Sir, thank you for making these videos... thick books like vasudevan become so much easier to understand once you give a concise overview of the important topics.
Sir , you are such a blessing for us. Thank you , Thank you , Thank you very much for your efforts and for giving us your precious time. Thanks a lot. 😊😊
Sir you have helped me cover the syllabus just before the exam Thank you so much 🙏🏻 Please do come up with videos on topics not covered on every 3-4 days U R A BLESSING ♥️
Thank u so much sir u have eased the biochemistry for us . Whenever I opened the book and got flattered first I have in mind is ur videos . Thank u so much once again
Sir if oxaloacetate is depleted and tca cycle cannot occur so acetyl coA is diverted towards ketone body synthesis then how during ketone body utilization can acetyl coA give 20 ATP by entering into tca cycle if tca cycle is not even operating?
Doubt..🙋♂️-as the liver has Glut-2 glucose transporter....and glut 2 is independent of insulin...then how does the DM causes lipogenisis,where the glucose can be uptaken by liver through a passive process...!!??🤔🤔
Who ever is watching this video....... Pay more attention on what sir is speaking than u pay on crush .............. N note down what sir is writing on board....... After 12 min u'll b confident to give even sminar on this topic....... 👍
Sir if tca cycle is not happening then how in energetics from two molecules of acetyl coa 20 atp is forming. There is lack of Oxaloacetate and the main reason for ketone bodies synthesis is diversion of tca cycle due to unhandling of acetyl coa by tca cycle?
Sir I have a doubt At 10.06 u say that 1 ATP is utilised but where?? And when succinyl CoA converts into succinate 1 GTP is formed which inturns form ATP , so why r u not calculating it
Sir, You started with TWO acetyl COA molecules and ended up with TWO acetyl COA molecules, already excess acetyl COA leads to ketone production but in the end of the ketone utilization process acetyl COA concentration remains the same , HOW THIS WORKS ?
Thank you so much for this explanation! I am doing a paper on the keto diet's effects on cellular respiration and I notice you mention only starvation and uncontrolled diabetes as conditions that induce the synthesis and utilization of ketones. Is it the same process for someone eating a diet of say no more than 20g of carbohydrates a day to induce ketosis?
Sir that means we can say in Diabetes Mellitus type 1 there in increase of glucose level outside the cell nd decrease of glucose level inside the cell???
Acetoacetate to beta OH butyrate is occurring in the presence of beta OH butyrate dehydrogenase but there is addition of hydrogen occur but sir you use dehydrogenase , i hope u answer this question.
In starvation, glucose in the body is low. So glycolysis does not occur, because there is no glucose to be broken down. So no pyruvate is formed and as a result OAA which is derived from pyruvate by action of Pyruvate carboxylase is not formed. Hence there is insufficiency of OAA and acetyl CoA cannot enter TCA cycle so it goes into ketogenesis.
Here 2 acetyl coA are produced. Each acetyl coA when undergoes TCA cycle generates 10 ATP. So, 20 ATPs are generated like this and according to sir 1 ATP is utilized to activate acetoacetate to acetoacetyl CoA. Hope it helps..
And the enzyme beta OH butyrate can make the beta OH butyrate from acetoacetate and also make acetoacetate from beta OH butyrate , how ? Dear sir i hope u answer this .
Sir your lecture is short , and cover all things on that topic , your lecture save our time , thank you so much sir , for supporting students.
Sir, thank you for making these videos... thick books like vasudevan become so much easier to understand once you give a concise overview of the important topics.
Sir me Pakistan ce hn ap boht acha lecture dety hy hr chez clear ho gati ha
Helps for PharmD students too. Thank you Sir!
Good 👍
Sir....u r awesome ..sir ....thank u ...u r a great teacher
Sir , you are such a blessing for us. Thank you , Thank you , Thank you very much for your efforts and for giving us your precious time. Thanks a lot. 😊😊
Sir you have helped me cover the syllabus just before the exam
Thank you so much 🙏🏻
Please do come up with videos on topics not covered on every 3-4 days
U R A BLESSING ♥️
Thank u so much sir u have eased the biochemistry for us . Whenever I opened the book and got flattered first I have in mind is ur videos . Thank u so much once again
Excellent lectures on all major topics of biochemistry
Previous year old paper dekhiye
th-cam.com/video/SMcinO3TMKM/w-d-xo.html
Sir your method of teaching is awesome
Thank you so much sir, because of u only I was able to get good mark in biochemistry of my University exam
I thought ketone bodies is a tough topic but it is very simple...
Sir you also teach very nice..
Thanks
Pregnancy unavallki ketone vosthe how
How can it slow Positive is vosthe yella chepandi
Where is 1 ATP utilized ? Why did we substract 1 from 22.5?
Activation of acetoacetate to acetoacetyl CoA required 1 ATP
Oh understood. Thanks sir
Thanks 🙏🙏🙏
@@dr.nancychauhan in beta oxidation activation of fatty acids to fatty acyl coA will consume two ATP right ? Then why here one ATP only ??
@@thescienceelixir3354 that are different reactants They are fatty acids
And here acetoacetate so Different
Simply fabulous lecture sir. Enjoyed and understood fully💯
great help as always ,very informative and precise .excellent sir
Sir u r the hero of biochemistry..... keep up ,,,,
Best and precise explanation thank uh sir! Keep going..keep guiding us!
Beautifully explained 👏 👌 ❤
Sir where is 1 ATP consumed?
Hmm red
@@drtomboycool5723 where?
@@aarya2285 conversation of acetoacetate to acetoacetyl CoA
It's simply an awesome lecture sir. Thank you ❤️☺️
Amazing way to elaborate the topic....
Thank you soo much for help ❤️
Sir if oxaloacetate is depleted and tca cycle cannot occur so acetyl coA is diverted towards ketone body synthesis then how during ketone body utilization can acetyl coA give 20 ATP by entering into tca cycle if tca cycle is not even operating?
Very clear explaination.
Doubt..🙋♂️-as the liver has Glut-2 glucose transporter....and glut 2 is independent of insulin...then how does the DM causes lipogenisis,where the glucose can be uptaken by liver through a passive process...!!??🤔🤔
Glucose uptake by liver is possible but other cells of body which transport through insulin dependent transporter can't get sufficient glucose
I just became a fan of your teaching sir💖💖💖💖💖💖
Sir why should we substract 1 ATP from 22.5 ATP in utilization
Plss clear my doubt
Activation of acetoacetate to acetoacetyl CoA require 1 molecule of ATP
Thanks a lot sir ......... Always be a fan of you sir ❤️ .
Who ever is watching this video.......
Pay more attention on what sir is speaking than u pay on crush ..............
N note down what sir is writing on board.......
After 12 min u'll b confident to give even sminar on this topic....... 👍
Sir during utalization of ketone bodies in which step one ATP Are used ?
Sir could you please explain energy supply briefly....
Thank You Sir 🙏🙏Great Explaination 🙂😇
Thanks, wonderful lecture...
Sir I'm Muslim from Pakistan...but really i love your lectures ❤....
Salam from 🇵🇰🇵🇰🇵🇰
Sir if tca cycle is not happening then how in energetics from two molecules of acetyl coa 20 atp is forming. There is lack of Oxaloacetate and the main reason for ketone bodies synthesis is diversion of tca cycle due to unhandling of acetyl coa by tca cycle?
May be the succinate derived frm activation of acetoacetate produces OAA which revives tca cycle ...... I'm thinking..........?????
@BiochemistrybyDrRajeshJambhulkar sir energetics i didnt understand...1 ATP is utilised where?
I’m rocking here in russian medical college, Watching your lectures🎉
Thank you sir ...... ur teaching is awesome sir🤩
Excellent sir,,,and thanks
Awsm lectures...
Thank u so much sir... ❤️❤️
Sir you explained it in a very easy way,
Made easier to understand
Really A Big thanks to you❤❤
Where are you from swaliha khan?
Bahot level Hy apka sir g
Thank you for helping me pass my exams 😭🙏🙏
Previous year old paper dekhiye
th-cam.com/video/SMcinO3TMKM/w-d-xo.html
Sir I have a doubt
At 10.06 u say that 1 ATP is utilised but where??
And when succinyl CoA converts into succinate 1 GTP is formed which inturns form ATP , so why r u not calculating it
Very clean explanation and short 😀
Excellent video
Sir exam ke liye asaan kr Diya aapne sb 🔥🔥🔥
Previous year old paper dekhiye
th-cam.com/video/SMcinO3TMKM/w-d-xo.html
Sir, during ATP production from Ketonebodies, where one ATP is utilized?
Krebs cycle me utilise hoga during succinyl coa to succinic acid
Sir where is that one ATP utilised in beta hydroxy butyric acid utilization
It is used in the activation of acetoacetate to acetoacetyl coA
Sir awesome video...keep making videos sir ....these videos are helping me a lot .
Sir you subtracted 1 ATP in ketone body utilization.. Where is the one atp used up in the pathway sir?
Sir you are a blessing ♥️
Thank you very much sir 🙏🏻👍🏻👍🏻
10:13 what about succinate will it not enter into tca cycle to produce atp
Medical physiology pr bhi videos bnaye sir G...
Previous year old paper dekhiye
th-cam.com/video/SMcinO3TMKM/w-d-xo.html
Well understood Sir. Are there instances when the brain cells catabolyse Ketone bodies to get ATPs
Tell about it's regulation...i cant understand regulation.....plz..give answer..sir..
Supperb explanation ❤ thank you sir
Your teaching is marvelous sir 🙏
Sir,
You started with TWO acetyl COA molecules and ended up with TWO acetyl COA molecules, already excess acetyl COA leads to ketone production but in the end of the ketone utilization process acetyl COA concentration remains the same , HOW THIS WORKS ?
I think the Acetyl COA will enter TCA cycle which will break them down.
That acetyl coA will enter kreb's cycle further ETC and produce energy
Thank u sooo mch sir❤
It helped us a lot..
Thank you so much for this explanation! I am doing a paper on the keto diet's effects on cellular respiration and I notice you mention only starvation and uncontrolled diabetes as conditions that induce the synthesis and utilization of ketones. Is it the same process for someone eating a diet of say no more than 20g of carbohydrates a day to induce ketosis?
Great explanation sir
You are great sir great 😃👍
The concept is so simple and clear….. thank you sir 👍🏻👍🏻👍🏻
Sir that means we can say in Diabetes Mellitus type 1 there in increase of glucose level outside the cell nd decrease of glucose level inside the cell???
Thank u sir ......nice teaching 💖💖💖
Previous year old paper dekhiye
th-cam.com/video/SMcinO3TMKM/w-d-xo.html
Aceto acetate to B-oh butarate why enzyme dehydrogenase it should be reductase right?
Great job
I wish i was a student in ur class sir . Very simple method to learn such hard topic . Thank u sir❤❤❤
Where we utilize 1 atp sir🤔 in 10.12⏳
Sir why minus 1 is done from net atp??
Brilliant JazakaAllah sir stay blessed
Sir, I have a doubt - acetyl coa is the first compound in ketogenesis. Then it can be directly converted to glucose via tca cycle???
Acetyl CoA is completely oxidised into 2CO2 in TCA cycle
sir, you explain every topic very simple way, thank you so much sir 🇧🇩
Ur very great sir.
Ketone bodies synthesis jab glucose level kam rahta tab hota hai but incase of diabetes mellitus glucose level toh increase rahta hai toh k.B kaise synthesis hongi ???plz explain
Where we use one atp sir
You minus that one atp🤔
Thanks a lot for making this easy..... doctor why oxaloacetate is deficient in diabetes mellitus ?
Glucose can't be utilized by cell.because of defective glucose uptake by cells.
Ok doctor thanks 👍
Lipid metabolism chapter seemed to be tough to remember. But it is cleared thanks to your explanation. Thank you Sir.
Acetoacetate to beta OH butyrate is occurring in the presence of beta OH butyrate dehydrogenase but there is addition of hydrogen occur but sir you use dehydrogenase , i hope u answer this question.
Adada Arumai arumai💐
3:40 why there is absence of oxaloacetate
In starvation, glucose in the body is low. So glycolysis does not occur, because there is no glucose to be broken down. So no pyruvate is formed and as a result OAA which is derived from pyruvate by action of Pyruvate carboxylase is not formed. Hence there is insufficiency of OAA and acetyl CoA cannot enter TCA cycle so it goes into ketogenesis.
@@___s___8071 can u please explain the energetics
Thank you so much sir👍🏻☺️
Sir good explanation
Excellent video, but where is 1 ATP is utilized sir
Thank you 😊
Why liver tissue can't utilizes ketone bodies...?
Plz reply
Thiophorase required for utilisation of KB absent in liver
@@Rajesh_Jambhulkar thank you sir
in satyanarana book. 1st enzyme is beta Ketothiolase and u write only thiolase.. please guide sir. where m i mistaken to understand?
Both correct
Thank u sooooooooooo much sir 🙏🙏🙏🙏🙏🙏🙏🙏🙂
Sir how 20ATPs are generated and where 1ATP is utilized ,I can't understand sir please clarify me sir
Did you find out ?
Here 2 acetyl coA are produced. Each acetyl coA when undergoes TCA cycle generates 10 ATP. So, 20 ATPs are generated like this and according to sir 1 ATP is utilized to activate acetoacetate to acetoacetyl CoA. Hope it helps..
Where did 1 ATP is used, To make it 21.5 ATP's?
Sir it's very helpful
Thank-you so much again
where is one ATP utilised
?
U can find the answer down in the comments 😊
Thanku so much 🙏 sir so helpful
Precursor for ketogenesis is acety coA Or acetoacety coA
Sir why 21.5 ATP is formed where 1 ATP IS UTILIZED???????
???????
And the enzyme beta OH butyrate can make the beta OH butyrate from acetoacetate and also make acetoacetate from beta OH butyrate , how ? Dear sir i hope u answer this .
Reversible reaction using NAD when dehydrogenase. H accepted by NAD from substrate,converted into NADH and H. Hence NAD is a Coenzyme or cosubstrate
Where is the last ATP utilisation occur???
what is the rate limiting step of ketogenesis, Doctor?
HMG coA synthase
HMG coA synthase
Tysm ❤❤❤❤