David Sinclair on NMN Minimal Dose and BEST Timing
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- เผยแพร่เมื่อ 8 ก.ย. 2024
- David Sinclair explains what’s the minimum NMN dose and the best timing for taking NMN supplement.
If you take NMN or consider taking this supplement, this is a crucial information.
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Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene.
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🔴Want NMN Protocols to skyrocket your NAD plus extra Bonuses?
Go Here: WellnessMessiah.com/Longevity
Didn’t hear clearly is the minimum dose 215mg or 250mg? Thanks in advance
@@eightofhearts 250mg
@@WellnessMessiah thank you!
@@eightofhearts Nice to meet you
I am sorry but I don’t think he looks younger than his real age. No hate I am just being honest. Sorry.
Best timing seems to be when David lifts his request to the FDA :(
Ha ha !
You cheeky!!
😅😅😅
😂😂 🤑
🤣
I'm 41 and been taking NMN + Resveratrol intermittently, for almost 4 yrs. Keep in mind, I never took more than 500mg. Thorough out those years, I probably took around 240mg every day for about 4-5 days, break a couple days, then now, I am trying out 500mg NMN + 80mg Resveratrol and 500 TMG every other day. I take every other day because one...I'm fairly small framed - 5'3.5" and 95 lbs. and also, I work out often and don't want the resveratrol to interfere with that, so I always take NMN and resveratrol within an hour or so of each other (Rsver. with mixed nuts for absorption) after my cardio and lift sessions around 11am. Timing of that seems to be going well, and not affecting sleep too much.
Hi Jennifer, you sound very educated. You're spot on with not taking resveratrol before exercise, only after.
There is more explanation to that in this video with Brad Stanfield vs Sinclair:
th-cam.com/video/Hsk-TyjywR4/w-d-xo.html
you may find this NMN video intersting th-cam.com/video/VWgiO_cIl70/w-d-xo.html
Jennifer mcrayd have you noticed your age reversed and have you found a lead and arcenic free nmn?
@@sinclairwestbury3331
Lead and arsenic now? I didn't realize that was an issue with this supplement.
How would reversatol effect workouts?
I take 1g a day breaking it into 4 parts. I take 2 types NMN with Antioxidants & NMN on its own. It is helping make my skin feels tighter & firmer.
Oh how awesome can you pls tell me which antioxidants?
NMN makes me tired if I take in morning. A close friend told me the same thing. Late afternoon/early evening seems to work best for me. There's a Japanese study that seems to confirm this timing for older people.
Hi Jay, yes, like you, I'm not too convinced about taking everything in the morning.
There is the value of personal testing like what you did. I intend to do it too :)
Have you tried taking 0.5 gram in the morning and 0.5 gram in the afternoon?
@@WellnessMessiah I've tried testing nmn on an empty stomach in the morning, and alternatively with first meal, always makes me tired before the afternoon. I do NAD drips monthly.
Really? I thought it gave people energy.
I’m the same. Was getting sleepy during the day taking it in the morning. Way I look at it is, your bodies repair/upkeep/growth/renewal etc happens while you sleep. So providing mitochondria with “energy” prior to sleep has you get better quality “upkeep” going on. I find the same with Pemf treatment. “Energise” the adrenals, makes you sleepy, coz while you have more energy at a cellular level, your body is gonna wanna sleep to get all those things done. Cells having more energy isn’t the same as “feeling more energetic”. Dopamine will leave you feeling like you have more energy. In reality, 99% of people have more than enough “energy” on board (stored fat etc), it doesn’t mean they feel “energetic”. Just my thoughts and experience.
@@trevorrogers8289 True, I find that NMN doesn't give me energy bursts but when I do anything I have extra energy than I expected. Was wondering which PEMF device you use and what strength it is? Also, have you looked into upemf...uni-directional pemf?
A series of 12 studies on a molecule called NMN (Nicotinamide Mononucleotide).
The conclusions are the following:
- NMN supplementation does not increase muscle NAD levels, which contradicts the theory that NMN supplementation can boost NAD levels.
- older adults who exercise have similar muscle NAD levels to younger adults, suggesting that exercise is essential for maintaining NAD levels.
- NMN supplementation did not show significant improvements in various measures of health and fitness, including body composition, blood sugar levels, insulin sensitivity, sleep quality, fatigue and exercise performance. Although NMN supplementation appears safe, its benefits are not as robust or compelling as some might expect based on the influencer hype surrounding NMN.
Studies on NMN supplementation have shown mixed results. Most studies have shown no improvement in muscle performance, body composition, blood pressure, cholesterol, or insulin levels. In fact, an increase in insulin levels was seen in one study, which is not a desired outcome.
Although NMN appears to be safe and increases blood NAD levels, it does not appear to improve muscle NAD. There is no improvement in VO2 max, strength, walking speed, sleep, fatigue, well-being, hearing, cognition or arterial stiffness.
In conclusion, human studies of NMN have been largely disappointing. The benefits experienced by social media influencers praising NMN are likely the result of better diet, exercise, and adequate sleep-that is, a placebo effect.
Additionally, there is evidence that NMN and NR supplements are broken down by our gut microbiome and not directly absorbed. Any small amount that is absorbed and enters our bloodstream is quickly broken down by our liver.
So while you may choose to buy NMN supplements, you should know that the benefits may be limited.
Well thank you! The way these influencers and educated people praise and Pretty much promoted as the holy grail for youth definitely could fool me! Actually it did. It’s so easy to just trust what these guys say And not even care to look for the research. It’s pretty sad it makes me wonder how much they’re getting paid people who spend thousands of dollars on these kinds of things just do to the hope alone. We are supposed to be able to trust these educated people. 🧐😑
What's your source of the twelve studies?
I can see and feel the benefits. I do not need a study to prove results.
@@MarieLamour-cv1jci agree with you, experience is always the best education and reality and not just “multiple researches” just like with collagen they say it doesn’t have a lot of researches to back it up, but it works a lot for people using it.
Speak for yourself and ofcourse if something is working for people "THEY" are always going to manufacture fake research papers contradicting all the good effects on people's health. I always say try it yourself regardless of what other say. So far PQQ has worked for Me just 10 minutes ago I bought liposomal nmn which is absorbed easier and liposomal resveratol. I'll try these 2 and see what happens. I'm sure it will have some positive effect.
I started taking RBS sublingual NMN under the tongue about a month and a half ago, it made me extremely groggy the first week and I almost stopped completely but I pushed through and by week two I wasn’t experiencing that anymore. I also take TMG, Resveratrol, Quercetin, and Spermidine. I’m going to add Berberine and NAC to my supp stack soon too.
Instead of regular Berberine, take Dihydroberberine. It's the better absorbed version and easy on gut bacteria.
You will become super human
Destroy your liver.
How much nmn u take?
NAC is amazing
I been taking 250 mg in the morning with coffee for about a month. I do feel very good, high energy, alert, focused, very minimal aches or pains, sleep is good and I do not wake up feeling tired. but this could be from my healthy eating and almost daily 5 or more mile morning run.
May I ask your age and weight the time of this? Don't mean to sound rude! I'm 27, 49kgs so I feel 250mg would be ideal for me currently
NR is the more efficient molecule because of its smaller molecular size offering direct cell entry and more Nad+ density per mass. And it is safer as Niagen has more extensive human studys and a more reliable supply chain. But NR is patented, so the NMN are manufactured in China and packaged in the US by numerous small firms without any patent infringement and the industry did massive marketing. Basically, people are buying less efficient and less reliable NMN simply because of its massive marketing budget.
would love to know more about this
Ok
Everything is manufactured in China. Did you just figure this out? Almost ALL supplements are from China lmao
I wouldn't recommend taking it in the evening unless you intend to pull an all-nighter. Sometimes I have to work a 32 or even a 40 hours shift (intense intelectual work). After 24 hours usually brain fog would set in but this time I took NMN and lo and behold brain fog didn’t set and mental alertness was normal in even at the 40 hours mark. I took my usual dose of 750mg in the morning when I started my shift, and then 500mg after 16 hours, another 500mg after 24 hours, and finally another 500mg after 32 hours.
Interesting again. So D. S. takes 1g NMN in the early morning. There is an interesting talk on the minimum dose of NMN. I hope people designing the next NMN trial will take it into account and and go over 250mg as it appears difficult to have significant results by staying at the minimum of dose and time.
Yes, Bernard! Especially that the gut, gut bacteria, and the liver consume a massive amount of NAD every hour.
Who knows how much is left for other tissues with such a low dose NMN!
@@WellnessMessiah so sublingual it's better?
500mg has had significant results for some.
@@AngelicaMaria1983 Theres no research on sublingual NMN. This is another area that has not yet been explored.
look for the study of 300mg,600mg,900mg. Confirms 600mg is optimal.
Hello Dr. Sinclair, is it true that if we take NMN, we also have to take TMG (trimethylglycine) as otherwise bad effects from methyl donor depletion occurs? Most of your videos do not mention TMG but i heard this by other specialists.
Yup take 500mg daily.
Yes you definitely need TMG for methylation when taking the NMN. The problem I have is I bought the Renue By Science capsules with NMN 250mg each capsule,TMG, zinc and baking soda,but 20mg zinc in 1 capsule is ridiculous. I initially was taking 4 a day ,thinking the combination of 4 1000 mg capsules was 20 mg,but 20 mg each capsule is way to much, so I have to find less zinc.
I have a question: If Sinclair discovers we can still get nmn from overseas, despite his ban, would he call the police?
I talked a person who owns a supplement company that manufactures NMN. He said that they will move to Mexico and sell it from there if the FDA makes it into a prescription only drug.
It seems that NMN raises the level of NAD and it's metabolites in blood.
But why?
I thought the model were that NMN would go into the cells, and there be converted into NAD+.
Furthermore, that NAD+ can't enter the cells. So what use is it in the blood?
It seems that the level of NMN doesn't increase in the blood. At least, no one has said it does.
How do I sync with my circadian rhythm? Not clear on the when of doing this?
So whats the deal with this and reservatol? Do you take 1g of each daily? Or can you take less if taking both?
Nmn has any drug interactions with Xarelto 20?
I am 75 Year old. 250 mg per day will bring any benefits?
Is there bleeding risk 250 or 500 mg MNM in the morning and Xarelto during dinner?
I would appreciate your help.
Thank you
Hi Cassamo, I really would like to help, but these are questions about drug interactions that are suitable for your doctor.
Asking this medical advice in a youtube comment thread is not gonna end up well
I've heard 1 250mg of NMN will not make a huge difference. I have severe CFS fibromyalgia and I see a huge difference. My energy is through the roof. I sleep well. You could call your pharmacist to look it up,because Dr's don't know what NMN is. TMG is important to take with NMN ,and I would start at 250mg but go up to 750mg .I take 1000 mg and energy is amazing TBH.
I bought good quality NMN and took 125 mg daily for two weeks. Omg! My liver or gallbladder got progressively more painful or achey. As soon as I stopped the pain stopped. Is it just me?
Sounds like you got fake NMN
I feel amazing, I take 1 gram,1000 mg. I bought mine from Renue By Science with TMG ,zinc. But 8 can't take that capsule anymore because it's to much zinc. If I take 4 capsules a day,and each capsule has 20 mg zincbin it I'll be sick from zinc poisoning.
Does NMN works on dog ? My dog is 16 years old and suffering from heart disease, will NMN help ?
Should Help ! I hope he’s still with you 🙏🏻🙏🏻
@@cococgb5389 hi, thanks for your reply. My dog is still with me and her situation is stable. I have been feeding her nmn for few months, her energy level is up and everything ok. I do believe nmn really help.
@@Alan13 I put NMN in a cheese ball and feed it to my dog. It is helping. I also occasionally give her magnesium, B complex, and MSM.
Taurine for fiddo
Ohhh taurine research that
which is the best to buy??
Agemate!
Have you looked at Resveratrol and NMN?
NMN v Gerovital? Are they opposed.. or can they work together? MW
So do you take it before food?
What is the best brand NMN? There are a lot on market, it’s confusing.
Pro Health longevity
Great again.
Doc,,.cant hear you clearly.. little slower? Louder? Thank you. M.W
I started and I am on Day 3 of 1 gram of NMN at 7:00am, confused how long should I wait for my coffee/breakfast 10, 20 minutes or more?
give it half and hour to eat, and then drink coffee, that's how I do it and it feels good.
Works good for me. Didn’t think it would but it does. 1 gram in the morning. I use to need a Power Nap now I dont
1 gram?
What about an NMN + Resveratrol supplement before exercise?
what about it?
Post + After
Let me ask, why not just NAD supplements?
Resveratrol or Pterostibene? Thx
Hi Rimon, can you please guide me? I implemented David Sinclair’s supplement 2023 with the only difference using berberine instead of metformin. Week 5 in I had an allergic reaction, a prickly, itchy red rash started on my hands, it spread up my arms, my face became red and swollen, from my eyebrows to the corner of my eyes went black. The redness and swelling was on my neck down onto the top of my chest. I stopped everything for nearly a week and everyday it slowly calmed down. These were purchased through donotage, so a good provider. Did I overload myself my taking everything at high levels straight away and should I have very slowly started these implementing them slowly one at a time. Your guidance would be greatly appreciated because for a time in the middle say within 2 weeks I felt fantastic…
Sounds like you took a high dose or bad batch.
In your opinion, what is the best brand of NMN you can purchase?
i've been taken a half gram in the morning before breaking fast and it seems to markedly change my attitude and activity level....
Sound it's working for you Mark! A decent dose.
I been doing 250 mg and feeling good results.
Can a cancer or hiv patient take NMN ???
Hi sir u have also skin waiting simplyment
Are the studies privately funded?
Great clip! Do you personally take NMN at this stage of life or do you wait until you are older at least 45+?
HI Glenn, how are you? I've experimented with NMN and NR back and forth. Right now I'm not taking it , mainly for financial reasons - I can purchase both my parents and my wife's parents health & longevity supplements instead of 1gram NMN for myself.
I care more about them right now.
However, I'm about to do NMN experiment myself for 90 days and publish results on this channel.
@@WellnessMessiah health and longevity supplements other than NMN like what?
@@ticketforlife2103 Resveratrol, high-quality fish oil, magnesium, and more others I'll share in this channel- require explanatory video.
Check the fish oil guide in this channel for such an explanation:
th-cam.com/video/PfS4cjph4kE/w-d-xo.html
Aging starts around 25
If you have no money for NMN take vitamin B3. NMN is sintetizised from this.
what if you work graveyard shift/
I am trying to find more on senescent cells, understanding their function, importance, and also have heard several places why it’s not good to kill off too many of them since they still serve a purpose. Can you help direct me to information I seek? Thanks!
Hi Crystal, great question!!! I'm just making a video about it haha.
In essence, for now, senescent cells, are basically healthy cells reaching "retirement age", are no longer useful, produce bad chemicals, and have lost their ability to die.
Besides killing them, there is another strategy to help them/your body. You'll see it in that video. I think it will come in 2 weeks.
You wouldn't believe how resveratrol affects these cells. - Teaser.
@@WellnessMessiah awesome! I’ll be looking forward to that!
So what do you think disfunctional cells may have left in functionality? Scenecents are waste. Ever heard about healthy waste? Keep watching Sinclairs videos and go away form fashion sales Men without a clue. Best of luck
I post videos on NMN and NR research and have several posted already if it helps.
@@Joyces-Favorite-Art-Tutorials Joyce NMN is not a supplement i'm impressed with. See my reviews of the human studies th-cam.com/play/PLmliBwDoqUP-KJu7BoXCVIaEWUQeIZfxg.html
As NMN is expensive, I have limited my daily intake to 300mg in combination with 1000mg of Niacin. Any thoughts?
look for the study of 300mg,600mg,900mg. Confirms 600mg is optimal.
Before you waste your money, look into it, its not what he says, he also makes millions from all sups that are sold!!
250 MG should be enough for most people.
@@mixalis6168can you direct to some good links that are reputable and confirm this?
Can i take nmn when im nursing
How can I buy this product and be sure it is quality?
Snort it
I take it with my one meal a day early evening. No effect on sleep at all though.
Thanks for sharing, very interesting.
Does NMN holds a risk to cancer cellgrowth if for example you have an inert/latent cancer treath? Thanks in advance for the reply
I've seen another video in which David said that the only group of people that shouldn't take nmn are cancer patients.
I just started taking this, 1000 mg in the morning mixed with yoghurt. Is 1000 too much ?
vitamin b3 linked to heart disease google it 🙂
There are so many nmn on the internet. Can anyone recommend a legit one? Perhaps nmn that Tony Robbins is selling has a great quality ? :)
Hey Gintaras, I assumed you're joking... Does Tony Robbins sell any supplements? Maybe personal growth supplements?
Tony Robbins and Peter Diamedis are stakeholders in the company LifeForce. They wrote a book about current and emerging science of longevity. The company has this year started selling supplements. One in particular is Pure Healthspan which has a number of ingredients that have been studied to help with age related health decline. Not in my price range at the moment though unfortunately.
strong coffee in AM with 1/8th teasp resveritrol and 1/8th NMN, 1/2 teas quercetin 1/2 ashwaganda and slug it down. feel myself changing... so strange so strong lol we'll see lol
Nice to meet you here, Robert. Sound you know what you're doing.
Can anybody please recommend a good quality NMN? Thanks
David said that you should buy brands that have GMP on the label, which stands for good manufacturing practices, he said that means it should be over 99% pure. There's a lot of fake nmn products out there.
Reque by Science is the brand recommended by Andrew Huberman, it's where I buy mine from, it has GMP on the label.
@@jackncoke171nice one
I take 1000 mg a day and I suffer from cfs,fibromyalgia and my energy is through the roof!
Thank you!
I'm really confused. Iv been taking nmn one capsual of around 250 for a few days, and it's made me feel sluggish and have to go bed by 10 (usually up until 1). Not sure if I should stop. I also have adhd which seems to have increased so may not be good for me.
try adding magnesium glycinate roughly two hours after the nmn.
i only take nmn occasionally, but when i take it without magnesium glycinate I quickly feel disoriented somehow.
Stop it, its not what he says, its all about he making $$$$$$$$4
seems everyone has a different reaction. I take 250MG in the morning with coffee a few hours before my first meal and feel great all day.
Should it be refrigerated?
I watched in another video that it shouldn't be refrigerated if the room temperature is normal and stable. If it's too hot , put it in the fridge. In any case, what you shouldn't do is take it out of the fridge and back again. My suggestion is open the bottle, take the pill while keeping the bottle in the fridge, don't take it out and back.
With or without food?
empty stomach. One hour or more before a meal in the morning.
I wonder if younger people such as myself would want lower mg I’ve been doing 150 for a while
Also been getting flush so that can suck
HI Chase how are you? I read all the NMN studies until 2019 and need to cover 2020-2022.
I'm just finishing the resveratrol series in the channel and will return to NMN to answer that for you.
Regarding the flush, have you tried to change brands?
@@WellnessMessiah a few ones! Niacin is the one that gets me the worst no matter what, it's horrible
Do you take it on an empty stomach?
DS takes it in empty stomach in the morning
Yes
Doesn’t sound like he knows. Riagev what about it?
1gram, is that 1 capsule or two? My 500mg NMN comes in capsules form and it says to take 1 capsule a day. Is this correct or do I need to take two capsules?. Any help of my question so I’m clear would be great. Thank you.
Perez Helen White Gary Hall Christopher
Definitely a correlation between a supplement’s cost and its placebo effect 🙄
What do you mean?
@@mywalletsecrets3734 Zero evidence that NMN improves longevity. In fact if you look at the raw data, NR caused a slight DECREASE in median lifespan when tested by the ITP
@@Maveric78 I can tell you that after 3 weeks of 250 mg of NMN, i lost a precancerious mole^^
@@NinorahDeux yup placebo effect is real… And more powerful the more you pay
@DW WL
I myself feel nothing for any supplements. Not even Creatine.
Remains to try Niacin, just to see if flushing is real!
I guess that you have to be really deficient to feel an effect of a supplement.
Or very susceptible to the placebo effect.
But you know, the placebo effect is real!
At least you get something out of it.
He takes NMN in the morning as the stomach is empty yet every bottle of NMN you purchase tells you to take with meals! WTF?
😂 gota love when they try to sell you something
I just got some and mine says best taken in the morning on an empty stomach.
Probably works just fine either way although I couldn't guarantee it.
BS. the instructions on my NMN clearly states to take on empty stomach one hour before meal.
Where can we buy NMN from plz
its all over the internet.
@@mhaas281 yes but there’s a lot of shit out there I want the best stuff
So... on an empty stomach in the morning, right?
How are you Hunt? According to what Sinclair says, yes.
There are conflicting studies on this, so probably it's worth testing how you feel with your body (energy, fatigue, sleep) based on different times. Especially morning vs afternoon.
Is NAN real or snake oil?
❤❤❤❤
Wth doc why you selling out
Show us photos as proof. And mice are not humans. Plenty of science on that.
All medicines are based upon mice and other animal studies besides human trials. They use mice that have been genetically modified to be very close to human DNA in many ways. I'll gamble on the mice. You can avoid NMN and just save your money if you want.
"exa-plains"
Why are people taking this very expensive NMN when Metformin, which is dirt cheap, will have the same effect...maybe even better.
Hi Robyn, excellent question!
The secret is creating synergy between different molecules targeting all different longevity genes.
Metformin and NMN work differently and are likely to have a synergetic effect. In the resveratrol series on this channel, I explain the different synergies between resveratrol, NMN (or other NAD+ boosters, NR, or niacin), and metformin. I believe this is why Sinclar takes all of them. Trying to cover all his bases.
@@WellnessMessiah thanks for reply. David is very privileged, and many aren’t so lucky. I pay a small fortune for my diet and nutraceuticals...and to take one more is too much. I’m hoping that Metformin will clear what I believe are zombie cells...fingers 🤞
@@robynhope219 The good news for you (and me) is that metformin has 1000 times more data than NMN, which doesn't have so many studies. We will be more sure about NMN as years go by.
@@WellnessMessiah good news, indeed. I am on metformin since 3 wks ago, and also take quercitin and other nutraceuticals. Bloody shame this stuff is so overpriced:-((
Metformin does not extend the life span of mice. David Sinclair gave mice NMN and they lived much longer than the typical mouse. I'll go with the mice and the NMN. You can stick with the metformin if you want to, but metformin will ruin your workout and make you weaker and have less stamina.
Sinclair is a scammer.
The best timing is before this snake takes it away
I can't abide that snake oil salesman. 😖