Dr. Argoff reviews small fiber neuropathy and outlines some recent advances in our understanding of the pathophysiology. Pointers for diagnosis and options for treatment are also provided.
This gives me hope. I'm in my 20s dealing with idiopathic neuropathy. Dont drink or smoke, not diabetic, healthy family history, active in fitness prior to this and ate clean. I'm at a loss 🤦🏾♀️
Even if you did smoke and were diabetic, it’s none of their GD business! Don’t apologize for your lifestyle or put yourself on some morally superior pedestal.I was a fireman and had a building collapse on me. We are all in the same bucket. The Government doesn’t give a damn. The game is population reduction. They want us dead! I wish I had better news for you but that’s the thick of it. Pull the plug ladies & gents. Kids too! They’re stark raving mad they are!
Mitch is right. Check into medication taken in last 6 months. There are some recognized to cause small fiber neuropathy (e.g., antibiotics, anti-cancer drugs).
Wow, what Dr. Argoff said right at the end struck a nerve. I gave up seeking help for so long out of frustration with doctors, and one of the last I saw for ages lambasted me for trying to address multiple symptoms and told me I had to make one new appointment for each symptom. I hope a lot of primary care providers are listening to this talk.
That's what doctors do now. I'm 78 and I remember 50 plus years ago that was not an issue, they could treat multiple issues at one visit and you didn't necessarily have to see a specialist. It's Americanized Medicine just like the pharmaceutical industry. It's all about the money and the insurance companies.
I have small fiber sensory neuropathy in both hands, feet, and in my right thigh but my neurologist refuse to give me a letter stating I can not work with this condition and he knows I am a patient register. I'm in a lot of pain I applied for Social Security Disability
My best friend just passed away from complications due to this disease. The pain she was in was extraordinary. I will miss her greatly but I rejoice that she does not have to suffer any more. The biggest tragedy of her story is that she suffered because she was refused adequate pain reliefe. This war on legitimate pain patients must stop! 😢. We can no longer condone the DEA controlling our doctors to the point they can not provide adequate pain relief to their patients. Rest In Peace Wendy.😢.
Do peripheral neuropathies ever indicate more serious pathologies due to decreased myelin in the smaller fibers that may not be visible on non and contrasted studies? SPS patient. Thanks.
I am not a medical doctor, but have done considerable research on this topic for about 10 years now. Small fibers are by definition unmyelinated nerve fibers (e.g., C fibers and the like). Some researchers view the pain syndromes caused by small fiber pathology as being due to deficient numbers of small fiber nerves, others view it as stemming more from basically intact but hyperactive fibers. These fibers control a number of physiological functions, including blood flow, oxygenation, and of course, pain and temperature sensation. It can be difficult to find a center where appropriate nerve biopsies can be taken and interpreted meaningfully for diagnosis. There is lots out there. Might want to look at reviews on the topic, and PubMed database. Prominent researchers in the field include Oaklander, Argoff, Rice, Younger, and Martinez-Lavin.
Dr, What do you think of the cannabinoid "CBN"? It's a small and medium blood vessel , nerve , and capillary anti inflammatory Also showing success in bone pain But it has the ability to both partially protect , and heal the myelin sheath I had a lifesaving ADCF surgery(in cervical ) after a vertebral collapse in my twenties for cord, nerve, and blood vessel auto immune issues as well as whiplash damage from a myoclonus dystonia My neurosurgeon who knew I had a medical marijuana card told me to use as much CBN as I could and that it would help my dysautonomia from the SCI and trauma Now 2 years after the surgery I began using CBN edibles but I feel the patches give me more relief Within 5 months I regained use of my bladder no longer need catheters And my feet and ankles where I rub THC+CBD+CBN lotion on The slider veins have vanished by about 50% and look WAY less aggravated They don't hurt at all compared to the burning and needles before And my lymph nodes around the ankle that were swollen are draining again Also I have pots that goes back-and-forth between hyper and hypo tension in my abdomen especially my stomach and kidneys from the dysautonomia After trying dozens of things because I was so tired of fainting and passing out I stated taking high doses of thiamine (with other B complex and extra B12 as neurologist told me too) even tho I never have drank or smoked in my life And the thiamine corrected my pots symptoms remarkably With the high dose vitamin B therapy and the high dose CBN I have less PVC's on my holter and my quality of life has improved Please look into it Enjoyed the video thank you ❣️
How do I get my md to listen to me? I also have BPD. She just looks me up and down then tells me how I just need to lose weight like that is the new catch n cure all.
Kudos for the video content! Excuse me for butting in, I would appreciate your thoughts. Have you ever tried - Taparton Sturdy Nerves Takeover (erm, check it on google should be there)? It is a smashing exclusive guide for Getting rid of Neuropathy minus the normal expense. Ive heard some interesting things about it and my best friend Jordan finally got excellent results with it.
You gotta treat them like they work for you, which they do. Another thing that's helped me is seeing female doctors. I'm a young man and they have more sympathy than any male neurologist I've seen. Fight for it and if you don't get what you want let them know you aren't happy.
@@DrLivelovelaugh it does for me but I also must manage my autoimmune disease well. If I don’t, the damage continues and IVIG is almost futile. IVIG does help with managing it too but not quite enough in my case. I’m on DMARDS, LDN and biologics as well.
Kudos for the Video! Sorry for the intrusion, I would love your opinion. Have you heard the talk about - Taparton Sturdy Nerves Takeover (do a google search)? It is a good one off product for Getting rid of Neuropathy without the hard work. Ive heard some pretty good things about it and my close friend Aubrey at last got great success with it.
Kudos for the Video! Excuse me for chiming in, I would love your initial thoughts. Have you heard about - Taparton Sturdy Nerves Takeover (erm, check it on google should be there)? It is a good one of a kind guide for Getting rid of Neuropathy minus the hard work. Ive heard some awesome things about it and my m8 at very last got amazing success with it.
I have Klippel Feil Syndrome and Syringomyelia which are rare spinal diseases. My BP and heart rate are high yet all tests are normal at Cardiologist. Told my chronic pain and nerve issues in foot and hands are fine from EMG. KFS is a Syndrome that causes lots of other issues in my body like, missing a kidney, endometriosis, colitis, Scoliosis and Spina Bifida Occulta. My doctors and insurance refuse to test me for small fiber neuropathy and have even said I most likely have it but they will not treat it so why bother.
there is no known effective treatment. I have suffered thru numerous types of treatment and NOTHING has helped except being put into a zombie trance with xanax or some other mind bending drug. No quality of life with that.
Fluoroquinolones and Metronidazole cause all these problems, they have ruined my life, I have all the symptoms and more of SFPN but every test always comes out ok, except my heart. How do we get doctors to listen. I had a functional doctor of chiropractic neurology say I had SFPN, but all my doctors want to ignore this and just keep doing MRIs cat scans x-rays blood test, over and over. I have been disabled from this for 3 1/2 years and trying to get disability, constantly being denied. I have a lawyer now, but without a real diagnosis of something it's hard to get. Fluoroquinolones and metronidazole have ruined my muscles, tendons, brain, heart. I have torn meniscus in both knees and shoulder, svt of the heart which fluoroquinolones cause, I have muscle weakness to the point on occasion my legs act like noodles and I wasn't able to walk, this happens if I stand to long or over exercise, which is very, very light exercise, when up until this happened I was stronger than some men. I have a compression fracture in my spine and constant muscles pain in my back, my legs from the thigh down are weak now, my brain feels out of it all the time, dizzy all the time, horrible brain fog and fatigue, in pain every day. I could go on, this is a nightmare and no one will help. I belong to a support group of over 10,000 people who this has happened to, it's called Fluoroquinolone toxicity 24/7 and many other groups, I also belong to a metronidazole toxicity group. It's an insult when doctors know zero about this and say it can't happen, they refuse to learn. I'm only getting worse with no help, I'm afraid one day I wont be able to walk. Both thes drugs say they cause all the symptoms I have, these aren't drugs you stop taking and the symptoms go away, they keep damaging.
I have a friend that finally got disability with these symptoms. She was diagnosed with dysautonomia. It took several years to get it, though. I have IST (a heart condition) that is probably related to this. A Small nerve biopsy showed I have SFN over 7 years ago, but only recently developed the IST. I have no idea if or when I took any drugs that you mention.
I've had fibromyalgia and migraines since the 1980s, but just developed "idiopathic small fiber polyneuropathy" since going through a cold turkey benzodiazepine withdrawal 34 months ago. Finally was diagnosed by a neurologist last month, but he still claims it is of an unknown cause - idiopathic. The cause is clear to me; the intense burning pain pain in neck, jaws, chest, hips, private area, GI problems, severe heart pounding/racing, many hypersensitivities, and increased migraines are started or worsened since a very difficult, life-threatening cold turkey benzo withdrawal (took them as directed for 28-1/2 YEARS! Was never told it was not to be given over 2-4 weeks). Doctor doesn't acknowledge this as the cause.
I have so many symptoms but the worst is the mental aspect that comes with your new normal which is never stable physically ... This is hell
This gives me hope. I'm in my 20s dealing with idiopathic neuropathy. Dont drink or smoke, not diabetic, healthy family history, active in fitness prior to this and ate clean. I'm at a loss 🤦🏾♀️
Do u take any medication?
Even if you did smoke and were diabetic, it’s none of their GD business! Don’t apologize for your lifestyle or put yourself on some morally superior pedestal.I was a fireman and had a building collapse on me. We are all in the same bucket. The Government doesn’t give a damn. The game is population reduction. They want us dead! I wish I had better news for you but that’s the thick of it. Pull the plug ladies & gents. Kids too! They’re stark raving mad they are!
@@mitch5222 I got it at 35 and it's gotten better. Not on medication .
Ja Ba not sure what made it improve but I just ate healthy and exercised all the time.
Mitch is right. Check into medication taken in last 6 months. There are some recognized to cause small fiber neuropathy (e.g., antibiotics, anti-cancer drugs).
Wow, what Dr. Argoff said right at the end struck a nerve. I gave up seeking help for so long out of frustration with doctors, and one of the last I saw for ages lambasted me for trying to address multiple symptoms and told me I had to make one new appointment for each symptom. I hope a lot of primary care providers are listening to this talk.
That's what doctors do now. I'm 78 and I remember 50 plus years ago that was not an issue, they could treat multiple issues at one visit and you didn't necessarily have to see a specialist. It's Americanized Medicine just like the pharmaceutical industry. It's all about the money and the insurance companies.
What are you talking about? He didn't say anything about treatment... just a possible better explanation.
I'm 19 and I literally just got my diagnosis for SFN today. I don't even know how to process this it's just so much.
So what's the treatment??? All hat no cattle!!!
I have small fiber sensory neuropathy in both hands, feet, and in my right thigh but my neurologist refuse to give me a letter stating I can not work with this condition and he knows I am a patient register. I'm in a lot of pain I applied for Social Security Disability
My best friend just passed away from complications due to this disease. The pain she was in was extraordinary. I will miss her greatly but I rejoice that she does not have to suffer any more. The biggest tragedy of her story is that she suffered because she was refused adequate pain reliefe. This war on legitimate pain patients must stop! 😢. We can no longer condone the DEA controlling our doctors to the point they can not provide adequate pain relief to their patients. Rest In Peace Wendy.😢.
You didn't say anything that would relieve my pain....just alota. BS
Not one time did he even elude he was going to help you... It's about catching a missing link in the way doctors are diagnosing diseases.
He said nothing new that would be called BIG NEWS. smh
Fibro & small fiber neuropathy here. Gabapentin helps some. Would love a cure!!
Wow, linking it to fibro. I have me/cfs and fibro and been suffering with small fiber neuropathy. Maybe these links can help determine a prognosis.
Do peripheral neuropathies ever indicate more serious pathologies due to decreased myelin in the smaller fibers that may not be visible on non and contrasted studies? SPS patient. Thanks.
I am not a medical doctor, but have done considerable research on this topic for about 10 years now.
Small fibers are by definition unmyelinated nerve fibers (e.g., C fibers and the like). Some researchers view the pain syndromes caused by small fiber pathology as being due to deficient numbers of small fiber nerves, others view it as stemming more from basically intact but hyperactive fibers. These fibers control a number of physiological functions, including blood flow, oxygenation, and of course, pain and temperature sensation. It can be difficult to find a center where appropriate nerve biopsies can be taken and interpreted meaningfully for diagnosis. There is lots out there. Might want to look at reviews on the topic, and PubMed database. Prominent researchers in the field include Oaklander, Argoff, Rice, Younger, and Martinez-Lavin.
I just found out that my IST (increased heart rate with all sorts of crazy symptoms) is probably related to this. So yes a heart condition..
@@kai-leeklymchuk744 Good for you! I am on same path, but you have really done some work. Please, do keep us posted.
Dr, What do you think of the cannabinoid
"CBN"?
It's a small and medium blood vessel , nerve , and capillary anti inflammatory
Also showing success in bone pain
But it has the ability to both partially protect , and heal the myelin sheath
I had a lifesaving ADCF surgery(in cervical ) after a vertebral collapse in my twenties for cord, nerve, and blood vessel auto immune issues as well as whiplash damage from a myoclonus dystonia
My neurosurgeon who knew I had a medical marijuana card told me to use as much CBN as I could and that it would help my dysautonomia from the SCI and trauma
Now 2 years after the surgery I began using CBN edibles but I feel the patches give me more relief
Within 5 months I regained use of my bladder no longer need catheters
And my feet and ankles where I rub THC+CBD+CBN lotion on
The slider veins have vanished by about 50% and look WAY less aggravated
They don't hurt at all compared to the burning and needles before
And my lymph nodes around the ankle that were swollen are draining again
Also I have pots that goes back-and-forth between hyper and hypo tension in my abdomen especially my stomach and kidneys from the dysautonomia
After trying dozens of things because I was so tired of fainting and passing out
I stated taking high doses of thiamine (with other B complex and extra B12 as neurologist told me too) even tho I never have drank or smoked in my life
And the thiamine corrected my pots symptoms remarkably
With the high dose vitamin B therapy and the high dose CBN I have less PVC's on my holter and my quality of life has improved
Please look into it
Enjoyed the video thank you ❣️
Thank u so much for this. My mom grows medical Marijuana and now I know where to start. This is really helpful.
How do I get my md to listen to me? I also have BPD. She just looks me up and down then tells me how I just need to lose weight like that is the new catch n cure all.
Go to another doctor if you can
Buffy, look into a zerocarb diet it helps me really much.
Kudos for the video content! Excuse me for butting in, I would appreciate your thoughts. Have you ever tried - Taparton Sturdy Nerves Takeover (erm, check it on google should be there)? It is a smashing exclusive guide for Getting rid of Neuropathy minus the normal expense. Ive heard some interesting things about it and my best friend Jordan finally got excellent results with it.
You gotta treat them like they work for you, which they do. Another thing that's helped me is seeing female doctors. I'm a young man and they have more sympathy than any male neurologist I've seen. Fight for it and if you don't get what you want let them know you aren't happy.
So what are the treatment options for small fiber neuropathy?
Unless you know a cause, symptom treatment with micro dosis of antisepressanta, Antiepileptics... It helps but made new Problems (weight)
IVIG
@@JumpingJenFlash does this help?
@@DrLivelovelaugh it does for me but I also must manage my autoimmune disease well. If I don’t, the damage continues and IVIG is almost futile. IVIG does help with managing it too but not quite enough in my case. I’m on DMARDS, LDN and biologics as well.
Click bait not something one would expect from a channel such as this.
So what is the "Big News" in SFN??
Kudos for the Video! Sorry for the intrusion, I would love your opinion. Have you heard the talk about - Taparton Sturdy Nerves Takeover (do a google search)? It is a good one off product for Getting rid of Neuropathy without the hard work. Ive heard some pretty good things about it and my close friend Aubrey at last got great success with it.
Kudos for the Video! Excuse me for chiming in, I would love your initial thoughts. Have you heard about - Taparton Sturdy Nerves Takeover (erm, check it on google should be there)? It is a good one of a kind guide for Getting rid of Neuropathy minus the hard work. Ive heard some awesome things about it and my m8 at very last got amazing success with it.
CBN is the big news lol
and? what’s the treatment?
I have Klippel Feil Syndrome and Syringomyelia which are rare spinal diseases. My BP and heart rate are high yet all tests are normal at Cardiologist. Told my chronic pain and nerve issues in foot and hands are fine from EMG. KFS is a Syndrome that causes lots of other issues in my body like, missing a kidney, endometriosis, colitis, Scoliosis and Spina Bifida Occulta. My doctors and insurance refuse to test me for small fiber neuropathy and have even said I most likely have it but they will not treat it so why bother.
there is no known effective treatment. I have suffered thru numerous types of treatment and NOTHING has helped except being put into a zombie trance with xanax or some other mind bending drug. No quality of life with that.
Lol I have small fiber neuropathy
Fluoroquinolones and Metronidazole cause all these problems, they have ruined my life, I have all the symptoms and more of SFPN but every test always comes out ok, except my heart. How do we get doctors to listen. I had a functional doctor of chiropractic neurology say I had SFPN, but all my doctors want to ignore this and just keep doing MRIs cat scans x-rays blood test, over and over. I have been disabled from this for 3 1/2 years and trying to get disability, constantly being denied. I have a lawyer now, but without a real diagnosis of something it's hard to get. Fluoroquinolones and metronidazole have ruined my muscles, tendons, brain, heart. I have torn meniscus in both knees and shoulder, svt of the heart which fluoroquinolones cause, I have muscle weakness to the point on occasion my legs act like noodles and I wasn't able to walk, this happens if I stand to long or over exercise, which is very, very light exercise, when up until this happened I was stronger than some men. I have a compression fracture in my spine and constant muscles pain in my back, my legs from the thigh down are weak now, my brain feels out of it all the time, dizzy all the time, horrible brain fog and fatigue, in pain every day. I could go on, this is a nightmare and no one will help. I belong to a support group of over 10,000 people who this has happened to, it's called Fluoroquinolone toxicity 24/7 and many other groups, I also belong to a metronidazole toxicity group. It's an insult when doctors know zero about this and say it can't happen, they refuse to learn. I'm only getting worse with no help, I'm afraid one day I wont be able to walk. Both thes drugs say they cause all the symptoms I have, these aren't drugs you stop taking and the symptoms go away, they keep damaging.
I have a friend that finally got disability with these symptoms. She was diagnosed with dysautonomia. It took several years to get it, though. I have IST (a heart condition) that is probably related to this. A Small nerve biopsy showed I have SFN over 7 years ago, but only recently developed the IST. I have no idea if or when I took any drugs that you mention.
@@Kris-ib8sn yes that is correct
How soon did you notice neuropathy after taking the medication
It happened to me too, horrible :(
I've had fibromyalgia and migraines since the 1980s, but just developed "idiopathic small fiber polyneuropathy" since going through a cold turkey benzodiazepine withdrawal 34 months ago. Finally was diagnosed by a neurologist last month, but he still claims it is of an unknown cause - idiopathic. The cause is clear to me; the intense burning pain pain in neck, jaws, chest, hips, private area, GI problems, severe heart pounding/racing, many hypersensitivities, and increased migraines are started or worsened since a very difficult, life-threatening cold turkey benzo withdrawal (took them as directed for 28-1/2 YEARS! Was never told it was not to be given over 2-4 weeks). Doctor doesn't acknowledge this as the cause.
Can SFN induced by antiboics regenrate ?
I'm also experiencing the same, what antibiotics did you take?
@@tatianapcorreia bactrim and Cipro. Have painful coldness in feet.
@@samoo8933 when did you take? I still have numbness in my head and all sorts of gi issues, after taking cipro and flagyl in 2020 :(
Got mine from b6 toxicity it sucks
Waiting for your click bait big news