Thyroid Hormones | Biosynthesis & Pharmacology

In this video, we discuss the biosynthesis of thyroid hormones, their mechanism of action, and any relevant targets in pharmacology.
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[@Spacetainment]

Do not let the memories of your past limit the potential of your future. There are no limits to what you can achieve on your journey through life, except in your mind. Accept yourself, love yourself, and keep moving forward.

[@fklstv7]

Great video, I love the simplicity of the way you laid out the pathways

[@himanshurana1897]

Excellent explanation

[@territowner8350]

You do not talk about Reverse T3, or what it means if the TSH is low and Free T3, and Free T4 are low, indicating a pituitary disorder. It does a patient no good to not test TSH, Free T3, Free T4, and Reverse T3. Endo's almost killed me twice because they were only checking TSH. They caused me to also have 2 thyroid surgeries because they did not check and see that I had a pituitary issue and because I was not making TSH, my thyroid gland (both sides) grew larger and larger to try to compensate and keep me alive. I could go on and on. Also, if a person is not converting T4 well (removing the wrong iodine atom), (the Selenium comment was good), they will make Reverse T3 which is not active but can sit or dock on the active sites on the cell, thus causing Free T3 to pool in the blood, but the patient feel lousy because it isn't being utilized in the cell because the active sites have inactive Reverse T3 molecules sitting in the active sites. For proper conversion of T4 to T3, Ferritin needs to be above 70. Ferritin provides the oxygen for the oxidative reaction which is part of conversion. Cortisol levels need to be optimized also for proper conversion. As a scientist, and a long time Thyroid/PAN Hypopituitary patient, I have been the lab rat. Your comment about giving T3 (Liothyronine), can be taken in a manner that is not toxic. Liothyronine s/b taken every 5 hours. Replacement of T3 and T4 hormones is not difficult if one understands what is happening, how long it lasts in the body, when the major repair work is done and why the body needs it at night, along with what optimal levels look like and how to dose T4 medications properly and then add T3 medication on lastly. Not hard if you do things in the proper order, so the patient gets the most benefit from what is being given. The mantra goes like this: Optimize Ferritin and Cortisol first. Then optimize thyroid levels (FT3, FT4, RT3), and lastly fix sex hormones (Estradiol, Progesterone, and Testosterone. Doing full blood work up on CMP, Thyroid hormones listed, Sex hormones, 8 am Cortisol, ATCH, LH, FSH, Aldosterone, Iron Panel, Ferritin, will give a person the picture of what is really going on. Piecemealing the blood work will keep a patient sick much longer than needed and these people have probably been suffering for years because no one did this type of testing to see what really is going on. You want "optimal levels", not just "in range" levels for patients to feel and live their best life.