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- เผยแพร่เมื่อ 24 ก.ย. 2024
- Beta (B) oxidation of fatty acid.
BY CURIOSITY
Respiratory oxidation of fatty acid is farmed as beta (B) oxidation which occurs in liver and adipose tissues.
It is infaet a catabolic barces and Produce greap amount of ATP and it was first discovered by Georg Franz knoop in 1904
In this process, the fatty acids are oxidized at the B carbon i. e, the 2nd carbon atom from the carboxyl group. The Process is completed in fine Steps and the enzymes required occur in the Mitochondria.
These Steps are as follows is.
1) Activation of fatty acid.
2). Dehydrogenation of activated fatty acid.
3) Hydration
4) oxidation of B hydroxyl-acyl CoA.
5) Reaction of keto acyl CoA with COA (Thiolysis)
1. Activation of fatty Acid
fatty acids are activated by their conversion to thioesters with the help of Coenzymes A. The energy for their Process is derived from ATP and the Enzyme involved is thiokinase.
(2) Dehydrogenation.
This reaction is a dehydrogenation. removing two hydrogen atoms from 2 and B carbon atoms at the batty acids.
This reaction is catalysed by PAD containing enzymes, acyl dehydrogenase Three types Of identified from dehydrogenase have been liver tissues. They differ according to their specificity to the Substrate.
The first prefers to act on long chain fatty acid (C14, 16, (18) while the Other two act on medium ar shar chains.
3) Hydration
In their 3rd Step a molecule of water is added across the double bond in the Presence of enzyme enal hydrase Producing an alcoholic group on the B- carbon. The Product is B-hydroxy-acyl COA. (Coenzyme A).
Eus oxidation of B Hydroxy-acyl CoA)
In this step, B hydrozry - acyl CoA is convert ed into B-keto derivetives that's why it is called Boxidation. The reaction is catalysed by the enzyme - B hydroxyl acyl dehydrogenase and NAD is as Hydrogen acceptar.
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