Immunotherapy Side Effects: What Patients Need to Know with Dr. Jeffery Weber
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- เผยแพร่เมื่อ 5 มิ.ย. 2024
- Jeffrey S. Weber, M.D., Ph.D., of NYU Langone Health discusses our current understanding of the side effects that may result from immunotherapy as well as current strategies that are being explored to minimize these potentially harmful side effects and improve the patient experience. #CRIwebinar www.cancerresearch.org/
Dr. Jeffrey S. Weber is the deputy director of NYU Langone Health’s Perlmutter Cancer Center, where he works with a multidisciplinary team of medical and surgical oncologists, dermatologists, and pathologists to treat patients with melanomas ranging from the most common to the most complex.
The "Cancer Immunotherapy and You" webinar series is produced by the Cancer Research Institute and is hosted by our science writer, Arthur Brodsky, Ph.D. The 2020 series is made possible with generous support from Bristol-Myers Squibb, ALkermes, and Foundation Medicine.
Browse our Cancer Immunotherapy and You Webinar Series playlist on TH-cam or visit the Webinars page on our website to see other webinars in this series. www.cancerresearch.org/events...
Established in 1953, the Cancer Research Institute (CRI) is a 501(c)(3) nonprofit organization dedicated to harnessing our immune system’s power to control and potentially cure all cancers. Our mission: Save more lives by fueling the discovery and development of powerful immunotherapies for all types of cancer. To accomplish this, we rely on donor support and collaborative partnerships to fund and carry out the most innovative clinical and laboratory research around the world, support the next generation of the field’s leaders, and serve as the trusted source of information on immunotherapy for cancer patients and their caregivers. www.cancerresearch.org
Cancer Research Institute is a registered 501(c)(3) nonprofit under EIN 13-1837442. Donations are tax-deductible to the fullest extent allowable under the law.
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This discussion perfectly describes my experience with immunotherapy. I completed two courses of nivo and ipi for melanoma and a week before I was to have my third round I developed severe diarrhea with vomiting that went on for several days. My oncologist prescribed steroids which had little effect. I ended up in the ER and being admitted for treatment in my local hospital. They tried everything they could but the symptoms didn't abate so I ended up being transferred to Northwestern Medical in Chicago since I had been consulting with an oncologist up there at the recommendation of my local oncologist. I spent nearly 3 weeks up there with no improvement in symptoms until the head oncologist made the call to treat me with remicade. I was ready to give up at that point and I had lost 35 lbs. Unbelievably, the remicade reversed the effects of the diarrhea within an few hours and I was able to go home the next day to recover. I only wish the remicade had been used earlier in my stay as it had been mentioned as a possibility. Anyway, would I go through the immunotherapy again? Absolutely. Those two courses I did go through have caused the lesions to in my lungs to shrink and to completely eradicate the lesions on my liver and spleen to disappear. I hope the trend with the lesions in my lungs continues.
Thank you for sharing! Wishing you all the best with your treatment.
How soon after your first infusion did you get side effects?
@@maxinemack9278 My reaction started after my second infusion, just a day or so before I was to have my third.
Omg! My friend who is 78 is about to get this treatment with chemo at the same time!
They did not go over any of these side effects with her. I am really concerned now
9
i am a patient at another highly regarded cancer center with similarly credentialled experts.
However, I have never heard a more patient-oriented and understandable presentation of the potential side-effects of immunotherapy treatment.
Kudos to Dr Weber
I was diagnosed with Stage 4 Melanoma that spread to my brain . I was put on Opdivo over 2 years ago . Infusion every 4 weeks . I didn't feel a thing . Come home and go right back to work. The brain tumors were dealt with by Truebeam and are undetectable now .My oncologist has told me " Seemingly it works for you " , Though his plan is 3 years of Opdivo . In the last few months I have become more nauseous, my skin is getting blotchy and I itch .All my blood test come back good . I have been told " If you had melanoma 5-8 years ago we wouldn't be having this conversation .
Yes my dad has stage 4 Pancreatic cancer. I am glad to get on here.
I had two doses of ipi nivo for stage 4 melanoma. Wiped my liver out ( fever for 2 days) Docs got straight onto it with 2mgs per kilo of methyl prednisone & mycophenalate which is no fun but liver numbers normalising. Hopefully I can get back to Nivo therapy. 🤞
Thanks you so much for this channel, this is a very important information for everyone. God bless you!
I had the chills really bad after taking Nivolumab once and now they just make sure I take a Loratidine tablet one hour before my treatment. I am so grateful, lucky I caught the big C when I did with all the wonderful medicine that is being used today. I love your tips on diet.
Thank you this video was amazing
Thanks for watching!
What about heart failure with keytruda?
Battling Stage 3 Merkel cell carcinoma and started avelumab on March 29. Had a fever within 6 hours of infusion which did dissipate within 12 hours.
Then the weakness in my fingers began. Started in fingers and then moved to hands. By the time I went to the ER my arms were weak and it had started in my legs.
After a week in hospital I am now out but battling trying to compensate for maybe 30% of normal hand/arm strength and 75% of normal leg strength. Of course add that to groin pain from my Merkel tumor. When the cure hurts.
All tests came back fine. My immune system attacked my nerve sheathing.
Cancer is hell.
We're wishing you the best of luck with your treatments, Tommy!
I have come to realise that I may not recognise the symptoms straight away, I have lots of days where I feel some way or another thats listed in the side effects, so chances are I would see it as me being my normal wierd self when it could be worse.
Suppose its better to be safe then sorry.
Started pembrolizumab 5 days ago for stage 3b) recurrent melanoma in my ankle that appeared this year, was originally in big toe which was amputated 4 yr ago
I receive immunotherapy and the severe migraines and sinus pressure that I’m dealing with is unreal.
We are sorry to hear you are experiencing side effects. Wishing you the best with the rest of your treatment!
I am on Nivolumab after having an esophagectomy. Two weeks ago I caught covid. There are about 10 side effects as mentioned. It's just a pain to always go to the Emergency dept when I have a fever as maybe I have an infection. My red blood cells are also low. I am hoping though it's keeping the cancer from returning.
@@CancerResearchInstitute Hi, I am on a course of nivolumab now after having esophageal cancer, chemo/radiotherapy and an esophagectomy. I noticed that my red blood cell count is quite low. Is this causing my lethargy, light headedness and fatigue. All the side effects you mentioned I am having and are quite treatable - just annoying as I am unable to do a full days work. I just get exhausted after 2-3 hours. I trust and I hope that this is keeping the cancer at bay. I had covid a fortnight ago which was ok. They gave me the antivirals and I was fine, now though I think it's back. This is my new normal. By the way, I live in Melbourne Australia.
Hang in there Anthony. I wish for your recovery.
I'm going for my first dose next week!
I'll be the first/only Fanconi Anemia patient and they'll be using me as an example case for others like me.
I am worried as I am already quite weak, have issues with my liver, have only one odd shaped kidney, and my nutrition is failing due to lack of eating because of the Esophageal cancer and not able to swallow well.
I'm already extremely underweight and lost weight a lot. I'm 5'2" and only 101 pounds. I also have type 2 diabetes.
BUT still, it's all I have available from medicine, so I'm hoping I am a 'good case'.
Hope, you're doing fine. 🙏🏻
May God Bless You. Trust in God
Dr Weber is very informative as I have recently been diagnosed w/ stage 4 melanoma ( I am actually on my wife's account here) and begin treatments next month or so...My big concern is I also have sarcoidosis and it looks like sarcoid and OPDIVO/Keytruda may not play nice w each other.........anyone in this similar situation?
Here's more information to discuss with the care team on immunotherapy for melanoma : www.cancerresearch.org/immunotherapy/cancer-types/melanoma
And more information on side effects: www.cancerresearch.org/immunotherapy-side-effects
@@CancerResearchInstitute thank you
@Thor Cleavelandson
Sorry to interrupt! Just reading your comment. In early 2o19 I was diagnosed with Melanoma stage 4, it went to my brain, and went through So much since then, WAY to much to write! But when treatment was at #5, I ended up with severe side effects. I don't want to startle you , just give you my STORY today!
I'm disease clear since April of 2020, After my severe side effects from immunotherapy OPdivo and IP ( S.P) i refused further treatment as I was getting sicker with the treatments, My Nuerologist said to a stear clear as the brain tumors were gone and not to continue unless it of course appeared in a lymph node that could cause further issues. I was sceptical before my Nuero team said this. For I had severly stiff joints, muscle pain, neuropathic pain, 24/7 ongoing sever PAIN.
She. You say stiff person syndrome? What are you describing? If you do not mind me asking?
I also have blured vision, tho Dr's said its 2o/20 odd. Still have straining , and maybe from inflammation!
BUT through all the side effects and almost dying 5 times from Immunotherapy! I really COULD NOT go through it anymore! aI told myself I'm going to TRY and get WELL through a. VERY healthy diet... VERY low sugar, take care of myself ,sleep well, hydrate, hydrate, stay active and away from inflammatory foods! Today I am still clear, and all are VERY puzzled, my Nuerologist team, my Oncologist, and all other doctors.
I do unfortunately have SEVERE pain and see a Pain Managment specialist to help me manage the PAIN! If I do NOT keep moving I feel VEFY stiff and uncomfortable, unbearable joint pain from head to toes ( literally head to toes) muscle pain, weakness if I miss a few days really try to move around,
When you say stiff person syndrome, is there such a syndrome ,or do you mean HOW you feel overall???? If you do not mind answering!
The medicine does NOT cover all the pain but it helps,I find exercise, movement as much as I can whether in bed or out. Ill cry while exercising, but if I don't I get VERY stiff!
I hope my message finds you ok ! And should you have any questions, feel free to ask!
Take cafe
What about pain in your arm that already has lymphedema
Unfortunately many of us are having other procedures with our immunotherapy. Had a lung biopsy with side effects from the anesthesia.
Thanks for sharing, Mary.
@@CancerResearchInstitute welcome.
hi (kiaora from NZ) .ive now had 43rounds of keytruda (pembrolizumab) for advanced melanoma (had brain tumour removed 2.5yrs ago). If it wasnt for keytruda id now be long gone (PTL). Ive experienced very view side effects (up until just this past week ie) ....some mild skin rashes etc but nothing to worry about. Ive focused a lot on my gut microbiome to support my own immune system....no diarreha constipation, loss of appetite etc. Im 65yrs old. Very little fatigue.....as i say up until this last week) . out of the blue my knee joints and spine (chronic condition) are giving me real grief....Im struggling to walk plus Im seriously fatigued. Perhaps time to check into oncologist??
Any idea how long before tests with bio markers to discover what patients will not ever respond to immune therapy? That way they can be spared ever being put on this and can move to try other meds?
Hi Catherine. There are some tests to detect biomarkers already being used to guide treatment. For example, doctors test for the level of PD-1/PD-L1 expression to determine whether a patient is a good candidate for a PD-1/PD-L1 checkpoint inhibitor. The field continues to evolve and improve, so we are working to create many more biomarker-based test and treatment regimens in future. www.cancerresearch.org/en-us/immunotherapy/what-is-immunotherapy/biomarkers-in-cancer-immunotherapy
Gotcha
I had the lung and pneumonia like side effect. Low blood pressure and extreme fatigue. 2 treatments so far. Had to wait to be weened off Prednisone for 2nd treatment. Hoping to stabilize. Side effects -bad - started 2 wks after 1st treatment. Have also COPD. Stage 4 uterine cancer.
I have recurrent advanced endometrial cancer and am considering pembrolizumab/lenvatinib treatment. I would like to know if you are on a similar regime and how you are coping now.
Is it common to use chemotherapy and immunology at the same time?
And what is the research on doing this, does it seem to help a lot more? This is what they did with my husband. He has now stopped the chemotherapy. And now he is having a lot of side effects, maybe the Keytruda is working better now I don’t know I hope so
Hi there, Every patients' journey with cancer and with immunotherapy treatments looks different. For more information on chemotherapy and immunotherapy treatments, take a look at our website: www.cancerresearch.org/blog/june-2016/difference-cancer-immunotherapy-and-chemotherapy
Just been diagnosed with thyroid cancer as well as a lymphoma on right side of neck. . Is there immunotherapy for this form of cancer? Doctors recommended total removal of my thyroid and I don’t know what they are going to do with my lymphoma. I am at a lost…
Hi there, There is immunotherapy for lymphoma. To learn more, please take a look at our website: www.cancerresearch.org/immunotherapy/cancer-types/lymphoma
Which immunotherapy drugs for lining of lungs only thing I can have
non-stop upper abdominal pain and cramping after round 2 of Keytruda.
How are you now?
Come to find out, the pain had nothing to do with Keytruda. I had a tumor on my spine that had fractured a vertebrae requiring emergency surgery. @@rkvlogs8082
I was diagnosed with stage3 CRC, I’m a candidate for Pembrolizumab with neoadjuvant, I have colitis now for a week. I’m on cipro, should I have this treatment with this condition, I’ve read that one of the side effects is colitis. Please advise!
Now how are you? God must bless you🙏🙏🙏🙏🙏
@@rkvlogs8082I’m good, but chose to only use Pembrolizumab, I’ve had 2 treatments, going for 3rd on the 11th of March. The pain in my stomach is gone, will get the results on 4 th of March when I get a scan.
So you talked to your doctor yo just focus on pembrolizumab without other chemo? What scan do they do to monitor you? Im asking because my treatment will starting next week. Praying for your total healing.
Is there immunotherapy that is used for ovarian cancer. My need some care and is willing to go to what ever clinic.
Hi Dan, For information regarding specific immunotherapy treatments for ovarian cancer, take a look at our website: www.cancerresearch.org/immunotherapy/cancer-types/ovarian-cancer
Is there really any immunotherapy drug approved or indicated for Advanced pancreatic cancer , metastated to liver?
Hi there, For more information on approved immunotherapy treatments for pancreatic cancer, take a look at our website: www.cancerresearch.org/immunotherapy/cancer-types/pancreatic-cancer
Hello, did you get any answer for your question? I'm also looking for the same. Please respond 🙏🏻🙏🏻🙏🏻
Can an 80-year-old Lung cancer patient take Immunotherapy?
My 80 yr old father has just been diagnosed with stage III lung cancer that is in the lymph node. His doctors advised SIX WEEKS of radiation, chemo and immunotherapy 5 days/ week. I am shocked! NO eighty year old could endure this.
@@mtmg3648 how is your father doing now? Did he get immunotherapy?
@@guruprasad7184 surprisingly well, for what it's worth. He's about to start week 5. Friday they said he may need to do an additional week, which was heartbreaking. I'm off to the airport now to fly back to be with him. He's tolerating the treatment, but we don't know if it's helping.
@@mtmg3648 okay..please keep updating about the development..so that we can get a big favor from you
@@mtmg3648 myb81 year old husband, just started 3 days ago with treatments for squamos cells carcinoma, and melanoma on the scalp. He got diarrhea the next day. Took diarrhea meds and he has been fine. He will get next infusion in 3 weeks.
Are there some immunotherapy drugs that are considered harsher than others? In other words do some have a higher propensity for side effects? I just had a complete nephrectomy 3 weeks ago due to a 8 centimeter tumor (renal cell carcinoma) on my kidney. It doesnt appear at this time that the cancer spread anywhere else and my lymph nodes came back negative. So as far as the doctors are concerned, Im cancer free at the moment. My surgeon said the only course of action is to have an abdominal and CT scan in 4 months to make sure it didnt come back.. However, an oncologist is recommending keytruda once every 3 weeks for year. Wondering if keytruda is a less harsh drug, or the same as others?
Hi Bryan- what great news about being cancer free! We have some information on our website about the different immunotherapy treatment types if you would like to read more there. However, as a nonprofit, we cannot give medical advice- so we suggest speaking with your care team about your next steps. Wishing you all the best! www.cancerresearch.org/immunotherapy/treatment-types/immunomodulators-checkpoint-inhibitors
I had a nephrectomy and after 4 years I had the first metathesis in the supra renal, 5 years later the second one in the spleen and now 3 years later on the Lung. Kidney cance is never a done deal, even though the physician will tell you after 8 years that you are cured. If there was an immunotherapy when I had my nephrectomy I would NO DOUBTS DO IT AFTER THE NEPHRECTOMY
I've had to stop immunotherapy for small cell lung cancer psoriasisform 90% coverage after 5th infusion ...just weaning off of steroids skin 100% OK...tumor had shrunk 60% .what now are the alternatives for me 🇬🇧
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