@@SiebertScience Hi there , i have a question , i heard of someone having B3 blood type what does it mean is it relevant in comparison to the + - Rh factor of the blood ... i could not find anything on it all over the internet and not even in a Medical physiology book
I just want to say thank you. For years, I have struggled with understanding ABO blood groups, and I have had to keep watching videos over and over to cram the idea in without fully understanding. It's really important to have a solid understanding of this as being on the wards, it became so apparent that transfusions are so common. I think the issue I was having with other videos is that people would not explain the bit about the donation of blood, and how you can remove the plasma and only donate the RBCs and you can leave out the antibodies- and this is why O blood type is so useful as you say, because it has no antigens, therefore, no matter the blood type and the antibodies in the plasma, there would be no reaction because O has no antigens. No one explained this, so i thought on the basis of donation, that the plasma was also given and would get confused as to how agglutination would not occur since O blood group has both antibodies. Truly exceptional video!
dude seriously tysm i have a bio test tomorrow and like idk why i found it hard to understand at first, so like i really needed this, your work is much appreciated frr
This helped so much!!! Could you give an example of the positive and negative Rh antigens? LIke if I had A+ blood, what does this mean for the Rh antigens?
Thank you, thank you, thank you! Makes perfect sense. You are my go to for my Anatomy class. I learn best by watching videos and I come to your channel every time!
"when blood is transfused we can actually separate out the red blood cells from the donated sample of the blood. From the rest of the blood. We could remove all the plasma. We don't have to worry about any antibodies from that donated blood. This few sentences solve all the problems. Why on earth it was not in our textbook.
@@SiebertScience I'm much obliged. The good news is that I've got the full mark! But I feel a bit ashamed because I don't have the full picture of what's happening, like what are antigens and antibodies, what're their chemical structure and main function. But I'm still on the beginning; I have lots of time to learn it all. But thank you so much for opening this door to me! I just noticed that I'm sending this message from my second account, but I'm Flying Feather btw.
I just want to tell you thank you for always explaining things well I never get disappointed Even as you are fast in the way you talk Everything sinks in well,you teach like you are really having a conversation Thank you so much This topic was my worst And you just made me love it 😍
I have couple questions: 1) is it known why do we have different blood types? why nature doesn't have just one universal type? 2) if O blood is donated to A blood, does O receive A's antigens and transform into A blood type? If yes, is it applied to all blood types? 3) if my blood is donated to another person, will he receive my DNA that comes along with the cell?
,,,,question 1....it's just a genetic possibility based on regional genetic development...the same with hair, eye and skin colours. Nothing special. It's said that group AB is a comparatively recent development based on interaction between Mongolian and central European populations. Question 2...it just merges with the existing blood in the body and there are no adverse reactions as long as there is no possibility of conflicting antigens and antibodies. See it as the same as pouring water in a leaking bath...there are only issues if the water has bleach in it at which point the bath water becomes toxic. Question 3...yes, but it will not excite your antibodies to attack it. Blood refreshes itself quite quickly and there will be no adverse reactions as the new, specific genetic code will soon be merged and then replaced. Water can be introduced into the blood stream to aid hydration as can glucose and sodium etc. and it's doesn't get attacked, either...
Fantastic explanation! I was wondering wouldn't the antibodies mess up the transfusion, and you explained that and several other important details that i haven't heard from others. 👍👍
you said we _can_ remove the plasma when giving a transfusion, let's say when donating O to A or B, is it always necessary to do so? I always thought you can just take blood and donate it without altering it in any way 🤔 but according to this it would be dangerous right
Really you are the best, I wouldn’t understand anything without your videos. You make it very easy for me to receive the information. All your videos are very helpful thanks so much, and I wish you were my professor 😂
Excellent explanation of blood types and the most commo antigens, it would be great if you make a video about indirect coombs and direct coombs, regards from Venezuela
Thanks for this amazing lecture of yours. I really appreciate your work and it helped me a lot. A video of 10 mins made me revise all the necessary points of this concept and I understood it in a more clear way👍 Really sir, Thanks a lot... The more I go in the depth of this topic, the more I get to know! And I'm sure, I'll acquire more knowledge of other facts as well.
I really appreciate this video, it was easy to understand and very informative. Now I know that because my blood type is A-, I cannot receive blood from my brother, whose blood type is O+. Could you make a video on how the Rh factor affects pregnancy?
I probably misunderstood your explanation about the O blood type. It has no antigens A or B, but it has both antibodies A and B. So, if this type of blood is donated to say A which has A antigens and B antibodies, wouldn't the A antibodies contained in the O cause a reaction with the A antigens?
Technically, all official websites and sources I've seen regarding the antibodies, refer to them as "anti-A" and "anti-B" antibodies. Not "A-antibodies " or B-antibodies". I've only seen letter prefixes used for antigens. "A-antigens" and "B-antigens". But I digress. We get the idea. But it could be confusing to some some people. Regardless, nicely done video! Also, good job talking about the removal of plasma before transfusion of red blood cells. Most videos don't even mention that and I see a lot of comments expressing confusion and asking how can a O blood type be given to the A, B and AB types if it contains the antibodies for all those antigens?. So, great job explaining that!
Dear sir, I have a question, According to the explanation, When donor's blood group is 100%same as the receiver's blood group, then you don't have to extract the plasma from donor's blood sample. But imagine, If donor's Blood group is A, and the receiver's blood group is AB, then you must extract the donor's blood plasma and remove it. because, donor's blood plasma contains B antibodies and they can react with the receiver's Blood Cells. Am I right ?
Thank you infinity ❤️your way of explaining exactly how I learn , I Cant learn much from class , but with drawing and explaining making it super useful. I hope I discover your channel sooner
thank you for making these videos. I fall asleep reading the textbook. I'm currently watching all the systems by you and I like how you make it fun by saying the adrenal glands are like party hats for the kidney lol. Yes I'm on your endocrine system video! keep doing what your doing and thank you for teaching me in a nonboring way. Your system is clear and I appreciate the pictures and drawings your the best !
I have a question, I was told I have O+ Blood, but when my blood was looked at I was told I also lack an entire group of antibodies, and that my doctor had never seen that before. Do you know what this could mean? I have been confused ever since as to if something is wrong with me or not and if this would cause problems if I ever needed a blood transfusion. I already know O types don’t have antigens, but what does me missing a whole antibody group as well mean?
Most people thinking about blood donations would imagine the entire blood is being donated - cells + plasma. But in reality the agglutination they are trying to avoid is only looking at donations of blood cells not the plasma. Plasma donations are a different set of rules.
I have an idea for a new video for you. Do a video on the rare blood type, cis-AB. This blood type which is the result a rare mutation is generally the same as a normal AB blood type in regards to the transfusion compatibilities etc, The difference in the cis-AB blood type from a normal AB type is in how it's constructed. Normal AB blood types as you know, inherit an A allele from one parent and a B allele from the other parent. But one of the two alleles in the cis-AB type person is an AB allele all its own. (Both the A & B versions of a blood type gene are found on one Allele). So, a person who has this blood type possess one allele being AB and the other allele being any of the other normal ABO types. This mutated cis-AB allele will dominate the other allele type no matter what type it is, resulting in the person always presenting as having AB type blood. One unique thing about a cis-AB person is that if for example, the genotype version combination of that person is the cis-AB allele and an O allele, that person could actually possibly parent a type O child if the other parent also possessed an O allele, which is something that would be impossible with a normal AB phenotype because a normal type AB person only has an A allele and a B allele to work with. The cis-AB blood type is very, very rare around the world, but is mostly found in the Korean and Japanese populations, But even in those populations it reaches a frequency of only 0.035% in Korea and 0.0012% in Japan.
How can I determine if I have Cis-AB ? I was told I am AB- and my child is o+ . Recently my child was confirmed that he is O+. My question is also that proving maternity with Cis-AB is easier than if you had chimerism ( which is way different than a mutation). I also have health issues so I want to make sure my blood group/type is correct so if anything, I won't be giving the wrong blood if needed.
![BOWKYLION - วิงวอน (ex-change) [Official MV]](http://i.ytimg.com/vi/cLdnZWDaO-w/mqdefault.jpg)
I just wanted to say this might be the most underrated video on TH-cam. Just did more for me in 10 minutes than my science teacher in 100 🐐
I appreciate the compliment! Good luck in your studies!
@@SiebertScience please make more videos
@@chucksokpala1918 chucks Okpala… igbo man lol.
Sir your videos are superb ❤
@@SiebertScience Hi there , i have a question , i heard of someone having B3 blood type what does it mean is it relevant in comparison to the + - Rh factor of the blood ... i could not find anything on it all over the internet and not even in a Medical physiology book
i am a nursing student and i have to say these lectures by him are so easy and quick to understand. he makes it so. thank you from all your viewers.
nursing students be like "iM a nuRsInG StuDeNT" before they say anything else
@@whatevervlogs9663 we got a hater here XD
I'll become a nurse after 12th.
I just want to say thank you. For years, I have struggled with understanding ABO blood groups, and I have had to keep watching videos over and over to cram the idea in without fully understanding. It's really important to have a solid understanding of this as being on the wards, it became so apparent that transfusions are so common. I think the issue I was having with other videos is that people would not explain the bit about the donation of blood, and how you can remove the plasma and only donate the RBCs and you can leave out the antibodies- and this is why O blood type is so useful as you say, because it has no antigens, therefore, no matter the blood type and the antibodies in the plasma, there would be no reaction because O has no antigens. No one explained this, so i thought on the basis of donation, that the plasma was also given and would get confused as to how agglutination would not occur since O blood group has both antibodies. Truly exceptional video!
10 mins ago, on the night before my test, this made no sense. now I completely got it. Ur a legend man thank u
Yay! Glad it was helpful.
dude seriously tysm i have a bio test tomorrow and like idk why i found it hard to understand at first, so like i really needed this, your work is much appreciated frr
This is the best explanation from all the TH-cam videos I watched
BEST EXPLANATION IVE EVER FOUND, THANK YOU
You're so welcome! Thanks for the comment.
This helped so much!!! Could you give an example of the positive and negative Rh antigens? LIke if I had A+ blood, what does this mean for the Rh antigens?
Thank you, thank you, thank you! Makes perfect sense. You are my go to for my Anatomy class. I learn best by watching videos and I come to your channel every time!
Also, you have a doppleganger in NY. You could be my friend Paul's twin.
great, keep making videos your way of teaching is natural , it is flawless.
my governmental exams are very soon and this section in biology was making me very stressed. You made it very easy thank you
thankyou for the best lecture ever
Such a good video with clear explanation and illustrations (I struggled for hours trying to find a video like it)! Thank you !😊
Makes sense, looking forward to another video to connect to this one
You are a genius when it comes to blood transfusion
This helped me so much in my college anatomy class. Thank you! sharing it to my class mates!
For the first time in over 15years since I was introduced to this topic, I have a better understanding on this topic. Thank you so much. #hatsoff
As a Nursing students your explanation was easy to understand 💯❤️🙏 thanks
Bro I actually love this video. Thank you so much, you’re an amazing teacher. Keep doing what you’re doing.
Thanks Seibert. You always make me fall in-love with science.🥰
Biggest thank you!!! You cleared up all my confusions on this subject.
Best analogy EVER of the ABO blood types/groups.
Amazing lecture by amazing teacher, it all make sense 😊❤
You are the best always on point
This is wonderful. This made more sense to me than how my uni explained it.
Thanks so much! Glad it was helpful.
Now it makes so much sense .. when people talk about it .. nice presentation
Thanks again, Ratan! Glad you've found the videos helpful.
"when blood is transfused we can actually separate out the red blood cells from the donated sample of the blood. From the rest of the blood. We could remove all the plasma. We don't have to worry about any antibodies from that donated blood.
This few sentences solve all the problems. Why on earth it was not in our textbook.
where were you when I was taking AP1 😭 love how easy to understand it is
You have explained this so beautifully! Thank you so much for explaining in a way we can all truly understand! Awesome!
High five if you're watching this 5 hours before your test!
this was really help, and exactly what I was searching for. Thank you, Siebert!
You’re welcome! Good luck on the test!
@@SiebertScience I'm much obliged. The good news is that I've got the full mark! But I feel a bit ashamed because I don't have the full picture of what's happening, like what are antigens and antibodies, what're their chemical structure and main function. But I'm still on the beginning; I have lots of time to learn it all. But thank you so much for opening this door to me!
I just noticed that I'm sending this message from my second account, but I'm Flying Feather btw.
Excellent explanation.
This video was so informative, and explained it better than the chapter.
Thanks so much,
You gave me exactly what I needed,
You made it clear within few minutes with so much ease.
Bravo!!!
One of the joys of being O-Negative is being able to donate blood knowing it could save anyone's life who needs blood.
I must be bad because as a O- my first thought is it sucks to b us during a blood shortage emergency
Just because of this single video , I have subscribed,liked, loved, saved and shared. Thank you thank you and thank you. ❤❤❤❤❤❤❤
Have a test tomorrow and this helped me 🙌 life saver ❤️
I wish I found this video earlier in my class. You explained better than my Immunohematology teacher.
Glad you found it helpful! Good luck in your studies!
Thank you so much for being so clear on your videos.
omg, you're my lifesaver!! I'm a pre-med student and this topic really confused me a lot but a big thanks to you! :))
Thaaaannkkkkk youuu !! That was so helpful 🙏🏻
Very good video with clear explanation
Super helpful!!
I just want to tell you thank you for always explaining things well
I never get disappointed
Even as you are fast in the way you talk
Everything sinks in well,you teach like you are really having a conversation
Thank you so much
This topic was my worst
And you just made me love it 😍
What a crystal clear explanation... awesome class
Thank you, clear and straightforward
thank you man, I work and study, I have less than 12 hours to my exam and you saved me.
Glad to be of service! Hope the test went well!
Cheers man, it was an awesome and conceptual video. Cleared all my doubts
Best explanation on TH-cam ❤❤❤❤🎉🎉🎉🎉
excellent video so straightforward and easy to understand . keep it up awesome work
Nicely & Simply Explain.
Best Teacher ever , Keep it up
It would be better if you can add like biochemistry .....
I have couple questions:
1) is it known why do we have different blood types? why nature doesn't have just one universal type?
2) if O blood is donated to A blood, does O receive A's antigens and transform into A blood type? If yes, is it applied to all blood types?
3) if my blood is donated to another person, will he receive my DNA that comes along with the cell?
,,,,question 1....it's just a genetic possibility based on regional genetic development...the same with hair, eye and skin colours. Nothing special. It's said that group AB is a comparatively recent development based on interaction between Mongolian and central European populations. Question 2...it just merges with the existing blood in the body and there are no adverse reactions as long as there is no possibility of conflicting antigens and antibodies. See it as the same as pouring water in a leaking bath...there are only issues if the water has bleach in it at which point the bath water becomes toxic. Question 3...yes, but it will not excite your antibodies to attack it. Blood refreshes itself quite quickly and there will be no adverse reactions as the new, specific genetic code will soon be merged and then replaced. Water can be introduced into the blood stream to aid hydration as can glucose and sodium etc. and it's doesn't get attacked, either...
Fantastic explanation! I was wondering wouldn't the antibodies mess up the transfusion, and you explained that and several other important details that i haven't heard from others. 👍👍
Amazing lecture sir😊
you said we _can_ remove the plasma when giving a transfusion, let's say when donating O to A or B, is it always necessary to do so? I always thought you can just take blood and donate it without altering it in any way 🤔 but according to this it would be dangerous right
Wow I love the illustration
Thanks for lifting me in that topic ,
Thank you so much for this. I was really struggling to understand this, thank you.
Really you are the best, I wouldn’t understand anything without your videos. You make it very easy for me to receive the information. All your videos are very helpful thanks so much, and I wish you were my professor 😂
Excellent explanation of blood types and the most commo antigens, it would be great if you make a video about indirect coombs and direct coombs, regards from Venezuela
Thanks this helped alot
Ahh finally understand this! Thank you so much sir.
Others make me confused. 😷
Wow, very well explained!
Great explanation of blood types!
Thanks!
Thanks for this amazing lecture of yours. I really appreciate your work and it helped me a lot. A video of 10 mins made me revise all the necessary points of this concept and I understood it in a more clear way👍
Really sir, Thanks a lot... The more I go in the depth of this topic, the more I get to know! And I'm sure, I'll acquire more knowledge of other facts as well.
knowing that "O+" or "O-" What's the difference that this two can or cannot donate blood. help understand. thank you.
Subscribed greatt videoooo❤❤❤
I really appreciate this video, it was easy to understand and very informative. Now I know that because my blood type is A-, I cannot receive blood from my brother, whose blood type is O+. Could you make a video on how the Rh factor affects pregnancy?
Smart guy easy to learn from him! Props keep up the great videos
Loved the way you explained this ! I understand it sooo much better
Glad you found it helpful!
I probably misunderstood your explanation about the O blood type. It has no antigens A or B, but it has both antibodies A and B. So, if this type of blood is donated to say A which has A antigens and B antibodies, wouldn't the A antibodies contained in the O cause a reaction with the A antigens?
Only the Blood cells are transfused not the plasma which contains the antibodies
Technically, all official websites and sources I've seen regarding the antibodies, refer to them as "anti-A" and "anti-B" antibodies. Not "A-antibodies " or B-antibodies". I've only seen letter prefixes used for antigens. "A-antigens" and "B-antigens". But I digress. We get the idea. But it could be confusing to some some people. Regardless, nicely done video! Also, good job talking about the removal of plasma before transfusion of red blood cells. Most videos don't even mention that and I see a lot of comments expressing confusion and asking how can a O blood type be given to the A, B and AB types if it contains the antibodies for all those antigens?. So, great job explaining that!
Well explained
Hi!! I love your videos! I was wondering if it was possible to make videos for pharmacology??
Dear sir, I have a question, According to the explanation, When donor's blood group is 100%same as the receiver's blood group, then you don't have to extract the plasma from donor's blood sample. But imagine, If donor's Blood group is A, and the receiver's blood group is AB, then you must extract the donor's blood plasma and remove it. because, donor's blood plasma contains B antibodies and they can react with the receiver's Blood Cells. Am I right ?
this was very useful,i want ask some question ,do you have a page asking questions
This video has more sense than other videos which are more confusing to me.
❤
Thank you infinity ❤️your way of explaining exactly how I learn , I Cant learn much from class , but with drawing and explaining making it super useful. I hope I discover your channel sooner
God bless you for teaching and sharing ❤❤❤❤❤
Outstanding bro
Excellent video! Thank you! Thank you! Thank you!!!
Simply explain, thanks
Very well explained! Love the beard and the baldhead!
When giving O blood to a patient with A blood, O blood has A and B antibodies. Can they interact with A antigen in a patient with A blood?
had same question, clearly not many paid attention.only explanation is that we donate RBCs only an not thhe plasma that contains antibodies
I understod this concept
Great explanation
Thank sir
You're welcome!
Wow!!! New subscriber here. Question, what do you when you’re doing ABO forward and reverse, then one patient is Rh is negative?
Ur lecture is perfect.. i like to know more about Cross marching
thanks so much 😆
Thanks so much for the video.
thank you for making these videos. I fall asleep reading the textbook. I'm currently watching all the systems by you and I like how you make it fun by saying the adrenal glands are like party hats for the kidney lol. Yes I'm on your endocrine system video! keep doing what your doing and thank you for teaching me in a nonboring way. Your system is clear and I appreciate the pictures and drawings your the best !
Best videos ever I'm learning a lot from this videos
I have a question, I was told I have O+ Blood, but when my blood was looked at I was told I also lack an entire group of antibodies, and that my doctor had never seen that before. Do you know what this could mean? I have been confused ever since as to if something is wrong with me or not and if this would cause problems if I ever needed a blood transfusion. I already know O types don’t have antigens, but what does me missing a whole antibody group as well mean?
Crystal clear ⭐
Excellence lesson ❤
Most people thinking about blood donations would imagine the entire blood is being donated - cells + plasma. But in reality the agglutination they are trying to avoid is only looking at donations of blood cells not the plasma. Plasma donations are a different set of rules.
Very good sir
Thankyou so much sir 😭🙏🏼
Great explanation thank you so much
I have an idea for a new video for you. Do a video on the rare blood type, cis-AB. This blood type which is the result a rare mutation is generally the same as a normal AB blood type in regards to the transfusion compatibilities etc, The difference in the cis-AB blood type from a normal AB type is in how it's constructed. Normal AB blood types as you know, inherit an A allele from one parent and a B allele from the other parent. But one of the two alleles in the cis-AB type person is an AB allele all its own. (Both the A & B versions of a blood type gene are found on one Allele). So, a person who has this blood type possess one allele being AB and the other allele being any of the other normal ABO types. This mutated cis-AB allele will dominate the other allele type no matter what type it is, resulting in the person always presenting as having AB type blood. One unique thing about a cis-AB person is that if for example, the genotype version combination of that person is the cis-AB allele and an O allele, that person could actually possibly parent a type O child if the other parent also possessed an O allele, which is something that would be impossible with a normal AB phenotype because a normal type AB person only has an A allele and a B allele to work with. The cis-AB blood type is very, very rare around the world, but is mostly found in the Korean and Japanese populations, But even in those populations it reaches a frequency of only 0.035% in Korea and 0.0012% in Japan.
I like people like you no homo ... You are very expressive, which makes you very rare just like the blood type that you are trying to describe
How can I determine if I have Cis-AB ? I was told I am AB- and my child is o+ . Recently my child was confirmed that he is O+. My question is also that proving maternity with Cis-AB is easier than if you had chimerism ( which is way different than a mutation).
I also have health issues so I want to make sure my blood group/type is correct so if anything, I won't be giving the wrong blood if needed.
O blood type with an unknown protein on my red blood cells , am I rh - or rh + ?
Thank you so much for this
I have a AB+ blood