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"Just as we've turned fire from a natural disaster into the spark of civilization, we've turned that machine that allows to simply make more of ourselves into something that allows us to understand the nature of who we are - all because we have the curiosity to deeply understand how something works, and the ingenuity to adapt it beyond its intended uses. This is what it means for me to be a scientist. This is what it means for me to be human." Shivers. I love that you always bring the topic back to why you care, and why everyone should care. This is who we are, this what we are, and that deserves all the poetry, awe and appreciation that you describe every video. Thank you.
Shout out to @clockwork for helping me with reviewing this video! Check his channel out if you want to know more about DNAP in its natural habitat! 0:25 th-cam.com/video/lv89fSt5jBY/w-d-xo.htmlsi=aCOlcY2nAj90GPSl
i’ve done this before in my lab! we did a redundant and nested pcr on isolated arabidopsis genes. we then used the genes to make a recombinant plasmid to introduce into e. coli. lots of fun :)
12:11 : *that’s* how sequencing is done?! That’s crazy/incredible! (“crazy” here is not meant in a “surely there’s a better way” sense, but in a “I’m shocked that it works that way” sense)
@Nanorooms It depends on what you want it for, CRSPR is powerful, and it can be used for many things that are ethically questionable. Not everyone can have it, but not just a few can have it... what's the solution?
Sisyphus enters... things need to be thought out WAY more for not only sustainability but for the future-proofing... so we can build off a better foundation.
everything can kind of be a tool if you think hard enough lol, but how you think to use it, and for what, is perhaps how we are going to actually stop creating more problems from the get go... who knows what the mind can achieve!
The first "RT" in "RTRT-PCR" is usually instead a "q" for "quantitative." Thus "qRT-PCR" is "quantitative reverse transcriptase PCR." It's the same thing.
It needs to go that high in order to split apart the DNA. The DNA polymerase used in these procedures is from a hot springs bacteria so it is pretty resistant to high heat. Imagine if that was in fahrenheit! That would mean that our DNA would split apart at 95 °F. That wouldn't be good. In reality our bodies use a protein called helicase to split the DNA, not temperature, but in the lab, temperature is more convenient.
Quality is off the roof! Respect ! Have you ever thought of cells as Atomic assemblers ? It is possible for cells to build a bone not like a skull but an engine and deposit iron instead of calcium, extrapolate these abilities to a device that can build any configuration of atoms from raw material! Gas to diamonds and ...
Phenomenal video. I've been interested in this topic recently, but not before this video did I have any idea how most of it works. Your explanations were simply excellent.
So these things literally just, start off as essentially nothing, then tangle and wrap around (this makes most effective use of space like a folded up spaghetti noodle) all these instructions for these inanimate objects that if enough of them clump together, it ends up with conciousnesses it makes no fucking sense.b
What happens when every day people get the power to adjust the dna of viruses and bacteria with technological assistance (even without a deep knowledge of biological sciences)
When it takes folks a month to make one video -- sometimes its cool to try other experimental ways of cross-pollinating. Think of it as like an almost-collab.
DNA is not what makes us, it is our biofields, u can have people with different dna act look and do everything the same proving dna is not a significant factor, whilst this advancement is new the understanding behind it is old and outdated
@@cillian_scott if the practice of molecular genetics isnt simplified so as to be accessible to the public, then placing an ad under the veil of scientific journalism is just that. why does this never happen with any other subject? its not like youtubers need to drag their "academic" guidance process throughout the span of 4 years just so they can monetize science for their own profit. corporate schooling 2.0. not ideal to spew 19 thousand words into a subject that requires 1.5 thousand words. at least try to hijack science in a less hateful manner. its almost funny.
I stopped being a public scientist because I don't think society deserves it. We need to go back to the guild structure from the renaissance. Most people just call us liars and hoaxers. After they way they acted during 2020, the general public should never get free science or the benefits of medicine ever again, imo.
John 14:21-23 ESV Whoever has my commandments and keeps them, he it is who loves me. And he who loves me will be loved by my Father, and I will love him and manifest myself to him." [22] Judas (not Iscariot) said to him, "Lord, how is it that you will manifest yourself to us, and not to the world?" [23] Jesus answered him, "If anyone loves me, he will keep my word, and my Father will love him, and we will come to him and make our home with him.
You aren’t a scientist for the right reason if you think like this. You should be working to advance humanity even if some “don’t deserve it” because there are many who do
too youtube Bot im not going to pay for youtube and stop forcing me to turn of my ad blocker. i am simply not going to. and if youtube keeps pushing youtube premium ill end up looking for another streaming site like wonderium or patreon and just avoid youtube all together. im just not gonna pay youtube. i know premium over priced and minimal benefits. i use to have youtube music until you change the plans after that over priced.
Yo! CEO of YoUTube here. Sorry about the ads. I was not aware of them before your comment. I'm glad that I read your comment. As I do not want to lose you as a customer, I will of course stop the ads from being shown immediately! Have a nice day!
To try everything Brilliant has to offer-free-for a full 30 days, visit brilliant.org/NanoRooms/ . You’ll also get 20% off an annual premium subscription.
Hey you should make a video on how all these processes and proteins were discovered and their shapes mapped
How much do annual subscriptions cost?
"Just as we've turned fire from a natural disaster into the spark of civilization, we've turned that machine that allows to simply make more of ourselves into something that allows us to understand the nature of who we are - all because we have the curiosity to deeply understand how something works, and the ingenuity to adapt it beyond its intended uses. This is what it means for me to be a scientist. This is what it means for me to be human."
Shivers. I love that you always bring the topic back to why you care, and why everyone should care. This is who we are, this what we are, and that deserves all the poetry, awe and appreciation that you describe every video. Thank you.
LET'S GOOOOOOOO
Clockwork? You're here too? 🫡
@@DanteGabriel-lx9bq You gotta use a symbiosis build when playing TH-cam! Way more fun gameplay loop!
didn't expect you here but it makes sense.
Where are we going?
Shout out to @clockwork for helping me with reviewing this video! Check his channel out if you want to know more about DNAP in its natural habitat! 0:25
th-cam.com/video/lv89fSt5jBY/w-d-xo.htmlsi=aCOlcY2nAj90GPSl
"although it might look simple and boring" as the most tangled and complex knot of biology you've ever seen rockets into your retinas.
Wild work
These videos deserve so much more attention!!! I just recommended your videos to my biology teacher and he ABSOLUTELY loves it!!!
i’ve done this before in my lab! we did a redundant and nested pcr on isolated arabidopsis genes. we then used the genes to make a recombinant plasmid to introduce into e. coli. lots of fun :)
12:11 : *that’s* how sequencing is done?! That’s crazy/incredible! (“crazy” here is not meant in a “surely there’s a better way” sense, but in a “I’m shocked that it works that way” sense)
Great, I wish it was cheaper, specially here in Brazil. Import such materials cost a life of work. :/
That’s rather sad :( biotech really needs to be more accessible.
@Nanorooms It depends on what you want it for, CRSPR is powerful, and it can be used for many things that are ethically questionable. Not everyone can have it, but not just a few can have it... what's the solution?
Wait in a few years things change when rnd is recovered.
Wow. Awesome how you explain this stuff. Got my sub. Can't wait to learn more!!
Amazing video, may I ask you what do you use to make these animations?
A few things went over my head, will rewatch paying more careful attention, amazing video, impressive visuals, good work
Great! I’m coming to learn more about this field! Will try to help make advicements✌️
The most important question is do they harden in response to physical trauma?
Like a newtonian fluid?
🫀🦾
Why would that be the most important question?
MAKING THE MOTHER OF ALL OMELETTES HERE JACK
@@Ebani nanomachines, son
14:39 wash away the anger?
I absolutely adore your videos.
This video is fucking great. Crazy how it has this few views.
Hope you keep making these in spite of the offensively low views to awsomeness ratio
I have broken through a few times! It’s just like science: keep failing until you understand the phenomena that is the yt algorithm.
Sisyphus enters... things need to be thought out WAY more for not only sustainability but for the future-proofing... so we can build off a better foundation.
everything can kind of be a tool if you think hard enough lol, but how you think to use it, and for what, is perhaps how we are going to actually stop creating more problems from the get go... who knows what the mind can achieve!
last couple of lines were fire
Great Video! I was wondering if you were considering touching on group-II intron reverse transcriptases (TGIRT/Induro) in the future RNA-seq video?
It might be a while until I cover RNA-sequencing though. But, one of the next few videos is gonna be about Oxford Nanopores.
@@Nanorooms Can’t wait to see it! I wish I had these videos during my undergrad
The first "RT" in "RTRT-PCR" is usually instead a "q" for "quantitative." Thus "qRT-PCR" is "quantitative reverse transcriptase PCR." It's the same thing.
Is celcius scale a mistake in 3:39 or is it really work in that high temperatures?
Oh no, they really go that high
It needs to go that high in order to split apart the DNA. The DNA polymerase used in these procedures is from a hot springs bacteria so it is pretty resistant to high heat.
Imagine if that was in fahrenheit! That would mean that our DNA would split apart at 95 °F. That wouldn't be good.
In reality our bodies use a protein called helicase to split the DNA, not temperature, but in the lab, temperature is more convenient.
Quality is off the roof! Respect !
Have you ever thought of cells as Atomic assemblers ?
It is possible for cells to build a bone not like a skull but an engine and deposit iron instead of calcium, extrapolate these abilities to a device that can build any configuration of atoms from raw material!
Gas to diamonds and ...
PCRs are hell, I will not bend on this
"Understanding your tools really well can lead to pretty creative ways of using them"
First game boy pokemon games:
Can tell a molecular biologist drew the structure at 1:55 😉 Only joking, was a great video and nice to see some footage from the lab!
I didn't realize the diagram was mirrored
Phenomenal video. I've been interested in this topic recently, but not before this video did I have any idea how most of it works. Your explanations were simply excellent.
captivat
So these things literally just, start off as essentially nothing, then tangle and wrap around (this makes most effective use of space like a folded up spaghetti noodle) all these instructions for these inanimate objects that if enough of them clump together, it ends up with conciousnesses it makes no fucking sense.b
Thanks fro this information
I love when you post
Nanomachine son~ 🤓
What happens when every day people get the power to adjust the dna of viruses and bacteria with technological assistance (even without a deep knowledge of biological sciences)
Trust me, there is nothing everyday people about genetics. There's a gap in cost and knowledge that is required to overcome to become everyday.
nice
Good video
Nice 👍
❤❤
Title:
Darwin: Am I a joke to you?
If you think it looks simple you aren't looking closely.
Q5 == MVP
The only bad thing is that it’s not as processive as Kappa-HiFi
Amazingly well done!
For a moment I thought it was Clockwork reuploading lol.
-It was 10 billion percent intentional-
When it takes folks a month to make one video -- sometimes its cool to try other experimental ways of cross-pollinating. Think of it as like an almost-collab.
@@Nanorooms Interesting delete
Yeah, titles are similar
“Might look simple and boring…” - what about that seems boring, let alone simple lmao?
Genen forms dna
love that ending
Perez Margaret Martin Angela Harris Jason
I’m here from clockwork’s community post
Hi 👋
astonishing
a "photocopying machine?"
DNA is not what makes us, it is our biofields, u can have people with different dna act look and do everything the same proving dna is not a significant factor, whilst this advancement is new the understanding behind it is old and outdated
❤
PCR - pipette, cry, repeat.
Tfw you see no bands on all 48 lanes 😭
Stop saying “advancement”. The word is “advance”. You sound ignorant.
aw poor bb 😢
can someone explain if this is new? or is the guy just mumbling in order to get his ad across?
Not new, don't know where you're coming from with that inference after, though.
@@cillian_scott if the practice of molecular genetics isnt simplified so as to be accessible to the public, then placing an ad under the veil of scientific journalism is just that.
why does this never happen with any other subject? its not like youtubers need to drag their "academic" guidance process throughout the span of 4 years just so they can monetize science for their own profit.
corporate schooling 2.0. not ideal to spew 19 thousand words into a subject that requires 1.5 thousand words. at least try to hijack science in a less hateful manner. its almost funny.
WT I just watched 😅
I stopped being a public scientist because I don't think society deserves it. We need to go back to the guild structure from the renaissance. Most people just call us liars and hoaxers. After they way they acted during 2020, the general public should never get free science or the benefits of medicine ever again, imo.
John 14:21-23 ESV
Whoever has my commandments and keeps them, he it is who loves me. And he who loves me will be loved by my Father, and I will love him and manifest myself to him." [22] Judas (not Iscariot) said to him, "Lord, how is it that you will manifest yourself to us, and not to the world?" [23] Jesus answered him, "If anyone loves me, he will keep my word, and my Father will love him, and we will come to him and make our home with him.
You aren’t a scientist for the right reason if you think like this. You should be working to advance humanity even if some “don’t deserve it” because there are many who do
If anyone is reading that cares - this is universe ending tech and could already be too late.
Gain of function
too youtube Bot im not going to pay for youtube and stop forcing me to turn of my ad blocker. i am simply not going to. and if youtube keeps pushing youtube premium ill end up looking for another streaming site like wonderium or patreon and just avoid youtube all together. im just not gonna pay youtube. i know premium over priced and minimal benefits. i use to have youtube music until you change the plans after that over priced.
Yo! CEO of YoUTube here. Sorry about the ads. I was not aware of them before your comment. I'm glad that I read your comment. As I do not want to lose you as a customer, I will of course stop the ads from being shown immediately! Have a nice day!