🎯 Key Takeaways for quick navigation: 00:00 *🤓 Introduction to MTHFR gene, methylation cycle, and estrogen detoxification.* 01:09 *🧬 MTHFR gene provides code for enzyme that converts folate to methylfolate (active form).* 02:04 *�ill S-adenosylmethionine (SAM) is the major methyl donor, requiring methylfolate.* 03:28 *🔄 Simple diagram showing synthesis of hormones from cholesterol.* 05:40 *⚗️ Phase 1 and 2 liver detox pathways for estrogen metabolism involving COMT enzyme.* 07:59 *📦 COMT requires methyl groups from SAM, which needs methylfolate, B12, zinc.* 10:01 *🍽️ Xenoestrogens, obesity, poor liver function can cause estrogen buildup.* 12:55 *🔄 Vicious cycle of estrogen increasing histamine and histamine increasing estrogen. * 15:24 *🚺 Signs/symptoms of estrogen excess like heavy periods, PMS, migraines.* 16:18 *🥗 Diet/lifestyle tips: avoid xenoestrogens, increase fiber, folate, methylfolate supplements.* Made with HARPA AI
Absolutely wonderful. Thank you so much for this video. COMT ++ for myself and son. Doing nearly all that you mentioned but was wonderful to have it explained.
@@JoanneKennedy I have a strategene report for my son and have the pathway planner. Trying to connect all the dots so wonderful seeing another Aussie working with strategene. Might have to organise an appointment to have a chat. It's a lot of homework. But explains so much.
What does adequate meat consumption vs excessive meat consumption look like? A lot of articles I have read say avoid l-tyrosine which is basically all meat in existence. Is there a portion to body weight calculation we are missing?
If you're sensitive to it you may need to restrict doses to once or twice a week until your body catches up detoxifying itself. Also keeping the dose near 100% daily value. I'm struggling a bit too but positive changes are unfolding.
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Thank you! I have both mutations and have estrogen dominance and histamine issues.
🎯 Key Takeaways for quick navigation:
00:00 *🤓 Introduction to MTHFR gene, methylation cycle, and estrogen detoxification.*
01:09 *🧬 MTHFR gene provides code for enzyme that converts folate to methylfolate (active form).*
02:04 *�ill S-adenosylmethionine (SAM) is the major methyl donor, requiring methylfolate.*
03:28 *🔄 Simple diagram showing synthesis of hormones from cholesterol.*
05:40 *⚗️ Phase 1 and 2 liver detox pathways for estrogen metabolism involving COMT enzyme.*
07:59 *📦 COMT requires methyl groups from SAM, which needs methylfolate, B12, zinc.*
10:01 *🍽️ Xenoestrogens, obesity, poor liver function can cause estrogen buildup.*
12:55 *🔄 Vicious cycle of estrogen increasing histamine and histamine increasing estrogen. *
15:24 *🚺 Signs/symptoms of estrogen excess like heavy periods, PMS, migraines.*
16:18 *🥗 Diet/lifestyle tips: avoid xenoestrogens, increase fiber, folate, methylfolate supplements.*
Made with HARPA AI
Absolutely wonderful. Thank you so much for this video. COMT ++ for myself and son. Doing nearly all that you mentioned but was wonderful to have it explained.
Lana Jane West thank you so much for taking the time to comment 🙏 very much appreciated!!
@@JoanneKennedy I have a strategene report for my son and have the pathway planner. Trying to connect all the dots so wonderful seeing another Aussie working with strategene. Might have to organise an appointment to have a chat. It's a lot of homework. But explains so much.
Lana Jane West the gene reports are interesting but it all comes down to working on diet, gut, nutrient deficiencies etc etc
Wonderful video with a wealth of information. Thank you! 😁🙏
Does this apply to men with MTHFR as well? Thanks!
This information is so good.
Thank you from the San Francisco area
What does adequate meat consumption vs excessive meat consumption look like? A lot of articles I have read say avoid l-tyrosine which is basically all meat in existence. Is there a portion to body weight calculation we are missing?
Wonderful...thank you 😊
Is also the Cyp21 involved ?
Supplements for slow comt?
Which company would you recommend for gene testing?
This was so helpful. I can’t believe I’ve only just found it! Thank you 🙏
Great video! Thanks so much!
Thank you Wendy. I’m glad you liked it!
You're very weclome. Glad you enjoyed it!
What are your thoughts on folinic acid for those of us who are sensitive to methylfolate?
If you're sensitive to it you may need to restrict doses to once or twice a week until your body catches up detoxifying itself. Also keeping the dose near 100% daily value. I'm struggling a bit too but positive changes are unfolding.
I think around 9:30 there may be an error? +/+ you said was slow and -/- fast, but I think it’s the reverse right?
What about man that have the MTHFR?
Very interesting and helpful: Thank you so much for doing this!!! 💖 Is there a way to contact you privately, perhaps by e-mail...
Hi you are speaking to soft to hear properly