This is astonishingly well done, as I'm recovering from COVID now, I am amazed how our bodies eventually , hopefully, stop this remarkable process from continuing.
Gorgeous video and I love the music. But as an expert on ribosomal frameshifting, it is a bit incorrect. The "knot" is actually just a pseudoknot. I get simplifying it to just say knot, but that's kind of a big difference. No knots in RNA that I know of. More importantly, the pseudoknot, doesn't cause the ribosome to stop, it actually enables it to keep going by pushing the ribosome into a different reading frame and not seeing the stop codon which is actually what makes the ribosome stop most of the time. Still, I will show this to my virology class.
Look for the "The lifecycle of SARS-CoV-2. Scientific version". It is the same video but with the scientific details, including calling it a pseudoknot.
The separately uploaded "scientific version," on Maastrich University's channel, does name the proteins. However, both contain an error regarding furin cleavage. There's a difference between spike protein cleavage in SARS vs. SARS-CoV-2 (Jackson et al., 2022, doi:10.1038/s41580-021-00418-x). This video better fits SARS. In the original SARS, both the first S1/S2 cut and the second S2' cut happen at the surface of the cell about to be infected. But in SARS-CoV-2, furin already cleaved S1/S2 well ahead of time, in the Golgi apparatus of the cell where the virus was made (and furin unlike TMPRSS2 is a soluble protein not a membrane protein). By the time the virus gets out of the origin cell and approaches the target cell, its S1 and S2 have already been cleaved and are only loosely non-covalently bonded.
Hi, thank you for your video. The animation is lit ! I was wondering, if the dmv is made from the host cell membrane, does that mean the vesicle ends up outside the cell? Then, when the subgenomic RNA exits the dmv thought it's pore, it needs to re-enter the cell thought another pore too?
Astonishing detail here, thankyou for sharing this. It's my understanding that some of the intracellular processes described in the video happen much faster than shown here. Is that right, or have I misunderstood this? Either way, it's chilling to see how ruthless viral reproduction is!
This video contains an error, but it's an educational one. The animation of spike cleavage would better fit the original SARS than SARS-CoV-2. In the original SARS, both the first cut (S1/S2) and the second cut (S2') happen at the surface of the target cell about to be infected, e.g. both might be done by the cell-surface protein TMPRSS2. But for SARS-CoV-2, the S1/S2 cut was already done well ahead of time, by the soluble protein furin in the Golgi apparatus of the cell where the virus was made. By the time the virus got out of the origin cell and towards the target cell, its S1 and S2 were already cleaved and already only loosely non-covalently bonded. Reference: Jackson et al., 2022 (doi:10.1038/s41580-021-00418-x).
A mechanism for all disease. Increased oxidative stress leads to oxidation, evidenced as Inflammation. A healthy cell is repleat in electrons and can therefore only be oxidised. Its a hypothesis.
thank you so much this video will help with my research, could I ask what is the piano melody in this video, sounds like something Hannibal Lecter would listen to
This film has been nominated for a Science & Education #Webby! We're up against some brilliant science videos, so please consider voting for us in the People's Voice Award here: vote.webbyawards.com/PublicVoting#/2023/video/general-video/science-education
Dendritic cells: hey boss there is something happening here, over T-CD4: Can you bring me some clues of what is going on? Over Dendritic cells: look what I've found, they are transforming our citiziens into zombies T-CD4 to T-CD8: hey Charlie, sniff this, good boy, good boy, seize them!
A deranged immunofabulist narrative. You can't just assume that is happening because it happens with other pathogens. Cells infected with SARS-COV-2 are preternaturally long-lived, highly resistant to CTL pressure and autophagy. The pathology conducted on survivors of the primary phase of the infection indicates that the immune system just ignores infected reservoirs and lets the virus take what it wants. Survivors think they're recovered, but they are not--they're honeymooning, and honeymoons always end
The mutation that is present in each variant of concern should read D614G instead of D416G.
This is an incredible video. Explained very well and beautiful animations, if they're sims I can only imagine how long it took to simulate
This is astonishingly well done, as I'm recovering from COVID now, I am amazed how our bodies eventually , hopefully, stop this remarkable process from continuing.
Gorgeous video and I love the music. But as an expert on ribosomal frameshifting, it is a bit incorrect. The "knot" is actually just a pseudoknot. I get simplifying it to just say knot, but that's kind of a big difference. No knots in RNA that I know of. More importantly, the pseudoknot, doesn't cause the ribosome to stop, it actually enables it to keep going by pushing the ribosome into a different reading frame and not seeing the stop codon which is actually what makes the ribosome stop most of the time. Still, I will show this to my virology class.
Look for the "The lifecycle of SARS-CoV-2. Scientific version". It is the same video but with the scientific details, including calling it a pseudoknot.
The best explanation and animation that I saw on this topic until now. Shame that there's this distracting background music over it
Wow! Amazing animation. Excellent job. 👏🏼👏🏼👏🏼
Excellent job in both scientific and artist work. Well done :)
None of the proteins are labelled. For instance where is the Furin Protease???
The separately uploaded "scientific version," on Maastrich University's channel, does name the proteins. However, both contain an error regarding furin cleavage.
There's a difference between spike protein cleavage in SARS vs. SARS-CoV-2 (Jackson et al., 2022, doi:10.1038/s41580-021-00418-x). This video better fits SARS. In the original SARS, both the first S1/S2 cut and the second S2' cut happen at the surface of the cell about to be infected. But in SARS-CoV-2, furin already cleaved S1/S2 well ahead of time, in the Golgi apparatus of the cell where the virus was made (and furin unlike TMPRSS2 is a soluble protein not a membrane protein). By the time the virus gets out of the origin cell and approaches the target cell, its S1 and S2 have already been cleaved and are only loosely non-covalently bonded.
I need to watch the whole channel now
Hi, thank you for your video. The animation is lit ! I was wondering, if the dmv is made from the host cell membrane, does that mean the vesicle ends up outside the cell? Then, when the subgenomic RNA exits the dmv thought it's pore, it needs to re-enter the cell thought another pore too?
Astonishing detail here, thankyou for sharing this. It's my understanding that some of the intracellular processes described in the video happen much faster than shown here. Is that right, or have I misunderstood this? Either way, it's chilling to see how ruthless viral reproduction is!
Yes, this is slowed down a lot.
Compliments! Q: what software did you use?
Animation and concept both was top-notch. 👏👏👏
this video just saved my genetics grade
This video contains an error, but it's an educational one. The animation of spike cleavage would better fit the original SARS than SARS-CoV-2.
In the original SARS, both the first cut (S1/S2) and the second cut (S2') happen at the surface of the target cell about to be infected, e.g. both might be done by the cell-surface protein TMPRSS2. But for SARS-CoV-2, the S1/S2 cut was already done well ahead of time, by the soluble protein furin in the Golgi apparatus of the cell where the virus was made. By the time the virus got out of the origin cell and towards the target cell, its S1 and S2 were already cleaved and already only loosely non-covalently bonded. Reference: Jackson et al., 2022 (doi:10.1038/s41580-021-00418-x).
At what point do symptoms start?
A mechanism for all disease. Increased oxidative stress leads to oxidation, evidenced as Inflammation.
A healthy cell is repleat in electrons and can therefore only be oxidised.
Its a hypothesis.
shouldnt we consider what your aunts insurance broker said on facebook about how it works before we say for sure?
I feel like I saw a dramatic movie, really nice video
Amazing video, well done!
Superb. Congratulations.
That is a beautiful animation!
Wonderful animations
thank you so much this video will help with my research, could I ask what is the piano melody in this video, sounds like something Hannibal Lecter would listen to
What an animation wow...💥
beautifully put.
A beautiful and an informative video
Amazing, thanks!
This film has been nominated for a Science & Education #Webby! We're up against some brilliant science videos, so please consider voting for us in the People's Voice Award here: vote.webbyawards.com/PublicVoting#/2023/video/general-video/science-education
Amazing 👏
Dendritic cells: hey boss there is something happening here, over
T-CD4: Can you bring me some clues of what is going on? Over
Dendritic cells: look what I've found, they are transforming our citiziens into zombies
T-CD4 to T-CD8: hey Charlie, sniff this, good boy, good boy, seize them!
Well done!
A deranged immunofabulist narrative. You can't just assume that is happening because it happens with other pathogens.
Cells infected with SARS-COV-2 are preternaturally long-lived, highly resistant to CTL pressure and autophagy. The pathology conducted on survivors of the primary phase of the infection indicates that the immune system just ignores infected reservoirs and lets the virus take what it wants. Survivors think they're recovered, but they are not--they're honeymooning, and honeymoons always end
this just made 6 hours of immonology lectures make sense in 6 seconds
Opper than The perfect.
😢
【ｐｒｏｍｏｓｍ】
Thank you Yahweh
Duru ne gani😅
Assmsunga😅
Naks a ne ajs😅 vegan😅
man i think my mom just died to sars cov 2 today cuz shes not waking up on the bed and she got sars cov 2 4 days ago 😭
Sorry for your loss
Lifecycle: Wuhan Institute of Virology ---> Wuhan seafood market ---> The whole world
Batcave---> Wuhan seafood market ---> The whole world
Hi
Manmade
Murav'i @