has this stuff has been gone unnoticed from the mass media??...i am EE engineer and i am speechless.... i have programmed CPLDs with VHDL, equivalent to Verilog and understand all the EE stuff, much less all the DNA/RNA etc on which i have a basic understanding .....i wish i could have participated in such project.....To me it is an historical moment....it is like hearing the angels in the creation collaborating with the Almighty Creator on how to create everything living that exist.....sorry for the pure evolutionist but for me this is one of the best probes that we cannot be the product of random collision of matter but of intentional design!
It is not pure evolution, it is probability and evolution. Billions of years puts everything into a different perspective. I'm not saying there is no God, Creator, or whatever, but that there are building blocks in biology (just like in almost everything else), does not mean anything (at least for me). I dont know why I said this, I know you just told your opinion, I guess so did I.
As what he says, it seems you need to learn embedded system in electrical engineering as well ,in combination with biology and genetics, to build such biological digital circuits. I used the several EE textbooks he shows to get my a** out of college. Wow, you are pursuing 3- 4 majors. Good luck, man!
Can the circuits that are designed be used in cells other than E.Coli? I know the video said that they have used it in yeast and mammalian cells but was wondering if there is an option in the program to switch it to different types of cells ( a tab or drop-down menu, etc). Also, where can one learn the Verilog programming language? Are there are any online/book resources you would recommend specifically to learn the language?
Yes, I know you can transfect animal cells with novel DNA, but given the complexity of the circuits you would have to test that these gates are not interfering with the cell or interfering with other gates when you insert them into a novel cell type.
Wait, so you can only have up to 16 NOR gates? Whereas the Apollo program needs 5600 NOR gates. That's a huge difference. We're still a long way off. Maybe if there's a way to isolate the cells from each other so that each gate won't interfere with the others.
That's an interesting thought. In this case we would also have to insure that they don't conjugate so that the circuits don't eventually get mixed and recombined as it typically happens with plasmids in vivo.
I know it's late, but, for a basic explanation: this isn't a matter of separating cells from eachother, it's a matter of what the inside of a cell is like. Cells are just membranes full of water and biochemicals, all of which have to move rapidly - and randomly - around the cell at all times.
I want to learn more about this field, I am fascinated w/ these limits of understanding and pushing the boundaries through novel approaches such as these. Programmer over here who also enjoys quantum *dynamics, and biology/genetics. Just as how we lay down metals for creating our gates, and the techniques and challenges that arise as our feature lengths reduce, I find it more important being able to understand how dna and rna 'code' build amino acids and the proteins/enzyme building blocks, their *dynamics, and their ... done typing....
(I'm a robots programmer) Can somebody please be so kind and tell me the thing I don't quite understand: For example I need bacteria to swim North if there's electrical current in the environment and swim South if there isn't. How will this signal reach DNA sequence and then reach flagellum and control bacterial movement and orientation in the Earth's magnetic field?
DNA stores the information required to create proteins which function in networks. For your project, you would need to encode in DNA a protein that is sensitive to a particular frequency of the EM. There is a protein by name of cryptochrome found in many flying species that has been theorized to be sensitive to the Earth's magnetic field.
Andrei ierdnA Search google for: Magnetotactic bacteria (or MTB) are a polyphyletic group of bacteria discovered by Richard P. Blakemore in 1975, that orient along the magnetic field lines of Earth's magnetic field. To perform this task, these bacteria have organelles called magnetosomes that contain magnetic crystals.
Andrei ierdnA Магнетосома (бактериальная магнитная наночастица, бактериальная магнитная частица, англ. magnetosome) - мембранная структура бактерий, характерная для обладающих магнитотаксисом бактерий, содержащая монодоменные ферромагнитные кристаллы. Обычно в клетке содержится от 15 до 20 кристаллов магнетита, которые вместе действуют как игла компаса, помогая бактерии ориентироваться относительно геомагнитных полей, и таким образом упрощая им поиск их излюбленной микроаэрофильной среды обитания. Частицы магнетита также обнаружены в эукариотических магнитотактических водорослях, клетки которых содержат несколько тысяч кристаллов.
Absolutely Amazing! I have these questions: How Genomic Science is related to this awesome field?, is it a good starting point to eventually do synthetic biology or exist better approaches (biology?, biotech?, etc) . The reason I am asking this is that here in Mexico we don't have Synthetic biology programs available in Universities BUT we have extremely good Genomic Sciences programs... is it a good fit?... Thank you for your time!
Absolutely. Like they never changed us so we don't take in Mg or Zn or make us vitD deficient etc. Off course they're not weaponising anything, like the Borrelia. Why would those 'god' scientists have bad plans?. Nature was imperfect for them, so they changed it and keep changing it. Try finding nutrious food! Off course nothing bad happens...
So will we be able to program a calculator and a list of all chinese symbols and a translator and download google earth into our brains? That way we wouldn't need to learn that first and we could instead learn more advanced things from an earlier age!
Hands down one of the best explanations of synthetic biology I've ever seen.
The most ambitious crossover event in history.
has this stuff has been gone unnoticed from the mass media??...i am EE engineer and i am speechless.... i have programmed CPLDs with VHDL, equivalent to Verilog and understand all the EE stuff, much less all the DNA/RNA etc on which i have a basic understanding .....i wish i could have participated in such project.....To me it is an historical moment....it is like hearing the angels in the creation collaborating with the Almighty Creator on how to create everything living that exist.....sorry for the pure evolutionist but for me this is one of the best probes that we cannot be the product of random collision of matter but of intentional design!
It is not pure evolution, it is probability and evolution. Billions of years puts everything into a different perspective. I'm not saying there is no God, Creator, or whatever, but that there are building blocks in biology (just like in almost everything else), does not mean anything (at least for me). I dont know why I said this, I know you just told your opinion, I guess so did I.
please continue doing such videos, thank you for sharing your knowledge with us, It is helpful for people in Developing countries
at 16:51 , connecting in series! That's amazing. That can help us make memory blocks on living cells!
and in 20:28, the epic moment! LOL. I'm familiar with the content in that moment. That's actually what I studied.
I promise that this is my last comment, 22:28 , I didn't think there's a way to upload our very own Verilog code
👍
This got me soo interested when I saw this in my biology class.
This is really next level stuff. I am super impressed at how far this has come. Are you worried about how this might be used in a negative way?
Now that's an interesting question considering what's going on in 2020.
@@goingclear2647 Tell me about it.
Think about it in the sense that I asked you this question a month ago.
Do not worry about replying to me. I just wanted to check you for a moment. And I did that. You got the message clear as day.
scientific dreams come true.
I am in Computer Sciences now but now I want to learn biology and genetics as well.
update?
Did you get any direct path to follow?
As what he says, it seems you need to learn embedded system in electrical engineering as well ,in combination with biology and genetics, to build such biological digital circuits. I used the several EE textbooks he shows to get my a** out of college. Wow, you are pursuing 3- 4 majors. Good luck, man!
worth learning biology....
Fantastic explanation.
Amazing !!!
Gated response. (10:45,18:45)
Be interesting to apply this to a bioreactor, ensuring programmable production processes.
Well, that was amazing!! Fast forward three more years and... blown away!
it's been 6 years
I will never see a burrito the same ever again.
Great for research and progress in medicine and many other fields.
science and computer technology intertwined.
Hi, so how far from the finish line are you with the program ?
Hey, thanks a lot for this video! It has really helped me with understanding the related paper. You are making some great progress, keep it up :)
Impressive! Thank you!
Super insightful - thanks so much for sharing!
Is there a video somewhere showing synthetic dna being made and what is the process called.
Can the circuits that are designed be used in cells other than E.Coli? I know the video said that they have used it in yeast and mammalian cells but was wondering if there is an option in the program to switch it to different types of cells ( a tab or drop-down menu, etc). Also, where can one learn the Verilog programming language? Are there are any online/book resources you would recommend specifically to learn the language?
Could this be done with yeast, fungi, protists, insect cells, and mammalian cells? I am mostly wondering about mammalian cells.
Yes, I know you can transfect animal cells with novel DNA, but given the complexity of the circuits you would have to test that these gates are not interfering with the cell or interfering with other gates when you insert them into a novel cell type.
22:21 What do the DNA sequences represent if the "inputs" or sensors are materials such as oxygen, etc.?
22:58 What are the "output" DNA sequences representing as well?
Wait, so you can only have up to 16 NOR gates? Whereas the Apollo program needs 5600 NOR gates. That's a huge difference. We're still a long way off. Maybe if there's a way to isolate the cells from each other so that each gate won't interfere with the others.
That's an interesting thought. In this case we would also have to insure that they don't conjugate so that the circuits don't eventually get mixed and recombined as it typically happens with plasmids in vivo.
I know it's late, but, for a basic explanation: this isn't a matter of separating cells from eachother, it's a matter of what the inside of a cell is like. Cells are just membranes full of water and biochemicals, all of which have to move rapidly - and randomly - around the cell at all times.
bacteries usually oscllates beetween wich Hertz or micro-hertz or Khz ??? I mean the green colored oscillating "walls" ??
I want to learn more about this field, I am fascinated w/ these limits of understanding and pushing the boundaries through novel approaches such as these. Programmer over here who also enjoys quantum *dynamics, and biology/genetics. Just as how we lay down metals for creating our gates, and the techniques and challenges that arise as our feature lengths reduce, I find it more important being able to understand how dna and rna 'code' build amino acids and the proteins/enzyme building blocks, their *dynamics, and their ... done typing....
I wonder thats why we have all those wired multi resistant and super aggressive bacteria, viruses and fungi.
(I'm a robots programmer) Can somebody please be so kind and tell me the thing I don't quite understand: For example I need bacteria to swim North if there's electrical current in the environment and swim South if there isn't. How will this signal reach DNA sequence and then reach flagellum and control bacterial movement and orientation in the Earth's magnetic field?
DNA stores the information required to create proteins which function in networks. For your project, you would need to encode in DNA a protein that is sensitive to a particular frequency of the EM. There is a protein by name of cryptochrome found in many flying species that has been theorized to be sensitive to the Earth's magnetic field.
Andrei ierdnA
Search google for: Magnetotactic bacteria (or MTB) are a polyphyletic group of bacteria discovered by Richard P. Blakemore in 1975, that orient along the magnetic field lines of Earth's magnetic field. To perform this task, these bacteria have organelles called magnetosomes that contain magnetic crystals.
Andrei ierdnA
Магнетосома (бактериальная магнитная наночастица, бактериальная магнитная частица, англ. magnetosome) - мембранная структура бактерий, характерная для обладающих магнитотаксисом бактерий, содержащая монодоменные ферромагнитные кристаллы. Обычно в клетке содержится от 15 до 20 кристаллов магнетита, которые вместе действуют как игла компаса, помогая бактерии ориентироваться относительно геомагнитных полей, и таким образом упрощая им поиск их излюбленной микроаэрофильной среды обитания. Частицы магнетита также обнаружены в эукариотических магнитотактических водорослях, клетки которых содержат несколько тысяч кристаллов.
can you build an abstract bacteria so
doesn't desired circuit interfere with bacterial gene itself?
What is the DNA for the output specifying?
proteins
Thanks for sharing this presentation!
This is what Ginkgo Bioworks does. I wanna work there someday.
Hi. How can we slow a high RNAP flow without accumulate it? Is there any time of back pressure regulator? How is that low level defined? Thanks
Would this be also possible for brain cell DNA.
Yes
you need a vector and the neuron in vivo
19:00 16 non-interfering gates / sets of promoters and repressors - use interference gates and it becomes a biological quantum computer :)
This is exciting, yet it is a whole lot of circuit building than programming itself.
Great Video, thanks a lot!
great talk!
👍👍👍👍 VERY WELL DONE THANKS
Incredible.
Absolutely Amazing! I have these questions: How Genomic Science is related to this awesome field?, is it a good starting point to eventually do synthetic biology or exist better approaches (biology?, biotech?, etc) . The reason I am asking this is that here in Mexico we don't have Synthetic biology programs available in Universities BUT we have extremely good Genomic Sciences programs... is it a good fit?... Thank you for your time!
I mean genomics and synthetic biology are pretty close together, if you know genomics you could easily switch to synthetic biology.
Great!
Lets hope they think BEFORE they do something.
Awesome...I would love to help on this project.
Thanks!!!
im sure theres no possible way for bad people to use this technology in a negative way right?
Absolutely.
Like they never changed us so we don't take in Mg or Zn or make us vitD deficient etc.
Off course they're not weaponising anything, like the Borrelia.
Why would those 'god' scientists have bad plans?. Nature was imperfect for them, so they changed it and keep changing it.
Try finding nutrious food!
Off course nothing bad happens...
very helpful
awesome!!!
Immortality is at hand.
How? 😂
amin zar, perhaps in the future, when editing human genes becomes possible. You can prevent cell decay, aka. Immortality.
safe and effective
Hope this can cure cancer , HIV ,etc ... soon.
Let's start building new systems!
Get your jab & shut up
That's how the Coronavirus got created
Wait what? Then why isn't a cheap bacterial-reaction test aviable for all metabolic diseases detectable trhough the urine? Or am I not up to date?
A new weapon for fighting Cancer cells
A new weapon period.
21:55
7:30
20:40
so awesome T_T
Ozinda
FUck. Thats some awesome shit.
HEll yeah it is! :)
Let us try to reverse engineer an entire human being...that will be great!
Wowwwwww 🙈🙈🙉🙉🙊🙊🙊
if only it was that easy...lol
So will we be able to program a calculator and a list of all chinese symbols and a translator and download google earth into our brains? That way we wouldn't need to learn that first and we could instead learn more advanced things from an earlier age!
i dont like this wet lab stuff. my lab is going to dry all the way to the end! i think its cruel.