Berberine and Pancreatic Beta Cells

Berberine has many important mechanisms. In the current series of talks we are presenting the mechanisms related to the management of Type 2 diabetes mellitus. In the current talk we look at the high level mechanism of how Berberine helps increase the insulin secretion.
Note: cell's depolarization process is intentionally skipped to keep the focus on the potassium channels.
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URL list from Sunday, Feb. 13, 2023
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel | Nature Communications
www.nature.com/articles/s4146...
AMP-activated protein kinase - Wikipedia
en.wikipedia.org/wiki/AMP-act...
Frontiers | Cerebral Gluconeogenesis and Diseases
www.frontiersin.org/articles/...
Phosphoenolpyruvate carboxykinase - Wikipedia
en.wikipedia.org/wiki/Phospho...
Gluconeogenesis - Wikipedia
en.wikipedia.org/wiki/Glucone...
Metformin - Wikipedia
en.wikipedia.org/wiki/Metformin
Sterol regulatory element-binding protein 1 - Wikipedia
en.wikipedia.org/wiki/Sterol_...
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis | PNAS
www.pnas.org/doi/10.1073/pnas...
Insulin Signaling Pathway | Antibodies.com
www.antibodies.com/insulin-si...
Regulation of SREBP by insulin signaling pathway | Download Scientific Diagram
www.researchgate.net/figure/R...
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

[@JohnSlack89]

Perfect level of detail and great amount of humor throughout. You're a great teacher.

[@j.dasilva4567]

Impressive. Watching from Portugal. Thank u so much.

[@1961Lara]

I love the lectures, but the drawings make it just that much better. I want to make t-Shirts from all of them!

[@pscot81]

Same here I itched all over my body and had to take antihistamine..was so disappointed couldn't continue taking it..just 3 days and had to stop.

[@karenf9137]

Great idea!!!!

[@KatieZeldin]

Omg, this lecture is fantastic! I wish at least half the teachers in my university were as brilliant as you😊

[@leaperrins8373]

What a great video!

[@nipagandhi7251]

Thank you Dr. Been and Dr. Paul Merik .

[@LongStoryShortWithDrBeen]

Thank you for your support!!

[@patricethomas9698]

Thank you so much. I have listed to so many other lectures and yours is the first that helped me to truly understand how Berberine works as I am prediabetic

[@billytheweasel]

thank you doctor Sayed! ..and our pal Paul :)
i' have renewed interest in berberine since my wife's cancer. hope there's more info on 'more insulin release' when insulin is anabolic vs decreased Warburg effect of glucose fueling cancer growth.
the surgeon and anesthesiologist had her stop berberine, made sense. but now i need to learn more. most good studies were out of china when i started researching it years ago.

[@leaperrins8373]

You would need to look into this and see if its suitable or something your wife would consider, but may be try methylene blue. Always research interactions with current medications though!

[@drsethsr]

I have MCAS, with many sensitivities to things, and Berberine is now an addition to my list. It caused flushing, brain fog.

[@billytheweasel]

were you able to isolate it or did it occur when you added it and that was the only change?

[@drsethsr]

​@@billytheweasel It was only change. I even broke open a 1000mg capsule and maybe tried 200mg, and still flared.

[@mariec4275]

Me too. I had major brain fog, dizziness, gas, bloating, nausea. I was only on 200mg. One time a day. I took it with a large meal.
My BS was not greatly changed on it. I could only do three days. Pretty bad.

[@carolematar3760]

Excellent explanation thank you

[@jjperry3995]

Thank you so much. With that mechanism I’m thinking the dose can be pre, post or during a meal. Is this correct.

[@bestcomment3589]

what effect will 660nm and 850nm have? many light panels sell with these levels.