A Guide to R32 and R454B Refrigerants

Why do we have to keep changes Refrigerants? Why is R32 and R454B replacing other refrigerants like R410A, R22, R12 and R11? How much does R32 and R454B cost compared to the others? Do I need to replace my refrigeration Tools and Equipment to work with the new refrigerants? Can I drop in R32 or R454B into an existing R410A, R22 or R12 system?
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