Plague Inc: Official Scenarios - Mad Cow Disease (Mega Brutal)

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  • เผยแพร่เมื่อ 12 ก.พ. 2018
  • FINALLY. With a tight strategy and a lot of luck, it CAN be beaten on Mega Brutal.
    If you enjoyed this video, consider hitting the Like button! It helps the channel grow by affecting search results on TH-cam.
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    No copyright infringement intended. Plague Inc. Evolved copyright is owned by their respective owners which includes but is not limited to Ndemic Creations. I did not make the game (or assets) and do not claim to. I do claim recording the video and audio associated with this playthrough.
    Music credit:
    "Shake Down"
    by Gavin Luke
    Provided by Epidemic Sound (www.epidemicsound.com)
  • เกม

ความคิดเห็น • 1K

  • @uqqr3464
    @uqqr3464 5 ปีที่แล้ว +2622

    *when he start and Saudi Arabia and instantly gets pork*
    *us Arabs: are we a joke to you?*

    • @dmichand5191
      @dmichand5191 4 ปีที่แล้ว +44

      Maybe...

    • @MostafaAhmed-bp7ce
      @MostafaAhmed-bp7ce 4 ปีที่แล้ว +44

      I dont think it really affects the game

    • @baimm5390
      @baimm5390 4 ปีที่แล้ว +146

      Mostafa Ahmed it’ll be cool if it did

    • @LazoGT
      @LazoGT 4 ปีที่แล้ว +14

      @@baimm5390 it does im pretty sure

    • @whitejester
      @whitejester 4 ปีที่แล้ว +88

      As a Muslim this is hilarious

  • @r4r1ty69
    @r4r1ty69 6 ปีที่แล้ว +1140

    9:42 I just want to see a boat get into Greenland (uninfected boat goes into Greenland)

    • @Anna-kj3np
      @Anna-kj3np 4 ปีที่แล้ว +75

      Punked by the universe. You see it all the time.

    • @hempellsravens
      @hempellsravens 4 ปีที่แล้ว +1

      No there was a boat going

    • @birdmonster115
      @birdmonster115 4 ปีที่แล้ว +1

      @@hempellsravens what?

    • @chudsoyjak
      @chudsoyjak 4 ปีที่แล้ว +1

      @Bobska is epic lol yes

    • @DiamondYoshi101
      @DiamondYoshi101 4 ปีที่แล้ว +20

      Pravus: Listen here you little S**t

  • @kyloluma1212
    @kyloluma1212 4 ปีที่แล้ว +934

    It is interesting because this isn’t really accurate to the real mad cow disease. It took about 5 years for people to begin to display symptoms and then it was 100% lethal

    • @user-rm6mx7np4l
      @user-rm6mx7np4l 2 ปีที่แล้ว +1

      its a mutation of the mad cow disease, its not the real thing

    • @krisspychissp
      @krisspychissp 2 ปีที่แล้ว +16

      If it was like that …
      I wish

    • @kichiroumitsurugi4363
      @kichiroumitsurugi4363 ปีที่แล้ว +152

      Another fun fact. Lethality in this game essentially calculates how long it takes for an infected person to die, as infected cannot recover without the cure in Plague Inc (unless you're doing Cure Mode, in which case Prion is given an automatic 100% Fatality Rate

    • @georgeuferov1497
      @georgeuferov1497 ปีที่แล้ว

      Creators of a Plague Inc. had to do a lot of simplifications and compromises when it comes to prions. In real life they are literally uncurable and can manifest spontaneously, but can be transmitted only by ingested. Moreover, some people are just blatantly resistant or immune to it. Although there are rumors about the possibility of prions transmitting through air, in which case we're screwed

    • @aeriona626
      @aeriona626 ปีที่แล้ว +95

      Prion diseases are also incurable (at least at the time of me writing this). Genuinely now idea how you’d cure widespread protein misfolding in the brain on a massive scale. Tracking infection sources would also suuuuck given it’s ridiculous incubation rate.

  • @overratedpancake9034
    @overratedpancake9034 6 ปีที่แล้ว +1805

    Let's try get 3 stars! I mean, how difficult could it be? :D
    *cries internally*

    • @shmegalodonschmuckington786
      @shmegalodonschmuckington786 6 ปีที่แล้ว +1

      Seba #Relatable

    • @tommyspringer3693
      @tommyspringer3693 5 ปีที่แล้ว +4

      I would like to see a stream where he must get 3 stars

    • @arthursantana2973
      @arthursantana2973 4 ปีที่แล้ว +3

      I tried it more than 20 times (mega brutal) and didn't get 3 stars ;-;
      It's almost impossble haushaauaha

    • @predrop
      @predrop 3 ปีที่แล้ว +8

      Finally
      3 stars
      After 182 tries

    • @iJeffersonNguyen
      @iJeffersonNguyen 3 ปีที่แล้ว +2

      @@predrop damn. Was it worth it?

  • @heronb.4965
    @heronb.4965 6 ปีที่แล้ว +820

    this is the most intense plague inc video i have ever seen

    • @slendergaming8171
      @slendergaming8171 6 ปีที่แล้ว +28

      When Pravus plays the Mad Cow Disease Scenario
      *Intense Gameplay*

    • @heronb.4965
      @heronb.4965 6 ปีที่แล้ว +25

      *intensity intensifies*

    • @arandomperson86
      @arandomperson86 6 ปีที่แล้ว +23

      *intensified intensity intensifies*

    • @roshotsutsujimorienjoyer
      @roshotsutsujimorienjoyer 6 ปีที่แล้ว

      NiRe me either and i’ve been binging theses all day

    • @Deadchannel547
      @Deadchannel547 4 ปีที่แล้ว +7

      wins on casual: aaaaaaaaaaa yes!
      wins on normal: YUS! LETS GO! OMG!
      wins on brutal: *BOW DOWN ####**#S**! I'M THE KING OF PLAGUE INC!*
      wins on mega brutal:
      I'm done, i'm done, i'm honestly done. I'm done with this game.

  • @pendalfus123
    @pendalfus123 6 ปีที่แล้ว +3516

    so your saying you had 22 times talking to yourself every time you try to record?

    • @Platonis-The-Warlock
      @Platonis-The-Warlock 6 ปีที่แล้ว +743

      Oh yeah, if he don't deleted it all - we need "Salty Pravus Rage and Cursing compilations"

    • @glowbomb1223
      @glowbomb1223 6 ปีที่แล้ว +248

      Yes please he needs some compilations.

    • @KlaweKlapki
      @KlaweKlapki 6 ปีที่แล้ว +335

      Mad pravus disease

    • @glowbomb1223
      @glowbomb1223 6 ปีที่แล้ว +79

      Dont even try to bakeract him, as Lord Pravus will smite thee with lightning from his rending gale, flood your spirit with seeking arrows, and fire faulty fireballs at your everything; before making your people worship him as your corpse is forgotten.

    • @rhythmicluke4555
      @rhythmicluke4555 6 ปีที่แล้ว +5

      Andrej Nedorezov “

  • @kpopcan_slap_me5557
    @kpopcan_slap_me5557 4 ปีที่แล้ว +1408

    Mad Cow Disease: exists
    Vegans: laugh in corner
    *Mad Cow Disease evolves to infect plants*
    Vegans: Wait no, that's illegal-

    • @MAGNITUDE16
      @MAGNITUDE16 3 ปีที่แล้ว +16

      What is meat cow disease

    • @fionnaclarissamuharlie168
      @fionnaclarissamuharlie168 3 ปีที่แล้ว +60

      Prions indeed can get into plants though, through corpse, for example.

    • @andrewaftontheandroidhedge2780
      @andrewaftontheandroidhedge2780 2 ปีที่แล้ว +7

      @@MAGNITUDE16 i think it makes zombie like cows becuse ppl get zombie like wen they eat human meat at least i think thats how it gos take this with a grain of salt

    • @user-rm6mx7np4l
      @user-rm6mx7np4l 2 ปีที่แล้ว +43

      @@andrewaftontheandroidhedge2780 no it doesnt

    • @Artizap_
      @Artizap_ 2 ปีที่แล้ว +6

      @@andrewaftontheandroidhedge2780
      No

  • @stardra
    @stardra ปีที่แล้ว +216

    did anyone else notice at 11:10 how Greenland just got absolutely WIPED with the prion in less than a second? Like jeez-

    • @aaiiuiiuua2407
      @aaiiuiiuua2407 ปีที่แล้ว +37

      DESERVED. GREENLAND IS A MENACE IN THIS GAME 💀💀

    • @thatbachus
      @thatbachus ปีที่แล้ว +8

      ​@@aaiiuiiuua2407 On GOD!!!🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️

    • @cinnamon_board
      @cinnamon_board 10 หลายเดือนก่อน

      No one
      People in Greenland
      🤒🤧🤒🤧🤒🤒🤧🤒🤧🤒🤧🤒🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤒🤒🤧🤧🤧🤧🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤧🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤧🤧🤧🤒🤒🤧🤧🤧🤧🤧🤧🤧🤧🤧🤧🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤒🤒🤒🤧🤒🤒🤒

    • @IsaiahRowland-jg7sg
      @IsaiahRowland-jg7sg 10 หลายเดือนก่อน +7

      ​@@aaiiuiiuua2407BLUD WOKE UP AND DECIDED TO SPIT FACTS 🔥🔥🔥🔊🔊🔊

    • @CrimsonXYR
      @CrimsonXYR 8 หลายเดือนก่อน +3

      @@aaiiuiiuua2407STOP SPEAKING FACTS 🗣️🗣️🗣️

  • @AM-gv9db
    @AM-gv9db 6 ปีที่แล้ว +128

    I was saved by the fish once too. I got detected super early and Caribbean shut its port before I could infect it. I wanted to give up, but decided to keep going as if nothing happened. When I only had around 100 000 people left alive someone in Caribbean ate infected fish and I immediately devolved some lethality so I could infect the country, and managed to complete the scenario. It felt really really good. This was on normal and I can't even finish the scenario on brutal becuase it's so darn hard.

  • @tdoyr2119
    @tdoyr2119 5 ปีที่แล้ว +805

    There is one problem with this game. IT DOESN’T COUNT THE RESEARCHERS IN ANTARCTICA!

    • @derpysheep5872
      @derpysheep5872 5 ปีที่แล้ว +10

      Michael kinney oof

    • @Alvah37
      @Alvah37 5 ปีที่แล้ว +134

      Yeah but they dont have any resources and there's a small amount of them

    • @graceliu8839
      @graceliu8839 5 ปีที่แล้ว +106

      Michael kinney The Thing got them

    • @zakosist
      @zakosist 5 ปีที่แล้ว +79

      I'm pretty sure researchers in antarctica are exclusively animal or environmental researchers, plus no people actually live there. But maybe I'm wrong

    • @-Kc1937-
      @-Kc1937- 4 ปีที่แล้ว +61

      @@zakosist apparently research shows that around 50 scientific researchers Live in Antarctica full time I'm also sure that between 100-200 researchers work in Antarctica daily so technically humanity wouldn't be wiped out.

  • @asclepihex
    @asclepihex 6 ปีที่แล้ว +404

    Rosalia bruises are black
    This wasn't done with ease
    But Pravus finally completed Mad Cow Disease!

    • @LolitaCraft
      @LolitaCraft 6 ปีที่แล้ว +8

      Nice Trauma Team reference :D

    • @realuity3075
      @realuity3075 6 ปีที่แล้ว +6

      Heck, Hexpresso, tis me, Real!
      Also why aren't there any Rosalias on Plague Inc it would be perfect

    • @peepeepooopooo7889
      @peepeepooopooo7889 6 ปีที่แล้ว +1

      Hexpresso nice free verse poem

    • @user-yg8sr4wv4x
      @user-yg8sr4wv4x 2 หลายเดือนก่อน

      You should be a poet

  • @theunitedstatesofamerica3556
    @theunitedstatesofamerica3556 4 ปีที่แล้ว +113

    Judge: anything else?
    6ix9ine: I know how to infect Greenland in Plague Inc.

    • @ElPastalero
      @ElPastalero 4 ปีที่แล้ว +10

      instantly forgiven

    • @emicharr
      @emicharr 3 ปีที่แล้ว +2

      Is pretty easy honestly i always play in brutal or mega brutal and it’s pretty easy a bit more than other countries but easy

    • @adibalabharat8247
      @adibalabharat8247 3 ปีที่แล้ว +4

      @@emicharr shut up

    • @nataneryyyyy
      @nataneryyyyy 2 ปีที่แล้ว +2

      @@emicharr you just got ratiod for being better

    • @nataneryyyyy
      @nataneryyyyy 2 ปีที่แล้ว +1

      @@emicharr good for you

  • @krishkapoor1833
    @krishkapoor1833 6 ปีที่แล้ว +269

    11:05 points at the Caribbean and calls it the Philippines

    • @linkachu5537
      @linkachu5537 6 ปีที่แล้ว +1

      ...

    • @treehugger0241
      @treehugger0241 6 ปีที่แล้ว +50

      I think we can forgive him for having a brain fart under the circumstances.

    • @iruka5083
      @iruka5083 6 ปีที่แล้ว

      krish kapoor a

    • @AltAttano-kq8my
      @AltAttano-kq8my 6 ปีที่แล้ว

      LAMB SAUCE LOCATED -dead-

    • @daltonmcghghy9215
      @daltonmcghghy9215 5 ปีที่แล้ว

      What about calling it Cuba half the time

  • @KeenoDaddy
    @KeenoDaddy 4 ปีที่แล้ว +66

    Out of so many Plague Inc games, it's great to see the other side of him where he finally breaks down and swears at the game's difficulty.

    • @KeenoDaddy
      @KeenoDaddy 4 ปีที่แล้ว +3

      GO FOR THE FISH GUYS! AAHHHH!!

    • @user-yg8sr4wv4x
      @user-yg8sr4wv4x 2 หลายเดือนก่อน

      When I didnt see

  • @kjlnbh9943
    @kjlnbh9943 6 ปีที่แล้ว +65

    On the first attempt when he said "get a boat into greenland," a non-infected boat entered. R.I.P.

  • @Fun001
    @Fun001 6 ปีที่แล้ว +177

    14:12 RIP Japan got nuked again.

    • @elsymartinez4522
      @elsymartinez4522 6 ปีที่แล้ว +12

      Japan when it happened:
      FUUUUUUKKK U AMERICA

    • @dlcshadowheartlordofdomina7504
      @dlcshadowheartlordofdomina7504 6 ปีที่แล้ว +13

      You thought it was America, but it was I, *DIO BRANDO*

    • @senorhace4746
      @senorhace4746 6 ปีที่แล้ว +9

      Logan is the 3rd atomic bomb drop on Japan

    • @tommyspringer3693
      @tommyspringer3693 5 ปีที่แล้ว +4

      I just realized the again part...

    • @Niiue
      @Niiue 4 ปีที่แล้ว +9

      DLCShadowHeart Lord of Domination You thought it was Dio, but it was me, NUCLEAR REACTOR!

  • @horner385
    @horner385 6 ปีที่แล้ว +193

    After this Pravus was like
    "HEY! HONEY! I FINALLY DID MAD COW DISEASE ON MEGA BRUTAL!"

    • @ainyaly_
      @ainyaly_ 6 ปีที่แล้ว +19

      But literally tho. Just had to check to see if Pravus recorded himself saying this to me because this is basically an exact quote.

    • @tommyspringer3693
      @tommyspringer3693 5 ปีที่แล้ว

      Finally, peace

    • @thedarkoverlordofall
      @thedarkoverlordofall 5 ปีที่แล้ว +2

      Ainyaly lmao you his wife?

  • @KingCheckOut
    @KingCheckOut 3 ปีที่แล้ว +27

    Image if he forgot to press record

  • @MourningButterflies
    @MourningButterflies 4 ปีที่แล้ว +43

    "Help you spread through many kinds of meat-"
    Oh cool, like what-
    "Starting with insects-"
    HOLD ON WHAT

    • @-Mr.O
      @-Mr.O 2 ปีที่แล้ว +6

      Yeah some people eat insects, kinda weird but apparently that’s actually somewhat healthy

    • @-Mr.O
      @-Mr.O ปีที่แล้ว

      @@rinustechtips yeah, people do
      Problem?

    • @-Mr.O
      @-Mr.O ปีที่แล้ว +1

      @@rinustechtips some bugs are healthy

  • @memeboi5504
    @memeboi5504 4 ปีที่แล้ว +30

    Scientist 1: I have a headache, blood from every hole, I forgot my name, I feel that my leg is paralysed, and I hear the Death whispers in my ears.
    Scientist 2: It's just flu
    Scientist 1: *lol okay, lets go do a vaccine*

    • @outtathepantry
      @outtathepantry 4 ปีที่แล้ว +2

      Poor anti vaxxers... They are screwed.

    • @Perseagatuna
      @Perseagatuna ปีที่แล้ว +13

      fr how do scientists in this game do even 1% of cure progress while confused, with dementia, paralyzed, with no sleep, while insane, while in a coma, etc.

  • @rndomclipz2431
    @rndomclipz2431 3 ปีที่แล้ว +105

    I love how Pravus explains his strategies. Many of his plays have also carried me to winning a lot of different scenarios (as well as just the normal disease types)

  • @Pluvita
    @Pluvita 6 ปีที่แล้ว +131

    FINALLY I KNEW THE LORD COULD DO IT

  • @irinahuerta1895
    @irinahuerta1895 6 ปีที่แล้ว +71

    I gave up after 4 attempts in normal and 2 in casual. I realized that if I could not beat it in casual there was no way in hell I was ready for normal. I'm actually still trying to beat it in freaking casual.... *Sobs forever*

    • @sadamiamani
      @sadamiamani 5 ปีที่แล้ว +1

      You probably gave up didnt you?

    • @ElPastalero
      @ElPastalero 4 ปีที่แล้ว +6

      It triggers me when people use (REDACTED) instead of [REDACTED]

    • @boilledwater_3306
      @boilledwater_3306 4 ปีที่แล้ว +2

      I fucken beat it on casual on first try, cure was like at 90%, not doing it on normal D:

    • @blueleviathan15
      @blueleviathan15 4 ปีที่แล้ว +1

      I beat it on casual first time, struggled on normal, then I used Pravus' strategy and beat it on normal and brutal

  • @horner385
    @horner385 6 ปีที่แล้ว +279

    If Dark Souls had a baby with Plague Inc, then it'll be Mad Cow Disease

    • @ck7993
      @ck7993 4 ปีที่แล้ว +7

      on mega brutal

    • @ElPastalero
      @ElPastalero 4 ปีที่แล้ว +6

      at 3 am

    • @fireinthehole_727
      @fireinthehole_727 4 ปีที่แล้ว +4

      And acute encephalitis is also a preloaded trait

    • @ElPastalero
      @ElPastalero 4 ปีที่แล้ว +3

      @@fireinthehole_727 at 3 am

    • @fireinthehole_727
      @fireinthehole_727 4 ปีที่แล้ว +4

      @@ElPastalero but like I said acute encephalitis is also a preloaded trait

  • @dragonfire101g
    @dragonfire101g 6 ปีที่แล้ว +170

    I remember doing a scenario and waiting for Genetic Reshuffle 3 and saving up. They finished the cure just as I had saved enough. I did it anyway. It worked.
    Beautifully

    • @user-jc1kq1qb5j
      @user-jc1kq1qb5j 5 ปีที่แล้ว +39

      Well,even if they make 100% cure and start curing people,you still can reshuffle or take a symptom like coma and they will have to make it to 100% before they are able to start curing people again. And those who were cured can still be infected again if cure is not 100%.

    • @modothegreat108
      @modothegreat108 5 ปีที่แล้ว +39

      "The cure is complete! Oh wait, the virus evolved again and now our cure doesn't work anymore."

  • @MORDArts
    @MORDArts 6 ปีที่แล้ว +136

    It's finally here! Praise Pravus!

  • @johnbailey5835
    @johnbailey5835 4 ปีที่แล้ว +16

    It can spread through consumption of fish.
    Me, a british person: well shit.

    • @NottsAiry
      @NottsAiry 2 หลายเดือนก่อน

      NOOOO OUR FISH AND CHIPS 😭😭😭😭😭

  • @goodva3027
    @goodva3027 6 ปีที่แล้ว +182

    >*God* left
    >*Pravus Gaiming* changed his name to *God*

    • @fireinthehole_727
      @fireinthehole_727 4 ปีที่แล้ว

      >Cyan has joined the chat
      Cyan: >Don't worry guys I have a plan
      >Cyan has left the *game*

  • @solarapacifica991
    @solarapacifica991 4 ปีที่แล้ว +19

    Select infection through avocado
    Californians: hehe I'm in danger

  • @dorukayhanwastaken
    @dorukayhanwastaken 6 ปีที่แล้ว +133

    4:52 "then we're gonna pick up a pork" Hold on a second, does this transmission work in Saudi Arabia and other Islamic countries?

    • @voxmustshutdown9665
      @voxmustshutdown9665 5 ปีที่แล้ว +7

      Nope,in real life pork is banned in Islamic countries I think

    • @zekedia2223
      @zekedia2223 4 ปีที่แล้ว +4

      In the game.

    • @neyoid
      @neyoid 4 ปีที่แล้ว +4

      @@voxmustshutdown9665 I think pork is allowed, just that most people in the country can't eat it.

    • @delta6378
      @delta6378 4 ปีที่แล้ว +2

      @@neyoid pork is illegall in saudi arabia

    • @jamison1477
      @jamison1477 4 ปีที่แล้ว +3

      perhaps the pork boost only starts working when it gets to other countries

  • @TheIndigoExperiment
    @TheIndigoExperiment 6 ปีที่แล้ว +14

    "Avocado's always been kind of a difficult one for me to swallow..."
    *groans intensely*

  • @WebmistressL
    @WebmistressL 6 ปีที่แล้ว +29

    No joke, I was thinking to myself "I hope Pravus gets this scenario done" sometime last night.
    TIMING!
    This scenario looks brutal - I'm already dreading doing it myself.

  • @rivia_jr1
    @rivia_jr1 6 ปีที่แล้ว +27

    13:41 Pravus got turned on

  • @armageddon3315
    @armageddon3315 6 ปีที่แล้ว +62

    The madman finally beat it!

    • @slendergaming8171
      @slendergaming8171 6 ปีที่แล้ว +2

      Looks like the madman defeated the madcow (Disease)

  • @ashimochi
    @ashimochi ปีที่แล้ว +6

    Mad cow's disease is the "common" name for Bovine Spongiform Encelopathy (or BSE). This condition on humans is called *variant* Creutzfeldt-Jakob's disease or CJD-v (the variant refers specifically to the one that is acquired by consuming infected tissue)
    The BSE outbreak that happened in England started due to, as a meaning of cutting costs, cows were fed with sheep remains, and sheep were already commonly enough affected by Scrapie (their version of the prion infection), so cattle meant for human consumption developed BSE, which passed consequently to human hosts. Prion diseases have a very slow onset and are hard to detect for the very same reason (nowadays can be detected by clinical exams such as the Western Blot, but coming up to even suspect a prion infection is the tough part)
    Prions are misfolded, anomalous proteins that cause other nearby proteins to misfold as well, and its onset in the brain results in a sponge like texture in the brain, giving it its name of *spongiform* encelopathy (sponge-like brain pathology).
    Unlike what the name "mad cow" might make you expect, no one goes in some sort of rage, the affected person or animal suffers brain deteroriation and starts losing mobility and physical control, in its last stage the host will be unable to move and will die when it reaches the point it can't even function properly. Prion diseases are a death sentence basically, and due to the nature of the pathogen (a protein) medical advances haven't gone too far into the matter, tried measures aren't able to cross the hemato-encephalic barrier (the barrier that works as some sort of firewall for your brain) while the prion has no issues. Most places have to get rid of cow brains and neurological tissue just in case, English veal has been unbanned in most countries relatively recently (I believe the last to lift said ban was France) and blood banks mostly rejected blood from people that spent time in England or Europe when the outbreak happened (this ban is also starting to get lifted as the pandemic left us short of blood donors in general). Some other interesting facts about prions is that soil that was used by infected sheep or cattle is deemed risky for further animal raising, as proteins are VERY HARD to actually destroy. They tried sterilizing procedures for medical equipment in contact with prions, but heat will only briefly inactivate the protein and said equipment is rendered unusable and has to be destroyed. Prions are also behind that moose disease that also had some sort of sensationalistic name (something in the like of zombie moose? Thrashing syndrome? Something like that, honestly I forgot) and has suspected links with Alzheimer's, though nothing can be confirmed as of yet, there's also suspicion that there might be multiple types of prions.

    • @ashimochi
      @ashimochi ปีที่แล้ว

      Yes I wrote this heck of a Bible under another comment but it took me a while so I'm here to show it thanks

    • @jamesdinius7769
      @jamesdinius7769 ปีที่แล้ว +1

      It's not even a case of basically. All known Prion diseases in both humans and animals are 100% lethal so far as we know, and are completely incurable. We know of a few others besides vCJD such as Familial Fatal Insomnia and Kuru. They also are usually only transmissible through the injection or consumption of contaminated fluids or tissues, most often brain matter, but it can also spread through blood and muscle tissue (though cases from consumption of muscle tissue are usually believed to be due to that meat being contaminated with brain matter). Some evidence suggests that prion-infected matter can be aerosolized and spread through inhalation, but this basically cannot occur naturally (though there are regulations regarding using pressure washers in slaughterhouses for this very reason).

    • @ashimochi
      @ashimochi ปีที่แล้ว

      @@jamesdinius7769 Yeah yeah, went mainly on vCJD because that's the one emulated in the scenario, and naturally making prions in game 100% lethal would bring balance issues. Prion diseases have long latencies and even if caught early by protein exams such as Western Blot... Uh, it doesn't help your case much, you are just getting more palliatives lol, I guess a realistic prion gameplay would be kind of boring as it's rather slow and silent, and the in-game prion's "prion features" are low infectivity, and evolutions taking longer to present themselves, supposedly they are harder to cure as well if I'm not mistaken, but I have a hard time buying that when some random country just goes and whips out a prion disease cure in like two minutes 🙄 are prions amazing in science? Yes. In-game? They are kinda one of the most boring pathogens to play as for me at least lol

    • @auronirahman2837
      @auronirahman2837 หลายเดือนก่อน

      the moose disease is 'zombie deer disease', and its also called chronic wasting disease! its the same thing but this type only affects the deer family, tho I do think it can infect some other rodent or something. tragic to see that it's incurable, but I guess we don't understand proteins well enough with our current science :(

    • @ashimochi
      @ashimochi หลายเดือนก่อน

      @@auronirahman2837 that was it! CWD! English is not my first language so sometimes I struggle with names 💀 proteins are indeed, a b!tch to work with

  • @Kozlowskijennifer
    @Kozlowskijennifer 5 ปีที่แล้ว +27

    When he says’ I’m not going for any Lethality’ 80.1 K people dead😹😹

  • @cecilleferrer2077
    @cecilleferrer2077 6 ปีที่แล้ว +1533

    Holy cow you did it! (Cheesy pun intended.) sorry I just I had to milk it. Ok now I'm bovinally done.
    Edit: oh wow 25 likes I am very grateful of this.
    Edit 2: 100 likes wooo I am dairy thankful.
    Edit 3: I think it's udderly awesome how so many people like my puns.

    • @dakotamew
      @dakotamew 6 ปีที่แล้ว +26

      N O terrible puns only black and white puns :>

    • @cecilleferrer2077
      @cecilleferrer2077 6 ปีที่แล้ว +3

      dakota mew give me an example of a black and white pun no cheating

    • @dakotamew
      @dakotamew 6 ปีที่แล้ว +3

      It was a terrible pun :C

    • @cecilleferrer2077
      @cecilleferrer2077 6 ปีที่แล้ว +4

      dakota mew so?

    • @galaxel1494
      @galaxel1494 6 ปีที่แล้ว +6

      i did not even laugh at the cow part the milk part made me laugh

  • @friedwater6519
    @friedwater6519 6 ปีที่แล้ว +11

    11:10 look at greenland

    • @classicsquidward4869
      @classicsquidward4869 3 ปีที่แล้ว +2

      Its been so long no one is talking about it how it explodes for the 3rd fricking time 🤣🤣

  • @igorsiuda8108
    @igorsiuda8108 ปีที่แล้ว +2

    This disease has two variants: Bovine Spongiform Encephalopathy (BSE) in bovine (especially cattle) and vCJD (Variant Creutzfeld-Jakob Disease) in human (also known, to differ form former, as human mad cow disease).

  • @cassww
    @cassww ปีที่แล้ว +2

    They should have made a joke with apple transmission saying “an apple a day gets the doctor aray”

  • @thedarkoverlordofall
    @thedarkoverlordofall 5 ปีที่แล้ว +24

    Praise Pravus! He sacrificed his sanity for a TH-cam video for us.

  • @DN0103
    @DN0103 4 ปีที่แล้ว +6

    You know what would be a funny name for the Mad Cow Disease? *"BURGERS"*

  • @kimjongun7569
    @kimjongun7569 6 ปีที่แล้ว +16

    Ohh,you're my best friend in a world we must defend!

    • @fridaykittens2287
      @fridaykittens2287 6 ปีที่แล้ว +1

      Kim Jong Un hello person from the other side of the world 🌍

    • @outtathepantry
      @outtathepantry 4 ปีที่แล้ว +1

      Pokémon, gotta catch em all...
      .
      .
      .
      All the diseases.... Just catch them, I need to beat the game.

  • @LuckyBird551
    @LuckyBird551 5 ปีที่แล้ว +12

    Try doing a custom scenario of Cholera, there are quite a few and it is often the "forgotten" plague because it usually happens in poor nations and does not usually spread out from them (like the outbreak in 2010 in Haiti)

  • @Derpixied
    @Derpixied 3 ปีที่แล้ว +8

    I know I'm really late but JEEZ I didn't know it was possible to beat this disease ON MEGA FRICKIN' BRUTAL!

  • @adryanus9
    @adryanus9 6 ปีที่แล้ว +33

    good job! Praise Pravus!

  • @glowbomb1223
    @glowbomb1223 6 ปีที่แล้ว +49

    Nothing can stand in the way of Lord Pravus. Praise be!

  • @greywhizzadventurer8535
    @greywhizzadventurer8535 6 ปีที่แล้ว +9

    Flipping well done my man. You really are the best at Plague Inc.

  • @thephantom604
    @thephantom604 6 ปีที่แล้ว +21

    Gg Lord Pravus and of course... PRAISE PRAVUS

  • @OrchidAlloy
    @OrchidAlloy 5 ปีที่แล้ว +9

    To think there are a few people on this planet that have gotten 3 stars on mega brutal

    • @fss1704
      @fss1704 4 ปีที่แล้ว

      OrchidAlloy the World Health Organization is one of them

    • @nhnavs7933
      @nhnavs7933 4 ปีที่แล้ว

      @@fss1704 that's not a person lol

  • @hydekido7506
    @hydekido7506 6 ปีที่แล้ว +4

    Finally!!I've been waiting for you to play this official scenario!

  • @funnyfunnyfunnyxd
    @funnyfunnyfunnyxd 4 ปีที่แล้ว +4

    i love how this popped up first in my recommended after loosing for the 10th time doing that damn mad cow disease scenario

  • @kezzerz
    @kezzerz 6 ปีที่แล้ว +3

    You don't know how I've been waiting for this its insane!
    Just like ur videos 💞

  • @lavender2453
    @lavender2453 6 ปีที่แล้ว +4

    I find your videos very long but I subscribed because of how much effort you put into them

    • @lavender2453
      @lavender2453 6 ปีที่แล้ว

      And I also appreciate how you actually read the pop ups!

  • @anyrandom_1884
    @anyrandom_1884 4 ปีที่แล้ว +2

    Potatoes are efficient in Ireland and Belarus

  • @meatystalactite531
    @meatystalactite531 4 ปีที่แล้ว

    I watched this video and ever since I've been watching your videos constantly. There's just something so alluring about them

  • @ascendedcat260
    @ascendedcat260 5 ปีที่แล้ว +3

    11:11 *looks at greenland* Well that escalated quickly

  • @MoondustManwise
    @MoondustManwise 6 ปีที่แล้ว +6

    Happy pravus makes me happy

  • @drvir
    @drvir 6 ปีที่แล้ว +1

    I knew you would eventually be able to do it!
    You're king of plague Inc after all!
    Praise Pravus!

  • @zakhinithezucchini4598
    @zakhinithezucchini4598 6 ปีที่แล้ว +1

    It only took me 3 attempts on mega brutal, I just bought a lot of transmission and traits with mutation chances, therefore, I can focus on ability traits, which really helped me so yea, but good one, Pravus, you really did well

  • @markuhlman3767
    @markuhlman3767 5 ปีที่แล้ว +3

    Omg...your videos are so fun to watch. Your reaction to your victory here is memorable to say the least. I found this game probably a year or two ago. Played for a while and gave it up. After stumbling upon some of your other videos I have reinstalled the game. You seem to have a different version. Looks different. Anyway, had to leave a comment and say hello after watching this one.

  • @user-ws9be6qi8z
    @user-ws9be6qi8z 6 ปีที่แล้ว +9

    You did it! *_Praise Pravus!_*

  • @lunarchy1075
    @lunarchy1075 4 ปีที่แล้ว +2

    "that's why you go for fish guys"
    -Pravus, 2018

  • @Kainoverlord75
    @Kainoverlord75 6 ปีที่แล้ว

    well done and good luck in the future also PRAISE PRAVUS!!!!!

  • @dyingisahobby9190
    @dyingisahobby9190 5 ปีที่แล้ว +5

    You have some beef with this scenario.

  • @gachadragon7525
    @gachadragon7525 5 ปีที่แล้ว +8

    Wow, great job! I love plauge inc, but suck at it, so to watch this makes me feel good ^^. Also P.S. I have never seen anyone get so exited over fish 😂

  • @evanjones9602
    @evanjones9602 ปีที่แล้ว +2

    From what I've seen, as of March 2023 a grand total of 12 people have gotten 3 stars on mega brutal on this scenario, and they had to use save scumming.

    • @sammy_sand_utubeyt6901
      @sammy_sand_utubeyt6901 ปีที่แล้ว

      Wow! That's terrifying. Thanks for letting us in the comments know!!

    • @agustinbarquero8898
      @agustinbarquero8898 8 หลายเดือนก่อน

      Wow! That's terrifying. Thanks for letting us in the comments know!!

  • @kevindavid8879
    @kevindavid8879 6 ปีที่แล้ว

    damn! gg, I haven't played mad cow yet, but I've herd that it's pretty crazy, been trying to look for some strategies before I dive head first, cause I know Ill just end up playing it over and over till I got it, and I'd end up driving myself crazy, thanks man, didn't actually know severity worked like that.. It explains A LOT! 🤔

  • @tectamk.thorne7837
    @tectamk.thorne7837 3 ปีที่แล้ว +8

    I think why Plague.Inc is less realistic is because once someone gets infected, they will be infected with it forever until some cure comes round or they die, as well as more.
    I’d like a game where rather than win or loss, the game will rate you out of 10. Yeah where wiping humanity is a challenge even on minimal difficulty. And the score scales on how much damage you do

  • @Conor_ish
    @Conor_ish 4 ปีที่แล้ว +3

    there is 30 minute ad about people saying chemicals

    • @ElPastalero
      @ElPastalero 4 ปีที่แล้ว

      Oh yeah, this is big brain time.

  • @saltychipps9936
    @saltychipps9936 3 ปีที่แล้ว +2

    Pravus: SCREW YOU MAD COW DISEASE
    Game: *crashes*
    Me: *smirks*

  • @euginarex5649
    @euginarex5649 3 ปีที่แล้ว +1

    Potatoes: Infected
    TechnoBlade: *Confused Scream*

  • @airmanon7213
    @airmanon7213 6 ปีที่แล้ว +6

    This link here shows a strategy for handling it with 3 stars: steamcommunity.com/sharedfiles/filedetails/?id=1258854729
    I had tried it myself on casual and did get the 3 stars, but I don't know if it works on higher difficulties

  • @killianmontgomery2777
    @killianmontgomery2777 6 ปีที่แล้ว +4

    And they had the balls to put this as the second scenario for people who didnt buy the next one

  • @thatgrumpychick4928
    @thatgrumpychick4928 2 ปีที่แล้ว +1

    13:40
    The squeal in your voice is hilarious. I'm glad you won

  • @epsilon-1125
    @epsilon-1125 5 ปีที่แล้ว

    Thanks I was really struggling with this scenario.

  • @leoncrazyman07
    @leoncrazyman07 6 ปีที่แล้ว +3

    Why the hell are these so addictive to watch? I don't even own Plague Inc!

    • @classicsquidward4869
      @classicsquidward4869 3 ปีที่แล้ว +3

      So true i basiclly watch pravus play plague inc EVERY SINGLE DAY
      (Not saying pravus is a bad youtuber i love his vids)

  • @anglegaming6
    @anglegaming6 6 ปีที่แล้ว +5

    Pravus be praised!

  • @doomplague5758
    @doomplague5758 3 ปีที่แล้ว +2

    LITERALLY EVERY TIME ITS ALWAYS GREENLAND THAT IS UP ON TOP MOCKING ME FOR THE DESTRUCTION IVE CAUSED FOR THE REST OF THE WORLD!!!!

  • @Muddragon104
    @Muddragon104 5 หลายเดือนก่อน

    Thank you for making these videos. Yes I have only been able to get two bio hazard symbols on casual. So I can only imagine how hard it is on mega brutal.

  • @piggehthepig5973
    @piggehthepig5973 6 ปีที่แล้ว +3

    at 7:32 We just won 2500$ on the pennsylvania Lottery

  • @ethanbailey5773
    @ethanbailey5773 6 ปีที่แล้ว +6

    PRAISE PRAVUS

  • @1kizwell
    @1kizwell 6 ปีที่แล้ว

    Classic Pravus Gaming video!!!

  • @flyingkoifish1011
    @flyingkoifish1011 6 ปีที่แล้ว

    Congratulations! You've finally done it!

  • @Decrupt
    @Decrupt 6 ปีที่แล้ว +6

    Praise Pravus

  • @Assassin-bk8lb
    @Assassin-bk8lb 6 ปีที่แล้ว +9

    22 attempts?
    I'm on attempt 46 and still failing.

  • @sarahtextingstories4640
    @sarahtextingstories4640 6 ปีที่แล้ว +1

    Me: plays this
    Game: infected fish has been eaten in Greenland
    Me: fuck yea

  • @scar445
    @scar445 6 ปีที่แล้ว +1

    "come on. come on. GET A BOAT IN THERE DANG YOU!!" im dead xD

  • @justtheletterV274
    @justtheletterV274 5 ปีที่แล้ว +9

    Every other game: Starts in India!
    This game:Start in Ind- never mind, beef doesn’t exist.
    China it is!

    • @purtlethetenguin
      @purtlethetenguin 3 ปีที่แล้ว

      gotta evolve it into cats & dogs then

    • @sovietsky5039
      @sovietsky5039 3 ปีที่แล้ว

      U mean saudi arabia

    • @legitimate8463
      @legitimate8463 2 ปีที่แล้ว

      @@sovietsky5039 but india has rural hot and humid while arabia only has hot and arid. Plus there is more population

  • @AGKaiju
    @AGKaiju 5 ปีที่แล้ว +5

    You almost crossed the cursing line.... I could tell right at the end.
    It was that bad, eh?

  • @classicsquidward4869
    @classicsquidward4869 3 ปีที่แล้ว +2

    Are we just not gonna talk about how greenland exploded for the 3rd time? 11:10

  • @NylaTheWolf
    @NylaTheWolf 6 ปีที่แล้ว +2

    Ah, I can't seem to get this right! Imma keep trying because this seems like a very solid strategy and you sound like you know what you're doing.
    Mainly my problem is not getting to kill off the world before the cure is finished, or them working on it too early or quickly. Or I'm not spreading quickly enough in Greenland and in two recent playthroughs in other countries that aren't islands.
    Watch, I'm going to beat it as soon as I post this comment XD

    • @MayPastel
      @MayPastel 6 ปีที่แล้ว +1

      YOU CAN DO IT NYLA!! I BELIEVE IN YOU!!!
      But seriously, congrats on winning one of the hardest scenarios!!

  • @KingofFray
    @KingofFray 6 ปีที่แล้ว +6

    moral of this video : don't eat fish

  • @chronicwakner9994
    @chronicwakner9994 6 ปีที่แล้ว +4

    you do realise that the Norwegian port goes to greenland to?

  • @dolan3623
    @dolan3623 6 ปีที่แล้ว +1

    I have a feeling that spontaneous infections in greenland will be a common thing. I got one when i played this scenario

  • @steelvenom8479
    @steelvenom8479 6 ปีที่แล้ว

    FINALLY! THANK YOU SO MUCH!

  • @smallpupper
    @smallpupper 5 ปีที่แล้ว +6

    how to win this:
    infinite dna cheat

  • @AlphaMors
    @AlphaMors 6 ปีที่แล้ว +3

    Did someone complete this with 3 stars?????? Its the only one left :(

  • @taco775
    @taco775 6 ปีที่แล้ว

    Good job Pravus

  • @commissionerwarden6347
    @commissionerwarden6347 4 ปีที่แล้ว

    Pravus gaming: Gets potato infectivity perk
    Ireland: Why do I hear boss music?