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Pharmacology | Autonomic Nervous System | INBDE, ADAT
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- เผยแพร่เมื่อ 17 ส.ค. 2024
- In this video, we discuss the physiology of the autonomic nervous system, as well as cholinergic and adrenergic medications. Thanks for watching!
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Best video for a brief overview even for mbbs students
Thank you Dr. Ryan you are an effective teacher. All the way from Philippines 🇵🇭 I want to express my gratitude in all of your videos! Thank you Mental Dental 🦷
I understood more during this 32 min video than 6 hours of lecture XD. Thank you for your explanations and visuals!
Great to hear!
Exactly !
same here
You did a great job doc🎉
Best lecture i have ever heard ♥️
Thank you so much, Dr Ryan! 🌸
Great lecture! Concise, well organized and excellent presentation. Thank you!
Thank you very much!!
Feels like it is for the first time that i have understood ANS & PSNS😆😁
THANK YOU THANK YOU THANK YOUUUUU! love, a med student that will actually get to go to sleep at a decent hour because of your concise explanation
You’re welcome!! Glad you can get some sleep 💤🤩
Thank you so much Rayan! You made dentistry a lot more easier😍
Second time watching this video. Much more clear now after going true some practice question from the Mosby’s Book. Likin completing a cicle
Thank you
That was incredibly helpful. Thank you🙂
Wonderful presentation
Excellent video! Easy to understand a very complex content.
honestly, thankyou❤️
Thank you Dr !!
Excellent explenation! Great lecture! I finally understood this topic! Thank you for making this easy!😍
So glad to hear that! 😁
Amazing lecture 👍
It made pharmacology simple for me
Thank you sir 😊😊
You made it so easy😊😊
Tysm..god bless you
Amazing video...ur a good teacher..keep going
Clonidine used to control Bap for people detoxing from opioids makes more sense why it is a drug of choice. I have worked in detox asan acupuncturist. Your videos are helping me understand so much. Thank you. They are clear and very understandable. I am studying fir my FL RDH prometric pt stimulated computer sections of the boards. I have almost no idea how to study. I graduated in 1981 scored 86 n nationals back then. 95 on clinical sun two states. Things h Ave changed. I am “rusty”. Clinical practice is different from academic understanding. Thank you.
I am so glad my videos are helping you! 😊
This is awesome 👏🏻
Thank you brother, this video helped a lot. Greetings from India.
Incredible how to make it easy thanks and big love to you ♥️♥️
Great way to explain this heavy topic, great job! Helped a lot.
Great teacher
Really outstanding
🎯 Key Takeaways for quick navigation:
00:00 📚 This video covers autonomic nervous system pharmacology, which is divided into the parasympathetic and sympathetic branches.
02:32 🧠 Understanding that both branches control the same organs but have opposing effects (fight-or-flight vs. rest and digest) is crucial.
04:26 🚦 Autonomic receptors include ionotropic (ion channels) and metabotropic (GPCRs) receptors, which play a significant role in drug action.
06:11 💊 Cholinergic receptors (muscarinic and nicotinic) are associated with the parasympathetic nervous system, while adrenergic receptors (alpha and beta) are linked to the sympathetic nervous system.
10:16 📖 The autonomic nervous system has specific drugs, including agonists and antagonists, that target these receptors to modulate their functions.
19:03 ⚙️ The synthesis of catecholamines (epinephrine and norepinephrine) and their receptors' actions on smooth muscle, heart, and more are discussed.
26:06 🔄 Drugs like sympathomimetics and sympatholytics either mimic or block sympathetic responses, affecting blood pressure, heart rate, and more.
27:13 🧠 Alpha 2 receptor agonists like clonidine and methyl dopa block the sympathetic nervous system in the central nervous system, producing antagonistic effects.
28:32 ⚖️ Epinephrine reversal refers to the conversion of its vasoconstrictor effect into a vasodilatory effect in the presence of an alpha blocker, highlighting drug interactions.
30:04 💔 Vasovagal reflex involves a malfunction where baroreceptors, controlled by both the sympathetic and parasympathetic systems, can lead to conditions like sinus bradycardia, demonstrating how the autonomic nervous system doesn't always function as intended.
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Great notes from the content covered in the video!
Thankyou so much Ryan!❤
You’re very welcome!
you really made it easy
thanks a lot
Difficult indeed, but THIS and slowly digesting "Tufts Pharmacology" helped me a LOT
Glad to hear that!
You are the best. Thank you so much
this video is really great
Very helpful. Thank you so much 🤗🌸
Thank you soo much sir very well explanation
Thank you 🙏
Thank you so much, your efforts of making the video was worth it☺👍👍👍
Just had my pharmacology test ,Thank you so much...
We need more video's 😊
I am reading a lot but nothing sinks in and just desert me. And I am here ☺
THANKYOU THANKYOU THANKYOU!!!
thank you for lectures it very helpful, keep it up
I really enjoyed this lecture alot🙌💃💃 thumb up👍
Thank you Doctor... Would you please help us with a lecture on autacoids as well?
4:00 I can say with certainty that when under a fight or flight situation (read: presenting in front of classmates) I can experience involuntary constriction of my bladder rather than relaxation
Thank you Dr Ryan for your videos! Just had a question regarding the preganglionic neuron for SNS. Shouldn’t both SNS and PSNS preganglionic be cholinergic?
Great video! I would have liked to know what each drug is prescribed for, easier for memorizing 😊
Hey Ryan, I'm a little confused why you have Nicotine as a Nicotinic antagonist. Your reasoning why makes sense, but wouldn't nicotine by definition be an agonist for nicotinic receptors? The Wiki on nicotine is also stating it is an agonist. Could you please clarify this? Thank you.
Yes, great question. Technically yes you’re right nicotine is an agonist of the receptor. However, it binds so tightly and reduces its responsiveness over time and desensitizes the receptor (acting more like an antagonist in the long run). A very interesting interaction to be sure!
I followed the video step by step while taking notes and I really understood clearly all of it until the Epinephrine reversal part were it was confusing
Plz make videos on general medicine, physiology
Do you recommend watching these videos in order? Thank you!!
If possible, I always recommend watching them in the order I have them in the playlist (and by the numbers in the top right corner) because I usually build on concepts I introduced in earlier videos. But you would be just fine watching them in any order if you preferred!
Mental Dental Thank you!
@@mentaldental best idea that you put number on each slides.thank you so much
Why the titles of all videos say PART II, Where are PARTS I?????
Hello Dr you said M3 relaxes smooth muscle? Should it contract smooth muscle to squeeze out the saliva etc? 12:36
How can baroreceptor be activated by high high blood pressure caused by one norepinephrine..Plz explain the mechanism
sorry i want to ask about the b2 receptors i did not get why the dont not cause vasoconstriction but cause vasodilation
so is it right to say that clonidine is an agonistic drug with a sympatholytic effect?
That is exactly right!
@@mentaldental thank you so much! love your lectures!
What do most of these words mean?? I'm so confused but this is kinda cool
Hey Ryan, great vid! I was able to follow through the whole video, but I have a question about the urinary bladder. If it's relaxed during SANS, then why is there a tendency for some people to urinate or defecate a lot when they're stressed or nervous? I'm really confused.
Hope you'll be able to answer my question. Thank you so much and more power to your channel!
Excellent question! So the sympathetic and parasympathetic nervous systems are just one control mechanism for urination and defecation. "Fight or flight" slows digestion and relaxes muscles of the bladder to make more room for urine. But there is also something called the enteric nervous system within the wall of the gut that responds to hormones, where certain chemical messengers released by the brain during periods of fear, stress, or anxiety can trigger the tendency you describe.
We see in movies that when people get scared they urinate in pant but our teacher said that's just made for fun in actual that doesn't happen at all thats against science but have you seen that in real life? If it was real then there should be exceptions mentioned in sympathetic actions..as simple as that
Yes ,,, ergo the " It scared the sh!# out of me. Or I was so scared I wet my pants" We see this in the animal kingdom as well. While in Hawaii, I picked up a big frog and it immediately peed on my hand. Somehow I don't think it was my natural calm and soothing nature or the fact that I am a frog whisperer. But perhaps rather, the prototypical Sympathetic response is sometimes trumped by the occasional Ultra sympathetic experience were the extemporaneous control comes from another part of the brain? 🤓
@@mentaldental I'm still a bit confused but thank you so much for the response!
do i have to learn each adrenergic antagonist and their MOA....
17:00
In ur video when u r describing alpha receptors u have written it causes urinary retention isn't that wrong?
Alpha receptors are associated with SNS so it should cause increase in urine flow @mentaldental
No pls
Alpha receptors are SNS, hence should cause bladder dilation, which will retain urine. That's why alpha blockers are prescribed during urine retention
Is this for NBDE part II or INBDE?? looks like Physiology more than Pharm
Hey Dr Ryan.
Your new subscriber here.
Please can u also make videos on mcqs related to the inbde ?
It would be a humble request
I have a bunch of multiple choice questions modeled after the INBDE on my Patreon page! www.patreon.com/mentaldental
@@mentaldental
Thankyou so much Dr Ryan .
I've just started my course n it's a great great help .
Lots of respect n love from Pakistan .
Hi! I have an assignment given by my lecturer to find out about the types of autonomic nervous system poisoning and I was really confused. Does ANS poisoning depending on the effect (parasympathetic and sympathetic) or is it depending on the mechanism of the toxin? (anticholinergic, cholinergic etc)
mostly when its related to poisoning and when its ANS-its Organophosphate posioning and arsenic poisoning we talk about that comes under metal poisoning refer KD Tripathi Pharmacology for the same thats what we use here
Hi! If we subscribe do we get access to the powerpoints or notes for these videos? It would save me a lot of time to be able to take notes on there as opposed to retyping the info! thanks!
Hello! You can get the slides one of two ways. You can either sign up on my Patreon page for at least $10/month www.patreon.com/mentaldental or send $30 to me directly via PayPal for the NBDE Part II slides only, $15 for the INBDE slides only (or $40 for both) www.paypal.me/mentaldental
Hi Rayan thanks for this great video. I just have a question
If the synaptic ganglion and medula binds to Nicotine wich is a Acetylcholine rector (AChR) any drug that is Anticholinergic would inhibits both PSNS AND SNS systems???
Great question! Anticholinergic medications selectively decrease or block the actions of acetylcholine on parasympathetic nervous system receptors on smooth muscle cells, glands, the heart, and the central nervous system, not as much at the adrenal medulla.
Hi there! @ Dr Ryan or other watchers. I am currently studying for Integrated Boards, and I'm honestly overwhelmed with allllll the content out there for boards ... for some reason Pharm set me off. Is this all really needed to learn for boards? :( It seems impossible to know so much about literally everything ever. Just let me know someone if i need to learn all this stuff because I am losing motivation
Hi, I feel your pain .... I'm the same. I just had to pause this video half way through to relax my brain!!!! I've given myself 12 weeks following Dr. Ryan's guide on patreon + those topics on Dental decks... praying this helps me cover all that's needed. All the best, hope we are able to overcome this hurdle....
Keep with it Bryan! Just go one day at a time, and review things multiple times before going to the next video if needed to really learn it well.
Hi why isn’t there all chapter
Hello Dr. Ryan,
I've been following your videos recently
Thank you so much for you great efforts!
Is this series of Pharmacology breaks down the Tufts file and enough or do I still have to go through Tufts file too after these videos? I hope I don't!
Hello, Dr. Ryan. Do you have more content of all subjects in Patreon? Am I missing a lot of important stuff if I only pay my monthly fee of $5.44/mo.? Would you highly recommend Patreon? Please advise me. Thanks in advance.
Hello! My Patreon website has a lot of bonus content that can make your studying easier and more fulfilling. At the $5 tier you will have access to hundreds of practice questions. With the $10 tier, you will get access to my video slides to take notes on. And the value goes up from there!
So alpha 2 agonist are sympatholytic. Wouldn't that mean vasodilation???
Correct! It mimics the effects of a sympathetic antagonist, and it can be used to combat high blood pressure by relaxing or dilating the blood vessels.
Hi Ryan, thank you for your video. I'm just wondering when will the new slides for pharm will be posted? please let me know. Thank you again
They are now posted on Patreon!
@@mentaldental I saw it. thanks a lot. appreciate it
Should I memorize all these drugs for the NBDE part 2?
I know it's a LOT to memorize, but if you can, all of these drugs could potentially appear on the exam so I included them all at least so you're familiar with them! However, your questions on these drugs will be limited, so you can choose how to best spend your study time.
@@mentaldental I'll keep that in mind! Thanks for the quick response!
Hi Dr! Are you still accepting donations in PayPal? Thank you
Yes!
I couldn’t find you today on PayPal
@@xiomarai.ruizmorales2897 It should be this link: www.paypal.me/mentaldental
I want to understand all chap ???
N
Actually I’m mbbs student so want help ??
But, there are adrenergic receptors on heart too, aren't them? why is that not mentioned here?
They are mentioned in the video! Beta-1 receptors, specifically.
this is the worst topic