The Cell Cycle and its Regulation
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- เผยแพร่เมื่อ 2 มิ.ย. 2024
- Your cells have to divide when you're growing, to heal wounds, and to replace dead cells. But how do cells know when to divide and when not to divide? We can't have cells just growing willy-nilly! That's what cancer is, and that's bad. Luckily, cells obey something called the cell cycle, which is regulated by a variety of signaling molecules, which tell the cell when to divide and when to chill out. Let's look at the phases of this cycle and some of its regulatory mechanisms now.
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I am a tutor in physiology, physics, chemistry, and mathematics, and I must say you have a very special way of breaking down the information in a comprehensible, sequential manner that is just really enjoyable to hear and watch. You are definitely helping a lot of people with your linear, step-by-step methods. I've always been fond of cell signaling pathways and understanding them from start to finish. Very well organized!
thanks very much!
Jared Nicholas Really. what physiology do you teach? cell biology?
I agree. easy to understand. Good job Professor Dave. I'm also a Science Teacher.
@@ProfessorDaveExplainswhich type of cells? Just asking am not medical profession. Is it stem cells or lymphocytes?
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I've been struggling in class to understand the checkpoints and have had no luck in finding videos that explain how it works. I greatly appreciate your help and finally have a sense as to what is going on!
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Good tutorial as always, Dave!
This helped a little on the subject, thanks. I even learned some extra information!
its reassuring to see that the numbers in my textbook line up perfectly with the examples you give. you are quite literally on the same page.
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Farhan Ahmed yes i wish if it was in arabic bt this is good too
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Quick question-
Chromosomes can be monads (a single chromatid) or dyads (sister chromatids held together by a centromere; a dyad has two identical strands of DNA held closely together in a location called the centromere). When a cell is in the G1 or Gap 1 Phase of their cell cycle, the nucleus contains monads but during the S phase the DNA is synthesized into the dyads that are seen in the G2 or Gap 2 phase.
*The strands are identical assuming that no copying errors (mutations) have occurred during the S phase of the cell cycle
Familiarize yourself with the conditions of a cell’s chromosomes during the G1 and G2 phases of the cell cycle.
The 4 phases of mitosis:
Prophase = chromosomes condense
Metaphase = chromosomes line up in the middle of the cell with reference to the two poles (the equatorial plate or metaphase plate) with each chromosome on its own spindle fiber (by itself)
Anaphase = separation of the chromosomes
Telophase = formation of two nuclear envelopes around the two chromosomal clusters and then the cell divides (cytokinesis)
Questions:
In humans, there are 46 chromosomes in the nucleus of a cell. When the cells are in the G1 phase the 46 chromosomes are 46 monads which are 46 single chromatids. During the S Phase the 46 monads become 46 dyads which are 46 sister chromatids that will split during the M Phase/Mitosis. What is in the nucleus of the cell after mitosis?
this is great video! really helped me understanding cell cycle regulation! thanks!
This was great.
So simplified!!
Thanks.
you are saving my life right now thank youuuu
Very nice job Prof Dave!
I’m a first year student of molecular biology! Thank you professor 👨🏫
Thank you so much for this informative video
Man I gotta love that iconic intro
Man , that was well expained. Thank you!
Amazing explanation thank you 🙂
Thank you brother Dave!
Thank you so much for this....now clearly understood...I can now prepare my presentation☺️...God bless🙏
Well explained, understandable and clear... Thank you prof. All your videos are very useful. I've been watching all of them.
Thank you ...well explained.
It's well explained. Thank u
Thank you so much for excellent explanation
This is so helpful!!
Thank youu
In school, we watch the explanation videos. At home, I watch the debate videos.
@dave So Cyclins and kinases provide the signal to help the cell move along through the checkpoints...but how do they know the cells are "fit" to continue forward to the next phase.
thank you biology jesus
Please make videos with more explanation ....request. Your videos are best .
İ wish to have you in my collage dude, i didn't just learn, i enjoyed it
Thanks . It helped me a lot.
thank you professor dave
great video really helpful thanks a lot
perfect!!! sugestion: video about mosaicism
one quick question dave. if nerve cells don't divide at all like you said, then how can doctors treat brain cancer? bcs, once the doctors get rid the tumor cells within the brain, don't they wait for certain amount of times so that the cells he cut form the new one. thanks
OMG THIS IS SO HELPFUL 🌺🌺🌺
Well done 👍
At this point its not my degree, its our degree!
thanks for the content as always!!
Very clear thank you
THANK YOU SO MUCH MAN!
You deserve way more subscribers
i agree! please tell your friends :)
Thank professor dave
You absolutely excellent.... Lacture
Thank you!
Thank you so much sir 🙏
Understood everything sir..😁
Thanks so much
Thank you ❤️
Your videos are great, thank you! FYI, the word "kinase" is pronounced KAI-nase.
Thank you 😊
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Thanks King
Can someone explain what the role of the Destruction-Box is ?
You have been carrying me since high school am am in university thanks
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5:00, 5:20, 5:52, 6:40!, 6:50!, 7:22!, 7:40!, 8:35, 9:44, 10:25, 10:51!, 11:08!
This is like watching Cr1TiKaL teach me about biology. Thanks!
Controlled cellular multiplication. And age related healing and Cancer treatment.
Thanks 👍👍
Thank you thank you
شكرا
I was asking my self how this signal are translated ??what is this signal??elecrones ??protons?? Need more detail...any way this is a very good channel respect from morocco
i talk about the signaling molecules in this clip! they interact with the genome to promote or inhibit gene expression. stay tuned for a future clip on regulation of gene expression.
Usually some proteins or hormones
The Best ever
Even though I don't speak English, I understood the pictures.
While cells are just being cells, Prof Dave is being his usual compartmentalized messiah self :)
Do cells grow during the g0 phase?
This is way better than crush-course.
0:12 looks like a big strong blue guy with red head. Noone you want to argue with trying to get into a club.
You gotta be using the campbell biology book
Best❤
Wow! This is great continent! Simple and accurate! Just consider revising your explanation on chromatin structure...As far as I know chromosomes only go supercoiled for cell division...the DNA is largely in a "loose" state for replication and storage... otherwise it couldn't be used. (I'm not considering heterochromatin here, of course)
Anyhow, great video!! :)
Todd pls!
Hey Todd!! aha come on phagocyte! - haha I need to talk to people, I've been studying too long
hi taylor
1:03 Why are they called daughter cells? And not son cells, for example?
we call it daughter cell since only *female* can reproduce.. so as it will grow it will become a mother cell and divide further.
hey hey joseph
i think there is an error at 1:57
😍😍😍✨ Thanks
i love science
I just like the into
Why don't we just cut that skin part where cell is dividing rapidly?
what is G zero phase?
it is explained in this clip, so watch again!
what is the difference between genome and gene?
an organism's genome is all of its DNA, and within the genome there are many genes. go through some of the other content in my biology playlist for more info on this!
Thank you sir
How is this guy a professor. He is what, 32?
EDIT: Also way too good teacher for a professor, especially in Cellbiology.
Psst spoiler, he is just a Bachelor.
I'm 37, it's a TH-cam channel, and I'm a science communicator with a BA and MS.
Lmao Kin-aces got me, it is usually pronounced kyn-ace
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Why nerve cells never divide?
something about chemical signaling, they must remain in the G0 state!
after studying biology in depth for many years I have slowly but surely started believing in a higher power. And after further research I have decided that there can only be 1 God responsible for the intricacy of the human body.
As long as you don't take it too far and become a YEC then that's perfectly fine I disagree strongly because of things like emergence but it's fine of that's what you wanna believe.
@@WokeandProud I do not understand what you mean by "taking it too far" secondly, things like emergence personally are not strong enough evidence to compensate for the incredible intricacy of the Universe and human physiology. However, I would not impose my beliefs on others. Although, there has to be a set of laws prohibiting homosexuality, illicit acitivities etc.
@@Osama_AlkadomiNo.