Fluoroquinolones: How Do They Work (i.e Ciprofloxacin)
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- เผยแพร่เมื่อ 15 มิ.ย. 2024
- Fluoroquinolones: How Do They Work (i.e Ciprofloxacin)
At NurseMinder it is all about helping nursing students, LPNs, registered nurses and patients improve their knowledge and skill around common nursing skills and knowledge.
Ciprofloxacin and levofloxacin are common generic named drugs that you would find in this classification of antibiotics that treat mainly gram-negative bacteria.
In this video, I share with you some fun and fast tips to learn how to recall information about these drugs without having to memorize pages of details.
From how they work, to the side effects and mechanism of action - I work to make pharmacology easy so you can better care for your patients and pass the NCLEX!.
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Please update your video about the adverse reactions of this drug, it's not only limited to ruptured tendons and weak muscles, there's now 7 black box warnings. I was poisoned by Levofloxacin and still dealing with issues after 2 years. This antibiotic is very dangerous and should only be prescribed in life or death situations when no alternative is found.
There are many side effects- I only cover a partial list
Thank you for referencing Myasthenia Gravis in this video! The more awareness the better! I have never heard it specifically referenced in an educational video before!
Thank you for sharing your experience:) and for adding to the conversation
Super helpful ❤thank you 🌹
You are welcome
I'd sue any single person who've ever prescribed fluoroquinolones.
It should be illegal and every wananbe 'doctor' should lose their law to keep working.
What makes you think that this medication has no value?
@@NurseMinder 'Medication' - good joke.
Hundreds of thousands of victims.
1 pill can destroy human's life.
Are we gonna ignore side effect and the fact that a victim will be living an infernal pain?
What kind of existance it is? Being disabled, feeling pain all day?
This shit destroys DNA at mitochondrium lvl in 100% of patients... Are we gonna talk about tendons, ligaments, internal organs, neuropathy or the fact that fluoroquinolones have the same toxicity lvl as anti-cancer chemioteraphy, but are being prescribed 'just because'?
This isn't antibiotic. It's a high class chemioterapeutic that ENTIRELY destroys human's life.
Bayern should be sued for marketing of Cipro which at 2010 was MOST PRESCRIBED DRUG IN USA!!!!
It's a fcking joke...
@@NurseMinder Also, read about Cipro did to USA Marines or situation in Persian Gulf and then ask me the question again.
@@NurseMinder Yes, you need to do research. You stated that fluoroquinolones do not enter cells that do not have bacteria. Then what damage could they do to a child or a breastfeeding infant?? They do go into any human cell, including brain cells, and do major damage either by adducting to the DNA, or killing off the DNA, probably mitochodrial DNA, since they control the functioning and energy the cell can generate. The adverse effects are severe and may be permanent. These antibiotics are being repositioned as anti-cancer drugs because they do go in and kill human cells. These drugs are TOXIC.
@@NurseMinder this medication is literally killing people. What kind of nurse are you that you aren't doing research before posting about a topic??
You made it easy .Thank you .
Thanks for writing! Means a lot
Fantastic Video explanation❤️
This truly gives me hope in studying pharmacology thank you
Yeah!
Thank you so much easy simple ❤️
Thank you :)
Thank you!
Youre a really good teacher
awe, blushing here
STILL HOPING SOMEONE WILL FIND A WAY TO COMBAT THESE HORRIBLE MUSCLE PAINS; LIKE ARTHRITUS AND FYBROMYALGIA I DID NOT HAVE BEFORE I TOOK LEVOFLOXACIN PLEASE POST IF YOI KNOW SOME WAY TO RID THE BODY OF LEVO. I HAVE BEEN FLOXED HAS BECOME A PART OF MY LIFE
Hey. I am sorry to hear about your experience. Your healthcare team would be the best resource
@@NurseMinder Yes, you need to do research. You stated that fluoroquinolones do not enter cells that do not have bacteria. Then what damage could they do to a child or a breastfeeding infant?? They do go into any human cell, including brain cells, and do major damage either by adducting to the DNA, or killing off the DNA, probably mitochodrial DNA, since they control the functioning and energy the cell can generate. The adverse effects are severe and may be permanent. These antibiotics are being repositioned as anti-cancer drugs because they do go in and kill human cells. These drugs are TOXIC.
@@NurseMinder Your healthcare team would be the best resource?? You've never been floxed!! We're told it couldn't have happened from these safe antibiotics, we must be crazy, a hypochondriac, it's psychosomatic. We need answers and solutions on how to fix our damaged cells and heal our damaged bodies and brains, not more medications for the pain like Lyrica and Gabapentin which do further damage to are brain cells. Where is the help for this after all these years of this poison being used?? Ask the Gulf War veterans from the early 1990's how much help they recieved for their floxing!! Mine started with Levaquin in 2008 (bad enough) and then Cipro in 2016 (life ruining)!! Seen so many doctors and specialists. They don't ever acknowledge the illness or damage, or how to treat it. They attempt to treat the symptoms with medications that often don't help, and that can also cause more damage to our fragile minds and bodies!! Yes, ask our healthcare teams!!
@@NurseMinder doctors and ER can't help FQ Toxicity. Stop your madness. Once you're floxed.. You're floxed.
@@NurseMinder Her healthcare team is most likely the reason why she's suffering today.
Why don't you just shut up and do some homework before doing a video on something you clearly don't have a clue about. There're people suffering and dying because of misinformation and ignorance. SMH.
this the best breakdown ever!!
Thanks!
Thank you so much! This is so helpful!
😊
Thank you 😍😍
You are amazing! This was an excellent breakdown. Thank you!
i give a 💕 for your presentation
thank you very much
Thank you :)
Cool
It is :)
Thanks
Thank youuuu!
You are welcome 🙏
Thank you but how does one recover from cipro toxicity?
Great question. I can add this to the list of videos to make :). I don’t have the answer right now and will have to read up on it.
Read Floxy Hope that may have some tips. The author is Lisa Bloomquist, if I remember right.
Try taking Thiamine the TTFD or Benfotamine versions
There is no cure. It just takes time. Many doctors will try to sell you a "protocol". It's all BS. There's nothing you can do except your body go thru the floxed process.
@@NurseMinder shouldn't you have already researched this medication before doing a video on it? THIS is exactly why people are getting disabled. Smh.
@@NurseMinder Yes, you need to do research. You stated that fluoroquinolones do not enter cells that do not have bacteria. Then what damage could they do to a child or a breastfeeding infant?? They do go into any human cell, including brain cells, and do major damage either by adducting to the DNA, or killing off the DNA, probably mitochodrial DNA, since they control the functioning and energy the cell can generate. The adverse effects are severe and may be permanent. These antibiotics are being repositioned as anti-cancer drugs because they do go in and kill human cells. These drugs are TOXIC.
Thanks 🙏🏻
Thanks for the comment
your videos are sooooo concise and informative, thank you!!!!!!!!!!!! Im watching them ONE BY ONE Lol
I am glad they help … I know I need to make more - and will when my book is done (communication skills to end bullying)
youre the best
This is really helpful;
I'm taking PHARM this summer. Best lecture ever( i like, share and subscribe)
OMG!!! I am so loving your pneumonics!! ( auto correct changed it to pneumonias, ha ha!)
Haha i am a visual learner as well
It’s not called pneumonics, lol, it’s called mnemonics.
I am wondering if the tendon rupture might be due to mitochondrial damage. I have heard that mitochondria are descendants of bacteria that formed a synergistic relationship with eucaryotic cells. Thus, if an antibiotic can damage the DNA of a bacteria, then it could potentially damage the mitochondria as well.
Damage to tendons seems like such an unexpected side effect from a drug that kills bacteria.
What are your thoughts, Tammy?
Great question! I am unsure and would love our community to share any insights they have
@@NurseMinder If you actually beleve what you're teaching, that bacteria only enter cells that have bacteria in them, and then only affect the DNA of the bacteria in those cells, you are misguided. The side effects that we floxies have could not be in so many different organs and systems in our bodies if that were the case. Not only that, but tendinitis and tendons snapping off is caused by tenocytes being killed off, or made disfunctional. Chondrocytes being killed off or made disfunctional is causing are cartilage to disappear, thus causing so many joint issues and slipped discs and arthritis. Even the FDA admits that the mechanism by which the fluoroquinolones work is not fully understood, but also admits that there are many problems being caused by fluoroquinolones that may be permanent, debilitating, and disabling (FQAD).
She said she doesn't know anything about FQ Toxicity.
@@larrydesgranges742 Whenever I see videos like this I get furious. They don't even understand what they're talking about, yet they keep talking and explaining. Awful.
Well it comes with a black box warning for a reason.
Love from Pakistan 🇵🇰❤️ great explanation i am doing GBSN
Hello Pakistan! Congratulations on your studies
Please can you make a video on macrolides
On the list
Thank you 🙏🙏🙏 .New Subsbcriber 🙋
Thank you 🙏. Happy to help
You spent a couple minutes on sun sensitivity and a few seconds on tendon rupture, but didn't mention the warning for permanent nerve damage, retinal detachment, or aortic dissection. Your understanding of these drugs falls in between 2008-2013, somewhere after the tendon rupture warning but before the peripheral neuropathy warning. Not acceptable, to put it kindly. And in the comments you say you'll read up on how to treat FQAD? Shouldn't you know that BEFORE releasing an "educational" video on the subject?
I'll explain now what REALLY makes these drugs different and give people the informed consent that medical professionals should I, as a lay person who was obliterated by Cipro 2 years ago know more than most doctors and pharmacists, because I had to advocate for myself when the doctors tried to cover up their malpractice and misdiagnose me with anything other than the 800 lb gorilla in the room.
Fluoroquinolones are a mitochondria intoxicant. It crosses the blood brain barrier in a way other antibiotics don't, and for that reason is targets healthy cells, including connective tissue and nerves. For this reason it was tested as a potential chemo drug. It is also a DNA adduct, meaning they cause damage caused by covalent attachment of a chemical molecule to DNA. The Cipro binds to the mitochondria and reprograms your DNA so it is routinely spitting out new, unhealthy cells. This results in depletion of antioxidants and a chronic state of oxidative stress. It is also why flares can happen months to years out, because the Cipro never truly leaves your body. NOW. It can and does improve greatly for a lot of people, because your body is always trying to return to homeostasis (your body knows it was poisoned and goes to work to clean it up, but this is serious poison and it’s a long process), but nobody is ever 100% the same after they take this drug. 80% is a good goal for most, particularly those with tendon injuries. Tendons heal but they are never exactly the same as they were before. Some get to 90 or 95%. Many have to settle for 60-70%, which is where I will likely end up (and boy I’ll take 70 after what I went through). I’m probably at 35% at 2 years, which may not seem like a lot but that’s up from 0 or 1%. I'm recovering ever so slowly and if you project out I’ll have another 35% healing in 2 more years and be at 70% at 4 years. Even a mild case can take a few months. Severe cases can take many years. A small amount never recover at all or get worse over time but this is a minority based on my experience. A lot comes down to your age, whether doctors gave you contradicted drugs like NSAIDs and steroids that multiply your reaction (they will deny this too), diet, etc. Again, few people get back to 100% of the person they were before after taking this neurotoxic poisonous Frankenstein bioweapon, but the human body is incredibly resilient, and a meaningful recovery is possible. After multiple ankle tendon injuries I’ll never ice skate or jump rope or rock climb again, however my walking has improved with surgeries and I do have the goal of jogging again.
It really goes to show that doctors, pharmacists, and the FDA have NO CLUE about the safety profile of the drugs they market as "safe and effective" often until 20-30 years and hundreds of thousands of bodies later. Cipro had been out for 33 years at the time of this video and had a warning for permanent nerve damage and retinal detachment for almost a decade and it was not mentioned in the video. To the video maker, it’s nothing personal. You seem like a very nice and charming person who wants to help, but videos like this do patients no favors.
I appreciate the sharing of your experience and there are a few things I will add
This video is not solely about Cipro - if it was, there would be a video for Cipro as an oral med, IV med, drops / each has its own drug monograph that is many pages long
2. These are educational videos and not a replacement for the content individuals receive for their medications, the content Is from current texts / resource
I wish I could go over everything- but that would be a very long video - much like your post
I do need to correct your assertion that it never leaves the body
10.1 Mechanism of Action
Ciprofloxacin, a synthetic fluoroquinolone, has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. Its bactericidal action is achieved through inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination.
CIPRO® and CIPRO® ORAL SUSPENSION Page 26 of 64
Ciprofloxacin retained some of its bactericidal activity after inhibition of RNA and protein synthesis by rifampin and chloramphenicol, respectively. These observations suggest ciprofloxacin may possess two bactericidal mechanisms, one mechanism resulting from the inhibition of DNA gyrase and a second mechanism which may be independent of RNA and protein synthesis.
Elimination:
Ciprofloxacin is largely excreted unchanged both renally and to a smaller extent non-renally. Renal clearance is between 0.18 to 0.3 L/h/kg and the total body clearance between 0.48 to 0.60 L/h/kg. Ciprofloxacin undergoes both glomerular filtration and tubular secretion.
Non-renal clearance of ciprofloxacin is mainly due to active transintestinal secretion as well as metabolization. 1% of the dose is excreted via the biliary route. Ciprofloxacin is present in the bile in high concentrations.
Ref: www.bayer.com/sites/default/files/2020-11/cipro-pm-en.pdf
@@NurseMinder I do not accept Bayer as a legitimate source of information for this drug. They concealed the devastation this drug causes for 20-25 years before the truth came out. They’ve settled billions for other drugs. I’d like to get your opinion on why people can flare 5-10 years out after being mostly recovered of the Cipro is eliminated in a week. You didn’t “correct” anything. This is still very much up for debate, and Bayer has an inherent conflict of interest and is not a valid source.
That being said, I know I came off aggressive as did a few others. I can tell you mean well. And I hope you don’t take this personally and come to resent Cipro victims. You don’t have to like me personally, but take my experience to heart. Remember permanent nerve damage, retinal detachment, and aortic dissection. Remember this can be widespread, there is no treatment or cure, and the tendonitis is a very different mechanism. It doesn’t go away in 6 weeks like standard tendonitis and doesn’t respond to physical therapy.
I was a healthy 31 year old when I was poisoned, left to die and gaslit. I didn’t deserve it. And anyone in my shoes would be bitter
@@NurseMinderIt leaves the body but the effects it has on your DNA can be permanent. This isn t being stressed enough anywhere. Permanent and irreversible side effects. I concur with the original comment if you do a presentation like this talk about apl the potential effects this class of drugs can have.
I am not nursing student but just subscribed bc you are amazing teacher
😊 thank you. This makes my day :)
Anyone taking this please read warning label ⚠️ ⛔️ I'd never take this toxic crap.
Any medicine taken deserves this attention
@@NurseMinder The leaflet inside the packaging says with or without food.
@@NurseMinder No, not all medicines are equally dangerous. Fluoroquinolones are reserved to their own 7th circle of hell.
They work for destroying your life and left you crippled
Devils drug
I think hearing patient experiences is important and it helps healthcare providers education and advocacy and patients to make informed choices. If you have a story to share, that would be helpful
@@NurseMinder th-cam.com/video/joXznzIrB9c/w-d-xo.html
This story is also made about him
If you read the comments of that video you will see that many peoples lives are destroyed by FQ antibiotics :( these FQ AB’s need to be prescribed as last option
I assumed that the Fluor prefix meant that it had fluoride in its composition, which would impact our thyroid also. I also assumed that the “quino” part meant that it contains a derivative of quinine which would work for malaria and other similar diseases.
Breaking down words helps us understand them. I have not read up on this, if you have a resource please add it
I love a good word and fluoroquinolones is just one more of those words that gives us TONS of clues! what was your favorite tip?
Protection from sunlight
Protect from light
Best TIP: stay away from Fluoroquinolones unless you're in a life/death situation. Realize that even nurses and doctors completely ignore Fluoroquinolone Toxicity.
Ive Come to one conclusion ive been poisoned and dokters swore an oat not to poison their patiënts .
And they do all the time with their chemicals. The day comes they will all know how stupid and irrisponible they were.
Hi Doctor I tested positive for gonorrhoea and the doctor gave me 1 single dose of 500mg Ciprofloxacin. Please I want to ask is it possible to have only 1 tablet of ciprofloxacin when you have gonorrhoea, And how long will it takes to Cure my gonorrhoea. Thank you
Yes, here is an article that talks about it pubmed.ncbi.nlm.nih.gov/7871449/
Thank you very much doctor
You're 1000000 times better off with the gonorrhea, trust me.
Ciprofloacin is safe for less than one year?
With any medication, the use of a drug is measured against any potential risk. Generally Cipro is not used in those less than 1 year
No such thing as a safe fluoroquinolone.
Look it up the side effects of this class of antibiotic. It's like playing russian roulette.
u only take fluoroquinolone if u dying
@@NurseMinder "Generally"? You're taking a wishy washy position on giving a neurotoxic bioweapon that caused permanent disability to a 1 year old? Your answer should be "this drug should NEVER be given to anyone under 18, and it is a last resort antibiotic for life threatening infections for everyone else"
Do doctors warn before prescribing fluoroquinolones ?
No they dont. Ive had diarrhea for 5 days went to urgent care. Doc gave me antibiotics i took them for a day upon realizing they were flurquilones. I threw them out waiting for a different script. My posterior tibial tendon is acting up and it rarely flares up
Ideally yes, and then again the pharmacist goes over them (at least where I live)
They don’t warn you that these drugs can cripple you for life and have black box warnings
Look for the fluoroquinoline toxicity facebook group
10.000 severely disabled people by this garbage poison
Look for the thousands of lawsuits against bayer and johnson and johnson because of these awful drugs
Many people take there lives because of the unbearable years long pain caused by side effects.
No. Most of them are clueless and don't give a damn. Once they've destroyed your life, good luck, you're on your own.
No my doc did not..
IT INTERFERES WITH MY DNA AND THI DRUG STOPS THAT; AND GOD KNOWS HOW THE PATHWAY FOLLLOW TO HIT THE FLOOR. SCAREY
She doesn't care. She is basically laughing us all off.
Who does not care?
It is a balance between what the drug helps with and the side effects. All drugs have several potential side effects
@@NurseMinder If you actually beleve what you're teaching, that bacteria only enter cells that have bacteria in them, and then only affect the DNA of the bacteria in those cells, you are misguided. The side effects that we floxies have could not be in so many different organs and systems in our bodies if that were the case. Not only that, but tendinitis and tendons snapping off is caused by tenocytes being killed off. Chondrocytes being killed off is causing are cartilage to disappear, thus causing so many joint issues and slipped discs and arthritis. Even the FDA admits that the mechanism by which the fluoroquinolones work is not fully understood, but also admits that there are many problems being caused by fluoroquinolones that may be permanent, debilitating, and disabling (FQAD).
@@NurseMinder lady, you are so outdated. The CDC health panel of 2021 even stated the RISKS outweigh the benefits. Europe has these medications banned unless for life/death situations for this exact reason. DO YOUR RESEARCH.
Informed consent
Yes, as with any medication
@@NurseMinder personally I have never heard a Dr obtain informed consent or even mention the black box warnings.
@@Anna-ww4pv Correct. As a concept it only exists on paper. It doesn't pay out in practical, real life. I've had doctors tell me they don't have to give informed consent because "if doctors took time to explain side effects they'd only see one person a day." As if I lose my rights to being educated about poisons because you have another copay to get to.
@@crispycruiser4654 True however, an injured person could bring charges. The medication is not to be first choice but, last choice. It was almost taken off the market.
@@Anna-ww4pv You really can't bring charges though. You should be able to, but laws around medical malpractice are lip service.
In my state, you have to have a board certified doctor in the same speciality testify that your doctor acted outside the standard of care. Doctors are a close knit fraternity who play golf and eat dinner at 5 star restaurants on weekends. They don't snitch on each other. The Supreme Court has also ruled you cannot sue the manufacturer, as the manufacturer greased the government to give them immunity.
Medical malpractice lawyers will not take a Cipro case because they know they're unwinnable. Since it's caused by a doctor 100/100 times, they know they can't win so they decline taking the case. The story has been identical with every single floxie.
Over 100,000 people die from medical malpractice every year, but there are only a few thousand lawsuits settled. The idea that you can get justice against a doctor and their "investigations" via the state medical board is nothing but an elaborate production, a dog and pony show to give the illusion of due process.
The "warinings" you're giving in this videos are the same useless BS my doctor gave me.
6 years ago. Still suffering.
Some people really never learn.
Hmmm. What makes these warnings useless? Education is a priority so patient’s can make informed decisions and know what to watch for
@@NurseMinder Photosensitivity, really? I remember that clueless doctor telling me the same exact thing plus "don't do any physical activity during the treatment". Well, I did exactly what he told me, and I ended up with chronic pain and neurological problems anyway. Is it so hard to you to understand that these antibiotics are not like the other ones? I've been part of the 2018 EMA hearing in London. They've been restricted, doctor should be extremely careful when prescribing this stuff, they're reserved for extreme situations. And here you are telling the world that they can cause photosensitivity. Please STFU and DO YOUR HOMEWORK MORE CAREFULLY. 🤦
100% agree with you thank god i only took around 7 pills 4 months later i cant sleep
@@loolme7939 ..hlo present how are you... are you OK now
@@bhanugoud9315 my burning leg pain got better but i do get pain in the leg now and then sleeping getting better i wish i never took this shit
😍🥰
💥
Please why are they given without food?
food in the stomach competes with the medication - when taken without food, we have better breakdown of the medication so it becomes useable
It destroys lives !
Anything we take will have side effects and with proper education and awareness, individuals will make decisions that are best for them
@@NurseMinder I know you have to keep your mouth closed because you're sponsored etc.. I get it. But karma finds everyone
BLACK BOX WARNING; WHY TAKE IT. I CANT WALK OR CLIMB STAIRS AFTER TAKING LEVOFLOXIN
I am sorry to hear about this.
Same here. NO NURSE should be advocating for this medication.
Its Poison !!!!
Amazing for destroy your life
This is a popular comment
Perfect for destroy your life
Are you sharing from personal experience?
@@NurseMinder 5 years … My achillis tendon still crystal
I am sorry to learn about this. If you would be willing to share how this impacts your daily life, all healthcare workers would benefit from understanding the lived experience
Just 2 pills, and 14 months later I'm stuck in bed most days from severe fatigue. Waiting to find out if I have nerve damage in my legs as I can only stand for a few minutes. All sorts of symptoms, thought I was going to die multiple times. Every day I wish I'd asked for a different drug :(
@@debbieattwell fluoroquinolones = Poison. Mais les médecins s’en foutent ils préfèrent vivre dans l’ignorance et blesser les gens
C’est très simple. Il détruit ta vie
Is this your personal experience? What would you be willing to share
@@NurseMinder th-cam.com/video/84XX-I5h8So/w-d-xo.html reportage en france et belgique
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