Order my new book: www.amazon.com/dp/B0CW1B2XM1 Timestamps: 00:00 Introduction 00:37 Twenty since Aubrey coined the Longevity Escape Velocity 11:13 When will we reach Longevity Escape Velocity 16:45 Slowing down aging vs regeneration 19:44 What breakthroughs we need for longevity escape velocity 24:00 Seven types of aging damage that needs to be repaired 24:37 Loss of cells and stem cells 33:57 Regenerating limbs and organs 36:10 Mitochondrial free radical theory of aging 41:15 Intracellular and Extracellular waste products 47:15 How far is gene therapy now? 49:15 Death resistant cells 53:52 Do you need long telomeres 57:15 Extracellular matrix stiffening and glycation 01:00:48 Biggest breakthroughs in the next 5 years 01:04:30 What to do to live until the longevity escape velocity
While a lot of this is speculation, I'm not sure many people appreciate how likely a lot of this is to become a reality. It's just a question of time and money. If all of the West were to devote its efforts and resources to this end, LEV would pretty much become a certainty in the next decade or so. That's why, speculation though it may be, it's incredibly important to make more people aware of this research and secure more funding.
Actually it's mostly men who are interested in this type of research and putting money into it. The only thing I can chalk this up to is that women are giving their extra energy into their families. (Men are giving at least ample time to family but women give almost all of theirs to family.) I am a lady but never had children and was born needing to get make aging and death optional. This confirms my opinion.
Exactly. Stay healthy and alive for ten more years is what he basically says because about them there is a good chance we hit LEV. I am more optimistic. I think we are likely already there.
"Right to try" should be introduced everywhere in the world. Because mice trials just dont cut it. On the other hand, I'm pretty sure solving brain-computer interfaces and immune-rejection will probably be a lot easier than solving all the problems the body accumulates with age and I dont see the problem with replacing an organ with a machine to live longer... except the brain of course.
Best futuristic longevity thing i have heard of is potentially getting an rna vaccine for that repair protein found in Deinococcus radiodurans (when given to ecoli it works too, I think gives them 40x more resistance to radiation??).
great interview 🙏🖖Aubrey de Grey is a legend 🫶 What perhaps needs to be said in addition: Aubrey's advice on what you can do for your personal longevity today is (in every one of his interviews) pretty limited. He always says: there's nothing you can do now except what your grandmother already told you. I would say „yes and no“ to that. Sleep, diet and exercise are important factors, but supplements and screenings can also be super important and make a 10-20 year difference. And if we reach the LEV 10-30 years, this is an important factor for many people...
Ray Kurzweil echoes similar sentiments though he is more optimistic than Aubrey asserting that vaccines and gene therapies emerging in the next 7 years or so will prevent much of the age related disease we currently experience.
So in regards to the defective mitochondrial selection I have a x-linked mitochondrial DNA mutation disease lhon, wouldn't all of my mitochondrial DNA be mutated so there are not two separate sets or families of the genes or DNA to choose from?
Question : on the first study lev mouse rejuvination, i think they took the same mouse group. Will they vary the genetics group mouse for the second study ?
Would have been nice to have a 5-second take on each of say 50 anti-aging tries most of us can do. 25 supplements, 10 or so drugs, and everything else. Maybe even just a thumbs up or thumbs down for each.
Thank you Siim and Aubrey. Very informative interview with a respected scientist. I see some skeptical people in the comments. These are the same ones in the 1920s that would have said we can never cure tuberculosis. People underestimate how quickly science progresses, especially with AI now further accelerating things. And in terms of theoretical practicality, just think about it like this: the body is a machine, and like any other machine, good maintenance and the right fuel will keep it running longer. But engineering the tech in the machine will also make it run longer. Our dna, cells, and organs are readily modifiable, we know this from CRISPR and successful gene therapies. We know that certain molecules can engineer our cells. We just need to pinpoint how to do this in the most efficient ways. Only a matter of time.
Id say most benefit from caloric restriction in humans comes simply from minimizing calories the closer to bedtime. Eating without any prospect of physical actitivity overloads the body with fat and little muscle gain, a terrible metabolic outcome.
Caloric restriction is not fasting. And fasting mimicking supplements and diets is not fasting. Nothing can mimick fasting. You need to target lots of pathways at once
@matthewclarke5008 easy. I am the expert her. I prefer dry fasting, more powerful. You just need to rotate between 1 day, 2 days and 3 days Dry fast for max autophagy. I would do 1 day dry fast weekly, 2 days dry fast monthly and 3 days dry fast every 3 months.
@@AceKinG2024 Thankyou for that, but for me it's so complex to remember in a busy life, is there an easier way to remember it, can't I just do a 3 day dry fast once a month and be done with it? Or is that too much?
1:03:30 50% chance of mouse "reversal" being published in 3 to 4 years, I give very low odds, as the interventions would have to be put into motion very soon, because it takes time to live their lives. And the avenues being taken today don't look capable of doing that.
I'd be interested to know how quickly the treatment could be formulated if LEV had more funds? Eg, if a nation were interested in investing taxpayers money to protect their citizens? thanks.
Notice how the addiction to credentials ever so subtly ruins research. People who seek prestige 'tow the line' to such an extent that the practice of science becomes cult like.
Siim, how about you sum it all up for us in a different video, I seem not to understand everything he says. He is either too deep into it or out of it. 😜
this is great but what about world war 3 that can come up anytime in next few years....the saddest part is longevity gang never ever talk about this real threat along with climate changes(this is very problematic with I can see now here in europe the summers are very long and whole day heat)
I take solace and the fact that we already have the tools to live longer, younger and better than anytime in history. And those tools and strategies will only get better. If that means I live a pretty long pretty good life, that's fine. And anything beyond that is icing on the cake
we have almost nothing... and what we have for the time is not completely proven to work or give great results, like metmorfin, also hard to get, the most accessible thing we have is sunscreen
@quantumspark343 your take is simply incorrect. We have the aggregation of known strategies and ability to measure biomarkers that maximize health span. In the rich enclave next to my city, the average life expectancy is 95 years old. That's just astounding compared to even the near past. Several potential gene edits and therapies have been tested in animals but are not quite to human trials (although some humans are already playing with them quietly). And progress is exponential.
How can he make a guess on 2035 when we don't have a single working age reversal treatment? At least when the tech companies make grandiose claims about the singularity they have progress to show in artificial intelligence.
While escape velocity is enticing, I don't subscribe. The reason is that I have looked at the statistics, and papers on the very elderly. At extreme age, it is not the same diseases killing them but merely delayed, as most purveyors of this philosophy/theory characterize. They may be recorded as "heart disease" or "kidney disease" but they are not the same diseases of these organs. As he alluded too, trantheritan amyloidosis is a common heart disease that kills the 105+ group, especially males. If the eldest people only made it to 90, we would never know about this disease. Similarly, there are likely many diseases that do not exist because no one has lived long enough to get them or there are so few cases as to go unnoticed. And this looks to be exactly what is happening. Unknown causes of death skyrocket in the 100+ population. Also, the number of things killing people goes up, and likely explodes. For those that die from 60 to 64 years, the percentage that don't die of the top 15 cause that kill this group, is 15.0%. This constantly grows, as these cohorts get older. In 100 and older, it is up to 26.6%. And this is underestimating the issue. Because like the heart disease example where they were actually dying of trantheritan amyloidosis, there are no doubt many things shoehorned into categories that actually represent different diseases than those with the same failing organs at earlier ages. And even within the categories, we see pretty dramatic shuffling and replacements of the top 15 things killing people. Cancer is the top cause of death for those 45-79, but cancer is down to 5th place in 100+. The reality looks more like running a gauntlet where different things come at you at different ages. And the number of things coming at you increases. More like some video games with many levels. Obviously, it is hard to ride this escape velocity wave if the number of diseases is growing exponentially, and they are mostly never seen before. When we discovered germ theory, did we instantly come up with cures for every pathogen? Many still elude us today, 160+ years later. What are the chances that the 10 new aging diseases they find each year or more, they can fully characterize, find a cure for, test and get approved before you get it or succumb to it? And it won't just be 10 a year, at some point it may be thousands a year. All this said, I am optimistic that we can extend human life a few hundred years, perhaps to 6 or 8 hundred years. And I am not saying escape velocity is impossible. If we do get nanites, and they can correct DNA, DNA methylation, set telomere lengths precisely, remove molecules with no role, and all the rest, that sounds like a cure to me. But that does not sound like the same thing as this wave riding. It is just a mater of living long enough to get the nanites and keep paying the gougers that will almost certainly make you keep paying them rent for the nanites. If you want to include organ replacement, well, that is just not a wave many people can surf.
I think this problem is more likely to be an issue in the more immediate future like getting current people to consistently live to 120+. 600-800 years from now is an insanely long time and "people" then will very likely be post-biological - or like you mentioned, have access to sophisticated technology allowing granular control over biology and genetics.
Not wanting to rot away and die in pain due to the grinding wheel of time is about as transhumanist as not wanting to die of sepsis because you cut your toe on a random rock in the forest.
Whew, arguments ? And if you go about how he's done it for 25 years without results well.. it's not an easy job nor a one man job, he is pushing things in the right direction which is already amazing
@@antoine.- 2035 --- Not much has happened in longevity science and absolutely no "Longevity Escape Velocity" has been reached nor is it on the horizon. The Aubreys at the time will claim it is and still fool many of course. Transhumanism is pseudoscience
He's doing research and advocacy, his worst sin might be making overly optimistic prognoses (if they turn out as such). The real frauds sell things and lie to desperate people that this one diet or supplement will fix their problem - while having no scientific basis. Aubrey does nothing of the sort.
He is many things but a fraud no. Even if things don't work out as his plans you can't deny the sheer commitment, he has to stick with his vision for over 20 years. Plus, now thou small there is a longevity industry on the rise. I think while they will never say it, but I think they own a lot for Grey being one of the first people to really push for it.
Order my new book: www.amazon.com/dp/B0CW1B2XM1
Timestamps:
00:00 Introduction
00:37 Twenty since Aubrey coined the Longevity Escape Velocity
11:13 When will we reach Longevity Escape Velocity
16:45 Slowing down aging vs regeneration
19:44 What breakthroughs we need for longevity escape velocity
24:00 Seven types of aging damage that needs to be repaired
24:37 Loss of cells and stem cells
33:57 Regenerating limbs and organs
36:10 Mitochondrial free radical theory of aging
41:15 Intracellular and Extracellular waste products
47:15 How far is gene therapy now?
49:15 Death resistant cells
53:52 Do you need long telomeres
57:15 Extracellular matrix stiffening and glycation
01:00:48 Biggest breakthroughs in the next 5 years
01:04:30 What to do to live until the longevity escape velocity
Nice timestamps ❤
I enjoyed being "a fly on the wall" for that conversation! Thanks for recording & sharing it!
Great interview!!! To have Aubrey de Grey in your show--WOW! WOW! WOW!!!
Awesome. Thanks Siim!
Love Aubrey! Great content man
While a lot of this is speculation, I'm not sure many people appreciate how likely a lot of this is to become a reality. It's just a question of time and money. If all of the West were to devote its efforts and resources to this end, LEV would pretty much become a certainty in the next decade or so. That's why, speculation though it may be, it's incredibly important to make more people aware of this research and secure more funding.
Facts
Worst case scenario 25 years out
Actually it's mostly men who are interested in this type of research and putting money into it. The only thing I can chalk this up to is that women are giving their extra energy into their families. (Men are giving at least ample time to family but women give almost all of theirs to family.) I am a lady but never had children and was born needing to get make aging and death optional. This confirms my opinion.
Exactly. Stay healthy and alive for ten more years is what he basically says because about them there is a good chance we hit LEV. I am more optimistic. I think we are likely already there.
What? Speculation AND a thing most likely to be real??? You need to learn what words mean.
greetings from Brazil 🇧🇷💚💛
My secret to longevity is "not to die every single day!"
Recursive longevity
Easy for a while...then gets hard. Active prevention and being optimally healthy every day would probably work better.
Stoked for this episode 🙌🏽
"Right to try" should be introduced everywhere in the world.
Because mice trials just dont cut it.
On the other hand, I'm pretty sure solving brain-computer interfaces and immune-rejection will probably be a lot easier than solving all the problems the body accumulates with age and I dont see the problem with replacing an organ with a machine to live longer... except the brain of course.
Love you Aubrey!!! ❤
Great work. Keep it up.
Hay everyone i got this ideal for longivity. Just dont die. Its a cutting edge ideal.
Ideal?
There always seem to be a clinical trial! Very slow moving but I feel A.I could help here.
Aubrey's take on methylene blue?
That would be interesting to know.
Well, he thinks it's preferable to Soylent Green.
Best futuristic longevity thing i have heard of is potentially getting an rna vaccine for that repair protein found in Deinococcus radiodurans (when given to ecoli it works too, I think gives them 40x more resistance to radiation??).
How do you reverse grey hair?
Copper?
Sounds good to me
Dude is like: stay alive, so you don’t die.
Direct proof, Aubrey is turning 99 next year !
ha
AGI solves everything.
That should be the main focus.
Glynac, NOVOS core, sirt 6 activator, nmn and tmg, spermidine and berberine
great interview 🙏🖖Aubrey de Grey is a legend 🫶
What perhaps needs to be said in addition: Aubrey's advice on what you can do for your personal longevity today is (in every one of his interviews) pretty limited.
He always says: there's nothing you can do now except what your grandmother already told you.
I would say „yes and no“ to that.
Sleep, diet and exercise are important factors, but supplements and screenings can also be super important and make a 10-20 year difference. And if we reach the LEV 10-30 years, this is an important factor for many people...
Ray Kurzweil echoes similar sentiments though he is more optimistic than Aubrey asserting that vaccines and gene therapies emerging in the next 7 years or so will prevent much of the age related disease we currently experience.
I'd bet in 2035, it will be re-targetted to 2045.
it always like that with these people... in this guy in particcular...
He said that there’s basically a 5% chance LEV will be achieved after 100 years. Something tells me that’s going to be 100%…
Peptides❤ ! Don't die ❤Decentralization ❤
So in regards to the defective mitochondrial selection I have a x-linked mitochondrial DNA mutation disease lhon, wouldn't all of my mitochondrial DNA be mutated so there are not two separate sets or families of the genes or DNA to choose from?
Question : on the first study lev mouse rejuvination, i think they took the same mouse group.
Will they vary the genetics group mouse for the second study ?
Would have been nice to have a 5-second take on each of say 50 anti-aging tries most of us can do. 25 supplements, 10 or so drugs, and everything else. Maybe even just a thumbs up or thumbs down for each.
Thank you Siim and Aubrey. Very informative interview with a respected scientist. I see some skeptical people in the comments. These are the same ones in the 1920s that would have said we can never cure tuberculosis. People underestimate how quickly science progresses, especially with AI now further accelerating things. And in terms of theoretical practicality, just think about it like this: the body is a machine, and like any other machine, good maintenance and the right fuel will keep it running longer. But engineering the tech in the machine will also make it run longer. Our dna, cells, and organs are readily modifiable, we know this from CRISPR and successful gene therapies. We know that certain molecules can engineer our cells. We just need to pinpoint how to do this in the most efficient ways. Only a matter of time.
no not really
Id say most benefit from caloric restriction in humans comes simply from minimizing calories the closer to bedtime. Eating without any prospect of physical actitivity overloads the body with fat and little muscle gain, a terrible metabolic outcome.
what does he think of working out? since he does not look like it.
01:04:30 interestingly, Aubrey is in the camp of "nothing much you can do right now". Just avoid the biggest risks.
Bryan Johnson would disagree lol
Caloric restriction is not fasting. And fasting mimicking supplements and diets is not fasting. Nothing can mimick fasting. You need to target lots of pathways at once
"Need".
The question is, what's the ideal fasting length, and how often, for longevity, outside of intermittent fasting, the longer fasts.
@matthewclarke5008 easy. I am the expert her. I prefer dry fasting, more powerful. You just need to rotate between 1 day, 2 days and 3 days Dry fast for max autophagy. I would do 1 day dry fast weekly, 2 days dry fast monthly and 3 days dry fast every 3 months.
@@AceKinG2024 Thankyou for that, but for me it's so complex to remember in a busy life, is there an easier way to remember it, can't I just do a 3 day dry fast once a month and be done with it? Or is that too much?
@matthewclarke5008 yes, 2 to 3 days Dry fast every month would be beneficial too.
We'll know age reversal has happened when Aubrey de Grey looks like he's 21. 😄
Yeah, right, all his life he was doing exactly that - predicting
If humans have to make the advances for LEV then it will take hundreds of years or more. The only chance that it happens sooner is AI
yeah, without AI were fu*ked
Oh it will come, the only question will be can you AFFORD it 😊
DEATH SHALL NOT PASS! LORD OF THE GENES.
1:03:30 50% chance of mouse "reversal" being published in 3 to 4 years, I give very low odds, as the interventions would have to be put into motion very soon, because it takes time to live their lives. And the avenues being taken today don't look capable of doing that.
yea he likes giving coin toss odds.
I'd be interested to know how quickly the treatment could be formulated if LEV had more funds? Eg, if a nation were interested in investing taxpayers money to protect their citizens? thanks.
Finding the Aging genes in simple mitochondria is the solution and the using mitlets to transport and target all cell tissues.
Um but it won't stop telomeres shortening.
Notice how the addiction to credentials ever so subtly ruins research.
People who seek prestige 'tow the line' to such an extent that the practice of science becomes cult like.
CARNIVORE
Siim, how about you sum it all up for us in a different video, I seem not to understand everything he says. He is either too deep into it or out of it. 😜
He drinks all day.
this is great but what about world war 3 that can come up anytime in next few years....the saddest part is longevity gang never ever talk about this real threat along with climate changes(this is very problematic with I can see now here in europe the summers are very long and whole day heat)
This was more like a philosophy class, than factual science. I enjoyed it, but it's not for everyone.
I take solace and the fact that we already have the tools to live longer, younger and better than anytime in history. And those tools and strategies will only get better. If that means I live a pretty long pretty good life, that's fine. And anything beyond that is icing on the cake
we have almost nothing... and what we have for the time is not completely proven to work or give great results, like metmorfin, also hard to get, the most accessible thing we have is sunscreen
@quantumspark343 your take is simply incorrect. We have the aggregation of known strategies and ability to measure biomarkers that maximize health span. In the rich enclave next to my city, the average life expectancy is 95 years old. That's just astounding compared to even the near past. Several potential gene edits and therapies have been tested in animals but are not quite to human trials (although some humans are already playing with them quietly). And progress is exponential.
@@bp51082 If you don't mind could you send a link to the gene edits and therapies? I'm just curious.
@@bp51082 Hi there If you don't mind could please sent a link to the gene edits and therapies? I'm just curious.
How can he make a guess on 2035 when we don't have a single working age reversal treatment? At least when the tech companies make grandiose claims about the singularity they have progress to show in artificial intelligence.
he's a futurist - or more polite, "visionary". Not a real scientist
This guy needs to shave he looks like a lord of the rings character.
Just find out how jellyfish stay immortal and you'll get your answer.
Expect this never happen
Stay alive 'til 35 .
He’s gotta work on his personal protocol.
It gets very annoying,when you start promoting your book in a middle of the conversation.
Bane !
His predictions have been worthless in the past. Research the issue yourself, don't rely on this guy
He said the same thing 20 years ago, now he’s spewing the same bs about the future.
Brave old Crusader. Respect.
This guy doesn't lead anything. He talks... a lot...
with a posh accent...
I yet to hear from this guys a single practical advice on how to reverse aging. None. He always come up with nonsense terms
Because the current practical advice isn't going to take us beyond 120 years of age. But yes, he's more of a visionary
@@SiimLand very true
At the very end he advises diet , exercise and staying away from dangerous countries 😂
@ClaudeDiamond after like 30 years of research, he comes up with this haha
@RandomGuy-lu1en he has been like 20 years doing research and he yet to come up with something that can be built upon. He us a scam artist
The whole idea, given who owns the capital and means of production, is silly. The average person is expected to quietly go into the night.
yes and the treatment will be so expensive only billionaires will be able to afford it. the rest of us will be ph@cked as usual.
Hmm... maybe the beard, but he looks significantly older than 61. He needs some rapa asap.
His skin is actually very good
If this man is serious why doe he have this beard?Did Einstein,Newton or Elon musk tried to look like lunatics😂?
Beards are awesome
His ex wife liked big beards.
Charles Darwin takes issue with your outrageous beardism! 😉
While escape velocity is enticing, I don't subscribe. The reason is that I have looked at the statistics, and papers on the very elderly. At extreme age, it is not the same diseases killing them but merely delayed, as most purveyors of this philosophy/theory characterize. They may be recorded as "heart disease" or "kidney disease" but they are not the same diseases of these organs. As he alluded too, trantheritan amyloidosis is a common heart disease that kills the 105+ group, especially males. If the eldest people only made it to 90, we would never know about this disease. Similarly, there are likely many diseases that do not exist because no one has lived long enough to get them or there are so few cases as to go unnoticed. And this looks to be exactly what is happening. Unknown causes of death skyrocket in the 100+ population. Also, the number of things killing people goes up, and likely explodes. For those that die from 60 to 64 years, the percentage that don't die of the top 15 cause that kill this group, is 15.0%. This constantly grows, as these cohorts get older. In 100 and older, it is up to 26.6%. And this is underestimating the issue. Because like the heart disease example where they were actually dying of trantheritan amyloidosis, there are no doubt many things shoehorned into categories that actually represent different diseases than those with the same failing organs at earlier ages. And even within the categories, we see pretty dramatic shuffling and replacements of the top 15 things killing people. Cancer is the top cause of death for those 45-79, but cancer is down to 5th place in 100+.
The reality looks more like running a gauntlet where different things come at you at different ages. And the number of things coming at you increases. More like some video games with many levels.
Obviously, it is hard to ride this escape velocity wave if the number of diseases is growing exponentially, and they are mostly never seen before.
When we discovered germ theory, did we instantly come up with cures for every pathogen? Many still elude us today, 160+ years later. What are the chances that the 10 new aging diseases they find each year or more, they can fully characterize, find a cure for, test and get approved before you get it or succumb to it? And it won't just be 10 a year, at some point it may be thousands a year.
All this said, I am optimistic that we can extend human life a few hundred years, perhaps to 6 or 8 hundred years.
And I am not saying escape velocity is impossible. If we do get nanites, and they can correct DNA, DNA methylation, set telomere lengths precisely, remove molecules with no role, and all the rest, that sounds like a cure to me. But that does not sound like the same thing as this wave riding. It is just a mater of living long enough to get the nanites and keep paying the gougers that will almost certainly make you keep paying them rent for the nanites.
If you want to include organ replacement, well, that is just not a wave many people can surf.
I think this problem is more likely to be an issue in the more immediate future like getting current people to consistently live to 120+.
600-800 years from now is an insanely long time and "people" then will very likely be post-biological - or like you mentioned, have access to sophisticated technology allowing granular control over biology and genetics.
another scam.
Transhumanist nonsense, this channel has officially Jumped the Shark.
This channel has always been about longevity.
Not wanting to rot away and die in pain due to the grinding wheel of time is about as transhumanist as not wanting to die of sepsis because you cut your toe on a random rock in the forest.
Yeah, it was all good for you, all the hundreds of videos, but now it's bad after one video...
@@marcell199311haha right
Oh cause you're not already a transhumanist ?
Technology has made your life unimaginably better and you're currently using it. Are you insane ?
I like you Siim but Aubrey is a fraud
Whew, arguments ?
And if you go about how he's done it for 25 years without results well.. it's not an easy job nor a one man job, he is pushing things in the right direction which is already amazing
@@antoine.- transhumanism is pseudoscience - so is the so called coming singularity
@@antoine.- 2035 --- Not much has happened in longevity science and absolutely no "Longevity Escape Velocity" has been reached nor is it on the horizon. The Aubreys at the time will claim it is and still fool many of course.
Transhumanism is pseudoscience
He's doing research and advocacy, his worst sin might be making overly optimistic prognoses (if they turn out as such). The real frauds sell things and lie to desperate people that this one diet or supplement will fix their problem - while having no scientific basis. Aubrey does nothing of the sort.
He is many things but a fraud no. Even if things don't work out as his plans you can't deny the sheer commitment, he has to stick with his vision for over 20 years. Plus, now thou small there is a longevity industry on the rise. I think while they will never say it, but I think they own a lot for Grey being one of the first people to really push for it.