Can methlation issues cause MCAS (mast cell activation syndome)? Though my dr is technically known as a functional dr, she doesn't think mcas or anything out of mainstream is out of her wheelhouse. When I have been at an immunologist twice since 2022 (denying any possibility of mcas)....trying to figure out how to get a proper diagnosis/possible treatment esp if there is no funding to go out of network. Suggestions? Is there a list of tests that insurance would typically cover...that we could give our dr (and main reason why it is necessary). Dr has agreed to order tests if available their contracted lab.
A note from Bryce: Methylation can play a direct role in MCAS because poor methylation can affect histamine metabolism which is crucial in managing mast cell activation. There are several tests that can help diagnose MCAS and related issues including Serum tryptase levels, Plasma histamine levels, 24-hour urine collection for N-methylhistamine, Total IgE and specific IgE levels. If your current doctor remains unconvinced, consider seeking a second opinion from another functional medicine practitioner or an allergist/immunologist familiar with MCAS.
A Note From Bryce: Besides methylation, there are several common genetic mutations that can impact nutritional status which we test for at The DNA Co. Here are a few notable ones: FUT2 (Fucosyltransferase 2) where variants in this gene can impact the absorption of Vitamin B12 and influence the gut microbiome, affecting overall nutrient absorption. SLC23A1 (Solute Carrier Family 23 Member 1) which is key for Vitamin C transport and deficiencies here can impact antioxidant status. GC (Group-Specific Component) and VDR (Vitamin D Receptor) that together affect Vitamin D binding and transport, influencing Vitamin D status and the body's response to Vitamin D and impact bone health and immune function respectively BCMO1 (Beta-Carotene Monooxygenase 1) which converts beta-carotene into active Vitamin A. Individuals with variants typically need to supplement retinol to maintain adequate Vitamin A levels for vision, immune function, and skin health.
Can methlation issues cause MCAS (mast cell activation syndome)? Though my dr is technically known as a functional dr, she doesn't think mcas or anything out of mainstream is out of her wheelhouse. When I have been at an immunologist twice since 2022 (denying any possibility of mcas)....trying to figure out how to get a proper diagnosis/possible treatment esp if there is no funding to go out of network. Suggestions? Is there a list of tests that insurance would typically cover...that we could give our dr (and main reason why it is necessary). Dr has agreed to order tests if available their contracted lab.
A note from Bryce:
Methylation can play a direct role in MCAS because poor methylation can affect histamine metabolism which is crucial in managing mast cell activation.
There are several tests that can help diagnose MCAS and related issues including Serum tryptase levels, Plasma histamine levels, 24-hour urine collection for N-methylhistamine, Total IgE and specific IgE levels.
If your current doctor remains unconvinced, consider seeking a second opinion from another functional medicine practitioner or an allergist/immunologist familiar with MCAS.
@@thednacompany4669 i am beginning to think they do not exist in my area ...or at not existing who is covered by insurance.
What are the most usual mutations in nutritional issues aside from methylation issues?
For me it is pyroluria, depletes zinc, B6, biotin, manganese, and magnesium.
A Note From Bryce:
Besides methylation, there are several common genetic mutations that can impact nutritional status which we test for at The DNA Co. Here are a few notable ones:
FUT2 (Fucosyltransferase 2) where variants in this gene can impact the absorption of Vitamin B12 and influence the gut microbiome, affecting overall nutrient absorption.
SLC23A1 (Solute Carrier Family 23 Member 1) which is key for Vitamin C transport and deficiencies here can impact antioxidant status.
GC (Group-Specific Component) and VDR (Vitamin D Receptor) that together affect Vitamin D binding and transport, influencing Vitamin D status and the body's response to Vitamin D and impact bone health and immune function respectively
BCMO1 (Beta-Carotene Monooxygenase 1) which converts beta-carotene into active Vitamin A. Individuals with variants typically need to supplement retinol to maintain adequate Vitamin A levels for vision, immune function, and skin health.
Amazing info shared 👏