Genetics, Brain Connections and Autism
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- เผยแพร่เมื่อ 8 เม.ย. 2020
- (Inside Science) -- Researchers used mice that had genetic changes like the ones found in autism patients and studied the electrical activity of the neurons in their brains. Certain types of cells are in charge of sending messages from one region of the brain to another. But scientists say the communication cells in autistic mouse brains are not sending signals or working properly. They want to find out why.
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Having worked in scientific research for 34 years, I can say with some authority that autistic traits are overrepresented in research scientists. I could not say what proportion could have a clinical diagnosis, but I am certain that it would be considerably higher than in the general population. I am autistic and have a PhD in molecular biology, I have in a very small way expanded the sum total of human knowledge during my research career. Not all autistic traits are deleterious, and some - such as being able to hyper-focus on a problem or project - are positively beneficial. Alleviating the severity of the more distressing traits of autism would be useful, but eliminating the beneficial traits would be an appalling disservice to humanity.
100% Agreed
Thank you for saying this.
Well said; if my neurobiology was to be adjusted to operate more like a neurotypical, you would have changed who “I” am for me. I am NOT neurotypical, and wouldn’t give up my autistic mind in exchange for “normality”. I am pretty damned cool 😎 as is
Well said!
Having these abilities can be nice sure, but they're not abilities when you need to switch them off yet can't, they aren't positively beneficial without some kind of hinderence on the other side, hyper focus is great when you need to hyperfocus...not so much when you don't need it, and being able to control hyper/hypo focus seems to be a variable you have neglected along with the part where the pros are also cons, for someone which a PhD you seem to lack a holistic view on the subject based on the lack of existing opposing information which is also fact, facts aren't against eachother they're in unison
Maybe the autistic brain is simply different and not disordered. Maybe the problem is the self-centered judgment that comes from people who are not autistic. People with autism have to tolerate differences from people without autism. Why can't people without autism tolerate differences of those with autism. Dominant culture prevails, but why should it have to?
Because of limited resources and competition. It’s human biology. That’s precisely why communism can never really work. We have a limited amount of resources in this earth and universe. Competition is inevitable.
Have you come across a person with a severe form of autism? Have you tried to communicate with them or care for their needs?!! Anyone who has would never say that it is simply "different". Manipulating with words and surrending to political correctness will not change the facts of life.
I am 36 years old and I am on the Autism spectrum I have PDD-NOS. And I don't need or want to be cured of Autism. For me I feel like there is nothing to cure. I am happy and I am comfortable with who I am.
@pristinejoel8802 Hi joel, chandru here from India. I have an son who has autism. What herbs are you using for your child. Thanks
if someone offered me to get surgery to get rid of my autism i would honestly refuse it, this is just me though. yes i sometimes wish i was "normal" and act normally but being autistic is apart of who i am and what makes me
Me too! Take away decades of autistic lived experience and I'd have nothing left. "Problems, disorders" she says. I don't want to experience the bigotry, aspiration, duplicity, cruel humour and endless emotional needs of a neurotypical brain.
Yeah I'm not really into surgeries myself lol.. unless it's something seriously life threatening
@@lovelifetechllc Had some of those, willingly. If they scarred my brain to remove my autism there'd be nothing left!
Best wishes
Same
I still hate it that it's called a 'disorder'.
The video starts off listing off all of the deficits. It could have started listing off all of the positives of autistic brains, but it failed to do that. They're not seeing the big picture.
It is, you're coping it's not.
By labeling autism as a 'disorder' the struggles autistic people face are given proper attention/validation. So I don't see how that's bad in any way? I am autistic myself and I'd rather have my struggles be validated and recognised by calling it a 'disorder', instead of my struggles being erased by calling autism a "special ability" or some shit
‘’Disorder’’ isn´t a bad word
@@voiceofreason2691 Yes...it is.
Part of the problem is all the indirect communication that even neurotypical people often miss; say what you mean instead of putting out "signals" or euphemisms and getting frustrated when people don't pick up on them.
Excuse my language but FUCK YES. I do not understand why and how humans came to decide that the only correct way to communicate was to beat around the bush and be as vague as possible. I don’t believe that autism is only an autist’s issue. It’s a sociological one and part of the problem is neurotypicals themselves.
@@kconrad5893 Exactly!
@PRISTINE JOEL sarcasm and non sequiturs are the exact opposite of what we need.
THANK YOU! What do you want, why, and when?
Enough rambling Mark Twain. You're not getting paid by the word.
Please stop thinking of us as a disorder.
What r ur symptoms
I wish there was no music so I could understand the speaker better
On the POSITIVE SIDE: many see ASD as a gift . Our ability to super-focus, attention to detail, and speaking honestly and directly which this country is seriously lacking. We see this world so differently, we see the true intentions of others, we feel other people's pain like it is our pain. I would like to know more about the GIFTS that others with Asperger's have.
Facts
Thank you!
I pretty much always know what time it is
Go to hell.
100% 👍🏼Fact!!! My husband is autistic and my son is autistic. I am not. They are amazing people. And oh so smart. They see true intentions of other people. I love that they are direct and they love me truly and protect me from other people who are fake when I dont see it and they do and so i feel safe. My husband is my best friend. Since i know how he is and that he thinks differently, when he says something to me, i don’t get offended even if others think i should. My husband is honest and direct and wants the best for me. This world would be better. All i offer is love patience and acceptance.
what if the neurons are communicating. just not in a way we can see with the science we have currently?
Our diversity as a species is beneficial. Particularly for those of us on the less severe side of autism, it allows us to perceive and view problems/aspects of the world in unique and potentially revolutionary ways. Autism is not something that needs to be eradicate, it's something that allows us as a species to develop faster. To eliminate this particular "handicap" on a grand scale would actually do more to handicap humanity as a whole. A series of calculators doing the same sum will all get the same number as a result and achieve what could have been achieved by just one machine; if you however, provide each calculator with a different sum, a different problem, they will collectively achieve far more. In this analogy, the sum and are how a person views a problem. To eliminate autism is the same as eliminating points of view, perceptions that lead to entirely different outcomes. To "cure" autism is to neuter creative thinking, limiting what sums we as calculators can solve. Difference isn't inherently bad. The idea of saying that autistic brains aren't functioning properly is no different from claiming that a husky is defective for not looking more like a great dane. Different is not synonymous with being wrong, and we shouldn't forget that.
Autism is gift I was born with and I love it and never want it to change
If researchers ever find a cure for autism, it's going to be disciplines like science that will suffer the most loss. STEM careers tend to be populated mostly by neurodivergent/autistic people.
I wonder if that is the end game in some way, to make less people who are passionately curious about the world and more people who simply blend well in to society and simply do what they're told with out much questioning or resistance.
That actually makes sense.
Find a way to "alleviate symptoms"? Good luck with that.
I am Autistic, I do not have Autism. You take away my Autism you take away how I think and experience the world: you take away my subjectivity. I don’t want to be rid of my Autism, but I want strategies to help manage anxiety, executive functioning, sensory overload etc. This research as presented in this video has a strong eugenics vibe.
that said a whole bunch of nothing, thanks!
I thought there are series of papers on microexon deletions in the synapse linking this to autism/autism-like disorders. Potentially causing issues as although the neurons are there, the ability to transmit signal between neurons becomes a problem due to thresholding issues
If there’s ever a cure I’m not gonna get it treated because I love being autistic, it makes me unique without it, I wouldn’t be extremely creative.❤️💪🏼🧠🇨🇦
I’d like it if society didn’t treat me like an idiot and put me in sped
Well I will, so you do you.
What a rare, positive outlook on having autism. I have a pretty severe form of autism and I absolutely hate it. Sometimes it is literal hell and medication is the only thing that keeps me going. The cons far outweigh the pros when you have a heavier form of autism. When all the fun traits of light autism get amplified they turn into traits that negatively impact your entire life, like being so "unique" that you're never understood by people and you feel like there's something seriously wrong with you, sending you down a path of self-loathing. I'd get rid of my autism in a heartbeat if it were possible, but it's not, so all a person can do is learn to live with it. Light autism needs no cure in my opinion, as it's pretty balanced with pros and cons, but for the more severe forms, I hope there will be a cure some day because it sucks, a lot.
As a person with autism, I can confidently state that the "background" music of this video is tremendously annoying.
This woman is a perfect example of autism, smart enough to research brain function, oblivious enough to try to 'cure' (and label something in such negative ways) something that she herself likely has which allows her to do said research!
An autistic person is deep and complex person
You need to target missing proteins. I’m not genius but I’d say the main problem is mutated genes and missing proteins that cause defective neurons/degenerative neurons...and it’s kinda frustrating that people explain Autism as just “having trouble reading emotion and sensory processing..yes they are typical syndrome but Autism mainly deals with cognitive problems that’s why life for autistic individuals is harder. Autism is more than just a sensory processing and an emotional misreading disorder..don’t know why most of society doesn’t understand this
Your concept is that we all the same....we not...your thought process is flawwed
they've found that 50%-90% are missing about 30% of their Purkinje Neuron Clusters in the cerebellum, the cerebellums are also noticeably flatter. They've also identified fragile X as a seperate cause, much of the research up to this point seem to me to indicate that they haven't seperated out fragile x in enough of the other studies to make sincere predictions. but they're geting closer, also a misdevelopemtn in the 6-12 month period is what's causing the damage.
but information is so difficult to find on the internet, it's really frustrating. Too many opinions about 'neurodiversity' and 'super powers' and monetary gain and too few about the hard science.
Why do so many videos have such LOUD MUSIC? It is difficult FOR ME to stay focused & hear the conversation. Yes, I have some ASD traits.
l think it is for adding more emotions
@@voiceofreason2691 for me, if too loud, like this vid, it takes away from the content. If I have to fight music to gain intellectual insight, I walk away. Lose/Lose
Maybe the nature made autism not curable because its not supposed to be curable lol. I'd miss seeing autistic people in the world...I don't want autistic communities to vanish. There are times I'd wish I could be a neurotypical at least for a day but that's just out of curiousity to know what it's like not to have certain difficulties... But I have really good even above average skills neurotypicals can't understand and it's a huge gift I wouldn't want to lose. Come on, there are so many inventions neurotypicals can thank the autistics for 😑
My child patient of autism what I do
Treat them like a normal child, learn about the disorder and prevent things that trigger them.
But most importantly: understand your child, let them explain how they experience the world.
Wow ....fantastic research.
AI will probably help with this. With sufficient data, it could find patterns we haven't detected
D fui dormir agora e muito obrigada por ter vindo as coisas ai Sim
Wrong approach.
I will not consent to brain surgery for autism. I’m not disordered. This is my brain.
I have autism. But I like the video that I’m watching
Really? I'm Autistic myself.
@@TheAutisticEducator cool
@@rowanberryjamproductions2500 I'm not sure you understood my subtle jibe!
Hello Rowan, how are you? I'm Daniel, I'm not autistic but I have an uncle who is...He is very bright with a great memory, the only thing lacking is a strong nerve connection. I struggled with physical limitations, I struggled with anxiety I failed public speaking classes 4 times unit I beg the teacher to let me pass, wasn't able to run a 1/4 mile without being in pain and was blind from my right eye. 3 years ago I healed most of the vision of my right eye and keep improving, I also feel my anxiety almost heated and I can now run for 5 miles without pain. I want to share this with you in hopes of improving your nerve connection throughout your body. All you need is breathe, movement, awareness of your body and time, optional message tools(Gua Shua) could order on Amazon. Here it is, so just become aware of an area on your body that you want to improve, for example your neck, stretch to the right or left, front or back. Stretch till you feel a bit a of pain then hold and relax, while holding take 3 deep slow breathes and on the third breathe, breathe it till your full then hold and squeeze your breathe as much as you can tolerate and stretch your neck as you do this, this will feel really good, try to stay relaxed as much as possible. Repeat and you feel you neck improve in its abilities and apply to any around of your body and I guarantee you will reconnect your nerves. Peace and Love, Daniel feel free to ask questions....thanks
@@danielrobles2808 I am Good, thx. Well I do struggle with anxiety and I am not very much autistic
No thanks I love the way my brain works. It makes me WAY smarter than the average bear. Autism is not the problem. research like this is. We have other conditions that go with our Autism that can make it difficult, but NT's are what makes it most difficult for us. OUR brains work properly. YOURS are the ones that don't!
Facts
Thank you! Preach!
Amen!
lndeed !
Ah yes, getting an overstimulation induced panic attack because a loud motorcycle drove past is definitely a quality of a fine functioning brain 👌
(Yes that was sarcasm and personal experience)
masochists unite 🍿 after this y’all should check out the autism speaks pamphlet, it’s a riot
Ngl she kind of seems like the one of the bad intended people
Oh thank goodness the first step has been taken to rid my curse.
I agree it is a curse it destroys my hopes and dreams my mother's ruined me so now I'll never know who I was supposed to be
@@anastasiaendey3304 i feel the exact same way i can't even Express it to my mother due to fear of repercussions.
May I ask are you both Autistic? My daughter is 8 she's nonverbal severely Autistic & I have been wanting to understand Autism from her point of view but she obviously cannot help as she cannot speak. I was wondering if maybe you may have some imput?
@@anastasiaendey3304 your not ruined. Yeah it feels like (what the hell is wrong with me). But we never stop learning. I know this is so cliche but, if you put your mind to something you want to learn. It will come easily for you. I think...I was autistic growing up. And my mom tried her best to help me in school and life. But now that I’m a mom, I learned to break out of that mindset. My son is 3 years old and he was just diagnosed with autism. To me it felt like it was the end of the world. And I’m trying my hardest to get help for him. And now in the 2000’s, medicine is more advance and there are more studies being done. So it’s a big relief off my shoulders. Early intervention will help my son feel a little normal, and a chance at being, someone successful in his life and as a person.
It's not a curse for all autistics. In some, for some of us, it's a gift. Too many autistics have been conditioned to believe we are a problem. We're not. The problem is society doesn't accept us. Society also doesn't accept other races, opposite genders, sexual orientations, etc. and we're never willing to work with, help, and tend to the needs of those who are different. Just because everyone says something doesn't make it true. Everyone used to say the world is flat. They were wrong, just like they're wrong about racism or sexism. They're wrong about us autistics. You are not the problem. Count your good qualities and ask, "Would I have these good qualities if I wasn't autistic?" Remember that everyone has problems, so everyone has deficits as well, but that shouldn't be what defines you. Likewise, autism has issues, but there's a lot of good that comes from it too. Focus on that and bring up your self esteem. You are a beautiful person.
Hang on a minute... "autistic mouse brains"? Just how did you diagnose mice as autistic?
This video has some weird vibes to it.
Pygnogenol
They need to just go ahead and put the mice away and only study on people, fk it.. I know mice are super similar to us, but just use a human.. I'm sure there's thousands of volunteers
Why do you say autism is a problem? Maybe the world formed by neurotypicals is the problem
Ah yes; you want to be able to point to "the problem", rather than research me, and other neurodivergent people, as unique organisms *sigh* Typical...
I am autistic and would never change the way my brain works to remove my autism. There may be a higher percentage of people with lower intelligence amongst those with autism than amongst neurotypicals, but there is also a higher percentage of people with higher intelligence amongst those with autism than amongst neurotypicals. It's just greater at both extremes. If you "cure" autism, you lose a lot of people who are very gifted at focusing, having specialized knowledge, and making connections others don't see. You lose many software engineers, scientists, and academics. The world needs a broad spectrum of people with different abilities. To Harrison Bergeron everyone into being the same would be a grave mistake.
Ableist bullshit, problematic language, completely offensive. 10/10 do not recommend
this is disgusting