Dont even try to bakeract him, as Lord Pravus will smite thee with lightning from his rending gale, flood your spirit with seeking arrows, and fire faulty fireballs at your everything; before making your people worship him as your corpse is forgotten.
It is interesting because this isn’t really accurate to the real mad cow disease. It took about 5 years for people to begin to display symptoms and then it was 100% lethal
Another fun fact. Lethality in this game essentially calculates how long it takes for an infected person to die, as infected cannot recover without the cure in Plague Inc (unless you're doing Cure Mode, in which case Prion is given an automatic 100% Fatality Rate
Creators of a Plague Inc. had to do a lot of simplifications and compromises when it comes to prions. In real life they are literally uncurable and can manifest spontaneously, but can be transmitted only by ingested. Moreover, some people are just blatantly resistant or immune to it. Although there are rumors about the possibility of prions transmitting through air, in which case we're screwed
Prion diseases are also incurable (at least at the time of me writing this). Genuinely now idea how you’d cure widespread protein misfolding in the brain on a massive scale. Tracking infection sources would also suuuuck given it’s ridiculous incubation rate.
wins on casual: aaaaaaaaaaa yes! wins on normal: YUS! LETS GO! OMG! wins on brutal: *BOW DOWN ####**#S**! I'M THE KING OF PLAGUE INC!* wins on mega brutal: I'm done, i'm done, i'm honestly done. I'm done with this game.
No one People in Greenland 🤒🤧🤒🤧🤒🤒🤧🤒🤧🤒🤧🤒🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤒🤒🤧🤧🤧🤧🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤧🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤧🤧🤧🤒🤒🤧🤧🤧🤧🤧🤧🤧🤧🤧🤧🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤒🤒🤒🤧🤒🤒🤒
@@MAGNITUDE16 i think it makes zombie like cows becuse ppl get zombie like wen they eat human meat at least i think thats how it gos take this with a grain of salt
@@zakosist apparently research shows that around 50 scientific researchers Live in Antarctica full time I'm also sure that between 100-200 researchers work in Antarctica daily so technically humanity wouldn't be wiped out.
I was saved by the fish once too. I got detected super early and Caribbean shut its port before I could infect it. I wanted to give up, but decided to keep going as if nothing happened. When I only had around 100 000 people left alive someone in Caribbean ate infected fish and I immediately devolved some lethality so I could infect the country, and managed to complete the scenario. It felt really really good. This was on normal and I can't even finish the scenario on brutal becuase it's so darn hard.
I love how Pravus explains his strategies. Many of his plays have also carried me to winning a lot of different scenarios (as well as just the normal disease types)
Scientist 1: I have a headache, blood from every hole, I forgot my name, I feel that my leg is paralysed, and I hear the Death whispers in my ears. Scientist 2: It's just flu Scientist 1: *lol okay, lets go do a vaccine*
fr how do scientists in this game do even 1% of cure progress while confused, with dementia, paralyzed, with no sleep, while insane, while in a coma, etc.
I remember doing a scenario and waiting for Genetic Reshuffle 3 and saving up. They finished the cure just as I had saved enough. I did it anyway. It worked. Beautifully
Well,even if they make 100% cure and start curing people,you still can reshuffle or take a symptom like coma and they will have to make it to 100% before they are able to start curing people again. And those who were cured can still be infected again if cure is not 100%.
I gave up after 4 attempts in normal and 2 in casual. I realized that if I could not beat it in casual there was no way in hell I was ready for normal. I'm actually still trying to beat it in freaking casual.... *Sobs forever*
No joke, I was thinking to myself "I hope Pravus gets this scenario done" sometime last night. TIMING! This scenario looks brutal - I'm already dreading doing it myself.
Holy cow you did it! (Cheesy pun intended.) sorry I just I had to milk it. Ok now I'm bovinally done. Edit: oh wow 25 likes I am very grateful of this. Edit 2: 100 likes wooo I am dairy thankful. Edit 3: I think it's udderly awesome how so many people like my puns.
Mad cow's disease is the "common" name for Bovine Spongiform Encelopathy (or BSE). This condition on humans is called *variant* Creutzfeldt-Jakob's disease or CJD-v (the variant refers specifically to the one that is acquired by consuming infected tissue) The BSE outbreak that happened in England started due to, as a meaning of cutting costs, cows were fed with sheep remains, and sheep were already commonly enough affected by Scrapie (their version of the prion infection), so cattle meant for human consumption developed BSE, which passed consequently to human hosts. Prion diseases have a very slow onset and are hard to detect for the very same reason (nowadays can be detected by clinical exams such as the Western Blot, but coming up to even suspect a prion infection is the tough part) Prions are misfolded, anomalous proteins that cause other nearby proteins to misfold as well, and its onset in the brain results in a sponge like texture in the brain, giving it its name of *spongiform* encelopathy (sponge-like brain pathology). Unlike what the name "mad cow" might make you expect, no one goes in some sort of rage, the affected person or animal suffers brain deteroriation and starts losing mobility and physical control, in its last stage the host will be unable to move and will die when it reaches the point it can't even function properly. Prion diseases are a death sentence basically, and due to the nature of the pathogen (a protein) medical advances haven't gone too far into the matter, tried measures aren't able to cross the hemato-encephalic barrier (the barrier that works as some sort of firewall for your brain) while the prion has no issues. Most places have to get rid of cow brains and neurological tissue just in case, English veal has been unbanned in most countries relatively recently (I believe the last to lift said ban was France) and blood banks mostly rejected blood from people that spent time in England or Europe when the outbreak happened (this ban is also starting to get lifted as the pandemic left us short of blood donors in general). Some other interesting facts about prions is that soil that was used by infected sheep or cattle is deemed risky for further animal raising, as proteins are VERY HARD to actually destroy. They tried sterilizing procedures for medical equipment in contact with prions, but heat will only briefly inactivate the protein and said equipment is rendered unusable and has to be destroyed. Prions are also behind that moose disease that also had some sort of sensationalistic name (something in the like of zombie moose? Thrashing syndrome? Something like that, honestly I forgot) and has suspected links with Alzheimer's, though nothing can be confirmed as of yet, there's also suspicion that there might be multiple types of prions.
It's not even a case of basically. All known Prion diseases in both humans and animals are 100% lethal so far as we know, and are completely incurable. We know of a few others besides vCJD such as Familial Fatal Insomnia and Kuru. They also are usually only transmissible through the injection or consumption of contaminated fluids or tissues, most often brain matter, but it can also spread through blood and muscle tissue (though cases from consumption of muscle tissue are usually believed to be due to that meat being contaminated with brain matter). Some evidence suggests that prion-infected matter can be aerosolized and spread through inhalation, but this basically cannot occur naturally (though there are regulations regarding using pressure washers in slaughterhouses for this very reason).
@@jamesdinius7769 Yeah yeah, went mainly on vCJD because that's the one emulated in the scenario, and naturally making prions in game 100% lethal would bring balance issues. Prion diseases have long latencies and even if caught early by protein exams such as Western Blot... Uh, it doesn't help your case much, you are just getting more palliatives lol, I guess a realistic prion gameplay would be kind of boring as it's rather slow and silent, and the in-game prion's "prion features" are low infectivity, and evolutions taking longer to present themselves, supposedly they are harder to cure as well if I'm not mistaken, but I have a hard time buying that when some random country just goes and whips out a prion disease cure in like two minutes 🙄 are prions amazing in science? Yes. In-game? They are kinda one of the most boring pathogens to play as for me at least lol
the moose disease is 'zombie deer disease', and its also called chronic wasting disease! its the same thing but this type only affects the deer family, tho I do think it can infect some other rodent or something. tragic to see that it's incurable, but I guess we don't understand proteins well enough with our current science :(
Try doing a custom scenario of Cholera, there are quite a few and it is often the "forgotten" plague because it usually happens in poor nations and does not usually spread out from them (like the outbreak in 2010 in Haiti)
This disease has two variants: Bovine Spongiform Encephalopathy (BSE) in bovine (especially cattle) and vCJD (Variant Creutzfeld-Jakob Disease) in human (also known, to differ form former, as human mad cow disease).
Wow, great job! I love plauge inc, but suck at it, so to watch this makes me feel good ^^. Also P.S. I have never seen anyone get so exited over fish 😂
Omg...your videos are so fun to watch. Your reaction to your victory here is memorable to say the least. I found this game probably a year or two ago. Played for a while and gave it up. After stumbling upon some of your other videos I have reinstalled the game. You seem to have a different version. Looks different. Anyway, had to leave a comment and say hello after watching this one.
I don't know if my game was just updated or something but when doing these scenarios, I can't devolve what I start with. It's straight up greyed out. I came here to look for a strategy only to find one I physically can't do :(
I think why Plague.Inc is less realistic is because once someone gets infected, they will be infected with it forever until some cure comes round or they die, as well as more. I’d like a game where rather than win or loss, the game will rate you out of 10. Yeah where wiping humanity is a challenge even on minimal difficulty. And the score scales on how much damage you do
It only took me 3 attempts on mega brutal, I just bought a lot of transmission and traits with mutation chances, therefore, I can focus on ability traits, which really helped me so yea, but good one, Pravus, you really did well
From what I've seen, as of March 2023 a grand total of 12 people have gotten 3 stars on mega brutal on this scenario, and they had to use save scumming.
Thank you for making these videos. Yes I have only been able to get two bio hazard symbols on casual. So I can only imagine how hard it is on mega brutal.
This link here shows a strategy for handling it with 3 stars: steamcommunity.com/sharedfiles/filedetails/?id=1258854729 I had tried it myself on casual and did get the 3 stars, but I don't know if it works on higher difficulties
Ah, I can't seem to get this right! Imma keep trying because this seems like a very solid strategy and you sound like you know what you're doing. Mainly my problem is not getting to kill off the world before the cure is finished, or them working on it too early or quickly. Or I'm not spreading quickly enough in Greenland and in two recent playthroughs in other countries that aren't islands. Watch, I'm going to beat it as soon as I post this comment XD
> Mad Cow Disease: Mega Brutal written guide < Notes: * This guide will more than likely NOT get you 3 biohazards. Pravus got 23990 points for it. * This guide utilizes the random infection via fish, so it is a bit luck based. * Once you get detected, stop devolving any mutations that massively increase severity 1. Genetic code: Catalytic Switch, Genetic Mime, Aquacyte, Extremophile, Trans-statis 2. Start in Saudi Arabia 3. Devolve: Confusion, Memory Loss, Psychosis, Headache 4. Devolve Acute Encephalitis, if mutated 5. Evolve in order: Insects, Poultry, Pork, Dairy. 6. Evolve in order: Hermetic Storage Resilience, Frozen Storage Resilience, Preservative Storage Resilience. 7. Evolve Fish 8. Evolve Plant Dissemination * If Russia is infected, stop following the guide and evolve Cold Resistance 1, 2, Potato. After that, continue following the steps 9. Evolve in order: Broccoli, Potato, Avocado (Optional: also evolve Maize) 10. Evolve Genetic Hardening 1, 2 11. Evolve Psychosis, Memory Loss (if not mutated) * If Greenland or any other island is not infected before the shutdown, restart the game 12. Evolve Human Cross-Infection 13. Once every country has been infected, evolve: Coughing, Pulmonary Oedema, Coma, Total Organ Failure. * Acute Encephalitis can now be allowed to be mutated/evolved. 14. Focus on slowing down the cure. Evolve: Confusion, Mania, Delirium, Insanity. 15. Save up DNA for Genetic Reshuffles and evolve them. While saving up, the whole world can get infected. 16. Optional: evolve Ataxia, Blindness, Paralysis, Hallucinations (if not mutated)
damn! gg, I haven't played mad cow yet, but I've herd that it's pretty crazy, been trying to look for some strategies before I dive head first, cause I know Ill just end up playing it over and over till I got it, and I'd end up driving myself crazy, thanks man, didn't actually know severity worked like that.. It explains A LOT! 🤔
9:42 I just want to see a boat get into Greenland (uninfected boat goes into Greenland)
Punked by the universe. You see it all the time.
No there was a boat going
@@hempellsravens what?
@Bobska is epic lol yes
Pravus: Listen here you little S**t
*when he start and Saudi Arabia and instantly gets pork*
*us Arabs: are we a joke to you?*
Maybe...
I dont think it really affects the game
Mostafa Ahmed it’ll be cool if it did
@@baimm5390 it does im pretty sure
As a Muslim this is hilarious
so your saying you had 22 times talking to yourself every time you try to record?
Oh yeah, if he don't deleted it all - we need "Salty Pravus Rage and Cursing compilations"
Yes please he needs some compilations.
Mad pravus disease
Dont even try to bakeract him, as Lord Pravus will smite thee with lightning from his rending gale, flood your spirit with seeking arrows, and fire faulty fireballs at your everything; before making your people worship him as your corpse is forgotten.
Andrej Nedorezov “
It is interesting because this isn’t really accurate to the real mad cow disease. It took about 5 years for people to begin to display symptoms and then it was 100% lethal
its a mutation of the mad cow disease, its not the real thing
If it was like that …
I wish
Another fun fact. Lethality in this game essentially calculates how long it takes for an infected person to die, as infected cannot recover without the cure in Plague Inc (unless you're doing Cure Mode, in which case Prion is given an automatic 100% Fatality Rate
Creators of a Plague Inc. had to do a lot of simplifications and compromises when it comes to prions. In real life they are literally uncurable and can manifest spontaneously, but can be transmitted only by ingested. Moreover, some people are just blatantly resistant or immune to it. Although there are rumors about the possibility of prions transmitting through air, in which case we're screwed
Prion diseases are also incurable (at least at the time of me writing this). Genuinely now idea how you’d cure widespread protein misfolding in the brain on a massive scale. Tracking infection sources would also suuuuck given it’s ridiculous incubation rate.
this is the most intense plague inc video i have ever seen
When Pravus plays the Mad Cow Disease Scenario
*Intense Gameplay*
*intensity intensifies*
*intensified intensity intensifies*
NiRe me either and i’ve been binging theses all day
wins on casual: aaaaaaaaaaa yes!
wins on normal: YUS! LETS GO! OMG!
wins on brutal: *BOW DOWN ####**#S**! I'M THE KING OF PLAGUE INC!*
wins on mega brutal:
I'm done, i'm done, i'm honestly done. I'm done with this game.
Let's try get 3 stars! I mean, how difficult could it be? :D
*cries internally*
Seba #Relatable
I would like to see a stream where he must get 3 stars
I tried it more than 20 times (mega brutal) and didn't get 3 stars ;-;
It's almost impossble haushaauaha
Finally
3 stars
After 182 tries
@@predrop damn. Was it worth it?
did anyone else notice at 11:10 how Greenland just got absolutely WIPED with the prion in less than a second? Like jeez-
DESERVED. GREENLAND IS A MENACE IN THIS GAME 💀💀
@@aaiiuiiuua2407 On GOD!!!🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️
No one
People in Greenland
🤒🤧🤒🤧🤒🤒🤧🤒🤧🤒🤧🤒🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤒🤒🤧🤧🤧🤧🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤧🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤧🤧🤧🤒🤒🤧🤧🤧🤧🤧🤧🤧🤧🤧🤧🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤒🤒🤒🤧🤒🤒🤒
@@aaiiuiiuua2407BLUD WOKE UP AND DECIDED TO SPIT FACTS 🔥🔥🔥🔊🔊🔊
@@aaiiuiiuua2407STOP SPEAKING FACTS 🗣️🗣️🗣️
Mad Cow Disease: exists
Vegans: laugh in corner
*Mad Cow Disease evolves to infect plants*
Vegans: Wait no, that's illegal-
What is meat cow disease
Prions indeed can get into plants though, through corpse, for example.
@@MAGNITUDE16 i think it makes zombie like cows becuse ppl get zombie like wen they eat human meat at least i think thats how it gos take this with a grain of salt
@@andrewaftontheandroidhedge2780 no it doesnt
@@andrewaftontheandroidhedge2780
No
There is one problem with this game. IT DOESN’T COUNT THE RESEARCHERS IN ANTARCTICA!
Michael kinney oof
Yeah but they dont have any resources and there's a small amount of them
Michael kinney The Thing got them
I'm pretty sure researchers in antarctica are exclusively animal or environmental researchers, plus no people actually live there. But maybe I'm wrong
@@zakosist apparently research shows that around 50 scientific researchers Live in Antarctica full time I'm also sure that between 100-200 researchers work in Antarctica daily so technically humanity wouldn't be wiped out.
I was saved by the fish once too. I got detected super early and Caribbean shut its port before I could infect it. I wanted to give up, but decided to keep going as if nothing happened. When I only had around 100 000 people left alive someone in Caribbean ate infected fish and I immediately devolved some lethality so I could infect the country, and managed to complete the scenario. It felt really really good. This was on normal and I can't even finish the scenario on brutal becuase it's so darn hard.
14:12 RIP Japan got nuked again.
Japan when it happened:
FUUUUUUKKK U AMERICA
You thought it was America, but it was I, *DIO BRANDO*
Logan is the 3rd atomic bomb drop on Japan
I just realized the again part...
DLCShadowHeart Lord of Domination You thought it was Dio, but it was me, NUCLEAR REACTOR!
Rosalia bruises are black
This wasn't done with ease
But Pravus finally completed Mad Cow Disease!
Nice Trauma Team reference :D
Heck, Hexpresso, tis me, Real!
Also why aren't there any Rosalias on Plague Inc it would be perfect
Hexpresso nice free verse poem
You should be a poet
11:05 points at the Caribbean and calls it the Philippines
...
I think we can forgive him for having a brain fart under the circumstances.
krish kapoor a
LAMB SAUCE LOCATED -dead-
What about calling it Cuba half the time
Out of so many Plague Inc games, it's great to see the other side of him where he finally breaks down and swears at the game's difficulty.
GO FOR THE FISH GUYS! AAHHHH!!
When I didnt see
Honestly, it’s a testament to how much of a beast Mega Brutal CJD is in this game that even Praxus breaks
I love how Pravus explains his strategies. Many of his plays have also carried me to winning a lot of different scenarios (as well as just the normal disease types)
It's finally here! Praise Pravus!
Praise Be!
Dankquillity praise be!
Scientist 1: I have a headache, blood from every hole, I forgot my name, I feel that my leg is paralysed, and I hear the Death whispers in my ears.
Scientist 2: It's just flu
Scientist 1: *lol okay, lets go do a vaccine*
Poor anti vaxxers... They are screwed.
fr how do scientists in this game do even 1% of cure progress while confused, with dementia, paralyzed, with no sleep, while insane, while in a coma, etc.
After this Pravus was like
"HEY! HONEY! I FINALLY DID MAD COW DISEASE ON MEGA BRUTAL!"
But literally tho. Just had to check to see if Pravus recorded himself saying this to me because this is basically an exact quote.
Finally, peace
Ainyaly lmao you his wife?
FINALLY I KNEW THE LORD COULD DO IT
4:52 "then we're gonna pick up a pork" Hold on a second, does this transmission work in Saudi Arabia and other Islamic countries?
Nope,in real life pork is banned in Islamic countries I think
In the game.
@@voxmustshutdown9665 I think pork is allowed, just that most people in the country can't eat it.
@@neyoid pork is illegall in saudi arabia
perhaps the pork boost only starts working when it gets to other countries
On the first attempt when he said "get a boat into greenland," a non-infected boat entered. R.I.P.
Judge: anything else?
6ix9ine: I know how to infect Greenland in Plague Inc.
instantly forgiven
Is pretty easy honestly i always play in brutal or mega brutal and it’s pretty easy a bit more than other countries but easy
@@emicharr shut up
@@emicharr you just got ratiod for being better
@@emicharr good for you
>*God* left
>*Pravus Gaiming* changed his name to *God*
>Cyan has joined the chat
Cyan: >Don't worry guys I have a plan
>Cyan has left the *game*
I remember doing a scenario and waiting for Genetic Reshuffle 3 and saving up. They finished the cure just as I had saved enough. I did it anyway. It worked.
Beautifully
Well,even if they make 100% cure and start curing people,you still can reshuffle or take a symptom like coma and they will have to make it to 100% before they are able to start curing people again. And those who were cured can still be infected again if cure is not 100%.
"The cure is complete! Oh wait, the virus evolved again and now our cure doesn't work anymore."
I gave up after 4 attempts in normal and 2 in casual. I realized that if I could not beat it in casual there was no way in hell I was ready for normal. I'm actually still trying to beat it in freaking casual.... *Sobs forever*
You probably gave up didnt you?
It triggers me when people use (REDACTED) instead of [REDACTED]
I fucken beat it on casual on first try, cure was like at 90%, not doing it on normal D:
I beat it on casual first time, struggled on normal, then I used Pravus' strategy and beat it on normal and brutal
If Dark Souls had a baby with Plague Inc, then it'll be Mad Cow Disease
on mega brutal
at 3 am
And acute encephalitis is also a preloaded trait
@@fireinthehole_727 at 3 am
@@ElPastalero but like I said acute encephalitis is also a preloaded trait
"Help you spread through many kinds of meat-"
Oh cool, like what-
"Starting with insects-"
HOLD ON WHAT
Yeah some people eat insects, kinda weird but apparently that’s actually somewhat healthy
@@rinustechtips yeah, people do
Problem?
@@rinustechtips some bugs are healthy
No joke, I was thinking to myself "I hope Pravus gets this scenario done" sometime last night.
TIMING!
This scenario looks brutal - I'm already dreading doing it myself.
Image if he forgot to press record
oof
The madman finally beat it!
Looks like the madman defeated the madcow (Disease)
Holy cow you did it! (Cheesy pun intended.) sorry I just I had to milk it. Ok now I'm bovinally done.
Edit: oh wow 25 likes I am very grateful of this.
Edit 2: 100 likes wooo I am dairy thankful.
Edit 3: I think it's udderly awesome how so many people like my puns.
N O terrible puns only black and white puns :>
dakota mew give me an example of a black and white pun no cheating
It was a terrible pun :C
dakota mew so?
i did not even laugh at the cow part the milk part made me laugh
It can spread through consumption of fish.
Me, a british person: well shit.
NOOOO OUR FISH AND CHIPS 😭😭😭😭😭
Select infection through avocado
Californians: hehe I'm in danger
"Avocado's always been kind of a difficult one for me to swallow..."
*groans intensely*
good job! Praise Pravus!
Adryanuz Praise be!
Adryanuz praise be
Flipping well done my man. You really are the best at Plague Inc.
Gg Lord Pravus and of course... PRAISE PRAVUS
Prais be!
Praise be
Nothing can stand in the way of Lord Pravus. Praise be!
Praise be!
Praise be
Praise be
Mad cow's disease is the "common" name for Bovine Spongiform Encelopathy (or BSE). This condition on humans is called *variant* Creutzfeldt-Jakob's disease or CJD-v (the variant refers specifically to the one that is acquired by consuming infected tissue)
The BSE outbreak that happened in England started due to, as a meaning of cutting costs, cows were fed with sheep remains, and sheep were already commonly enough affected by Scrapie (their version of the prion infection), so cattle meant for human consumption developed BSE, which passed consequently to human hosts. Prion diseases have a very slow onset and are hard to detect for the very same reason (nowadays can be detected by clinical exams such as the Western Blot, but coming up to even suspect a prion infection is the tough part)
Prions are misfolded, anomalous proteins that cause other nearby proteins to misfold as well, and its onset in the brain results in a sponge like texture in the brain, giving it its name of *spongiform* encelopathy (sponge-like brain pathology).
Unlike what the name "mad cow" might make you expect, no one goes in some sort of rage, the affected person or animal suffers brain deteroriation and starts losing mobility and physical control, in its last stage the host will be unable to move and will die when it reaches the point it can't even function properly. Prion diseases are a death sentence basically, and due to the nature of the pathogen (a protein) medical advances haven't gone too far into the matter, tried measures aren't able to cross the hemato-encephalic barrier (the barrier that works as some sort of firewall for your brain) while the prion has no issues. Most places have to get rid of cow brains and neurological tissue just in case, English veal has been unbanned in most countries relatively recently (I believe the last to lift said ban was France) and blood banks mostly rejected blood from people that spent time in England or Europe when the outbreak happened (this ban is also starting to get lifted as the pandemic left us short of blood donors in general). Some other interesting facts about prions is that soil that was used by infected sheep or cattle is deemed risky for further animal raising, as proteins are VERY HARD to actually destroy. They tried sterilizing procedures for medical equipment in contact with prions, but heat will only briefly inactivate the protein and said equipment is rendered unusable and has to be destroyed. Prions are also behind that moose disease that also had some sort of sensationalistic name (something in the like of zombie moose? Thrashing syndrome? Something like that, honestly I forgot) and has suspected links with Alzheimer's, though nothing can be confirmed as of yet, there's also suspicion that there might be multiple types of prions.
Yes I wrote this heck of a Bible under another comment but it took me a while so I'm here to show it thanks
It's not even a case of basically. All known Prion diseases in both humans and animals are 100% lethal so far as we know, and are completely incurable. We know of a few others besides vCJD such as Familial Fatal Insomnia and Kuru. They also are usually only transmissible through the injection or consumption of contaminated fluids or tissues, most often brain matter, but it can also spread through blood and muscle tissue (though cases from consumption of muscle tissue are usually believed to be due to that meat being contaminated with brain matter). Some evidence suggests that prion-infected matter can be aerosolized and spread through inhalation, but this basically cannot occur naturally (though there are regulations regarding using pressure washers in slaughterhouses for this very reason).
@@jamesdinius7769 Yeah yeah, went mainly on vCJD because that's the one emulated in the scenario, and naturally making prions in game 100% lethal would bring balance issues. Prion diseases have long latencies and even if caught early by protein exams such as Western Blot... Uh, it doesn't help your case much, you are just getting more palliatives lol, I guess a realistic prion gameplay would be kind of boring as it's rather slow and silent, and the in-game prion's "prion features" are low infectivity, and evolutions taking longer to present themselves, supposedly they are harder to cure as well if I'm not mistaken, but I have a hard time buying that when some random country just goes and whips out a prion disease cure in like two minutes 🙄 are prions amazing in science? Yes. In-game? They are kinda one of the most boring pathogens to play as for me at least lol
the moose disease is 'zombie deer disease', and its also called chronic wasting disease! its the same thing but this type only affects the deer family, tho I do think it can infect some other rodent or something. tragic to see that it's incurable, but I guess we don't understand proteins well enough with our current science :(
@@auronirahman2837 that was it! CWD! English is not my first language so sometimes I struggle with names 💀 proteins are indeed, a b!tch to work with
When he says’ I’m not going for any Lethality’ 80.1 K people dead😹😹
Who uses those emoji's?
davidjesus me
Ironic.
15:12 theres about 2 people left in all of botswana, and their top priority is to make nutritional paste....
Ohh,you're my best friend in a world we must defend!
Kim Jong Un hello person from the other side of the world 🌍
Pokémon, gotta catch em all...
.
.
.
All the diseases.... Just catch them, I need to beat the game.
Finally!!I've been waiting for you to play this official scenario!
Praise Pravus! He sacrificed his sanity for a TH-cam video for us.
Try doing a custom scenario of Cholera, there are quite a few and it is often the "forgotten" plague because it usually happens in poor nations and does not usually spread out from them (like the outbreak in 2010 in Haiti)
You know what would be a funny name for the Mad Cow Disease? *"BURGERS"*
13:40
The squeal in your voice is hilarious. I'm glad you won
11:10 look at greenland
Its been so long no one is talking about it how it explodes for the 3rd fricking time 🤣🤣
I know I'm really late but JEEZ I didn't know it was possible to beat this disease ON MEGA FRICKIN' BRUTAL!
You don't know how I've been waiting for this its insane!
Just like ur videos 💞
They should have made a joke with apple transmission saying “an apple a day gets the doctor aray”
I find your videos very long but I subscribed because of how much effort you put into them
And I also appreciate how you actually read the pop ups!
You did it! *_Praise Pravus!_*
Praise be!
To think there are a few people on this planet that have gotten 3 stars on mega brutal
OrchidAlloy the World Health Organization is one of them
@@fss1704 that's not a person lol
This disease has two variants: Bovine Spongiform Encephalopathy (BSE) in bovine (especially cattle) and vCJD (Variant Creutzfeld-Jakob Disease) in human (also known, to differ form former, as human mad cow disease).
11:11 *looks at greenland* Well that escalated quickly
Pravus: SCREW YOU MAD COW DISEASE
Game: *crashes*
Me: *smirks*
Happy pravus makes me happy
i love how this popped up first in my recommended after loosing for the 10th time doing that damn mad cow disease scenario
Wow, great job! I love plauge inc, but suck at it, so to watch this makes me feel good ^^. Also P.S. I have never seen anyone get so exited over fish 😂
I watched this video and ever since I've been watching your videos constantly. There's just something so alluring about them
Omg...your videos are so fun to watch. Your reaction to your victory here is memorable to say the least. I found this game probably a year or two ago. Played for a while and gave it up. After stumbling upon some of your other videos I have reinstalled the game. You seem to have a different version. Looks different. Anyway, had to leave a comment and say hello after watching this one.
I don't know if my game was just updated or something but when doing these scenarios, I can't devolve what I start with. It's straight up greyed out. I came here to look for a strategy only to find one I physically can't do :(
I think why Plague.Inc is less realistic is because once someone gets infected, they will be infected with it forever until some cure comes round or they die, as well as more.
I’d like a game where rather than win or loss, the game will rate you out of 10. Yeah where wiping humanity is a challenge even on minimal difficulty. And the score scales on how much damage you do
It only took me 3 attempts on mega brutal, I just bought a lot of transmission and traits with mutation chances, therefore, I can focus on ability traits, which really helped me so yea, but good one, Pravus, you really did well
And they had the balls to put this as the second scenario for people who didnt buy the next one
Potatoes: Infected
TechnoBlade: *Confused Scream*
Every other game: Starts in India!
This game:Start in Ind- never mind, beef doesn’t exist.
China it is!
gotta evolve it into cats & dogs then
U mean saudi arabia
@@sovietsky5039 but india has rural hot and humid while arabia only has hot and arid. Plus there is more population
I knew you would eventually be able to do it!
You're king of plague Inc after all!
Praise Pravus!
Pravus be praised!
Praise be!
Praise be!!!
"that's why you go for fish guys"
-Pravus, 2018
22 attempts?
I'm on attempt 46 and still failing.
Have you beat it yet?
well done and good luck in the future also PRAISE PRAVUS!!!!!
Why the hell are these so addictive to watch? I don't even own Plague Inc!
So true i basiclly watch pravus play plague inc EVERY SINGLE DAY
(Not saying pravus is a bad youtuber i love his vids)
Are we just not gonna talk about how greenland exploded for the 3rd time? 11:10
at 7:32 We just won 2500$ on the pennsylvania Lottery
From what I've seen, as of March 2023 a grand total of 12 people have gotten 3 stars on mega brutal on this scenario, and they had to use save scumming.
Wow! That's terrifying. Thanks for letting us in the comments know!!
Wow! That's terrifying. Thanks for letting us in the comments know!!
You have some beef with this scenario.
Thank you for making these videos. Yes I have only been able to get two bio hazard symbols on casual. So I can only imagine how hard it is on mega brutal.
This link here shows a strategy for handling it with 3 stars: steamcommunity.com/sharedfiles/filedetails/?id=1258854729
I had tried it myself on casual and did get the 3 stars, but I don't know if it works on higher difficulties
Pravus gaming: Gets potato infectivity perk
Ireland: Why do I hear boss music?
there is 30 minute ad about people saying chemicals
Oh yeah, this is big brain time.
Ah, I can't seem to get this right! Imma keep trying because this seems like a very solid strategy and you sound like you know what you're doing.
Mainly my problem is not getting to kill off the world before the cure is finished, or them working on it too early or quickly. Or I'm not spreading quickly enough in Greenland and in two recent playthroughs in other countries that aren't islands.
Watch, I'm going to beat it as soon as I post this comment XD
YOU CAN DO IT NYLA!! I BELIEVE IN YOU!!!
But seriously, congrats on winning one of the hardest scenarios!!
PRAISE PRAVUS
Praise Be!
"come on. come on. GET A BOAT IN THERE DANG YOU!!" im dead xD
Praise Pravus
Praise be!
> Mad Cow Disease: Mega Brutal written guide <
Notes:
* This guide will more than likely NOT get you 3 biohazards. Pravus got 23990 points for it.
* This guide utilizes the random infection via fish, so it is a bit luck based.
* Once you get detected, stop devolving any mutations that massively increase severity
1. Genetic code: Catalytic Switch, Genetic Mime, Aquacyte, Extremophile, Trans-statis
2. Start in Saudi Arabia
3. Devolve: Confusion, Memory Loss, Psychosis, Headache
4. Devolve Acute Encephalitis, if mutated
5. Evolve in order: Insects, Poultry, Pork, Dairy.
6. Evolve in order: Hermetic Storage Resilience, Frozen Storage Resilience, Preservative Storage Resilience.
7. Evolve Fish
8. Evolve Plant Dissemination
* If Russia is infected, stop following the guide and evolve Cold Resistance 1, 2, Potato. After that, continue following the steps
9. Evolve in order: Broccoli, Potato, Avocado (Optional: also evolve Maize)
10. Evolve Genetic Hardening 1, 2
11. Evolve Psychosis, Memory Loss (if not mutated)
* If Greenland or any other island is not infected before the shutdown, restart the game
12. Evolve Human Cross-Infection
13. Once every country has been infected, evolve: Coughing, Pulmonary Oedema, Coma, Total Organ Failure.
* Acute Encephalitis can now be allowed to be mutated/evolved.
14. Focus on slowing down the cure. Evolve: Confusion, Mania, Delirium, Insanity.
15. Save up DNA for Genetic Reshuffles and evolve them. While saving up, the whole world can get infected.
16. Optional: evolve Ataxia, Blindness, Paralysis, Hallucinations (if not mutated)
You almost crossed the cursing line.... I could tell right at the end.
It was that bad, eh?
damn! gg, I haven't played mad cow yet, but I've herd that it's pretty crazy, been trying to look for some strategies before I dive head first, cause I know Ill just end up playing it over and over till I got it, and I'd end up driving myself crazy, thanks man, didn't actually know severity worked like that.. It explains A LOT! 🤔
moral of this video : don't eat fish
dont eat ANYTHING
dont even exist
You remember you ordered *fish* and chip
OK now I'm thinking Greenland is the best place to go when there's a disease in real life
you do realise that the Norwegian port goes to greenland to?
Congratulations! You've finally done it!
how to win this:
infinite dna cheat
You don't get an achievement cuz cheats
Cyan The Meme OwO UwU bruh just hack
I have a feeling that spontaneous infections in greenland will be a common thing. I got one when i played this scenario
13:41 Pravus got turned on
I may not have Plague Inc Evolved, but I will beat this 3 star mega brutal! For Pravus!
if the lord cant, what can a peasant do?
14:37 little did they know at that time...
Did someone complete this with 3 stars?????? Its the only one left :(
Pravus: I need everybody to drop dead
Japan: Aye aye, captain