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- เผยแพร่เมื่อ 27 ก.ย. 2024
- We are all familiar with caffeine's stimulatory effects, but how does it actually work? Check out this episode of Medicurio to learn more about the world's most commonly used psychoactive drug.
I ended off with saying how caffeine has a variety of medicinal uses, but didn't really go in depth. If you would like to learn more, continue reading.
Caffeine as an adjuvant painkiller: Scientists aren't too sure how caffeine can boost the effects of various NSAIDs, but they have a few possible theories: caffeine may slow down the breakdown of NSAIDs, resulting in longer duration of their effect; block pain neurons that use adenosine as a neurotransmitter; or change a person's mood so that even though there is pain, the person doesn't really care about it. If you are interested, this Cochrane review (a paper that summarized the results of over 40 different studies) goes more in-depth into this phenomenon: onlinelibrary.w...
Caffeine can prevent neurodegenerative disease: There have been studies that found a correlation between drinking a few cups of coffee a day and slower onset of neurodegenerative diseases, but it is still unclear how caffeine does this. If you recall from the video, when adenosine stimulates A2A receptors on wake-promoting neurons, those neurons increase in activity. A2A receptors are also found on other neurons and also increase their activity. The idea is that in neurodegenerative diseases, these neurons actually begin to become overworked and die off. When caffeine binds to A2A receptors, it actually allows them to rest, making caffeine a neuroprotective agent. Keep in mind that this is just one theory and may be shown to be completely wrong in a few years time when new research shows an entirely different mechanism, but it is the best guess that scientists have now.
Hello everyone! Apologies for not posting sooner, I have been swamped with schoolwork for the past few weeks.
I can't believe that I got my 1000th subscriber a few days ago! You guys are absolutely amazing and I truly appreciate your supportive comments in my videos. Thank you all so much!
I also have a Twitter account now, so feel free to follow me! twitter.com/medicurio
You should do video about LSD, THC and Amphetamine variant ( Medicine prescribe for ADHD )
You are amazing i am studying from you alot of information . Thank you ❤
Very good organized presentation 👏👏👏
"Somehow, caffeine can enhance their painkilling properties" - this will be down to adenosine receptors on the smooth muscles of blood vessels, causing them to constrict (which is what leads to the increase in blood pressure and faster heartbeat rate). One common cause of headache/migraine is caffeine withdrawal, which results in excessive vaso-dilation especially in the brain... this expansion of blood vessels can be very painful, so this pain can be mediated by taking some caffeine (giving people the "slow weening" process) and also anti-inflammatories like ibuprofen which also has a vaso-constrictor effect that counters the caffeine withdrawal through a different pathway (prostacyclin receptors) thus is usually a better option as it doesn't extend the withdrawal process, but may not be sufficient on its own for consumers of large amounts of caffeine.
so much subs by now.
3:25 "...So you wake up feeling refreshed."
No, no I do not.
• Riftis • me neither
So?? This is simply related to your adenosine removal rate *during your sleep* .
And caffeine actually *increases* this rate too (by keeping adenosine less often bound to receptors and thus more open to removal), which is why some people also consume caffeine before taking a power nap as well.
I've never actually woke up refreshed. Not once on my lifetime.
lmao same i feel like the adenosine just gets more
@@lahtine7431 i dont wanna call you a liar but i have a hard time believing that. i mean as a baby/toddler/kid that is very hard to believe.....i think youre exaggerating. but i know how annoying exhaustion is, same for me here since a few months.
extremely informative, this saved me hours of time on Google scholar, thank you for your contribution!
After seeing this ... this confirms my aim to quit it completely once and for all. Always losing control ...dosage higher and higher.
😂
I really enjoyed this video. Well-described and explained. Your voice-overs are also very good! Easy to listen to and understand! Keep up the good work!
Came from Tier Zoo and enjoying it :D
Further down the video and I noticed that having music in the back would help during your pauses
Came from. Tier Zoo as well.
Music will make the voice harder to understand, and if it's simple enough to not be engaging in its own right, it'll soon be repetitive and annoying. Some things are better without music.
Mee too :'D
Me too!
This was so clear and so visually understandable that it's now got me studying how different chemicals affect the body and brain thank you for your amazing work.
Thank you. This deserves to be in a school curriculum. I love biochemistry with a focus on drugs.
I love biochemistry with focus on drugs, too...
I quit coffee and caffeine myself so i know how hard it can be. I actually have a couple videos on my channel about how ingot through it all and why I decided to step away from it for good! Great video! Thank you!
you suck
i went from 2g caffeine / day to quitting caffeine and trust me that first week all you want to do is sleep
2000 mgs a day? Jesus
yep.
that must have been so painful omg
I cant sleep
such a good vid! Decidedto quit my coffee consumption even tho I " only" have one cup a day.
If caffeine disappears in 2 - 4 hours, why can I not fall asleep that night, like 8 hours after I've drunk coffee
Caffeine's duration is quite variable between people, so you might just break down caffeine slower than other people simply due to your genetics. I do have to clarify that not all the caffeine disappears within a few hours, only that enough caffeine is eliminated to no longer have a significant stimulatory effect in most people, but if you are genetically more sensitive to caffeine, that residual caffeine may still have an effect and increase the duration of caffeine's effect.
for me one cup of coffee equals 12 hours...or more...i thinkt he ceffeine has long left the brain byt his time but the chaos it caused is still there
the 2-4 hours is BS, actually the cafeine just starts working after 2 hours. Cafeine has a halftime of 6 hours.
*drank
it can take up to 2 months for caffeine to get out of your system.
I'm just an undergraduate student, and I just clicked this video, even though I don't have this topic in my syllabus, I clearly understood each and every point you said. The explanations are very clear.
I can't start my day without caffeine, morning coffee is a must ☕️😌
I'm watching this video at 3:06AM because I might've had a lot of coffee trying to study for exams...I'm always tired though unless I tell myself I need to study :( This was a very informative video; thank you! :)
most underrated channel on youtube! thanks brother.
A cup of coffee will not fix a lifetime of bad food choices. Chronic diseases are lifestyle caused. Love the video - very informative.
Wow, this was explained in such a simple and understandable way! Thank you!
Most underrated channel ever.
I love coffee. It is nice to know how it works and how it affects my brain. Thank u.
Very informative. Thanks for uploading. A note though, acetaminophen (paracetamol) is not an anti-inflammatory.
Thank you!! My Neuroscience Professor breezed passed this slide and I didn't understand it at all.
The diagrams helped!
This video has been of a tremendous help for me. Very well explained and illustrated, which makes it easy to understand. Thank you very much for sharing it with us!
BRUUUH WHY DOES THIS VIDEO ONLY HAS 165k views? This info is amazing!! Wow! Im subscribing now! Thanks for all this info man!
This explains why I sometimes need an afternoon nap, even after my morning coffee ☕
I loved this video! I'm an MD studying for a addiction boards and it was a great way to break up the reading and boring lectures!
I am doing a report about caffeine, I found this to be very helpful! Thanks!!
So it only takes one week to recover?????
I was stalling my productivity to prevent being non-alert in the future. Screw it, I am going take all the caffeine I can buy until I get my degree.
It actually takes 2-3 months to fully recover. First week is worst
I have only been drinking tea for 3 weeks now. It has caffeine but a lot less. Not I am at a point where I don't drink caffeine except from tea, and I don't feel withdrawal on a day without. You can try that.
Ive just had the gnarliest caffeine crash of my life, 3 straight days of sleeping and complete exhaustion fatigue, quitting for sure
Coffee makes me extremely tired after just one cup and lasts all day. My brain is so tired and I'm not sleeping well to move out the adenosine. Time to give it up for good.
Supplemented what was explained in my lecture perfectly!
It might've already been mentioned but acetaminophen (Tylenol) is not an NSAID, but an analgesic...easily confused! But you were right about aspirin, it is classified as anti-inflammatory!
Came here to say the same thing lol, great video tho
This was a great video! I don't usually subscribe after one video but I've been convinced easily here.
I'm sad to see that you have so few videos on your channel, but if they're all as high quality as this one I'll eagerly watch them. BTW, you're one of the top searchers if someone searches for this topic.
That’s a very very good explanation how caffeine effects our neurons. Thank you so much for such a detailed information. Great work! 3:53 Amazing!
Dude you're about to get swamped with subs from tier zoo
;o
This is the best informational video I have seen on yt
See also the "Caffeine Blues" book.
How didn't I know this amazing channel before?! Your videos are REALLY good!
I appreciate your Informative lecture! Side note: I would recommend editing "7:40", as acetaminophen is not an NSAID (Non-Steriodal Anti-Inflammtory Drug).
Loved this video. Incredibly well made and explained. Thanks
History, science and great visuals. Keep it up!
This is TOP TIER channel and content. Insane Detail and easy to follow !
i quit 3 weeks ago. And i am still having headaches . It can take up to a year to feel completely normal.
Excellent job. This will be helpful for my patients.
Came here from tierZoo
Found good channel
Really interesting. Will be showing this vid to my coffee addicted friend!
man i wish i could make videos this good.
"recent research has found that moderate daily caffeine intake seems to prevent various neurodegenerative diseases such as Alzheimer’s and Parkinson’s"
I'll go out on a limb and say that future research will show that daily caffeine intake does not generally prevent various neurodegenerative diseases.
agreed lol
Thank you very much, I have been trying to get to the bottom of my sleep problem for years, soon as I unwind I fall asleep, it is frustrating to loose so much time so regularly
Your videos are great! learning about how the body works is plugging into all kinds of thoughts. Thank you!
Nice video. Just going to point out that according to Wikipedia, acetaminophen is "not generally considered an NSAID". (Came here from Tier Zoo, beware of incoming angry cheetah mains.)
This was awesome, and extremely helpful !
Awesome Channel! This is exactly the kind of content I always wanted.
Me: up at 2am studying for biology
My biology video: GO TO SLEEP. NOW.
Great video! Cramming for my presentation in a few hours and this really helped!!
what a nice presentation
To avoid the problems of growing tolerance I keep breaks.
Every 2-3 month I have week or two without coffee.
Every week I have a day or do which I do without caffeine.
Those days I eat and sleep according how I feel. Filling the resources, vitamins and minerals and fats and proteins, that have been concumed while working long days energized by caffeine.
Oh boy, how good it tastes, when you’ve been some time without.
Less you consume, better it tastes. Applies with everything.
….those resting days, I lay in bed, eat well and watch documentaries about subjects that are related to my current work… …and have a naps every once brain chemistry so says.
I went from 200-400+ mg caffeine every day for the past 4+ years to now one green tea bag every other day. Next week it'll be 1 cup every 2 days and so on a so forth until I feel normal on 1 cup per week like it used to be. My energy definitely feels more stable throughout the day but I'm still getting used to myself without caffeine. It feels foreign...
The body is perfect and does not need stimulants to enhance it.
My coffee is already a medical substance to me. I mean, it's nice to get that kick in the morning, and I make it taste good, but its purpose is to deliver a naturally medicated steam extract. I use half decent espresso grind and add all the following in bulk so it's easy to just put a few spoons of the pre mixed stuff in the thing in the morning.
Turmeric root powder(for the anti-inflammatory properties of curcumin)
Galangal root powder(because modern research suggests extracts of it to be effective cancer fighting and regulating compounds).
Fresh ground pepper(because curcumin and pepperine boost each others absorption and effect, and I assume that it probably helps do the same with galangal root as it's in the same family as turmeric).
A little cinnamon(flavor and metabolic boost)
Even less nutmeg(for flavor, but it's probs good for something)
I could probably be better about measuring everything out to get stoichiometric uptake ratios of this and that, but I haven't yet. The ones to not add too much of are cinnamon and nutmeg, everything else is just eyeballed for now. Not insignificant but not nearly a major fraction.
I use a cheap, unregulated espresso machine with a steam wand btw, and you can get them at thrift stores for pretty cheap.
I melt a small spoonful of coconut oil in a cup with the wand, take the first 20 seconds of the drip into that and swap the coffee pot in.
I *_carefully_* (because it's super easy to just blast it all out of the cup at this point and it is... So frustrating.) steam mix the coconut oil and medicated espresso together and this is done for a couple of reasons.
1) The curcumin, pepperine and likely the beneficial compounds in galangal root and all _very_ fat soluble so the oil takes them up well, and..
2) Coconut oil has a high amount of MCTs, which are a preferred energy source for the body and brain, especially after a fast such as what sleeping causes. I'd love to use pure MTC oil, but this is all surprisingly low budget out of necessity.
The combination of these factors mean that my body is going to preferentially uptake these fats which are laden with the beneficial compounds I want and distribute them well throughout the body.
Then I dilute the mixture with whatever amount of milk I want(because yum) and get it back up to a palatable temp with the steam wand.
The result is a distinctly nuttier, mildly earthy, deeply flavored brew with a great mouth feel, 0 bitterness, and a list of heath benefits that haven't been assessed by the FDA (Federal Death and Addiction organization to me).
The rest that was brewed off (which contains all the bitter compounds) gets tossed in the fridge and I split that into a bit more milk over the next few mornings so I wind up getting the really good cup 1-2 a week.
I personally perceive a reduction in inflammation, less joint pain, and improvements in mood, but it could all be in my head and everyone's body is different anyway so take my experience as anecdote. I do recommend trying a cup though, if not just for the flavor.
So caffeine affects me pretty badly. I can have a tiny bit, like a sip of coffee or a cup of green tea, but if I were to drink a whole cup of coffee I would be jittery to the point where my hands would be shaking, heart racing, and I would feel awful.
Is that because I have a low tolerance? Maybe I have very few adenosine receptors?
I also have anxiety issues and often have trouble falling asleep. Would having fewer adenosine receptors make it more difficult to fall asleep? It almost seems to make sense that if I were to try and slowly increase my caffeine intake (and thus increase the amount of adenosine receptors I have), I would feel better? Just a thought.
Lower adenosine receptors, slower breakdown of caffeine, or slight differences in your adenosine receptor structures that cause caffeine to bind even better than adenosine are all possible reasons why you may be super sensitive to caffeine. These are simply due to your genetics. I've also read that people who have anxiety issues are usually more sensitive to caffeine, the idea being that the stimulatory effects of caffeine just exacerbate the anxiety. Because of this, generally it is not advisable for people with anxiety issues to take caffeine. In theory, less adenosine receptors could be a reason why you have trouble sleeping, and your idea could possibly work. However, sleep is very complex and does not just involve adenosine receptors, but many other hormones and neurotransmitters as well that may also be affected by caffeine in unknown ways. You should talk to a doctor if this is worrying you, as well as stopping caffeine intake since it may worsen your anxiety issues.
Yep some genetics cause you be sensitive and others can cause you to be more tolerable. A caffeine sensitive person could take 10 mg and feel like it’s was 100 while a caffeine tolerable could take 200mg and only feel like 50.
@@iceeyhound3866 true
You stole my words🤣🤣
Thank you so much... Loved the way you explained it better than how it is explained at uni 👍
4:40 Caffeine Tolerance
This may be due to your neurons synthesizing more adenosine receptors to compensate for the receptors blocked by caffeine
Caffeine does not disappear in 2-4 hours. It has a half life in the body of about 8 hours. So if you consume 100mg, 8 hours later there is around 50mg.
To prevent Alzheimer's people should drink coffee in moderation because sleep is the main way to clean our brain from neurodegenerative plaques. Since our brains get washed by the cerebrospinal fluid while we sleep.
Another interesting thing for people with insomnia like me might be the increased metabolic rate of a caffeine affected brain. So drinking coffee might increase the amount of adenosine produced in the brain while not being affected by it as long as the caffeine effects haven't worn off. In other words adenosine accumulates in the brain and only affects it once caffeine is breaken down. So drinking coffee or tea in the morning might help people with insomnia. There should nonetheless be a strict personal rule in place not to drink caffeineted beverages after a certain time. While the creator of the video said that the breakdown of caffeine takes between 2 and 4 hours, it has to be mentioned that this intervall refers to the biological half-life of caffeine. This means that caffeine is breaken down by 50% after 2 to 4 hours. So drink your coffee as early as possible maybe after waking up. If you're not an insomniac like I am then you might want drink your coffee after a meal at mid-day to counter the afternoon slump.
These are great! Your videos are digestible and interesting, thanks for making them! I was wondering, what are the odds of you making a video on liver disease?
Helped me so much with my homework thanks dude
Why them does coffe make me fall asleep almost instantly??
omg I really like this video! I've never found such informative and beneficial thing Thx for making this one
So does eating food and increasing ATP in the body technically make more adenosine and tiredness
Just brilliantly explained. Thanks!
So both of them bind. Both coffee and adenosine. Why does one binding makes us sleep and the other not? i.e. what else happens once adenosine binds, as opposed to when coffee binds?
Excellent presentation!
Wait, the adenosine don't decompose without binding to the receptors?
Thank you for such an informative video.
Excellent, understandable explanations!
Thank you for medical channel
Edit: MEDI-SEMPI NOTICED ME!!
Excellent content. love it!
Thanks for explanation.
Western world may not be as developed as it is nowadays without coffee*
*Video sponsored by Starbucks.
This video was very informative!
I’ve never even noticed the slightest amount of affect from caffeine ever
Excellent
Ok, so follow up question. What are the side effects of chronic high adenosine level in the brain due to habitual coffee drinking? Is the average nights sleep sufficient to prevent any ill effects from masking the brains signals to take a nap so it can clean up house?
They said that caffeine can only do a temporary insomnia but why my insomnia lasts up to 6 months now?? Can someone answer me please so I will know something to cure mine.
Thank you very much for this video!
Great video ❤
Thanks for posting this! Can you comment on why some people experience a greater diuretic effect than others?
A few factors likely play a role. Someone who takes caffeine daily (e.g. drinks coffee every day) will likely experience less of a diuretic effect than someone who rarely takes caffeine simply because of caffeine tolerance (the body is no longer sensitive to caffeine). Another possible reason is due to your genetics. Some people may naturally have more adenosine receptors or slightly different adenosine receptors that affect the sensitivity of the body to caffeine and its diuretic effects, or they may break down caffeine at different rates which changes the amount of time caffeine affects your body and kidneys.
Also, it's important to remember that most of the time we are taking caffeine as a dissolved form (tea, coffee, etc.), so the amount of water in those drinks also should be considered. An espresso shot and a cup of coffee both have roughly the same amount of caffeine, but you would probably experience a greater diuretic effect after drinking that cup of coffee because there was just more water in that drink.
@@Medicurio can you tell me can coffee upregulate gaba receptors after downregulation by drugs? Please reply I'm currently drinking a lot of coffee to upregulate gaba receptors
Coffee was drank first in Ethiopia
I under stand that caffeine takes the place of adenosine
adenosine binds to a1 receptor that keeps brain awake, making it less active
adendosine bind to a2 receptor, making you sleepy
caffeine binds to the same receptors, but cannot activate them
caffeine can only prevent adenosine from binding
so how does caffeine make you feel more awake?
Does caffeine removes adenosine from receptors that already binded with adenosine? I cant find the answer pls help
thanks a lot,, awesome,,
would if u gotta work nightshifts and gotta stay awake. whats the key there
really amazingly good video
Thanks!!
so what im getting here: if you pull an all nighter, coffee can help, but dont do this too often because that could be bad.
I got sleep epilepsy because I got addicted to energy drinks in the night. I've started to get better after a whilst - what's the best way of getting the adenosine mechanism back up a gear after being addicted to coffee for so long and possibly still having bits built up etc
great video. described well.
4:46 The body's adaptability!
that was really useful . thanks a lot