metabolic syndrome patients: bit.ly/3IE6C0Q
Fisetin enhances longevity in mice: bit.ly/3o10hom
Quercetin and fatty liver disease: bit.ly/3H4KWdF
Dasatinib and quercetin decrease senescent cell burden: bit.ly/35pCHuY
Mice fed rapamycin late in life live longer: go.nature.com/3F0yud3
Spermidine induces life extension and cardioprotection in mice: go.nature.com/3fXL5nn
Spermidine and older subjects with cognitive decline: bit.ly/3IG0MMy
Healthspan and lifespan in mice are improved by metformin: go.nature.com/3JSRZbs
Metformin, age-related diseases, and mortality: bit.ly/3KG0iaS
Targeting aging with metformin (TAME) trial: bit.ly/3eU9ABk
Treating mice with berberine extends lifespan: bit.ly/3AwkO9l
Lifespan in fruit flies is prolonged by berberine: bit.ly/3nYpwYt
Berberine and metabolic disorders: bit.ly/3KUpwCC
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. - วิทยาศาสตร์และเทคโนโลยี
Correction and clarification: At time point 1:07:37, I said I take 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. I apologize for the confusion.
You mentioned physedin or fysadine, but I can’t seem to find the correct spelling. If you could spell that I can investigate. Thank you for your time.
@@brianruppert1071 Fisetin
@@ExbotHero , thank you!! For some reason my computer couldn't track it down. I appreciate it, mate.
@@brianruppert1071 You're welcome my friend. 😊
Can you share what brands he recommends
I aged a full week waiting for this podcast 🙃
Well, you can reverse it back now 🤣🤣
🤣😂😳
double dose for a week and you will have gained an extra week ,im dreading the leap year I can't order enough
@@StarBoyyX you have some time...nxt L/Y 2024...🙃
@@fitafita7931 yup! Sinclair speaks and we're instantly younger😅
The co host is great. He has a very effective way to be both a “layman” as he asks questions while at the same time, generally savvy on the topics. Also, I congratulate you both on not taking yourselves too seriously. We already get enough of that with certain scientists.
I couldn’t agree more. Cohost totally makes this a next level podcast/conversation.
Agreed 100% - you took the words out of my fingers. 😁
Yes I thought that too - big shout out to Matt
Agree. He’s lovely as Sinclair mentioned 🥰
Technically he's the host, given that he's the one conducting the interview. But you're right. It's like nearly every time a question pops into my head, it's the very next question out of Matt's mouth.
I’m obsessed. I’m so excited about this research. I’m 50yo. I haven’t had any living parents, grandparents etc in over 10 years. I’m determined to change this for my family!
cute pic
My uncle was more educated than this man, and in the same field, and he died in his late 50s from cancer.
I promise you none of this stuff has any real effect on your longevity.
Live a healthy life, don't go taking a bunch of pills and potions and spending a load of money.
Take care lovely.
@@DoubtingThomas333 what does your uncle being more educated have to do with this. How was his lifestyle???
You re so cute fem
@@lizzie2301Look up criticisms of David Sinclair. There is at least one drug he claims reduces aging that has been proven over and over does not.
Great that you go deep into dosage, timings and other details on the supplements. So frustrating when others don’t do that.
I’m a simple man. I see a new Video from Dr. Sinclair and I immediately hit “like”.
This comment will age well, I predict
Me also, like first😂
As do I !
Me too!
This comment is great on the molecular level 🤐😅
I HAVE BEEN ON NMN FOR 2. MONTHS AND HAVE NOTICED A DRAMATIC IMPROVEMENT IN MY ENERGY & A DECREASED NEED FOR SLEEP. THANKS FOR YOUR AMAZING CONTRIBUTION ❤❤❤❤❤❤❤❤❤❤
Good for you 👍✌️. May i ask if you noticed any changes with your face skin? In terms of acnes and scar marks, if you have.... hopefully you don't have though....
Huge benefits for my face and skin
@@roberttorrie2651 thanks a lot, appreciated 👍
Which Brand please?
@Meem Aly wow I've been using it maybe 10 days and I swear my birthmark on my neck which is light in color is fading.
This is all so very fascinating! Thank you for speaking to the public directly without the media filter! You are both of a lovely generous spirit
David Sinclair and his Co author have produced one of the greatest blog for those managing their health. Bravo.
Thank you, Dr. Sinclair! I look forward so much to this podcast series. You truly are helping me 🙂
I was so stoked when I saw you started this channel. Loved watching you as a guest on other podcasts, so this is a treat.
Great job so far!
Why ?
@@mixalis6168 Why what?
@@ashleyjwilliamshand very good point!
@@ashleyjwilliamshand why, so you can grow a brain and ask better questions lol
@@bozorebebo9422 I didn't ask a question in my original comment post on this video, I asked "why what?" to the person that commented "why?"
Thanks for providing health and wellness on a massive scale!
I really enjoy these two and how well they get along. I learn so much in each of their podcasts.
Biggest Salute to professor David Sinclair...
Really looking forward to the Centennial podcast! brilliant podcast, you two are a great team!
I just finished your incredible book Lifespan-for the third time. First reading was an audio version and I stopped every hour to cry hard. I read a lot for a leadership program that I teach for the Air Force and thank you btw for mentioning USA air supremacy.
LITERALLY THE MOST INCREDIBLE INFORMATION!!!! I tried to relay it all to my own adult professional child and her husband and sounded like a blithering idiot bc I get so emotional. I am thrilled to find this podcast so I do not have to try.
Your optimism is a leadership trait; you’re an educator, not merely a scientist. Your book’s messages were mostly about longevity, but also part existential, part environmental, and part economical. As a teacher myself a huge obstacle is keeping my students and coachees happy about humanity. I am as wound up at the end of your book as I am at the beginning.
Thank you for your genius and your optimism.
I have been taking resveratrol for several years now. Unfortunately I am confused. Many evidences suggest on the contrary. Why doesn't Dr. Sinclare clearly answer the question raised by Dr. Brad Stanfield. I think there are many worried people around the world who have been taking resveratrol waiting for Dr. Sinclair's response. Please!
I can't believe this is free content
People should look into the FDA nmn supplement ban and its connection with Sinclair.
I did. Nothing burger.
Thank u! Really appreciate you being so direct about how to supplement these ingredients. And David you look amazing for ur age and that make me believe you… and love the fact that u do so much in your own labs… instead of reading from others’ report only!
Have been following David since the early Resveratrol days. Was super excited when this series started. Thank you for your continued efforts to expand our knowledge on this topic. You and Matt make a great duo and I hope this series continues beyond the current scope.
@@johnf4680 what do you mean?
Thank you! I appreciate your information and the sense of respect you seem to have for human kind and life in general. I wish both of you vibrant health and long life. 💚 I listened to your book on Audible. It's great.
Love your podcasts! The synergy is always courteous and encouraging. Keep up the great work 👏🏼👏🏼👏🏼
ya, you guys make a good team.
I'm taking a similar supplement regime myself and have been doing it for a couple of years now. 67 Y.O and feel more energetic and certainly fitter than any time since my early 50s. loving these podcasts learning so much from them, thank you.
Hi can you tell me please some names you take I need more to know the spelling , when he said Nmn quercetin and visetin or I don’t think writing right he mention desitin too, if I’m right. Thank you in advance
Great to see David covering rapamycin a bit more than in the past.
The co-host is such a nice guy!!! Makes the podcast just perfect
Fantastic co host! Great questions .. great balance of talking and allowing David sinclair to speak!
I really like the chat/questions format with this super knowledgeable co-host that makes it so much more valuable than with a real layman! Thanks both
I discovered Dr. Sinclair from Dr. Andrew Huberman's youtube channel. This is amazing information from Dr. Sinclair. Thank you for sharing your knowledge!
Love this series of episodes. Very informative and hopeful for those of us in their 70s. Vanity would have driven my interest before, now it is quality of life. Especially cognitive function as I'm watching friends in their late 70s and 80s, mentally declining. Not all but so many.
7-Oh and I drive a van full of handicapped and You and I both want my brains to work at capacity lol
We could talk about Huperzine A
Right behind you! 68 mother of two. Need to remain here as long as possible with healthy body and mind! My son passed during COVID. Being a mom of a 9 & 8 years of age need all help available!
I’m so grateful for having discovered you!! I hope to find the right manufacturers for these products.. 🙏🏼
Finally an interviewer that makes good use of time by letting Dave talk without interrupting and pushing off tangent. Thanks
I am a physicist by education. I used to think the biology was an easy subject. Not any more. Listening to this very interesting podcast, I marvel at the complexity of biological systems. This podcast is very informative and easy to understand. I plan to use some of the supplements outlined in this podcast. Excellent
Wow exactly my thoughts. Physics and mathematics is very simple compared to biology. I came to the conclusion biology plays with physics the way we play with math, which makes it very difficult to predict and understand
You should look up quantum biology.
@@armaniwebb4467 This is incorrect. Physics and maths are not simple in comparison. They are the hardest subjects.
@@creativesource3514 perhaps. But it is an elementary matter. I can explain to you the orbits of planets, their gravitational pull, their magnetic sphere. I can plot trajectories across the stars, how the stara form, hell i can make a star here on earth. I can tell you the age of the universe.
In the same breath I cannot tell you in a fundamental level how a cell transcribes genes, I cannot tell you how the proteins are transported and constructed, I cannot tell you how a protein is folded, I cannot tell you how a cell structures it's self, I cannot tell you how all this produces consciousness, I cannot explain the quantum mechanical effects of biology and how cells utilize it.
My point isn't that we don't know per se, as there are things we don't know about physics. But my point is more so to showcase that to understand how these biology systems fully function is nearly impossible due to the complexity. I can breakdown the solar system and its functions and interactions much more easily then I can explain a drop of blood.
@@armaniwebb4467 I'm a head and neck cancer surgeon. I find what I do pretty basic compared to what you do, general relativity and quantum and what's going to be next. I study undergrad physics in those two in my free time and my mind boggles at the complexities.
Thank you David - I am a huge fan of your work!
I truly appreciate everything you are working toward, even if much of it you have to hint at in over 40 hours of videos :). Who doesn't love a puzzle? You bring the thoughts and ideals of a future unlike any I would have thought to see in our lifetime. Thank you!
Cohost is great! Matthew great job explaining and discussing the finer details! Bravo senor!
Another excellent podcast David - we love your work!
A few drugs to add to your inventory list where possible ;)
@@nickl826 We already have NMN, resveratrol, quercetin, fisetin, berberine & spermidine which he talks about here. Jump on our email list, we do the research so you don't have to 🙂
@@donotageteam451 I don't see the email here. Should Berberine be taken in the morning too? What happens to traditional supplements, take them also or not?
came here to post this
Hello. Are these products refundable if we don't like them. The do not age..
Love the podcast- great episode! I have heard I should be taking TMG with NMN - would love to hear if you do this. Thanks again for your work in the area of aging!
Your partner contributes a lot to the interview! Excellent match, glad to see this information presented in an accessible way.
Hi doctor. Thank you for your intellect! Thank you for existing ! Thank you for posting all this content. It’s so rich with knowledge. Thank you for your work.
Grateful for the information you guys are offering 🙏
Id been waiting for this one . Thank you so much for these podcasts, keep them coming .
Thanks for this - I love the way you and Matt interact - All scientists need a Matt to help explain to lay people
Thank you for another amazing podcast! The shows notes, the timestamps and the explanations were very digestible (pardon the pun). Seriously thank you David, Matthew, And the team at Harvard medical school working hard to bring us the best longevity science to date. I can't believe that this information is freely available for all of us
Thanks for this podcast, I appreciate all your work and I been trying to follow your regimen. I wish that you could tell or advise us which you think is the best choice NMN supplements. I been paying a lot for it and still not sure if they are true to their advertising or I pick the right one.
I had heard of NMN on another podcast about a year ago.
I then dud a little research and started taking NMN. I found out it that it has changed my life for the better. My anxiety had pretty much gone away. My energy is by far more focused, and for the most part, I feel great.
I have other heath issues that dragged me down prio to NMN. I've tried many supplements and haven't had any luck, but NMN is doing wonders for me.
I have bought a year supply since places have quit selling the product.
This is pure gold, thank you so much!
Dr. Sinclair, hope you will discuss how NMN affects kidneys. Kidneys are crucial to life but are not discussed often. Thank you!
How does it effect the kidneys?
Thanks David & Matthew absolutely amazing series. I have a very important request: Can you do an episode on what molecules/drugs are safe if we already have cancer... some of the common cancers .. prostrate, breast, bowel, lung cancer .... that would b gr8.... if that's possible given the huge diversity that's present in these disease processes & stages. Are there any universals for particular molecules or types of cancer? Etc
Agreed, a podcast on NCEs will be important.
Thank you Dr. Sinclair! Be well!
Great stuff. Hopefully we can get a list of blood test to take and how often to measure effectiveness and if it causes any problems. Apart from the physical or mental impact
Highlight of my week. As soon as I listened to these I started OMAD, changed my diet and exercise routine. I've sent this to all my friends and family. Pure gold!
What is OMAD?
@@cmsotube One Meal A Day = OMAD, IF = Intermittent Fasting. You're wellcome.
Thank you so much. This information not only helpful to me but also to my parents and family. 🙏🙏🙏
You guys are changing my life.
Hi David and Matt- class is in session. Get here early and sit in the front of class!
What are your thoughts on apigenin? Especially in a post menopausal female on estrogen replacement-thank you for this terrific podcast and lending us your knowledge
I'm glad I read "Lifespan", thus I understand much better this conversation
Great to know all of these molecules. Thanks for the information
Any Q&A session some day on your channel?
Thank you for the invaluable information.
Great episode, thank you!
Thank you for sharing your knowledge based on facts, sir Sinclair.
I love the pod cast and the supplement and practical tip recommends to stay forever young :)
David, thank you for sharing your knowledge to help others! Question about Berberine- when should I take it? At night, the same as when you take Metformin?
I was hoping that you would discuss Methylation concerns and the use of TMG to mitigate.
Also, I find the piece that’s often missing from
Such discussions is for pregnant & breastfeeding mothers.
Women in general are always missing from specific discussions. Because of hormones, women may respond to fasting differently than men, for example.
Love all episodes of your podcast.
Just randomly found you here on yt and into the world of longevity and I'm never going back!! About to buy your book as well! 🙌🙌
My life has changed after taking NMN supplement... I was very sickly and weak years ago, but when I learned about this product, it gave me hope to progress all the things I stopped doing before, like gardening.. I feel so alive and well with vitruvin NMN and trans-resveratrol..
You must be rich..I can’t afford these supplements ☹️
Second comment: I want to add that I am following much of your protocol and I have so much energy it is incredible! I am relatively young (33), but have been dealing with fatigue for a long time. Particularly the day after intense exercise (BJJ). I have trouble focusing and getting through the day even with heavily optimized sleep. I am currently alternating between 16 and 22 hour fasts. When I do eat, it is mostly a low protein, high carb, plant based food (with some junk thrown in because I'm human and still working on things). I am taking NMN, resveratrol and Metformin. And I feel like a million bucks! I am recovering well, focused, creativity is up. I am honestly shocked and hope this is able to sustain itself for the next few months (I do not plan on doing all of this indefinitely).
Same!! Wow
What brand of NMN, reservatrol amd metaform are you taking?
Where do you get those? Is there reliable source?
Brand name please
You're fatigued AND spend your days doing "intense exercise?"
Thank You Dr David Sinclair.
Love it team. Well done. Thanks.
I knew this podcast would change everything...I would need to know about my lifespan.
Great work, great information.
Thanks for all your great advice. I really enjoy watching your videos, they provide a lot of knowledge and are very helpful on a daily basis in choosing food when shopping, etc. Thank you ❤✨
Really loving the podcast series. Great refresher for the book. Finding some of the supplements in Australia is harder than the US. Any recommended labs?
I'm looking forward to listening to this. I hope you talk about olive oil and avocado oil. Many health benefits.
I saw Dr. Sinclair on a podcast giving a lecture on Resveratrol, it was for a wine convention, everyone, including Dr. Sinclair was drinking red wine!! The lecture was very educational and entertaining!!🤩👍🏽
Looking forward to next week!
Thank you thank you for this podcast and especially the show notes
I can't wait for the episode on hair regrowth / regeneration. I know it was a topic announced for future episodes. 🙏
Add to that hair regrowth issue: are the topicals used to increase eyebrow regrowth safe? I have used Beverly Hills Dr. Brow and in about 3 months it started to regrow , by 6 months even helper regrow the outer halves of my brows. So it works even if I don't, after 1.5 years, have the thick brows of my youth. Still, worth the bother. Amaz. Has much less expensive versions, but I do not know how to judge them nor have I found associated effectiveness studies.
Im waiting for that too as a female that is losing her hair :(
Where did you heard this topic? Maybe one of the previous videos?
Yes plz
Just go to More Plates More Dates for that. Derek and the channel Hairliciously are at the vanguard for TH-cam hairloss content. Good luck! : )
Am inceput postul intermitent in ultimele zile ale anului trecut.După trei saptamani am facut o verificare si vârsta metabolica a scăzut cu 4 ani.fata de cat era anterior...inca mai am de recuperat,dar imi place foarte mult noul stil de viata.
Final!! Waited forever for this episode! All episodes are very interesting. Just got the book!!!!!!
I hope to live enough to watch all the episodes
I would really like to express my appreciation to z work u guys are doing. Keep up z good job!
Bravo!
What you said about NAD levels and alcohol just proved that my supplements are working. I’m not a drinker but when occasionally I have some alcohol I feel very bad next day. Last week I had few too many drinks and the next day I was feeling pretty well. Still had little hangover but wasn’t sick.
Why drink? Who in their right mind drinks alcohol? Its not fun or good at all and everyone knows most people drink and do stupid things and feel stupid the next day- so WHY?
@rdallas81 it is a lot of fun. not as much as in the teens or twenties but still. Uplifts the mood and relaxes.
Awesome information, thanks so much for sharing your knowledge 🙏🏻🙏🏻👏❤️
Thank you for the information.. just joined the levels membership.. inam diabetes. But my doctor refused to prescribe CGM for me for two years ..I need this machine for supervising my intermittent diet .
Finally got it ..
What quality content, been so eyeopening for me to read the book and listen in here. I literally feel when my mindset is that I'm getting younger, I in fact am.
Yes! I'm glad I found out about this at a relatively healthy and young point of my life (37). Trying to tailor a plan for my specific needs and goals.
Now I need to find out how to get my husband on board more! He is a "Joe Rogan" type of guy so he is more attracted to his brand of lifestyle choice if you get what I mean but want to get him over on the Dr Sinclair side
Resveratrol, 1gram per day, in the morning with yogurt or olive oil,basil, and vinegar (needs fat to be absorbed)
Nicotinamide mononucleotide(NMN), 1-2 grams, in the morning with same yogurt/olive oil
Quercetin and fisetin, 500 mg each, once per day, in the morning
Spermidine, 1-2 mg per day, in the morning
Metformin (prescription drug), 800 mg, in the evening
Great info!! Looking forward to more videos!!
It's difficult to evaluate something with no visible consequences, but the research points to a positive outcome. It's probably best to utilize while you're under physical duress. This product has met my expectations in that it has made me feel more energetic in the morning and throughout the day since I started using it. I'll keep taking Vitruvin Health Anti-aging supplement since it keeps me energetic throughout the day.
Important to emphasize ‘the threshold level’ as David discussed in his interview with Rhonda Patrick PhD , the ‘natural clearing process ‘ of the body that will eliminate NMN supplements , Resveratrol from the body - and David’s idea of ‘pulsing ‘ these supplements every other day , then fasting and exercising
In that interview with Dr. Patrick he mentions that young mice lived longer if the protocol was pulsed rather than if they received the supplements daily, but he doesn't pulse his own protocol. Is that because he's middle aged and every day is more efficacious, or did you come away thinking that the pulsing is an emerging idea which he is still vetting before switching his own protocol
Thank you Dr. Sinclair and Mr. LaPlante for the podcast. I have been fasting since I saw your interview at Joe Rogans and like to try some of the supplements you are taking. I understand you do not recommend taking any of these but do you have any trusted source where we can purchase these? Your good friend (and podcast twin) Dr. Huberman recommends Thorne which does not have what you were speaking of in this episode. Thanks again for your work
Lord David really does look younger and his Skin is glowing.. Gosh hopefully he will do a podcast in the near future regarding supplements that are effective and proven to be safe that we can consider using at this very moment .
Thank you David Sinclair 😊🙏
hey you guys spoke about the cosmetic aspects of this all. is that episode out yet? thanks
Thank you Dr, David! I would love to be part of your study. Thank you for all the information you share with us 🙏🎊💕
So would I, where can I sign up??
⛄️AWESOME & AMAZING YOU ARE MR.SINCLAIR !!!
THANKYOU SO MUCH !!!
Always informative, thank you.
I usually never wait for podcasts releases…. But this one is much different!