COMT GENE Mutations, Symptoms & Treatment Explained (Catechol o Methyltransferase)
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- เผยแพร่เมื่อ 18 ม.ค. 2025
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This video is the last video in a series on Genetic Testing for Mental Health. It discusses the COMT (Catechol o methyltransferase) gene. This genetic SNP will be of any interest to anyone that has an interest in genetic testing for mental illness, genetic testing nutrition, genetic testing for autism and genetic testing for anxiety. Genetic weaknesses in the COMT gene are relevant to depression, anxiety, bipolar disorder and panic disorder.
In this video Dr Janelle discusses symptoms associated with the COMT gene mutation, and she explains why changes in the COMT gene lead to these symptoms. Finally diet, lifestyle and supplement changes you can make to help support your COMT enzyme activity are discussed.
If you haven't met Dr Janelle Sinclair before, she is a Biochemist (PhD) and natural medicine practitioner. On this TH-cam channel we discuss natural strategies for depression and anxiety. If you're interested in that topic subscribe and hit the bell button so you're notified about our new weekly videos.
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*Dr Janelle Sinclair received her PhD in biochemistry from the University of Basel, Switzerland in 2003. Her use of "doctor" or "Dr." in relation to herself solely refers to that degree. Dr Janelle is a licensed natural health practitioner in New Zealand. The content contained in this video is strictly the opinion of Dr Janelle Sinclair, and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. It does not create a doctor-patient relationship between Dr Sinclair and you. Dr Janelle nor Conscious Health Ltd are not liable or responsible for any possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content should seek advice from a physician or qualified health provider with any questions you may have regarding a medical condition or interactions of supplements with medications. This description may contain affiliate links.
Have you had your COMT gene tested? What did you find? Did you relate to anything that was said in this video? I'd love to hear.
Dr Janelle Sinclair Doctor what do you think of KETO AND Intermittant fast (IF) for women with PCOS?? Please doctor
Thank you for this helpful video. Is decaf coffee also bad, or is the caffeine the problem? Many thanks!
@@jaycole2109yes decaf ok. it's the caffeine that is the problem
Dr Janelle Sinclair Thank you so much, Doctor Sinclair.I appreciate your expertise and invaluable help!
Hello Dr., I have my COMT gene with the polymorphism Val158Met. You have mentioned as the "best" scenario, but actually it's not, at least for me, because I was diagnosed on the bipolar espectrum, and it's exactly like this: at some moments I'm very anxious, neurotic and stressed, but soon I feel depressed, apathetic and with lack of motivation. It's hard to find a balance, I'm on medication now, but I intend to discover more natural ways to achieve this balance. Greetings from Brazil.
I love the bucket analogy, because I cannot remember all the processes as I read Ben Lynch‘s book. This will help me explain to my daughter what I think is happening in her brain. She certainly won’t read the book because she does not have the ability to maintain focus. Thank you so much for this brilliant video.
So interesting! I figured my heterozygous COMT was a bad thing but it sounds like it's the best COMT configuration. Although I'm not homozygous COMT, I could really relate to that slide: workaholic tendencies, thinker, activity in the morning, stress management, calming activities at night. I can't tolerate caffeine at all or stimulants in general. Last year, a doctor mixed epinephrine with the lidocaine he injected in me and I ended up in the ER. Of course, the ER doctor did nothing and acted like I was crazy. I'm excited to watch your video on caffeine. Thank you for putting all this info out!
I think more people should understand this. Im 46 and have struggled my whole life with anxiety problems, and then starting in my 20's insomnia problems. I burned out over and over again because of work and life events. I feel lucky to be alive actually with what I've been through.
I got the Methylation test done recently and I have the COMT mutation. So it explains my struggles.
I will watch some more of your videos, thanks 👍.
How are you managing it?
How did you get the test? I want to get it
That was so helpful! Especially the info for low COMT on doing your main activity in the AM and do relaxing things in the evening.
Just found out I have a Comt mutation and wow.. it’s such a relief finally knowing why I have such high stress levels. This mutation describes me to the T. Thank you so much for this informative video.
I love this video. Key word is insomnia. Daughter with schizophrenia n a zombie on anti dopamine and Parkinsons tremors. Your video is truly brilliant. Thank you
Same here. Forced back on to anti psych meds and both of us really against it...but paraia and delusions are back
This was wildly helpful. Thank you!
Interesting! My partner took my methylated b vits and they made him really jittery, plus he can't handle caffeine. Makes me think he may have the double mutation!
Thank you for posting this. Great info
My pleasure. Did you see the videos on mthfr and also genetics for mental health?
I have homogenous mutant COMT V158M and COMT H68H genes. I definitely can't deal with caffeine- Matcha is the worst. I end up shakey Anderson scatter brained as my thoughts are running through my head too fast to follow anything through properly. Haven't found any B12 impact. I can definitely be an over worked stress'o'holic at times! Will have to try the Phosphatidylserine! Thanks for the tip😊
How did you get your genes tested? I’m looking for a good gene test. Help
I was re-watching this and noticed the methy-B12 part. That's exactly when I had an AH-HA moment, because I had been taking methylB12 and it was just doing something really weird to me, like I was ramped up and haven't been able to come down.
Glad to hear that you had an aha moment. 👍
@@DrJanelleSinclair So if I am a +/+, would this also mean that taking something like TMG for extra methyl donors would have a potential negative effect on me?
It’s so crazy because during chemo I had to take folic acid to counteract some of the poisonous aspects of the chemo drug and my temper was crazy.
What happens if u have mthfr and symtoms of both slow and fast comt?
I love you so much for this video.
Last one was awesome
My first video. Very good.thank you. I subscribed. I have my genes on25 pages, but not everything is perfectly explained, and updates are always occurring. Thank you for a very practical view on the gene (summary) and then the food/ supplements/ behavioral traits that correlate. I appreciate it.
Great content! Greetings from Brazil
My pleasure. Did it answer all of your questions?
great suggestions and overall teaching!
I have the G/G genotype indicating fast COMT however I am severely prone to anxiety, insomnia, high energy, high motivation, and high intelligence. So perhaps there is more to the equation than COMT alone.
Also, I read some advice that consuming more methyl groups will actually be beneficial for people with fast COMT activity since your body depletes them more quickly. Quick depletion means you need to quickly refill.
So far I’ve tried supplementing with betaine, inositol, and I’ve increased my choline intake significantly from consuming 6 to 7 egg yolks per day, I’ve also added methylated B9 and B12.
I am feeling a lot better than I did before starting these supplements.
Magnesium supplements are high priority for anxiety. I'd also rule out zinc and iron deficiency.
What is the evolutionary purpose of this gene? What kind of environment makes it necessary?
What kind of magnesium supplement do you suggest?
I love how calm you are.
This makes so much sense! Thank you for the explanation! My naturopath has put me on a fairly high dose of methyl b vitamins to help my adrenals and my anxiety has shot through the roof! I’ve also never coped well with caffeine or dark chocolate. Just wondering - would you recommend avoiding ginseng as it is a stimulant too?
You might be sensitive to methyl donors
I have slow COMT and avoid methylated vitamins. There's one called B-Minus that is all the Bs except B12. They're all unmethylated
You can choose which kind of B12 is best for you. I tried a normal B12 and it made me feel manic like I was going crazy or something. Very scary. If you want to add a methyl donor of some kind be careful and start slow. I just take Creatine since it frees up the body from making it's own creatine, which takes up a lot of methyl donors.
I'm heterozygous and have symptoms of both. ADHD, Lack of motivation, anhedonia, anxiety and depression
It's unlikely due to the comt gene. There lots of other factors. Maybe look at my video on dopamine and maybe think about doing my online course. Register your interest at www.drjanellesinclair.com/ecourse
@@DrJanelleSinclair Ok will do. I have mutations for MAOA and MAOB and VDR and taq
@@dmxdex vdr stands for vitamin d receptors. Check out your vitamin d level as it can really impact mental health. Check out my video on that.
@@dmxdex th-cam.com/video/rJ76CwFzU34/w-d-xo.html
@@DrJanelleSinclair I have the mutation. I have a few including MAOA and MAOB. A new site called myhappygenes is going to help me with a supplement plan once you can upload your Gene's to their database
The comt-gene mutation is literally a cognitive superpower if you manage to master it.
It's a fine balance for sure!
@@DrJanelleSinclair it is a trickier act but the potential to utilize it is guaranteed
How did YOU master it. I'm curious...
Tell us how!!!! Please!!!
Just found out I have this slow COMPT and mfthr! Thought I was loosing my mind over the years because of the anger anxiety and panic atacks. My mood was all over the place and sleep was getting worse each year. Glad I took the gene test! Good info @DrJanellesinclair Best of luck to everyone battling these problems! Stay away from benzodiazepines unless you have go take them. Been battling benzodiazepines withdrawals for 4 years and it was the scariest thing ever. I had panic atacks / anxiety. Wish I would have taken gene test or technology had allowed me to take gene long ago. It feels like a loosing battle but hang in there people you can change quickly and feel amazing if you eat right take your supplements exercise and change bad habits Also stay away from stress best you can. I have only been on supplements for slow COMPT and mfthr a few months and feeling like a superhuman especially with slow COMPT. 💪✌❤
Subscribed!
Also thank you for all of these tips. I have severe anxiety so I am looking to build a solid methylation protocol that might be able to help me.
Were you able tô Find it? I have severe anxiety too, slow comt and mutation in mthfr! Not sure what to do..
@@mariomello3495supplements for d and b vitamins
How do you get tested?
Where can i get tested for this please
did you figure it out?
Can SAM-e help with the ++ mutation?
It drove my blood pressure higher....be very careful with SAM-e. I am COMT ++
What medications help when COMT ++ presents with depression and anxiety? Thanks great video.
Heroin
Was just diagnosed with COMT Met/Met and MTHFR, I’m really having a hard time understanding it all and this gave me a better idea. I’d love more information. I have debilitating symptoms, cyclic vomiting, I basically can’t function. My anxiety is unbearable
Please also see my free online course on how to heal depression and anxiety naturally. www.drjanellesinclair.com/ecourse
Hello, do you have a video about gene 5HTT?
@@zaryltopchubaeva8515 no ☺️
I always hypothesized that I had dopamine deficiency. Now I know
I wonder if Prozac is making things worse
CAn you say more on adrenal support for fast comt?
Great video! Thank you. Do you recommend taking Sam E for a slow comt if have both missing? Not expressing too many of these symptoms, but susceptible to stress. I’ve heard some people getting worse with Sam e.
I'm a bit cautious with SAMe to be honest
@@DrJanelleSinclair I agree....I took SAM e several years ago and it drove my blood pressure higher. I think I was taking 400 mg. a day which I realize now was a high dose.
I'm a homozygous AA mutant.
I've spent my whole life wondering what the hell is wrong with me. Turns out, nothing, but my insatiable need to know really helped when I finally did have something wrong with me.
I don't ever sleep, never have. I have PMDD, and small inconveniences can feel like the end of the world.
Omg! I know how you feel I’m the same I have 2 C677T and recently I’ve come to think I have the COMT snps because supplementing made me worse. I hope you don’t mind me commenting on your comment. But I’m really trying to find out how to handle my situation and to help my grandchildren understand. Good luck and prayers for your situation.
I have found that sometimes when my nervous system is in overdrive, a decaf coffee will chill me out but I do not understand why unless I am going up and down.
Can men test for COMT ?
Hi Janelle, I have the COMT GA and its really bizarre because I have ALL the sx of the homogenous SNIP , and have done all my life, have you come across this before? thank you for your content 😌
@@Organicmentalfitness yes. There's many causes for anxiety. I would look at other causes. See my free online course using natural medicine for resolving depression and anxiety naturally. I would especially consider nutritional deficiencies such as zinc and magnesium. Check out session 5. www.drjanellesinclair.com/ecourse
🙋♀️ Question-I’m COMPT G/A-does that mean I don’t have problems with neurotransmitter balance? Since the intermediate COMT wasn’t really discussed it left me wondering. 🤔
My M.D told me to cut out/ limit intake of berry’s and green tea and avoid L-Tyrosine & high protein meats which actually seems to help me most of the time. So confused. 🤷♀️
Yes there's no problems for someone with intermediate COMT.
I have heterozygous SNP and I’m always depressed, fatigued and I have ADHD
Then look at other causes of depression like nutritional deficiencies
Any recommendations for Adrenal Support supplements?
How can I get a test?
Doctor what do you think of KETO AND IF for women with PCOS?? Please doctor
So if I have MTHFR and fast COMT, would I do better with methyl groups from methyl b12, methyfolate, TMG, etc? I’m assuming I break down methyl groups quickly and would therefore require more methyl groups?
Good doses of methylated b12 and folate - yes.
Great narrative, Janelle...I am homo ++ and all the above is amazingly accurate! Since I am hetero on MTFHR, i started taking methylating agents that made me MUCH worse immediately. Hydroxo B12 and betaine work amazingly well!
Great video thank you. Curious however as to your thoughts on diet. Is it particularly important to lower protein and increase carbs to lower dopamine? What about fats, especially saturated fat? I have the ++ slow comt gene and unfortunately cannot eat many carbs either due to oxalate sensitivities.
Protein is very important for neurotransmitters. Don't reduce it in your diet because they also help create other balancing neurotransmitters. I don't think most people eat enough protein.
@@DrJanelleSinclair Thanks so much for your response and great work😁
Great video! Very helpful. Can you please advise if L-Theanine has the same adverse effects as ECGC for Slow COMT AA? Thank you!
Thanks contrarymary. ☺️ I haven't come across any data saying it's contraindicated. Just start on a small amount and increase slowly if you are concerned.
My rs4680 snp is GA. You didn't mention what that means? Is it the same as AG?
@@darylsims7274 yes
Does slow comt affect detoxification of hormones?
Yes. Estrogen.
For you dopamine you can also supplement with copper, L tyrosine is converted in to LDOPA through (b6, iron and folate), LDOPA breaks with magnesium and b6, Dopamine breaks in to noradrenaline by Vitamine C and COPPER, (Hole Food because of the co factor tyrosinase, just vit C íll lower you ceruloplasmin levels by not bean about to connect cooper to ceruloplasmin and also drops copper levels, best is acerola pulp) Noradreline breaks by SAMe in to adrenaline.
Check your copper levls and ceruloplasmin fisrt.
Please clean up your comment so it is without flaws in the text. I love your respons, but it is hard to make sense out of it all. Thanks in advance.
Thanks for this video! Does a COMT 61 variation (-/-) have any known health / neurological significance?
I got my Nutrition Genome results back and I have a host of weaknesses. Slow MTHFR, COMT, MAO-A, HNMT, PEMT. Fast FAAH. This explains a lot. Now I am watching your videos trying to learn how I can support these weaknesses. It's no mystery now why I have anxiety and histamine related issues. You mention using HydroxoB12 and Folinic Acid for COMT weakness, but don't say the dosages. Would they be same dosages as the methylfolate and methylB12?
@@bob.bobman yes same dosages. Check out my mthfr report at my website
What can we use instead of coffee if COMT ++? What about cacao? Any other stimulant herb?
I love the taste of coffee 😢
I wish we would not call genetic weakness. It is also a strength obviously.
I have MTHFR, COMT AND VDQ mutation. Who can I consult to help support my body?
My COMT testing came up as high estrogen, and I have high dopamine, was encouraged to take I3C. I have had anxiety and bad depression. I didn’t realize magnesium and vit C were helpful. My b12 seemed fine but B6 low.
Remember to stay off caffeine too. It'll be one of the most important things to follow. Maybe some phosphatidylserine if you're not going to sleep easily
I am COMT ++ and use Indole3carbinol ...have used it for over 10 years and will always continue to use it. It was recommended & a requirement by my Alternative Medicine MD .when I started using bioidentical hormone therapy....it helps to clear excess estrogen from the body. I take 200 mg. with breakfast or 100 mg. at breakfast and 100 mg. at lunch.
Would it be safe to tske during pregnancy @@DrJanelleSinclair
Hi, are there any particular DNA tests you would recommend to understand genetic make-up?
The slow COMT is also related to higher intelligence
How much phenols are too much for a slow comt that is symptomatic? In general I mean. And is that the same as polyphenols?
I must have the double +/+. Inget easily bored. I like moving to new places and I get so much pleasure from being in new places and doing something different. I am not scared of changes and risks.
But I hate not being able to tolerate caffeine and too much stress
i have COMT, have OCD and paranoia
I hope this gave you some helpful tips
@@DrJanelleSinclairUnfortunately, through desperation, I’ve tried a multitude of supplemental and nutritional approaches to no avail. From my understanding traumatic events are generally a catalyst for the manifestation of various “dirty genes” I’ve experienced a host of traumatic events which culminated into a remarkable amount of mental and emotional anguish . I’ve experienced a psychotic episode which was precipitated by the usage of marijuana and I’ve never been the same since. I’m particularly interested in the conception of genome editing.
@@Nietskii check out my online course that I've recently uploaded to TH-cam (it's now free). You could see if there's any concepts that you haven't looked into. With OCD definitely double check vitamin D levels and rule out and check for strep infections in the gut.
I have one copy of MTHFR C677T allele + heterozygous A1298C + Slow COMT! Should I avoid dark leafy greens because of their high phenol content or should I consume them because of high folic acid ? what about Keto diet do you think I should consider it to loose weight or is it going to be harsh on my liver?
I can't afford to have this testing done. Doctors don't do it, and in Texas naturopaths aren't covered by insurance.
I see most of the traits of the slow COMT variant in myself. I have also experienced extremely prolonged effect of certain types of medication, especially psychiatric. Any sleep aid will turn me into a zombie for days despite me taking half of what other people normally do. Could this also be a sign that I have the slow variant?
I have comt slow. I'm a mess with agitation, restless,"anxiety" but nothing is wrong. It dictates my life& work choices, sucks. it's about half the day this goes on. Anyway I also take 1/8 of a melatonin& I can sleep 16hr. FYI
Interestingly, SNPedia actually suggests ADHD is associated with A;A or Met/Met (worrier). This is obviously a bit strange given ADHD is linked to low dopamine levels and A;A individuals tend to have a lot more of it in their prefrontal cortex. Here you listed it as being connected to G;G. To me, it makes more sense that it would be. However, I am A;A and do have ADHD. Of course this could be entirely unrelated but I always wondered if there was some connection.
I also have an MTHFR mutation so I have taken methylated folate over the years to help with this. So it was interesting to hear it might harm me in other ways I wasn't considering.
Afaik ADHD can actually be cause by too low OR too high dopa. Yeah mthfr can cause your dopa to be low, then when you're methylated you start to get normal dopa levels which becomes too high for you to handle because of comt.
met/met here. if you monitor the chemical transimition you will be better able to focus for longer
@@bendikklungsyr2393 how to monitor chemical transimission?
@@pm6828 what to do then if you have problem with MTFHR AND COMT???
Thank you, very pedagogic and informative!
But it isn't that simple that low dopamine are corresponding to ADHD. Low COMT activity actually increases chances for having ADHD significantly. It's beacase too high dopamine in prefrontal cortex can lead to overload. Too high noradrenaline causes restlessness.
Indicators of low COMT activity caused ADHD are co-problems with anxiety, psychotic signs and high ability to hyperfocus.
I drink decaf and sometimes it will calm my nervous system.
I need help. I'm heading down a dark road, I had no idea this was at root. Mine is the ++
Thank you!
So, AA is what you show here as +|+ in red?
Hello, Doctor..I have a question, please. When I drink coffee, I feel a shiver in the hand, that is, when I hold a cup of water, my hand trembles. What is the reason for this? Is the comt gene related?
Did you see my video on coffee and anxiety? The most likely reason is an adrenaline/cortisol release.
@@DrJanelleSinclair Thank you. I will watch the video and write to you in the comments about my condition
So this is why caffeine makes me feel normal. I'm GG. lol I don't feel fully here without it.
You may benefit from tyrosine also
COMT Val158Met G>A GA is what my gene results say so is that slow or fast ?? Any insight 🙏🏻
It's heterozygous. You're not slow or fast, you could say it's in the middle. It's the best result.
@@DrJanelleSinclair thank you for the response I have so many symptoms of it being slow and fast though I feel sure it seems better to have but I feel trickier to fix because if you having symptoms of both and not categorize to one or the other, so I guess you treat the symptoms in my case and not take in account of my genes
@@cjbake3238 other factors play a role in mental health other than genetics. See my course that I've just uploaded to TH-cam for free. It covers diet, food intolerances, blood sugars, gut health and deficiencies. It's very comprehensive
th-cam.com/video/W7gAOBjmahg/w-d-xo.html
Can melasma be a symptom of the mthfr defect?
Thank you so much for this video.
So, I have one MTHFR mutation, and I am AG heterozygous for the Val158Met which you mentioned is the best type to be ... but I struggle with anxiety and panic attacks. I’ve done therapy, I live a healthy lifestyle etc, but five years later, I’m still dealing with it (it’s better but still affects my life) and it feels physical (physiological) rather than “I’m worrying all the time” etc. So confusing.... if I have the most ideal COMT .. why do I deal with anxiety. I also had my neurotransmitters checked and I have perfect dopamine but low serotonin, low PEA and low adrenaline / noradrenaline ... makes no sense to me!
Brittany anxiety isn't just caused by our genetics, there's lots of other physiological causes. I suggest that you check out my videos on a) sugar and anxiety b) Zinc deficiency c) Brain fog, depression and gut health. All of these videos are very relevant to anxiety. Adrenal fatigue may be another contributing factor. Let me know if you have any other questions after you watch these videos. If anxiety runs in the family, zinc deficiency can be very important. (The videos I mentioned are videos that I created first, so look back right to the beginning)
When you say you have one MTHFR mutation, are you heterzygous or homozygous for C667T? or for A1298C?
Dr Janelle Sinclair will do :) Thank you!
Dr Janelle Sinclair heterozygous for A12198C
@@Kayyy8585 I personally think that your mthfr and comt gene variations won't play a significant contributing factor to the anxiety and depression. If you were homozygous for a mthfr SNP it might. I would investigate nutrient deficiencies, gut health or hormones.
What if the other COMT SNP: rs5031015 is GG but COMT SNP: RS4680 is AA. What does that mean? Is that balanced?
@@chhopraki I haven't found any research to say that the first SNP you mentioned is clinically relevant.
rs5031015 (G/G):
• Higher COMT expression: The G/G genotype at rs5031015 is associated with higher expression of the COMT enzyme. This means the body likely produces more COMT enzyme, which can somewhat counterbalance the slower activity from the Met/Met variant of rs4680.
• Potential effect: While the rs4680 (Met/Met) variant slows enzyme activity, the increased expression due to rs5031015 (G/G) means the body is producing more COMT enzyme. As a result, one might experience a slightly faster rate of dopamine breakdown than someone with both the low-activity rs4680 (A/A) and low-expression variants of rs5031015.
Had mine tested recently. I have “very fast” COMT but normal dopamine. Though it shows my Norepinephrine and my epinephrine very slow. The fatigue is about to kill me. Any suggestions for me?
@@jeremyfouse5075 try l-tyrosine supplementation 2-6g per day split across the day before 4pm on an empty stomach
I had my COMT tested and it doesn’t say if I’m AA or GG. It says V158M and ➕⬇️/➕⬇️ in red. I have no idea what this really means.
If it's ++ it means you have the slow COMT.
@@DrJanelleSinclair okay…thank you for clarifying. I do struggle with stress and anxiety, but I have a lot of the symptoms of the fast…for example, I’m always tired and have a terrible memory. I did take the MTHFR test too and it is ➕⬇️/➖ maybe that’s why?
@@dawnrunyon2495 see my mthfr videos
Oh so correct me if I'm wrong but normal is bad??? I just found out yesterday that I have comt gg....which if this is the case, then I'm actually relieved because I have to force myself to do fun and enjoyable things.
How to fix gene -+ guys? Does anyone know?
I have all the symptoms of the homozygous of the wild/normal type, BUT I am homozygous for the mutant type (+/+). What does that mean?
@@petrichor100 it means that this isn't the reason for your depression or fatigue. Check out my free online course that teaches you how to resolve depression and anxiety naturally. www.drjanellesinclair.com/ecourse
@@petrichor100 consider gut health, poor diet, B12 deficiency, etc
@@DrJanelleSinclair Thank you for your response. where can I find your online course ?
@@petrichor100 see the link above
I have COMT 472 AG and I am not sure what part of the video describes this mutation. Does anyone know at what time? Is it the same as +/+?
It's +/- which is heterozygous, which is in the middle and the best outcome
@@DrJanelleSinclair Thx for explaining and the best video on TH-cam for explaining this gene. Greetings from Denmark 🇩🇰
What about A\G let's talk about this gene please😢
What do you mean by A/G?
@@DrJanelleSinclair how to fix them how to become more stress-resistant in stressful situations and how to improve your concentrate when you're learning something, I mean this
@@zaryltopchubaeva8515 watch the video and see the comments for the 'fast' COMT gene. Phosphatidylserine and adrenalherbs will help.
@@zaryltopchubaeva8515 also check out my full course on depression and anxiety. It's free and it'll really help with anxiety, memory and mood.
@@zaryltopchubaeva8515 www.drjanellesinclair.com/ecourse
I tested negative MTHFR,do this mean i am negative on COMT mutation?
No you'll have to look at the results for the COMT gene. They are two different mutations.
@@DrJanelleSinclair Thank you for replying. Unfortunately in my country there is no laboratory who can test for COMT gene mutation.
@@moiaccaunt have you looked at 23andme.com or ancestryDNA.com? They offer ancestry information AND raw DNA data. You just have to put the raw DNA data through a software program to analyse.
@@DrJanelleSinclair wow...thank you very much for such an useful information
If you get 23andMe, you can upload your raw data for free to Genetics Genie, and immediately see whether you have these genes. And you may find some surprise relatives too!
Hi Dr. I don’t have test done but I fit slow comt symptoms but find matcha tea relaxing and helps with attention. So I’m mix of the two but I don’t feel normal 😂
I have two COMPT mutations. rs4680 GA (+/-) and rs4633 CT (+/-) And lately, I have been experiencing extreme anxiety and having daily anxiety attacks. I also have three MTHFR gene mutations 😑 so I get it so hard.... but we CANNOT take folic acid, so please don't recommend that. I'm definitely going to look into the alternatives you mentioned to the B12 though.
She recommended folinic acid. Not the same thing as folic acid. Do your homework.
folic acid is synthetic and therefore your body does not truly recognize it nor use it as it would if not synthetic plus it can interfere with absorbing Folate ... I actually use folate but I see Folinic Acid is also suggested if Folate is not the best fit for you
I have slow COMT tested and it fits 100%. Now, how do I reduce phenols in food? They are in everything that's healthy, like vegetables, fruits etc... Any recommendations would be greatly apprecciated! :)
Good question!
Is she related to David Sinclair
I'm homozygous comt but also homozygous drd2, pretty sure they cancel each other
Have your dr do blood work my dr took 10 viles out of me
Yep AA comt and homozygous for mthfr also. So as soon as i try treat mthfr with methyls it revs up my comt worse. I've just tested my whole blood histamine and homocysteine so im very interested is seeing the results as to over or undermethylation.
Have you seen my mthfr treatment video? I discuss trouble shooting and what to do if you have comt++. Also check out my free mthfr report www.drjanellesinclair.com/mthfr. I think you might find it useful
Wie een korte samenvatting hiervan wil in het Nederlands, laat het mij gerust weten...
Anyone suggesting eliminating caffeine just doesn’t get my vote.
Is Val Val ++ or - - I definite have the anxiety of + +. I am Val Val
I thought it was norepinephrine
Noradrenaline is the same thing as norepinephrine
@@DrJanelleSinclair thank you!
@@DrJanelleSinclair I just learned that I am COMT met/met. So I’m trying to sort all this out…..
The slowness of her voice makes it hard to stay focused
I mastered it all with mushrooms
Ladies, also check your thyroid.
Adrenochrome
Ancestral, not wild type! Lol.