NMN 2+ Years: Good Or Bad? Our Liver, Kidney, Lipid & Glucose Markers | Review By Modern Healthspan
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- เผยแพร่เมื่อ 22 ก.ค. 2022
- In this video we look at some key blood markers after we have been taking NMN for more than 2.5 years which was inspired by Dr. David Sinclair.
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Other Supplements that we take
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Pure NMN Powder 100g tinyurl.com/ys4hxwyf
PURE Resveratrol Crystalline Powder (100 Grams) tinyurl.com/54dbnpmy
NOW Foods, TMG, 1,000 mg, 100 Tablets iherb.co/hjsroit
Celery Seed, 505 mg, 100 VegCaps iherb.co/BvKGp8p2
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NOW Foods, Quercetin with Bromelain, 120 Veg Capsules iherb.co/8hbZ6DB
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California Gold Nutrition, Immune 4, 60 Veggie Capsules (FIRST TIME BUY $1 - LIMITED OFFER)
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California Gold Nutrition, Lutein with Zeaxanthin, 20 mg, 60 Veggie Softgels
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People are less likely to give bad reviews on products on which they have invested a fair amount of cash, or stand to benefit by giving out good reviews.
Interesting TH-cam upload / very informative and thanks for the "Renue By Science" 10% discount... I'll try it out on the 8th of March when I do my next order! 😎👍Have a BIG delivery from Renue By Science today! Hope it all goes well and I can try the product before the days pretty much over.. Am excited!
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Love your channel and the way you measure for success. cheers
I’d also like to say how great your looking I remember when I first came across your TH-cam videos and you are looking younger and fitter and stronger now then a couple of years ago
Re: Uric Acid. I suggest you look up "PRAL - Potential Renal Acid Load" as that is a related topic and I think would make for a very interesting video series.
Re: High Density Lipoproteins. I would say that there is more controversy here. It seems to be true that high density lipoproteins go up with exercise meaning that it can be a marker for good health, but it also seems to go up with LDL and overall cholesterols, meaning it can also be a marker for bad health. This (like "large fluffy LDL") also is likely to be an area where the "butter is back" industry scientists have muddied the water.
The C-Reactive Protein scores look really promising. Did you see that Dr. Katcher is closely monitoring inflammation markers in his E5 work?
Hi, regarding Allergies ... (my research and opinion)
I discovered that Allergies or Intollerances are generally caused by Nutrician Deficiences.
In chemistry terms - Limiting Reagents.
The body needs the substances to complete burning out offending builups of some residue substances.
Build ups of certain substances can cause Immune Responses, thus supplementing deficiencies will allow
for the build ups to be processed out of the body.
Good reference, thank you! I always heard of taking capsules may not good to liver, but seems the liver function of both of you are fine, makes me relieved.
Hi Sparkling thanks for your comment. Yes our liver function does seem to be.
NMN protects the liver not harms it
Thanks for sharing Richard. 👍🏻
Hi Ron, thanks!
Hello Richard just received my blood work.first time my liver, kidneys ,glucose and thyroid were normal.my
triglycerides were elevated 1st time. Been on nmn,tmg,and all the other longevity supplements for 2 months.been using a mix of donotage and renue by science but making a change to donotage
Thanks Richard for this information. I am interested because I also take NMN.
Hi Matz, thanks I do hope that you find the information helpful.
Your recent review about NMN improves HDL, hbA1c, seems reflect it on both of your markers, mine is improving as well, so 3 guinea pigs anecdotally proved:-).
Hi Ray, thanks for sharing!
I appreciate your information. My HDL has been 100, 99 the last few years. Glad to know that's a good level. I do not worry about elevated cholesterol, watch "The cholesterol Myth" by Dr. Zac Bush. I would like to do a coronary calcium scan since I had a bad diet and low Vit D for years. I am very interested in your experiment on when to take NMN. I do night shift and was not sure about when to take it. Thanks so much!
isnt hdl normally around 50?
Cholesterol isn't the problem, it's calcification of tissue due to lack of tetrahedrobiopterin.
Cholesterol is a rate limiting enzyme for the utilisation of protein, and is involved in wound repair.
I've worked out why tetrahydrpbiopterin levels drop with age, and how to correct it. Working on patents, though. It's so simple I can't resist making money on it.
@@username-yn5yo yes I think 50 is what is recommended
Hi Kat, thanks for sharing. Your HDL levels are looking really good. Did you do anything special to raise them to that level?
I will watch Dr Bush. I have also watched videos from Dr Michael Lustgarten which tell a similar story with 130 - 140 LDL being associated with lowest all cause mortality.
I will certainly be posting the results from my sleep NMN and Oura ring test when I get them.
Hey Mr. Modern healthspan can you tell me what your experience is with Nrh/Nmnh?
Hi can you give me the name of a good supplement supplier I’m based in Australia and am looking to take the same stack as Dr David Sinclair
Thanks for sharing the blood test info. Two comments:
1: Uric acid has some important functions in the body and so good to keep it low (ex: under 5.5 mg/dL), but not too low.
2: You mentioned that it was your first time doing CRP (I assume it is hsCRP). FYI in case you'd like to target it: a common ideal level target I've seen is under 1.0 and even under 0.50 mg/L.
Interesting on CRP. Mine is usually 0 and the only time it’s not been 0 was when I had a sinus infection.
@@ManifestingItAll Congrats at 0.0. I did not think that was possible.
Mine is at 0.21, which I am very happy about.
Hi Terry, thanks for your comment. On Uric Acid, I would agree, mine is higher than I would like and something that I need to improve. On the CRP, it was just CRP, the hsCRP was more expensive and we were looking for a general understanding of whether we had high levels of inflammation, rather than being specifically concerned about CVD. Perhaps next time we should use hsCRP and get a more sensitive reading.
@@ModernHealthspan Got it on the CRP. FYI: I do not know if it is available where you live but Life Extension offers very good priced male and female blood panels that include a large amount of measured items.
Is uric acid urea?
Can you please help: I'm a woman 50 on HRT since a year (progesterone pill, estrogen vaginal and testosterone cream). Should I stop this before starting on NMN, since I read NMN raises estrogen and testosterone? HRT is not solving all my problems but at least I’m able to have an intimate relationship (avoiding dryness and pain). If you cant answer this I need to be recommended a doctor I can speak to. NMN is not mainstream and my doctor will likely not know what it is or recommend it. I would love it if my menopause was reverses but even if not, I would like to be as rejuvenated as possible in every way.
By the way you definitely look younger, darker hair, less wrinkles, face is firmer!!
Hi Maggie, thank you! that is really great to hear.
Any positive results from your years of taking nmn?
How do you lower Uric Acid? Thanks for sharing Richard.
Hi Thanks for your question. Based on our discussion with Dr Perlmutter I am doing most of the right things (low sugar, no sodas) but I will try taking quercetin also celery seed extract and cutting down on the alcohol. If you are looking for general guidelines on uric acid, you could watch our interview series with Dr. Perlmutter.
Thank you for the reply. Is Uric Acid on a normal blood test? Thank you.
It’s so expensive I’m debating do I renew this.
Hi Richard, thank you for this update. how your wife manage to come down from 137 TG to 35!?? with out statins?
Do you still take Renue Liposomal?
An you take this is you have ulcerative proctitis?
Richard, One other item to mention. You mentioned getting your and your wife's HDL > 100.
As I recall, there was a study that came out recently and surprisingly concluded that cardiovascular disease risk increases once HDL got above a certain level - I think 90 mg/dL. And so seems to be a sweet spot between 60 to 90 or so. So you may want to look at the study.
My HDL is 92 mg/dL. I'm not concerned and will see what else comes out on it.
Hi Terry, thanks for sharing. Let me see if I can find that trial. Certainly some thing to think about but I have some way to go before I am close to that range.
I think that there is research supporting both low HDL and high HDL. I think that the real story is that HDL is a marker that can't be used in isolation and has to be incorporated into a larger story. You have to know *why* HDL levels are what they are to know if they are good or bad. At least that is my top guess based on the research I have seen.
@@jefflittle8913 Simplify it and understand.
HDL, VLDL and LDL are just like taxies 🚕 that carry the passenger called cholesterol.
HDL (high density lipoprotein), is kind of lipoprotein which is throwing your cholesterol out of the body. It ferries cholesterol from liver to intestines to be thrown out in poop.
Whereas VLDL and LDL are types of lipoproteins which ferry cholesterol within your body to different locations, to different organs via blood.
That's why if you have more VLDL and LDL, that means more cholesterol traffic within your body, or more problems. And if you have decent amount of HDL that means your body is healthy enough to send more cholesterol out of body.
HDL high means more cholesterol going out of your body.
But then if *much* more cholesterol is going out of your body, then it means it was there in your body to begin with. 🤷.
That means logically speaking *much* more HDL than a certain amount should also mean a bad thing in my opinion.
So it seems like you're saying that various numbers are "good" or "ok." But how do they compare to pre-NMN numbers? Did you take these tests prior to starting NMN? If so, how do they compare? Cheers.
Hi Scott, thanks for your question. We started this focus on health and longevity about the same time that we started taking NMN. I did not get my blood markers done before then. So, it would certainly be good to be able to compare them but I don't have the numbers.
@@ModernHealthspan Ah bummer. Would be interesting to see before and after numbers. Glad to see you're going strong though. Thanks for following up.
I wonder, are you taking NMN sublingually? Renue by Science has several articles promoting the benefits of sublingual tablets vs the lower absorption rates associated with the gastrointestinal tract.
Hi Thanks for your question. I am taking NMN sublingually at the moment, but will probably switch back to orally with liposomal NMN. I have found that some form of sublingual NMN work for me and some do not. (I like powder but not the lozenges so much). I think that the theory behind both is good but we don't have a great deal of data on the efficacy of them.
Interesting results but to better isolate effect of NMN Would be interesting to suspend taking it for 3 months and then repeat tests
Hi Joe, thanks for your comment. It would be good to do that kind of comparison but there are too many variables to draw any conclusions. So I think what we can say is that NMN does not seem to have any negative impact on my key markers.
@@ModernHealthspan not sure about that. Why not remove it but keep all the other variables constant.
Nmn is posion to the body!
Would someone who's 28 benefit from taking nmn?
I thought Sinclair and other were taking TMG to lower homocysteine. What were your starting and ending homocysteine numbers?
Hi Jack, thanks for your comment. One of the issues with low methyl groups is excess homocysteine so that is why I take both TMG and methyl folate. However the test I took did not have the homocysteine levels included.
@@ModernHealthspan I just saw this in a comment in another video:
"Warning-High doses of dried parsley like 40ml/day reduced my platelets below the reference range. .5-1.5g NMN uses up methyl donors and my homocysteine went from 7 to 17. So please do this under the advice of a physician.:
If anyone is going to supplement with NMN, Niacinamide, NR or Niacin above RDA amounts for niacin, it would seem to be prudent to get a homocysteine test. Mortality rates start increasing over 9. There is a reasonable chance you're over that if you're taking high dose NMN, even if you take methyl donor supplements.
Hello Richard, Your videos are immensely valuable! :) I'm wondering if you take a B vitamins complex, in addition to NMN? Is it fine to take niacin in addition to NMN? I have been taking Seeking Health's B-Minus Complex which contains 50 mg niacin but I don't know if that's compatible with NMN. All best wishes ^_^
What is the consensus optimal dose of NMN & Resveratrol each day? Also, why aren’t you taking Spermidine, part of Sinclair’s regimen?
Hi Heimi, thanks for your question. I do not make recommendations, but Dr. Sinclair takes 1g of each I believe. I have taken 1g but because I am taking liposomal NMN I am now taking 500 mg.
I have thought of spermidine and may well add that to my supplements but have not got around to it yet.
@@ModernHealthspan thank you
500mg of NMN and Resveratrol with oil olive every morning
@@giannidiolosa8804 thanks Gianni
According to the captions, you're into anime now. An unorthodox approach
Hi Adam, thanks for the comment. Hah, probably the autogenerated comments. The only anime I liked was Dragon Ball!
AST/ALT ratio can be high due to alcohol abuse, usually >3-4. Otherwise I'm not aware of any other clinical significance. Also, you ALT and AST numbers are low so I wouldn't worry.
Hi thanks! that is great to hear!
What dosage are you taking for NMN and Transreservatol??
Hi Maggie, thanks for the question. I was taking 1g NMN and 1g resveratrol. I am now taking about 500 mg of liposomal NMN. I have temporarily switched to pterostilbene of which I am taking 500 mg.
@@ModernHealthspan Does that mean you take two capsules of the liposomal NMN? Thank you.
You are not wrong about sleep. I'm awake at 2.30am watching your video.
I'm on day four no sleep. You get a bit shaky after a while. Would not recommend
@@manmoth4 damn. Good luck with that.
@@manmoth4 uhhhh i guarantee you this isnt healthy
@@username-yn5yo It's not exactly choice lol
Hi Thanks for your comment and watching the video so late at night! Sleep is certainly important.
You FBG is much lower than it was previously, could this be due to the liposomal NMN? Were you already on the liposomal NMN on 19/9/21?
Hi thanks for the comment. I was pleasantly surprised by my number this time. I started Lipo NMN in July 2021, so would have been taking it on 19/9/21 for a couple of months.
@@ModernHealthspan Hi Richard. I noticed in your 2022 supplement list video that you take TMG with your liposomal NMN, but is it necessary? On the renuebyscience site, they say:
(talking about non liposomal NMN )...
This can result in "methylation problems" where there are insufficient methyl donors that are critical for other needs and promotes age related health problems. (r)
TMG MAY HELP RESTORE METHYL GROUPS WHEN NAM LEVELS ARE TOO HIGH
As a result, it is common practice now for those taking NMN or NR to take TMG or other methyl donors. (r)
That is thought to help with the problem of excessive NAM buildup from taking high dosage NMN or NR capsules, but excess TMG can also lead to problems. (r)
LIPOSOMAL DELIVERY IS THE SOLUTION
A far better solution is to take a form of NMN or NR that protects the active ingredient from digestion to NAM.
Sublingual delivery of NMN delivers up to 30% of NMN to the bloodstream, so much less is digested to NAM and depletion of methyl groups is much less of a problem.
Liposomes are even better, as they can protect NAD+ metabolites from digestion and degradation in stomach, liver, and bloodstream.
Liposomal delivery prevents your expensive NAD+ precursors from being digested to NAM, which is a waste of money, and can actually be bad for your health.
Richard what are your units for CRP? I'm used to seeing mg/L reported in US for high sensitivity CRP (hsCRP). With goal of staying below 0.3 mg/L.
Hi Peter, thanks for the question. They are nmol/L. The mg/L was
@@ModernHealthspan My last hsCRP was 0.24 mg/L from Labcorp here in US. Not sure of their detection limit but might be 0.2. In any case, I recall Micheal Lustgarten showing that lower the better down to < 0.3 mg/L. Detection limit difference could be due to difference in the test, CRP vs hsCRP. Being less than 0.6 mg/L is good though.
What's your ratio of NMN and TMG?
Hi Otto, Thanks for the question. I aim for 1 to 1, but I also take methyl folate, and now that I have switched to Liposomal NMN I have reduced the dosage. Si I still aim for 1g of TMG but do not always take that every day.
@@ModernHealthspan
Is there any evidence of the benifit of liposomal NMN?
My conclusion after watching take and promote NMN was a waste of money. Sorry but diet and exercise could do better imo
I would be more concerned about the effect that NMN may have on lowering CD38, a vital protein located on the immune system's white blood cells. I wonder if by taking NMN, you might be lowering your resistance to diseases. The only legitimate reason I can find for taking MNN is if you has asthma, which can be relieved by lowering CD38 in some cases.
Hi Paul, thanks for your comment, though I do not follow it. I thought CD38 could consume NMN as well as NAD, it increased in old age and was one of the reasons for lower NAD levels in the body.
In fact I take apigenin specifically to lower my CD38. I have not heard that it was important for the immune system. Could you point me to a study on this? I would be very interested to learn more. Thanks
@@ModernHealthspan This might be a good primer: en.wikipedia.org/wiki/CD38
So I just compared your cholestrol with my own stats. You are promoting "modern healthspan" yet you rack in a total cholestrol of 215... versus my 127? Where the total Cholestrol/score is 3.10 versus your 2.76. Look specifically at LDLD you are at 127 where I am at 64, Your HDL 78 versus mine 41,..
What does that show? You have alot more lipids going about which isn't a good thing where ApoB gives us a good indicator of the risk of plaque formation. Lower seems to be better always.
I can conclude from this that your focus on Modern Healthspan but you are leaning too much on supplements and did not adjust the diet for it. Leading to these higher scores that could easily be lowered signifcantly by just gettting rid of some more saturated fat in the diet. You are doing yourself a disservice by not adjusting dietary patterns for better outcomes. After 2 years of awareness these numbers shouldn't be this high.
Als for your USA "averages" you might be in the "safe zone".. For EU standard (alot better in healthspan and health promotion) You are over the top end of all these scores. That is a bad thing. Try cutting out animal saturated fats it will do wonders on these scores.
He is a low-carb shill.
Cholesterol ratios are irrelevant, your values are way too high. You know nothing, Mr. Modern.