Personally, I suspect that there is some role for serum osmolarity in HF which has been shown to activate the endogenous fructose production (the polyol pathway) which in turn induces insulin resistance/hyperinsulinaemia and much of damage of the cardio-metabolic syndrome seems to be actually mediated by fructose metabolism. Of course, salt intake, especially in people already affected by insulin resistance may contribute to high serum osmolarity (as well as high blood sugar levels which are also connected to the metabolic syndrome...). However, it seems that salt deprivation may be a double-egded sword if it leads to defficiencies. Anyway, I'm looking forward to hear this talk!
Thanks a lot! This double-edge sword will definitely be part of the discussion - even though fructose production will not be touched upon. For those who are interested to read more, there are recent papers on this (e. g. www.ncbi.nlm.nih.gov/pmc/articles/PMC6645632/).
Personally, I suspect that there is some role for serum osmolarity in HF which has been shown to activate the endogenous fructose production (the polyol pathway) which in turn induces insulin resistance/hyperinsulinaemia and much of damage of the cardio-metabolic syndrome seems to be actually mediated by fructose metabolism.
Of course, salt intake, especially in people already affected by insulin resistance may contribute to high serum osmolarity (as well as high blood sugar levels which are also connected to the metabolic syndrome...).
However, it seems that salt deprivation may be a double-egded sword if it leads to defficiencies.
Anyway, I'm looking forward to hear this talk!
Thanks a lot! This double-edge sword will definitely be part of the discussion - even though fructose production will not be touched upon. For those who are interested to read more, there are recent papers on this (e. g. www.ncbi.nlm.nih.gov/pmc/articles/PMC6645632/).