Biosignaling | Receptor Desensitization by Beta-arrestin

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[@Desertimpala]

TYSM!! I've been trying to understand this for days.

[@shahardubiner3070]

thank you! that is the clearest explanation i've heard, now it finally makes sense

[@CatalystUniversity]

Thank you, Shahar!

[@rocioflores4155]

Best explanation ever!

[@katiejenkins3399]

Thank you so much! This is so helpful.

[@rouiqa_lab2922]

Thank you so much, this really helped!

[@schobbejak6400]

very clear, like your voice

[@atharvsart8364]

Thank you. Sir, will you please explain about beta blocker gradual withdrawal effect

[@lizb0]

really good and nice explanation if you need a fast overview of the processes. and some extra knowledge as well. thank you very much

[@CatalystUniversity]

Thank you!

[@fontexstudios]

this is not desensitization (of receptrs) in my opinion. Is just the reduction of the number of receptors. This is desentitization of a system, not "receptor desensitization" as in the title. isnt it?

[@nachiketadesai4188]

It can be thought of as receptor downregulation.

[@al8xi8]

thank uuuuuuuu

[@enesgurer]

finally i found non-indian lecturer

[@relaxingpitch3555]

How much time dora it take to bruno back receptora after kong exposure?

[@ansatabassum7007]

in this way we also can read the book

[@alexanderdiederichs7332]

Are GCPRs internalized everytime upon activation?

[@PolochAngriff]

The figure is missing a key part of the process, Protein Kinase A is activated by cAMP following the conversion of ATP to cAMP by the AC which is activated by the dissociated alpha sub unit. PKA activates Bark.

[@devendu4752]

ok

[@fatman9644]

I am not really sure, but wouldnt this result in inhibitory GPCR being unable to be desensitized?

[@royalfrog3958]

Is their a way bring those receptors back up to the membrane or make more receptors to get the same amount of receptors that were there before?

[@MelOloughlin]

They can be reinserted back to the plasma membrane through through dephosphorylation . This is known as resensitization.

[@InquilineKea]

wait so this is involved in addiction??

[@rajashreechakraborty747]

Beta ARK is is Beta Adrenergic Receptor Kinase and not Beta arrestin receptor kinase

[@CatalystUniversity]

You are correct; this is my mistake.