Lp(a) and CVD Risk: 15-Year Outcomes in the Bruneck Study
ฝัง
- เผยแพร่เมื่อ 7 ก.ย. 2024
- Data may help settle debate on the role Lp(a) to guide clinical decision-making. CSWN talks with Sotirios Tsimikas, MD,
of the Vascular Medicine program at the University of California San Diego, about Lp(a) and CVD risk. This interview was conducted at ESC 2014.
Further reading:
Willeit P, et al. J Am Coll Cardiol. 2014;64:851-60.
content.onlinej...
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Thanks for video. My Lp(a) several years ago were in 3 figures. I take niacin
Please i have questions regarding to lipoprotein a how can I contact you for answering please
Are you serious ?
@@20891 😁YES!!!!
CRP is a marker for inflammation. It barely can be categorized as a root cause for CVD.
Lpa has an important role in wound healing, and 8-10 days after a surgery you can see an up-regulation of up to 4x !
Of course it gets elevated if plaques rupture and platelets get activated... To categorize it as a root cause for CVD is absolutely ridiculous.
The correct questions are: what causes the inflammation of the endothelium and the artery wall? ... and :NO it is NOT because total C is high... gosh that is outdated like hell... but what to expect by someone who still believes the lies constructed by the F-study... And the second question is, why are there lesions of the vessels and too much activated platelet in the first place? The answer in both cases is oxidation. Oxidation by what? Glucose under the condition of a lack of glutathione .
The maching diet: >50% Carbs, >40% of the fats saturated, >5% omega6-6, too much protein, and deficiency in B-vitamins. Additional poor microbiom and after 10..20y you find what you want to find. Those are the root causes.
True, there is a genetic factor for Lpa. And? the role of Lpa is what? prevent a clot from dissolving in wound healing.
If you don't have plaques, or vessel damage, woh cares about LPa?
It is even just the other way round: if you do not have enough Lpa, the changes to die from cancer increase.
Wow, keep being proud for FIFTEEN years of followup, nice data, perhaps, mindlessly analyzed
You are correct !
Yes yes yes. Cardiologists seem to be going round and round about lipidology. What you say makes more sense than these apparently idiots. Do you have any factual or unbiased studies to back up your statements?
Nothing you've said is correct. What an embarassing analysis. The role of Lpa isn't preventing a clot from dissolving. Low levels of Lpa don't related to cancer mortality. The role of Lp(a) is directly in atherosclerosis. It is a highly atherogenic particle. hsCRP is a marker for higher risk of CAD per the Jupiter trial. The multiple studies he cites showing a causal relationship between high Lp(a) and MACE events were not measured in teh setting of acute plaque rupture. Why are you even babbling on about that?
@@RHt09 🤣 I will certainly not teach you
@@monnoo8221 How can you teach nonsense to somebody? LOL
Now that’s it’s 2018 has the testing been completed and the drug sent to the FDA?
These studies are flawed. No measure of sugar intake or inflammation. Without sugar and inflammation, maybe there is no CVD risk. LDL isn't the risk.
Any studies to back up what you say?
@@rony7338 Of course note. This idiot is all up and down the comment section posting this nonsense. There are MANY non-diabetics who have no signs of insulin resistance who have heart attacks.
A sub particle of LDL called Lp-a is what initiates plaque build-up and your level of it is considered an independent risk factor.
Two people with identical cholesterol levels but the one well over 30mg/dl can be 2-3 times greater risk. Glad I got mine checked I'm at 20mg/dl.
Reversing my heart disease with the Linus Pauling Heart Protocol.
Subtle talking down of Niacin - but hey, we may have drug we can sell you soon🤔
That drug is called Juxtapid
Lol
Talking down? He didn't talk it down. He said studies have clearly not shown niacin to be helpful in CAD event reduction but these studies were not done in people with high Lp(a) so we can't exclude it as a therapeutic. Learn to less more and talk less.
My lp a is at 228 and has risen even though I’ve been taking niacin
U almost have to use s
detective techniques with food intake. Speaking from personal experience. Get a copy of the book 8 week Cholesterol Cure by kalwaski ( sp) 🙏 also kalwaski encouraged reader to eat oat BRAN because of the soluble fiber. Best of health to u and yours 😇🙏
Does niacin help ?
Try taking higher level vitamin C supplementation. Bare minimum, 1,000mg (1 gram) per day. But shoot for somewhere between 2,500mg - 4,000mg per day. Sodium ascorbate, not calcium ascorbate. Take 1/2 in the morning and 1/2 at night. Do this every day. Don’t miss any days. Do this for 6 months to a year and recheck your Lp(a) levels. Take a CoQ supplement every day too. Keep taking the naicin as well.
Also stop eating seed oils! All of them. No canola oils. They may damage the artery lining due to oxidation and inflammation.
what was intentionally muted out at the 7:54-7:58 mark?
Hi. I'm 61 years old and have inherited high LP(a) Doctor told me I'm at high risk, but there was noting to do about it. Nine years ago it was 403mg/l. I consider my self quite healthy, not smoking, but but a bit obese in later years, but got down to slim this year. Last check this summer (after loss of weight 96 - 70 kg) it was the same at 400mg/l. I had a scan last week which show litle to no plaque in my arteries. Doc told me my cardio age was 34-39 years and that only 3% persons at my age had better score. That was quite surprising. Maybe there is a lot of people having high cholesterol/Lp(a) without plaque/cardio deceases like me? Would be interesting to know. Is healthy metabolic condition, not beeing inflamed or prediabetic/diabetic (despite my overweight i later years) , the reason I'm still fine? I will not take any drug to reduce my LP(a).
56, slightly high LPa cardiac calcium score of 2
did you or do you eat a lot of sugar over your lifetime?
@@danielriccardi6408 Hello I have never been drinking lot of sugary drinks or having cakes or sweets beqause my mother was a dentist and quite strickt! Later in life I went on without much sugar. Last year even more strickt as Im on a ketogenic diet now. So close to zero last year. Health is super 🙂
wow that is great to hear! did you not eat a lot of sugar or did you not worry about it? I wonder how much sugar and carbs play a role. I ate a ton of sugar my whole life and was borderline diabetic until I cut it out. But my LPa went up I think bc I tried keto and ate more fat.
OR........ lp(a) is not a risk factor ! bingo !
My lpa is 257.......60 years old 3 stents & 3 way bypass...... I'm pretty sure I'm almost done. :(
Sorry.
How are you doing today?! How was your LDL when you needed stents?
Did you eat lots of sugar and carbs? Any inflammation markers measured in your blood ?