Allergies: The Science of Why Your Body Hates You

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  • เผยแพร่เมื่อ 16 มิ.ย. 2024
  • Did you know that one of the biggest discoveries in our understanding of allergies was thanks to a completely failed experiment?
    From pollen to peanuts, allergies can be the bane of our existence. Hold on tight for this wild ride of an episode that takes us through time. By the end, you'll see how Paris, sea anemone toxin, Prince Albert I of Monaco, and eczema are all linked to allergies...and what we can do about preventing and treating them in the future.
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ความคิดเห็น • 224

  • @prettypic444
    @prettypic444 หลายเดือนก่อน +128

    “Just because someone had ONE good idea doesn’t mean ALL their ideas had merit” SAY IT LOUDER FOR THE PEOPLE IN THE BACK!!!
    (Also, as someone with some pretty extreme cat allergies, the opening of this video was physically painful for me)

    • @kananaskiscountry8191
      @kananaskiscountry8191 หลายเดือนก่อน +1

      ur allergic to cat fur (not cats) = feathers (not just from one bird) = yeast (any kind of bread & baking) = Pollen (all kinds of plants, trees, grass, marijauna, etc) = dust (house dust) = grain dust (grain on a farm) - [totally different dust and grain dust] and more to comoe when we talk allergies

    • @zapfanzapfan
      @zapfanzapfan 22 วันที่ผ่านมา

      So, lick a cat? Little bit every day to teach your immune system.

  • @stevezastrow9252
    @stevezastrow9252 หลายเดือนก่อน +30

    it wasn't a failed experiment, it was an unexpected result.

  • @AnonymousFreakYT
    @AnonymousFreakYT หลายเดือนก่อน +58

    Thank you for crediting Chicken as the primary contributor to the video. As any cat will attest, cats should always be primary.

    • @jpe1
      @jpe1 หลายเดือนก่อน +2

      I’m glad I saw this comment, I was confused when I saw Chicken listed in the credits, but from the context of this comment, I’ll assume the cat was named Chicken.
      Not a typical cat name, so I didn’t make the connection without your comment, and then I re-watched the end, and yes, she calls the cat Chicken. Whatever…

  • @lizziereid5908
    @lizziereid5908 หลายเดือนก่อน +52

    I had NO idea that eczema gives way to particles through the skin which the body sees as invaders! That’s so fascinating! Thank you for sharing this, me and lots of my family have eczema so this is super helpful to know.

    • @kagitsune
      @kagitsune 20 วันที่ผ่านมา +3

      Yes! I remember reading about an adult eczema patient who was using goat milk cream to soothe the rashes, and she later developed a goat milk allergy!

  • @jadedrealist
    @jadedrealist หลายเดือนก่อน +26

    When I was young an allergy test told me I was allergic to dogs, cats, peanuts/soy, milk and dust mites. I broke out in hives whenever I was near any of these things, but I ate peanut butter by the spoonfull, my family always had pets both dogs and cats, and I was a pretty messy kid. I lived on benedryl but over time I stopped having reactions/hives and I've credited that to facing my allergies head on. I'm happy to see there was some actual science to that and not just a coincidence.

    • @nari5161
      @nari5161 หลายเดือนก่อน +1

      I've never not been in constant contact/proximity to any of my allergens and I still have all of them. The man said exposure to allergens in moderation is a form of treatment and the woman was treating with filtered air to give the immune system a break. Neither suggested constant exposure was therapeutic. The guy just suggested not to avoid entirely. You might be older, but if you're teen-early 20s, some childhood allergies/eczema/autoimmune conditions tend to go away, and for some of those people they return in adulthood.

    • @aidanklobuchar1798
      @aidanklobuchar1798 หลายเดือนก่อน +5

      @@nari5161 Also, if he could eat peanut butter by the spoonfull and not _immediately_ end up in the ICU, it was a very minor peanut allergy to begin with.

  • @chunkyshrapnel
    @chunkyshrapnel หลายเดือนก่อน +30

    When I started this video, I didn't expect to learn new stuff about my eczema. Really interesting!

  • @juanitamccaslin2389
    @juanitamccaslin2389 หลายเดือนก่อน +40

    I was always told that if you had allergies and eczema than more times than not, you would also have the "cousin" asthma.

    • @sewerrat7612
      @sewerrat7612 หลายเดือนก่อน +1

      Yeah seems to track most family has excena and asthma not sure about food allergy thing know alot of people with excess none with food allergies alot with other allergies though.

    • @AifDaimon
      @AifDaimon หลายเดือนก่อน +2

      ​@@sewerrat7612well, I can't consume eggs directly.. Scrambled, boiled, half-boiled even.. Had one of those as a kid, and I ended up with a nasty rash on my back. I've avoided eating eggs ever since, even though consuming foods that have eggs as an ingredient pose no problems for me

    • @hazelgrunts
      @hazelgrunts หลายเดือนก่อน +2

      I’ve had all three (peanut allergy, eczema, and asthma) although I’ve outgrown my allergy and I’m okay to eat peanuts now.

    • @elylioney6390
      @elylioney6390 10 วันที่ผ่านมา

      That seems 2 b true in my family

    • @AifDaimon
      @AifDaimon 10 วันที่ผ่านมา

      @@elylioney6390 yours has it rougher than mine, apparently.. My childhood egg allergy seems to be linked to my inability to have silicone smartwatch straps worn on my skin

  • @KristenRowenPliske
    @KristenRowenPliske หลายเดือนก่อน +14

    Allergies are weird & don’t always follow the rules. ☹️
    I have cats. I’ve always had cats but my oldest daughter is slightly allergic to their dander. All four of them are allergic to dogs. Neither I nor my husband are allergic to either.
    Another daughter had very severe excema as a child. It has calmed down some but she doesn’t have seasonal allergies or food allergies (just the dog one). She does have very reactive asthma though, triggered by exercise or a cold or fumes/smog.
    I’m allergic to fresh tomatoes & the juice from a fresh tomato. First popped up when I was little & I developed severe hives not long after eating some. I kinda forgot I was allergic until I got my first job at a Subway, back when they sliced everything by hand. I sliced some up, got splattered by juice & broke out in an itchy rash up my arms. My mom reminded me that I’m allergic to tomatoes. 🤦🏽‍♀️. Even now I’ll break out into a faint rash on my chest if there are fresh tomatoes in a sauce or stir fry. I could always tolerate ketchup & tomato sauces (minus the chunks, of course) so I do agree that the small exposures over time have lessened the immune response. I don’t even bother telling people I’m allergic; I just don’t eat them, decline them or pick them out if I need to.
    I have environmental allergies, worse in the spring but otherwise all year. I only get excema flare ups if my allergies are strong.

  • @petercarioscia9189
    @petercarioscia9189 หลายเดือนก่อน +8

    11:50 I started exposing my son to peanut butter orally by around 6 months. Now, 18 months old, PBJ are his favorite snack food.

  • @user-ck3uu8rj3x
    @user-ck3uu8rj3x หลายเดือนก่อน +32

    So the "too clean ' hypothesis is being discarded in favour of the ' not being dirty enough ' hypothesis?
    Surely not just the same thing?

    • @thawhiteazn
      @thawhiteazn หลายเดือนก่อน +21

      I had the same thought lol. It seems the distinction is that while the exposure to microbes from a young age is the causal factor in both theories, the old theory is that the exposure strengthened our immune system against infection in a manner akin to working out to increase muscle mass whereas the newer theory is that the fact your because body has never come across those microbes it doesn’t know how to classify them at all, leading to your body assuming everything is a pathogen.
      I think it’s a valid distinction, but ultimately the two theories are still not far off from each other.

    • @rocketGimbal
      @rocketGimbal หลายเดือนก่อน +42

      The difference is the harmfulness of the microbes/particles. The “too clean” hypothesis was claiming that allergies were caused by not having enough contact with germs that make us sick. The “not dirty enough” should be taken more literally, we aren’t in contact with enough dirt or other things in our environment that don’t necessarily make us sick.
      In other words, one (too clean) is saying ‘not enough of the bad stuff’. While the other is saying ‘not enough of the good stuff’. We dont need to let our kids get sick too help them with allergies, we need to make sure they have (proper) contact with the good stuff though.

    • @pbsterra
      @pbsterra  หลายเดือนก่อน +23

      Yes! @rocketGimbal is exactly right here, this is the very important distinction!

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 หลายเดือนก่อน

      @@rocketGimbal There was a presentation on Fralin a few years ago by Dr Beatriz León Ruiz about early exposure to airborne LPS from manure as being protective against asthma. That 'farm fresh air'.

    • @Appletank8
      @Appletank8 หลายเดือนก่อน +4

      ​@@rocketGimbalDoes this mean one should get like, a giant list of the most common allergens, collect them, grind it into dust, and vaguely sprinkle it into baby food?

  • @rhyothemisprinceps1617
    @rhyothemisprinceps1617 หลายเดือนก่อน +32

    What explains adult onset of allergies? I ate peanut & egg as a child - no problem. Now I'm allergic to a bunch of things including egg & I have eczema which is triggered by eating corn (tested positive for corn allergy with skin prick testing). I haven't tried eating peanuts since I can't eat other legumes (chickpeas, pinto beans, soy). I can eat almond butter so I'm happy about that. My daughter developed severe oral allergy syndrome & Celiac around the same time I developed allergies & eczema. We are both allergic to birch pollen. Weird coincidence - a few days ago I was thinking about making a small tent-like structure out of Tyvek and attaching it to my room Hepa filter to create a positive pressure filtered air chamber around my upper body when I sleep (sort of like an oxygen tent).

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 หลายเดือนก่อน +2

      CW - some TMI health stuff to follow --
      I'm thankful that with the help of the Corn Allergy Girl blog I was able to eliminate corn to the point where I don't have eczema flares (since it was in the nether regions it also caused very painful fissures and also the potential to cause terrible infections since that area is sometimes not the cleanest part of the body (I also have IBS-C, but occasionally I still go no. 2 ;-) ). Before that, though, I had to use Eucrisa since steroids did not work. Eucrisa is a miracle drug - but it costs $600 USD a tube.

    • @megb9700
      @megb9700 หลายเดือนก่อน +15

      You can develop allergies to stuff you are exposed to during a bad virus, or severe sickness, or pregnancies. Your body is in overload and just treats random stuff as enemies.

    • @TylerSmithMusic1
      @TylerSmithMusic1 23 วันที่ผ่านมา

      Autoimmune disease becoming more active possibly?

    • @kagitsune
      @kagitsune 20 วันที่ผ่านมา +3

      ​@@megb9700I was going to say! I'm not a doctor, but this reminds me of what I have heard from folks with Mast Cell Activation disorder. Sudden, ever-changing allergies, usually brought on by some viral infection (whether mild or severe 😬)

    • @faeriesmak
      @faeriesmak 13 วันที่ผ่านมา +1

      I developed oral allergy syndrome and am also allergic to birch, dust mites, coconut…and anything related to birch in any way. I NEVER had allergies when I was a kid.

  • @auroraglacialis
    @auroraglacialis หลายเดือนก่อน +117

    So to prevent cat allergy you would have to eat cats as a kid? 😂

    • @DeRien8
      @DeRien8 หลายเดือนก่อน +47

      The main cat allergen is caused by a protein concentrated in cat saliva and waste called FLD1. So, more like swallowing cat dander, and considering how much babies put in their mouths, glomming onto a cat wouldn't be surprising behavior.

    • @nasonguy
      @nasonguy หลายเดือนก่อน +26

      I’ve been allergic to cats all of my life. Like super bad instant reaction. Puffy scratchy eyes, sneezing snotty mess, wheezing. Real bad.
      My partner and children wanted a cat sssooo bad that I finally caved and just consigned myself to a life of taking Claritin.
      The allergies were brutal for a couple months, and tolerable for about a year, and are now entirely gone.
      I can’t help but wonder if it’s because that little effer walks all over everything and gets his dander and spit all over everywhere, including our food and kitchen.

    • @aaronfredrickson9538
      @aaronfredrickson9538 หลายเดือนก่อน +8

      Yup. Same for my brother. He wasn’t allergic as a kid. Became ridiculously allergic not having cats. He caved and got a cat for his family and shortly thereafter…. Allergies gone

    • @maolcogi
      @maolcogi หลายเดือนก่อน +11

      @@DeRien8 I was such a weird child, I remember putting our kittens heads in my mouth. Not for long, and not violently or anything, just playing. I am not allergic to cats now. xD

    • @MilleniumOfTheComet
      @MilleniumOfTheComet หลายเดือนก่อน

      No, just lick them 🤣

  • @michelebriere9569
    @michelebriere9569 หลายเดือนก่อน +3

    I was raised in the NE. I never had allergies until I moved to southern Arizona. I'm 58, and have had cats my entire life. Never had a problem with them until I moved down here. What's really odd is that since allergies took over 24/7/365, I haven't had a cold in almost 40 years.

  • @sunla
    @sunla 28 วันที่ผ่านมา +3

    My kiddo would have eczema on her legs. My first response was to put cortisone on it. The moment she was able to, she ate peanuts. Weirdly, she gets contact dermatitis with olives and olive oil, so I assumed she is allergic to olives (like her great grandma on her dad's side). As a baby just barely eating solids, we learned this because my mother in law gave her a piece of her firehouse sub sandwich, which was drenched in olive oil, and she got rashes everywhere it touched. She only really nibbled the sandwich, and everywhere near her mouth was rashy. She has had this response multiple times to light exposure of olives and olive oil.
    Wonder how much genetics may play a role

  • @catc8927
    @catc8927 หลายเดือนก่อน +2

    Minor quibble, the primary cat allergen is not their hair, but Fel d 1, a protein in their sebaceous secretions and saliva. It gets stuck to their dander, which then sticks to us or our clothes when we come into contact with them.
    Hairless cats like Sphynx aren’t considered hypoallergenic, while a long-haired cat breed like the Balinese is often considered less allergenic due to lower Fel d 1 levels.

  • @robynpicknell7801
    @robynpicknell7801 หลายเดือนก่อน +5

    This was fascinating! Glad to hear that the "Clean Hypothesis" has been disproved, sort of. Really, really pleased to see the BUS finally being praised for once for the work it does when it comes to research and development. Especially in the Allergy field of medicine given how so many more children are being affected by this issue in today's modern world.

    • @robynpicknell7801
      @robynpicknell7801 หลายเดือนก่อน

      NHS! Hate predictive text! Especially when you can't turn it off!!!😡

  • @hermeticbear
    @hermeticbear หลายเดือนก่อน +7

    It's so fascinating.
    I didn't develop an allergy to animal stuff (both cats and dogs) until I hit puberty. I always grew up with cats and dogs, and they often would sleep with us, we would pet them etc.
    But then one day, I noticed I was getting congested, watery eyes, and sneezing at bed time. After several months of wondering what is going on, I was home one day and I saw the family housecat sleeping on my pillow in my bedroom. I shooshed her off, swapped the pillowcase, and closed my door. No allergic reactions that night when I went to bed.
    Later I found through visiting the home of friends and family that the greater the concentration of animal dander? (honestly I'm not sure) the more severe the reaction.
    I even found that just petting a dog or cat and not washing my hands afterwards would cause me to sneeze or get watery eyes or experience congestion.
    I haven't been in a very highly animal laden space in a while, but it seems my reaction has tapered off somewhat, although I am very attentive to washing my hands after a pet a dog or cat. I like to hope that this allergy will just go away as mysteriously as it developed, but now I usually prepare if I know I'm going to be visiting someone's home who has a housepet that I bring some allergy meds.

    • @dramalexie
      @dramalexie 17 วันที่ผ่านมา

      same for me! I had cats and dogs (outside) since I was a baby and never had allergies. Some time in high school I developed allergies to cats, all grass, most trees, and dust mites! Now I can't even pet a cat without getting a rash on my arms😭Since moving out of my parent's house and away from pets, my animal allergies only seem to get more severe. AND I've had eczema my whole life. It was worse as a kid but totally under control as an adult. I really hope more people and funding go to studying allergy treatments!

  • @ElicBehexan
    @ElicBehexan หลายเดือนก่อน +24

    I didn't learn about my problems with food until I was out of college (22.) Mom never mentioned my having skin problems. Now, in those critical first bunch of months - until I was close to 2, I lived in a state where corn consumption was not as much as it is today. Then we moved to Texas. I don't remember having issues with corn until I hit puberty. Now, I didn't connect my migraines with eating corn, but I will say that Mom made pancakes every Wednesday, and we used cheap syrup=corn syrup with artificial maple flavoring. I got sick every Wednesday, throwing up sick, severe headaches, etc. Even today, if I smell artificial maple flavoring I get queasy. I have no problem with real maple smell or taste. At about 30, after spending 8 years mostly avoiding corn protein, if I got into it, I became really sick: tunnel vision, dizzy, migraines, and extreme inflammation in my body. I could barely eat since if I ate more than a few bites of anything more than saltine crackers, I got sick. And yet, I got tested last year for food allergies and they didn't find anything... so, my body won't let me even smell corn without reacting then, if I'm not allergic, what am I? My most serious reaction I ever got I didn't even know I had gotten into corn until after I started reacting.

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 หลายเดือนก่อน +7

      What type of allergy testing did you get? I don't think blood tests are reliable. I had a skin prick test for environmental allergies since I thought that I had oral allergy syndrome like my daughter; I asked them to add in corn as the only food allergen to the test since I strongly suspected it as a trigger. Unfortunately I was right, I am allergic to corn. It's in everything. I'm very similar to Corn Allergy Girl (has an eponymous blog) in terms of symptoms (e.g., I also have weird reactions to Cucurbits) but thankfully unlike CAG I have not switched from corn causing skin reactions to anaphylaxis. I'm scared I will, though.

    • @ElicBehexan
      @ElicBehexan หลายเดือนก่อน

      @@rhyothemisprinceps1617 I did do skin prick tests. However, in 1985 I went to an allergist who did what he called 'provoking' tests and I was nearly falling out of my chair before the 10 minutes was up. I had an almost as bad reaction to apples, but I can eat them after avoiding them for months. I also had a bad reaction to beef, but if I only eat it once a week, I can handle it. Really, the only food I absolutely can not handle is corn and I also have a lot of trouble with peppers. Despite black pepper and the hollow peppers not being related, they both give me bad reactions so I do my best to avoid them.

    • @Insan1tyW0lf
      @Insan1tyW0lf หลายเดือนก่อน

      ​​​​​@@rhyothemisprinceps1617 The last time I got a skin allergy test, the test confirmed my peanut allergy but missed my definitely-there soy (allergic to multiple but not all members of the _fabaceae_ family) and my cat/dog allergies. When I asked the allergist about this they speculated that the samples used possibly didn't contain the specific allergen I reacted to, or enough of it. When I asked what was the point of a sample simply labeled "dog" if it couldn't reliably capture a dog allergy, they shrugged and suggested I buy a $300 epinephrine auto injector.
      I know the tests are not a complete waste, but they're heavily reliant on the controlled execution and subjective interpretation by a specialist, and I really wish the process was less archaic after 100 years.
      That's no endorsement of the blood tests though. Blood tests (as far as I understand) look for IgG instead of IgE since it doesn't require immediate exposure to the target allergen, but the relationship between IgG and food allergies or sensitivities is not fully established or understood, so while the test does reliably indicate the presence of protein-specific IgG, that in and of itself doesn't tell you as much as some would like to claim (or sell you).
      Ultimately we still have a long way to go to understand allergies, and I hope we get there sooner rather than later.

    • @Wiimeiser
      @Wiimeiser หลายเดือนก่อน +4

      It's likely that they're denying it because high fructose corn syrup is used in basically _everything_ in at least some parts of the US. I'm lucky to be Australian.

    • @briebel2684
      @briebel2684 หลายเดือนก่อน +3

      If you have a bunch of environmental allergies, watch out for Yellow dye #5 AKA Tartrazine. Some places it is put in nearly everything yellow, green, or orange. It's actually been banned in some countries, but for some reason the FDA keeps it legal in food in the USA.
      Believe it or not I can taste it in foods, almost like a copper taste. So I've learned to just spit out any food that tastes even a little bit copper-y.

  • @birdstrum1555
    @birdstrum1555 หลายเดือนก่อน +4

    Was literally battling with dust allergies this morning, very timely.

    • @Maichen13
      @Maichen13 หลายเดือนก่อน

      Same here. Had to take meds cause I kicked up a bunch of dust in my home office.

  • @snapcracklepops
    @snapcracklepops 23 วันที่ผ่านมา +1

    I used to have cat allergies but now that I take care of a stray cat and often visit my brother, who also used to have cat allergies but now owns several cats, I am no longer allergic to cats.

  • @wezul
    @wezul หลายเดือนก่อน +5

    I just have to say, I LOVE the rainbow glasses!

  • @BozackZodiack
    @BozackZodiack หลายเดือนก่อน +2

    This was both a very well produced and SUPER interesting video - thank you for this!!

  • @oiartsun
    @oiartsun หลายเดือนก่อน +3

    I was born and raised in California, I've lived here my whole life, and particularly in my childhood I spent plenty of time outdoors. However, much to my chagrin, I have suffered my whole adult life from allergies, specifically to the plants in my home state. It's an unfortunate reality for me, because as a baby I also suffered from several food allergies that my parents managed to rid me of through the kind of incremental exposure described in the video. But the plant allergies just won't go away. I have to take Cetirizine Hydrochloride every day and Astepro for the especially bad days.

  • @elmsfu
    @elmsfu หลายเดือนก่อน +15

    Always love the videos! Just retold all this to my partner.
    Minor nit: all the timeline dates seem off by a decade starting at 4:18 (eg 1546 is between 1540 and 1550)

    • @AthAthanasius
      @AthAthanasius หลายเดือนก่อน +3

      Yeah, whoever did that bit of graphic design was clearly not even trying to be accurate with those placements. Nnnnngggggg.

  • @falsificationism
    @falsificationism หลายเดือนก่อน +5

    I'm confused. The presenter stated "the hygiene hypothesis is outdated," but then went on to essentially explain that we need "old friends" which sounded a LOT like the hygiene hypothesis.
    Can anyone in the comments clarify?

    • @Insan1tyW0lf
      @Insan1tyW0lf หลายเดือนก่อน +12

      The ideas are similar, but apparently the "hygiene hypothesis" was primarily concerned with our reduced exposure to _harmful_ microbes, where the "old friends hypothesis" is primarily concerned with our reduced exposure to _harmless_ microbes.
      As I understand it, the older idea was that with fewer dangerous targets to attack, the immune system started to attack more non-dangerous targets (a sort of "fewer safe outlets for aggression" or "disproportionate aggression"). The more recent idea seems to be that with less exposure to neutral or friendly microbes, the immune system becomes more likely to misidentify harmless things as hostile ("insufficient socialization").

    • @falsificationism
      @falsificationism หลายเดือนก่อน +2

      @@Insan1tyW0lf Very clear explanation, thank you! Still sounds like the behavioral takeaway is pretty common sense. I hate when people try to overdo it on the technical distinctions.
      1) Don't expose yourself to harmful microbes, because yeah...don't randomly try to microdose syphilis.
      2) Cultivate a diverse microbiome. I imagine this includes spending plenty of time in nature, eating diverse plants, etc.
      Anyway, thanks again, this was great!

  • @ByNextus
    @ByNextus หลายเดือนก่อน +3

    Well, here is another thing. In my childhood, I had two cats. Both of them were completely fine to me. However, once the first one died, and the second died of poisoning, I developed allergies later on. The thing is, for the past years, I have had a very difficult life. I was very stressed physically and mentally. So I suppose the stress changed my body - it took away from my life the animals that I loved. The same went for dogs, btw.
    It turned out that I had allergies to dust mites, too. But this case is weird because, as a kid, I did not wanna bother cleaning my desk from dust. Yet, here I am.

  • @oofbih6397
    @oofbih6397 หลายเดือนก่อน +3

    I love this video and the vibes of the production

  • @IanGrams
    @IanGrams หลายเดือนก่อน +2

    Dang, that conversation with Dr. Lack was insightful. I had never heard the "skin before gut" idea before but it sure makes a lot of sense. Though, no one tell the homeopaths about that peanut allergy treatment or we'll never hear the end of it 😜
    I had never heard of the relationship between eczema and food allergies either. I suppose I should count myself lucky I didn't develop eczema until 10 or so because I also don't have any food allergies.
    Thanks for another excellent episode!

  • @samuelpaulini
    @samuelpaulini หลายเดือนก่อน +1

    Thanks for this episode!

  • @Imperiused
    @Imperiused หลายเดือนก่อน +2

    This was so good. The Eczema revelation blew my mind!

  • @Enn-
    @Enn- หลายเดือนก่อน +1

    Thanks! This is great info.

  • @wasabiapple2924
    @wasabiapple2924 หลายเดือนก่อน +2

    Awesome video! I gotta shout out to the video editor, Claire! Fantastic job!

  • @CAMacKenzie
    @CAMacKenzie 8 วันที่ผ่านมา +2

    This "old friends" hypothesis and the hygene hypothesis seem very similar to me, indeed, "old friends" is almost exactly as I had understood the hygene hypothesis.

  • @mascadadelpantion8018
    @mascadadelpantion8018 หลายเดือนก่อน +7

    Beautiful Intro to a video I just love animals

  • @Trask899
    @Trask899 หลายเดือนก่อน

    Another well made, informative, and fun video in this series! Also, shoutout to the video transitions, very creative haha.

  • @kiltedpiper98
    @kiltedpiper98 หลายเดือนก่อน

    Outstanding episode! Learned a lot, enjoyed the humor. Keep em coming

  • @dosadnizub
    @dosadnizub หลายเดือนก่อน +7

    I always thought that the immune system is a bit like neutral networks, with adrenaline acting as "temperature",
    The more the organism is hyped up, it'll hallucinate more, and basically do any different kind of autoimmune shenanigans

  • @Cuddly-Cactus
    @Cuddly-Cactus 23 วันที่ผ่านมา +1

    As a life-long pollen allergy sufferer, I can say that I was definitely exposed to a lot of pollen, especially as a little kid, I grew up in New England and still reside there, and every single spring and summer I ran around outside barefoot much of the time.
    So being a free range kid back in the days when parents actually told kids, what are you doing inside? Go outside and just be home in time for dinner! And I didn't even need to be told that since I was lucky enough to grow up in a place with ample front and backyards so whenever it wasn't down pouring or snowing heavily I was taking my shoes and socks off and running around outside enjoying climbing trees and picking flowers that were abundant on my property.
    So it just never made any sense to me whenever someone said that the reason my body is allergic to pollen is because I wasn't exposed to it enough as a kid, since quite the opposite is true. Besides even if I grew up in a more urban area, pollen counts are still high in cities as well as more rural areas.
    There is another fascinating video that delves into the reasons behind some of the most common allergies and it describes a link between venom and other toxins evolving into allergies. This theory makes the most sense and it has to do with the way we humans have evolved. Wish they mentioned that here.

    • @cjsard4678
      @cjsard4678 16 วันที่ผ่านมา

      I think this was more of a look at allergies developed in childhood. It doesn't fit in with my food allergy I developed in my mid-teens, after I know I had eaten that food before. But it is interesting to me about the correlation with eczema, which I also developed not long after my allergies did.

  • @manhurter
    @manhurter หลายเดือนก่อน +2

    Very informative.

  • @mostlyvoid.partiallystars
    @mostlyvoid.partiallystars หลายเดือนก่อน +3

    Omg when you rubbed face on cat I was cringing so hard haha. I mean I don’t have the same cat allergy but if I did that with juniper I’d be miserable for weeks!

  • @MadScienceWorkshoppe
    @MadScienceWorkshoppe หลายเดือนก่อน +1

    Very interesting stuff! This my have given some insight into how certain issues crept in around the time I started working in food prep.

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 หลายเดือนก่อน +1

      Some commercial disinfectants used in the food industry contain quaternium ammonium compounds (quats) that can cause occupational asthma and allergic sensitization.

  • @youtou252
    @youtou252 หลายเดือนก่อน +2

    not just my body : my mind too

  • @OrianJamieson28
    @OrianJamieson28 26 วันที่ผ่านมา

    loved this episode!

  • @MxOshy
    @MxOshy 23 วันที่ผ่านมา +1

    I would love to watch an episode about adult onset allergies.
    Also, love the Noo Works

  • @corlisscrabtree3647
    @corlisscrabtree3647 หลายเดือนก่อน

    Thank you 🙏

  • @elr5475
    @elr5475 หลายเดือนก่อน +1

    Love this presenter ❤️

    • @pt8077
      @pt8077 หลายเดือนก่อน

      She’s so adorable and smart of course.

  • @windlessoriginals1150
    @windlessoriginals1150 22 วันที่ผ่านมา

    Thank you

  • @sas5076
    @sas5076 หลายเดือนก่อน

    Holy moly, wow! Thank you!

  • @briebel2684
    @briebel2684 หลายเดือนก่อน +1

    I have a ton of environmental allergies, including cats, dogs, horses, grass pollen, rag weed pollen. Most of those allergies were greatly reduced by therapy shots. The cat allergy was the only one that resisted the therapy. I did grow up out in the country around 2 cats, and it certainly didn't help. 🤷‍♂️
    Also had an anaphylactic reaction to Candy Corn when I was 10. The allergy doctor thought it was probably Yellow #5 (tartrazine). To this day I have to avoid anything with yellow 5, otherwise I get major intestinal distress if eaten, or rashes if in shampoo or soap.
    Ironically, no allergies to nuts or shellfish. 🤷‍♂️🤣

  • @Beryllahawk
    @Beryllahawk 27 วันที่ผ่านมา

    Great video!

  • @smiththewright
    @smiththewright หลายเดือนก่อน

    Great video! ☀

  • @StarLightNow
    @StarLightNow 20 วันที่ผ่านมา

    Fantastic stuff

  • @bjdefilippo447
    @bjdefilippo447 27 วันที่ผ่านมา

    Fascinating info, especially the skin's role in immune responses.

  • @erikb3799
    @erikb3799 24 วันที่ผ่านมา +1

    The "old friends" and "too much clean" models seem basically the same. The "old friends" sound a lot like germs that are lacking in the "too much clean" model.

    • @cjsard4678
      @cjsard4678 16 วันที่ผ่านมา

      It's definitely more of a connotation thing. Instead of focusing on the part where you aren't getting enough of the bad germs for your immune system to fight, it's more about not getting enough exposure to things that are good for you in a way that doesn't make your immune system freak out thinking it's gonna kill you.

  • @miguelsilva-bb4wk
    @miguelsilva-bb4wk หลายเดือนก่อน +1

    You have been killing it with this production quality and editing style!

  • @Tala-ft1dl
    @Tala-ft1dl หลายเดือนก่อน

    I Like this video and I need a lot of it! Please make more 💙🤝🏻

  • @jedimindfrak82
    @jedimindfrak82 หลายเดือนก่อน +5

    Maren is just the best science educator on TH-cam.

  • @CCSMrChen
    @CCSMrChen หลายเดือนก่อน

    This video has an Answer in Progress vibe to it. Especially the scene in front of a projector.

  • @DragonFae16
    @DragonFae16 หลายเดือนก่อน

    What I'd be interested in is research into allergies and intolerances that seemingly spontaneously appear in adulthood. In my case, I developed a pepper and dairy protein allergy in my late 20s, likely triggered by a medication that seriously messed with my digestive system. Most of the effects recovered after I stopped that medication, but these two allergies have remained even though it's been a number of years since.

  • @ioresult
    @ioresult หลายเดือนก่อน

    Hey Maren, missed you!

  • @rapturesrevenge
    @rapturesrevenge หลายเดือนก่อน

    This was fascinating! Thank you so much for looking into this and presenting it! I have environmental allergies that developed over time. I'm even allergic to my own cats! Since Hell would have to freeze over before I ever give up having kitties in my life, I always figured I'd just have to suffer with the runny, itchy eyes and nose, the sneezing, and the horrifically itchy skin for the rest of my life. Now, I was recently diagnosed with eczema (after years of just being told I was itchy because I have "dry skin"), so maybe I'll bring this video up whenever I go see an allergist.
    Again, thank you so, so much for presenting this. I never knew allergies were this complex. Also, thank you for giving me hope that one day, I will be able to live without itching, sneezing, and using an entire box of Kleenex in three days. Maybe it will make colds, the flu, and other respiratory illnesses less intense, too. :)

    • @catc8927
      @catc8927 หลายเดือนก่อน +1

      I definitely recommend going to see an allergist if you haven’t already. Allergy shots combined with helpful lifestyle changes (HEPA filters, how to do laundry to kill dust mites, etc) have made springtime more bearable for me, and a box of Kleenex now lasts me months. I still have pretty intense upper respiratory reactions when I do get sick, sadly, but my reaction to mosquito bites calmed down a ton after I began regular allergy shots.
      Allergists are aware of the correlation with eczema and asthma, and will screen you for all three (the “atopic trio”), since having two makes having the third even more likely.

    • @rapturesrevenge
      @rapturesrevenge หลายเดือนก่อน

      @@catc8927 yeah I do laundry weekly, run the vacuum 2-4 times a week, and run an air purifier in my room. My room is easily the cleanest in the house since I spend most of my time there. The rest of the house needs a good deep clean, and I will be wearing goggles, an N95 mask with a bandana over that, a light junk hoodie, and long pants, just like I do when I go outside to mow. When I'm done, the mask goes in the trash, clothes go in the wash, and I jump in the shower.
      Guess I just have to bite the bullet and go get tested.

  • @AnimeShinigami13
    @AnimeShinigami13 28 วันที่ผ่านมา

    I love that the hygene hypothesis basically got an update with the old friends hypothesis. Also this video reminded me to get out the ergonomic mousepad I bought to keep something on my desk from triggering eczema in my wrist. >.> also guess where I get eczema? MY FINGERS!!!! 😭😭😭😭😭😭

  • @kyt-nh1ef
    @kyt-nh1ef หลายเดือนก่อน +4

    I'm severely allergic to cats to the point of allergic asthma
    I have 3 cats
    🙃

  • @seatbelttruck
    @seatbelttruck 17 วันที่ผ่านมา

    This is all really interesting. I wonder how adult onset allergies work, though. I had skin allergies as a kid, but didn't have any noticeable respiratory allergies until I reached adulthood. It seems like quantity of exposure might be at play for me, since I developed a cat allergy while regularly volunteering at a shelter, and pollen counts have been increasing due to global warming. I've also had a skin allergy to grass since I was a baby, and now I suspect the pollen that I'm allergic to may be grass, due to pollen counts on days when my allergies were particularly bad, so that could just be an evolution of the original allergy. Still, I lived with cats for over a decade before I had any signs of allergies, which just seems strange to me (though I didn't have regular exposure as an infant).

  • @SadisticSenpai61
    @SadisticSenpai61 หลายเดือนก่อน

    The interesting thing is that the "ppl aren't exposed to enough germs these days" crowd is _almost_ right. They're just wrong about exactly what it is that kids need to be exposed to - kids need to be exposed to allergens.
    It also explains why my mom is mildly allergic to cats, but both my brother and I have no allergies whatsoever to cats. We have had cats ever since I can remember. I know I've eaten and drank cat hair plenty of time both when I was young and probably even today.

  • @thatawesomegeekykid
    @thatawesomegeekykid หลายเดือนก่อน

    What about allergies that are acquired? I hung out with cats on a regular basis growing up, but suddenly, in my mid 20s, I couldn’t be around them for more than 5-10 minutes without an allergic reaction.

  • @iamarizonaball2642
    @iamarizonaball2642 หลายเดือนก่อน

    Hello! Bit of an odd question but… I’ve been trying to raise awareness about cacti’s extinction crisis by rping as a saguaro online for over 3 years now.

  • @nerikzniek5922
    @nerikzniek5922 22 วันที่ผ่านมา

    Been doing sublingual immunotherapy for cat and dog allergies before I started I had asthma but now I have a puppy

  • @AnitaLife27
    @AnitaLife27 13 วันที่ผ่านมา

    It’s NOT cat HAIR. It’s the cat’s chemistry. A hairless cat would make me react the same way.

  • @RXP91
    @RXP91 หลายเดือนก่อน

    So I've been sleeping with a HEPA filter on for a while & my hayfever has definitely improved this year.

  • @xpatrstarx
    @xpatrstarx หลายเดือนก่อน +1

    Thanks pbs. Now i will start my cat hair diet. Not looking forward to the hair balls but would love to snuggle my fur babies

  • @veronicapelli2945
    @veronicapelli2945 หลายเดือนก่อน

    Cute cat!!!

  • @DJofSparta
    @DJofSparta หลายเดือนก่อน

    Wow, I had environmental allergies years ago and I also have eczema. I was curious if there was a connection. I pretty much couldn't avoid dust and pollen so I guess I eventually dosed myself into immunity. Although I grew up loving shrimp and now as an adult I'm allergic. :\

  • @deawinter
    @deawinter หลายเดือนก่อน

    I was glad to hear that they are putting a particular focus on detecting eczema on dark skin. Especially because if it can detect eczema on a black person it 100% also could on my pasty-ass skin tone.

  • @i18nGuy
    @i18nGuy หลายเดือนก่อน +2

    If not being exposed to peanuts early on leads to allergies, what about having parents with particular diets? For example, vegan parents so the child is not exposed to eggs. Will they later have allergic reactions to non-vegan environments? What is it about peanuts that makes the body react whereas other objects not experienced in childhood do not have the same effect?

    • @Insan1tyW0lf
      @Insan1tyW0lf หลายเดือนก่อน

      I expect there's a lot more going on than just "were you exposed early enough to [specific food]", or else we'd all have a lot more allergies.
      How many kids drink coffee? There are lots foods or other potential allergens we won't be exposed to until later in life for many reasons, yet we won't react to the vast majority of them.

  • @maolcogi
    @maolcogi หลายเดือนก่อน

    Love the idea of infinite wealth and just doing science. I used my GI bill to try and get a degree in physics, I got up to Physics 2 and Calculus 2 but ran out of money, at least I got an AA. I had an actual dream not too long ago that I won a hundred million dollars and just lived off the interest on it just living life as a career student. What a glorious dream.

  • @minaballerina
    @minaballerina หลายเดือนก่อน +1

    i had a cat as a young kid and the developed a cat allergy in my teens 😭

  • @asandstorm
    @asandstorm หลายเดือนก่อน

    So how do we get the word out about preventing/treating allergies based on the new findings?

  • @ZeMarkKrazee
    @ZeMarkKrazee หลายเดือนก่อน

    Interesting! I was a pretty adventurous child and have a high number of allergies, but, oddly, none to food. Not sure what happened there haha. Also, please note the C in eczema (not eGGzema). 👍🏻

  • @palantir135
    @palantir135 หลายเดือนก่อน

    Not every reaction of your body has to be an allergic one. You can also be oversensitive to a certain substance. I for example am not allergic to pollen (it has been tested) but I developed more or less the same symptoms like sneezing, sore throat etc. when I come in contact with certain pollen. I heed the same drugs as for hai fever.

  • @carolc.776
    @carolc.776 หลายเดือนก่อน

    So glad i dont have allergies or am allergic to anything that i know of. Im 40 so i think i am good.

  • @DrachenGothik666
    @DrachenGothik666 10 วันที่ผ่านมา

    This was an interesting episode, though I admit I kept getting distracted by her rainbow glasses because I have a pair that look almost the exact same. Slightly different shape & mine have an embossed pattern on upper frame & arms, where hers don't, but otherwise identical. Cool beans. I'm _such_ a magpie, easily distracted. Derp.

  • @MatthewCaban
    @MatthewCaban หลายเดือนก่อน

    Drug Desensitization in a hospital setting is quite interesting as well

  • @LiiMuRi
    @LiiMuRi หลายเดือนก่อน

    I have pollen allergies, and when I was younger also food allergies to apples, tomatoes and such, probably due to a cross-allergy with the pollen. I got itchy mouth when I ate the foods that caused the allergy, but nothing more serious than that. However, I kept eating those things, even though it sometimes was very annoying for the following hour or so due to the itchiness. Today I have no food allergies any more! The pollen allergies persist, maybe I should start eating pollen 🤔 (Note: I don't suggest anyone with dangerous food allergies to start self-experimenting with desensitization, it can be dangerous)

  • @1One2Three5Eight13
    @1One2Three5Eight13 หลายเดือนก่อน

    Question as to why Chu et al from 2019, the survey paper looking at oral immunotherapy studies for peanut allergies that found that it didn't have a positive effect, wasn't mentioned. Was there a problem with the study that makes it not relevant to Dr. Lack's comments on peanut allergies, or is he just continuing the work from that paper, looking for the "safer peanut allergy treatment approaches"?

  • @robynkolozsvari
    @robynkolozsvari หลายเดือนก่อน +2

    so not actually important but it caught my eye- what's going on with the timeline visuals? you put 910 CE before 900 CE, 1546 after 1550, what is happening?

    • @johnalbin
      @johnalbin หลายเดือนก่อน

      Yeah it was super distracting.
      I’m worried that AI was used to make these visuals because they haven’t learned that AI makes “reasonable-looking” art, text and graphics; AI does not make _factual_ art, text and graphics.

  • @okkasannan3283
    @okkasannan3283 15 วันที่ผ่านมา

    So, to get rid of the cat hair allergy, you just got to eat cat hair from time to time, gotcha

  • @BarbarosaAlexander
    @BarbarosaAlexander 18 วันที่ผ่านมา

    And now it's ALL been disproven by someone with an internet connection and a disproportionate love of kale smoothies.

  • @Dungeon_Dunce2011
    @Dungeon_Dunce2011 หลายเดือนก่อน

    You said that allergies happen when the first time you interact with something that's when you could get the allergy.But I only develpoed my allergies at the age of 10 or so, after a long time of playing outside and playing wioth dogs as a kid. Could you explain this please? To be spefific, I have pollen and fur allergies.

  • @sirjimmy71
    @sirjimmy71 18 วันที่ผ่านมา

    I haven't read all the comments, so I don't know if it's already been asked -- does this mean we can ingest orally small doses of poison ivy and acquire immunity to it? Or is the reaction to poison ivy a different type of bodily response?

  • @Xo1ot1
    @Xo1ot1 หลายเดือนก่อน +1

    Nice glasses.

  • @SubtleMischief
    @SubtleMischief หลายเดือนก่อน

    Thanks for a fantastic video!
    All hail the Algorithm!

  • @AnitaLife27
    @AnitaLife27 13 วันที่ผ่านมา

    “What Causes Symptoms of Cat Allergies?
    About 10% of the U.S. population has pet allergies, and cats are among the most common culprits. Cat allergies are twice as common as dog allergies. But contrary to what you might think, it's not the fur or hair that's the real problem. People with cat allergies are really allergic to proteins in the cat's saliva, urine, and dander (dried flakes of skin). You're also more likely to have a pet allergy if someone else in your family also has one.”
    WebMD

  • @jessiboyer7309
    @jessiboyer7309 หลายเดือนก่อน +3

    Why does my cat chatter at me every time I sneeze? Is he mocking me?

    • @DrewSprague1218
      @DrewSprague1218 หลายเดือนก่อน +7

      Probably not. He's probably worried about you and is chattering a "you good?" after you sneezed

  • @LS-xy7zt
    @LS-xy7zt หลายเดือนก่อน

    My cat hates when I sneeze too! He glares at me and chatters.

  • @benedixtify
    @benedixtify 21 วันที่ผ่านมา

    A good excuse to send yourself to Paris...

  • @timothygreer188
    @timothygreer188 14 วันที่ผ่านมา

    Does this mean if we lick a cat, little by little, we can grow immunity? Not sure I'm ready for the hairballs

  • @SahilP2648
    @SahilP2648 หลายเดือนก่อน

    I might be wrong about this but for some reason in this video the left audio channel volume is lower than the right. Some editing mistake which got overlooked I think.

  • @AnirudhTammireddy
    @AnirudhTammireddy หลายเดือนก่อน +1

    My bad for thinking host is bad preemptively. Good presentation!

  • @engir63
    @engir63 หลายเดือนก่อน +1

    I am like her with cats only worse. I love long hairs but my eyes turn red and swell up and I sneeze uncontrollably after being around a cat for any amount of time and being in a home with a cat even without the cat present is no better.