the purpose of "reuptake" of the neurotransmitters is for it to be "degraded thereby less availability in the synaptic cleft so by inhibiting this "reuptake" basically increasing the availability of this transmitters in the synaptic cleft.
Reuptake inhibitors do not slow transmission down, but rather increase the amount of neurotransmitter in the synapse (becuase one mechanism of removing NT is reuptake into the presynaptic neuron. The other methods of removing NT from a synapse include enzymatic degredation and simple diffusion) avaliable for binding to the post synaptic receptors. This works to increases the activity of the post synaptic neuron.
Mr. Linares, please, please, please, keep going on your giving of knowledge. This video is totally my day. You are super freaking amazing. Keep on with your bad self. Make videos as long a you can tolerate. You are so important to us future and current nurse!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Thanks mate, I really enjoy watching your videos. I have a slight observation here; With the TCAs, Norepinephrine & serotonin re uptake into presynaptic neurons are inhibited which means there are more Nor & Ser available in the synaptic cleft for more neurotransmission (hence their antidepressive effects). The side effects however arises because they block cholinergic, histamnine and alpha adrenergic receptors (dry mouth and hypotension).
hey mr Bam & Slam.. I took my nclex and pass on 75 the first time last week. thanks to your funny vids. this is great for a dude on a budget... thanks man..
I absolutely love your videos! I understand and enjoy learning more when I watch your videos. I could literally watch these for hours! I wish it wasn't to expensive to join. I wish there was like a free trial for a month or something. Just wondering, on top of going to class/ lectures will I still need to read my textbook even after watching these videos?
OK, I guess i'll re-explain the common and believed myth of ssri's, tri-cyclics and the general sri problem. What they believe is the answer to depression by using snri's, sri's, ssri's, is the opposite of the solution. You block the receptors for seratonin, you break the body's ability to receive, metabolise (use) seratonin, and the seratonin production cycle process. This is very simple. Blocking seratonin re-uptake leads to the inability of the seratonin receptors to receive and respond to the body and brains natural 'happiness balancing chemical', and breaks the link to respond by creating more, as the re-uptake receptors are also blocked and believe that they are 'full'. The brain, in desperation, switches to using dopamine to compensate. This is why sri's, snri's, and ssri's are so dangerous, and lead to erratic behaviour, suicidal ideation, and many other terrible reactions caused simply by seratonin being blocked for re-uptake, and dopamine being used as a substitute by the cns as an emergency replacement, when no actual danger situation is present, and therefore side-effects such as panic attacks and other impulsive reactions result. Any residual seratonin left in the cns by being prevented from absorbsion, is over-ridden by the much faster, stronger chemical actions of dopamine, produced as direct response to seratonin being 'gone', as the re-uptake receptors being unable to receive seratonin respond by reacting to the belief that no seratonin is present, and call for emergency dopamine release. Dopamine is only designed as an emergency neuro-transmitter, it works too fast, and wears out in a very short time, and is designed as an emergency neuro-transmitter for emergency situations only. This is why such erratic behaviours are displayed within a very short time of seratonin re-uptake inhibitors being administered. Seratonin re-uptake is artificially blocked by the sri, ssri, snri family of medications, therefore the body's ability to assess seratonin levels and production levels to keep seratonin in balance are interfered with and the body and brain and cns are forced to switch to using dopamine as a backup, and then other backup neurotransmitters, as each brain chemical neurotransmitter wears out, with increasingly erratic and disasterous results. The answer to chemical depression is NOT to stop the brain absorbing seratonin, which is what re-uptake inhibitors actually do, in the brain, gut, and cns, but actually to increase seratonin uptake and production to GIVE the correct level of seratonin needed by the brain, body, and cns. A way to acheive this is to increase seratonin in the body, NOT to block the very receptors that utilise and metabolise seratonin, as well as regulating seratonin production and absorbsion in the gut, to be transmitted via the cns to be recieved and utilised by the brain. To explain simply, if a patient requires a bath, they will not get a successful bath if one was to fill the bath to the brim with coal, no?
I have a question can anyone answer plzzz. As you said the nor epinephrine and serotonin both's reuptake is inhibited .then why there is slow down of communication for Nor epinephrine and there is increase communication for serotonin? communication for both of them should be same or what?
he has reuptake inhibition backwards in this video, irresponsible, inaccurate information. Seems a nice guy but poorly research, SSRI increases the amount of serotonin at the synaptic cleft........SNRI, increases the amount of Norepinepherine at the synapic cleft Tricyclic medications do some of the same, older and more side effects usually (depends on the individual) but they also INCREASE the amount of serotonin or norepinephrine at the synaptic cleft.
@@torirachellexo good question, you dont have to, you can join for free too at simplenursing.com/membership - we typically send out flash sales every semester via this email list
Soon as I pass the NCLEX, I'm going to make some psychiatric med videos for nursing. Everything on TH-cam is either med school level or is straight garbage.
A doctor wants me to mention this to my primary doctor the class that you just had with meds and blocking and going to the wrong places I forget anti CL I'm pretty sure I have it both what should I do oh my God my heart has been slow for so long I'm afraid for it to speed up
where is it? i'm subscribed and i haven't been seeing any courses, and limited videos. i'm finding longer and more beneficial content on youtube, why is that???
Oh wow, this video is a throwback! Please view our newest ones on our website (bit.ly/3urJSzi) fully remastered and subscribe to our TH-cam channel to check out all of our new videos posted weekly!
Although I like the contents you have in the video, it makes me dizzy. Please do not make unnecessary movement of the camera like in the beginning. Thank you in advance.
we have a few hundred reviews now :) You can also try it for free. We just launched our new Pharmacology master class! Master the Top 70 drugs :) Try it free click here Simplenursing.com/membership
Your pathophys explanation is very confusing. Communication at the synapse is not slowed down. Antidepressants make the neurotransmitter more available postsynaptically. Kahn Academy explains these things much better
dude is way to close to the camera. the patho section skipped ahead so there are obviously editing issues too. Guy has a good voice but he is not ready for prime time.
A doctor wants me to mention this to my primary doctor the class that you just had with meds and blocking and going to the wrong places I forget anti CL I'm pretty sure I have it both what should I do oh my God my heart has been slow for so long I'm afraid for it to speed up
![[LIVE] : ONE ลุมพินี 88 | คู่เอก "ป้อมเพชร vs อัสลามจอน"](http://i.ytimg.com/vi/1ZqTVVbMgbo/mqdefault.jpg)
If you want access to all of the content you NEED to pass nursing school & the NCLEX, create a FREE account here: bit.ly/3QTIQUe
The book "30 Days to Reduce Depression" by Harper Daniels is recommended. Gives good daily mindfulness exercises. Worth a try.
the purpose of "reuptake" of the neurotransmitters is for it to be "degraded thereby less availability in the synaptic cleft so by inhibiting this "reuptake" basically increasing the availability of this transmitters in the synaptic cleft.
Reuptake inhibitors do not slow transmission down, but rather increase the amount of neurotransmitter in the synapse (becuase one mechanism of removing NT is reuptake into the presynaptic neuron. The other methods of removing NT from a synapse include enzymatic degredation and simple diffusion) avaliable for binding to the post synaptic receptors. This works to increases the activity of the post synaptic neuron.
I'm investigating top treatment for depression and discovered a fantastic resource at Sebs shy remedy (google it if you are interested)
doesnt say what it is
TCAs worked fastest for me. Like 2-3 days. Nortryptiline.
Mr. Linares, please, please, please, keep going on your giving of knowledge. This video is totally my day. You are super freaking amazing. Keep on with your bad self. Make videos as long a you can tolerate. You are so important to us future and current nurse!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Thanks mate, I really enjoy watching your videos. I have a slight observation here;
With the TCAs, Norepinephrine & serotonin re uptake into presynaptic neurons are inhibited which means there are more Nor & Ser available in the synaptic cleft for more neurotransmission (hence their antidepressive effects). The side effects however arises because they block cholinergic, histamnine and alpha adrenergic receptors (dry mouth and hypotension).
Great description of why monitor for suicidal ideation
hey mr Bam & Slam.. I took my nclex and pass on 75 the first time last week. thanks to your funny vids. this is great for a dude on a budget... thanks man..
Would be nice if I could see the bottom of the screen rather than it being covered up. -___-
You keep it very simplified and your talented at explaining!
thank you so much!
Literally save my life with pharm thank you ❤️
you are so very welcome! Be sure to take the free quiz here simplenursing.com/membership
Love you Nurse Mike, i do not like the sample click box that is sitting on the bottom of this screen.
I absolutely love your videos! I understand and enjoy learning more when I watch your videos. I could literally watch these for hours! I wish it wasn't to expensive to join. I wish there was like a free trial for a month or something. Just wondering, on top of going to class/ lectures will I still need to read my textbook even after watching these videos?
Thank you ♥
You are awesome you bit all nursing school Teacher
Wow that was so good, nobody's ever explained it like that before :)
Could you please include the link to Patho in the description? Thanks.
You're an awesome teacher!!
You rock! Thanks for helping us understand tough subjects!
OK, I guess i'll re-explain the common and believed myth of ssri's, tri-cyclics and the general sri problem. What they believe is the answer to depression by using snri's, sri's, ssri's, is the opposite of the solution. You block the receptors for seratonin, you break the body's ability to receive, metabolise (use) seratonin, and the seratonin production cycle process. This is very simple. Blocking seratonin re-uptake leads to the inability of the seratonin receptors to receive and respond to the body and brains natural 'happiness balancing chemical', and breaks the link to respond by creating more, as the re-uptake receptors are also blocked and believe that they are 'full'. The brain, in desperation, switches to using dopamine to compensate. This is why sri's, snri's, and ssri's are so dangerous, and lead to erratic behaviour, suicidal ideation, and many other terrible reactions caused simply by seratonin being blocked for re-uptake, and dopamine being used as a substitute by the cns as an emergency replacement, when no actual danger situation is present, and therefore side-effects such as panic attacks and other impulsive reactions result. Any residual seratonin left in the cns by being prevented from absorbsion, is over-ridden by the much faster, stronger chemical actions of dopamine, produced as direct response to seratonin being 'gone', as the re-uptake receptors being unable to receive seratonin respond by reacting to the belief that no seratonin is present, and call for emergency dopamine release. Dopamine is only designed as an emergency neuro-transmitter, it works too fast, and wears out in a very short time, and is designed as an emergency neuro-transmitter for emergency situations only. This is why such erratic behaviours are displayed within a very short time of seratonin re-uptake inhibitors being administered. Seratonin re-uptake is artificially blocked by the sri, ssri, snri family of medications, therefore the body's ability to assess seratonin levels and production levels to keep seratonin in balance are interfered with and the body and brain and cns are forced to switch to using dopamine as a backup, and then other backup neurotransmitters, as each brain chemical neurotransmitter wears out, with increasingly erratic and disasterous results. The answer to chemical depression is NOT to stop the brain absorbing seratonin, which is what re-uptake inhibitors actually do, in the brain, gut, and cns, but actually to increase seratonin uptake and production to GIVE the correct level of seratonin needed by the brain, body, and cns. A way to acheive this is to increase seratonin in the body, NOT to block the very receptors that utilise and metabolise seratonin, as well as regulating seratonin production and absorbsion in the gut, to be transmitted via the cns to be recieved and utilised by the brain. To explain simply, if a patient requires a bath, they will not get a successful bath if one was to fill the bath to the brim with coal, no?
why do patients feel better after taking meds and when they are compliant with them they are less likely to return to in-patient care?
You said TCAs delay communication between neurons but I thought they enhance neurotransmission???
The book "30 Days to Reduce Depression" by Harper Daniels is recommended. Gives good daily mindfulness exercises. Worth a try.
He’s so cute 😩
I have a question can anyone answer plzzz. As you said the nor epinephrine and serotonin both's reuptake is inhibited .then why there is slow down of communication for Nor epinephrine and there is increase communication for serotonin? communication for both of them should be same or what?
Sir please answer melitracen tricyclic antidesprent it is secondary amine
what is the link to the pathophysiology video mentioned above.
hello sir u r really good psychiatric lecture
can you post the rest?
what about SNRI anti depressants such as Cymbalta and Effexor?
Do think Amitriptyline works well for neuropathy pain? I've heard that. Rich CNA
It is commonly prescribed in my country as an adjuvant for pain medications.
It would really help to have a camera stand so the camera doesn’t shake
he has reuptake inhibition backwards in this video, irresponsible, inaccurate information. Seems a nice guy but poorly research, SSRI increases the amount of serotonin at the synaptic cleft........SNRI, increases the amount of Norepinepherine at the synapic cleft Tricyclic medications do some of the same, older and more side effects usually (depends on the individual) but they also INCREASE the amount of serotonin or norepinephrine at the synaptic cleft.
Quintessential things!
Is there a coupon for signing up
actually you can email at
help@simplenursing.com or DM us in our Instagram account @simplenursing.com_
Don’t I have to apply the coupon first before making a account ? What is the email for
@@torirachellexo good question, you dont have to, you can join for free too at simplenursing.com/membership - we typically send out flash sales every semester via this email list
Man those call outs on the bottom are OBNOXIOUS as hell.
Thanks a lot for your help, do you sell books for Nursing 101-103
Soon as I pass the NCLEX, I'm going to make some psychiatric med videos for nursing. Everything on TH-cam is either med school level or is straight garbage.
Do you help lpn for the nclex
Ideations*
Your bloody awesome!! This is the only way I make sense of anything lol!! THANKKKKYOUUUUUU #happystudentnurse
You rock
can anyone please help me to find how the serotonin reuptake inhibtor affect the human body beside its action on the serotonin... thanks
A doctor wants me to mention this to my primary doctor the class that you just had with meds and blocking and going to the wrong places I forget anti CL I'm pretty sure I have it both what should I do oh my God my heart has been slow for so long I'm afraid for it to speed up
where is it? i'm subscribed and i haven't been seeing any courses, and limited videos. i'm finding longer and more beneficial content on youtube, why is that???
This was befor the website..
Oh wow, this video is a throwback! Please view our newest ones on our website (bit.ly/3urJSzi) fully remastered and subscribe to our TH-cam channel to check out all of our new videos posted weekly!
Can somebody pleaSE TELL ME HOW I FIND MY PATHO??? Pleaseeee!!!
Thank you! Get the full 15 video course + study guides & quiz bank! Try it free at Simplenursing.com/nursing-school
Although I like the contents you have in the video, it makes me dizzy. Please do not make unnecessary movement of the camera like in the beginning. Thank you in advance.
Anybody bought the simple nursing things online
we have a few hundred reviews now :) You can also try it for free. We just launched our new Pharmacology master class!
Master the Top 70 drugs :) Try it free click here Simplenursing.com/membership
This is too much going on,,,,,you are like a TCA,,,
Where's part 2?
I am from Hong Kong. How can I join and pay?
Your pathophys explanation is very confusing. Communication at the synapse is not slowed down. Antidepressants make the neurotransmitter more available postsynaptically. Kahn Academy explains these things much better
dude is way to close to the camera. the patho section skipped ahead so there are obviously editing issues too. Guy has a good voice but he is not ready for prime time.
A doctor wants me to mention this to my primary doctor the class that you just had with meds and blocking and going to the wrong places I forget anti CL I'm pretty sure I have it both what should I do oh my God my heart has been slow for so long I'm afraid for it to speed up