Dave Feldman: Citizen Scientist Exposes LDL Cholesterol Myths
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- เผยแพร่เมื่อ 28 มิ.ย. 2024
- Heart disease experts have always emphasized the importance of maintaining low levels of LDL cholesterol, commonly known as "bad cholesterol."
Here comes David Feldman, an engineer who was on the verge of developing diabetes. In an effort to better his health, he made the decision to try a low-carb, high-fat diet. Even his sister and father followed suit. As a result, his LDL cholesterol levels increased, but his family did not experience the same effect. Many people believe that genetics play a crucial role in how the body processes a high-fat diet, but David's findings challenged this notion.
As if he was debugging a problem, it fueled his curiosity to explore the reasons behind this inconsistency. In this episode, David Feldman presents the lipid energy model, how high levels of LDL cholesterol may not always equal the risk of heart disease, and the goals of the Citizen Science Foundation to further the research on the field of cholesterol and lipidology.
Quick Guide
01:22 Introduction
07:08 The effects of a low-carb, high-fat diet on him and his family
13:39 An engineer debugging a problem in his health
16:32 Metabolism and how fats are moved in our bodies
21:51 The lipid energy model and atherosclerosis
28:55 LDL cholesterol levels and their relation to heart disease
31:33 Studies on high levels of LDL through the Citizen Science Foundation
43:55 Lowering the LDL
48:23 Closing and contacts
Get to know our guest
David Feldman is an engineer who initiated the Citizen Science Foundation dedicated to advancing citizen science in the field of cholesterol and lipid research.
“Metabolism is this counterbalance between anabolism, which is the building up of stuff, and catabolism, which is the breaking down of stuff. And metabolism is how good you are at building up and breaking down stuff in a good balance. That's really what metabolism is. And nowhere is that more important than fuel. We care a lot about how good you are at putting fuel away, that you're consuming, and getting it back out.” - David Feldman
Connect with him
Cholesterol Code: cholesterolcode.com
Citizen Science Foundation: citizensciencefoundation.org/
Own Your Labs: ownyourlabs.com/
Twitter: / realdavefeldman
Episode snippets
14:03 - 15:24 - Dysfunctional lipid metabolism
18:21 - 19:45 - Good metabolism
32:13 - 34:19 - To gather data through the Citizen Science Foundation
38:15 - 39:49 - Reopening the conversation that not all high LDL is bad
46:06 - 46:56 - Not putting patients into medical treatments when it's not needed
Follow Dr. Ovadia:
Twitter: @iFixHearts
Website: OvadiaHeartHealth.com
Metabolic Health Quiz: iFixHearts.com
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Thanking the universe for engineers like Dave who think methodically and orderly to solve problems using the resources at their fingertips.
Dave is doing incredible work, much appreciated.
Setting out to DISprove one's hypothesis is the hallmark of a great scientist!
As a Chemical/Environmental Engineer who now is a student of biochemistry and in ketosis with a "high LDL," I am surprised this discussion did not focus on particle size as well as why the five metabolic syndrome items ignore LDL if it is allegedly so important to good health. Although my A1c is 5.2, low BP, High HDL, and low Trig, my former doc wanted to put me on statins, which I refused and found a new doc. I am so glad that Dave Feldman is getting the recognition he deserves for his work in this field.
My current understanding is that particle size is not as important as some of those other things you mentioned. Smaller particles are more likely to get "stuck" but each particle has less cholesterol. Larger particles are less likely to get stuck, but by definition, they have more cholesterol. I'm not sure if they necessarily equal each other, but the field is a bit more leveled 🤷♂️
Statins double your risk for dementia. Among other side effects. Cholesterol is necessary for your body.
The CAC test is more important if you are concerned about cardiovascular health having low BP.
Thank you for this conversation! Please don't forget us non athlete LMHRs.
What is LMHR?
@@hendrikap831Lean Mass Hyper Responder. A thin person whose LDL went up considerably after starting low carb or keto.
@@hendrikap831 LMHR = Lean Mass Hyper Responder = People who have ordinary lipid profiles on SAD, but after going low-carb develop high HDL, low trigs, and high LDL, and who do NOT have FH/identified genetic reasons for high cholesterol. So named "lean mass" not because it's definitional, but because we tend to be very lean. Average study cohort is BMI about 20-22ish, if I'm recalling correctly.
Great video gentlemen. Thanks to Dave for leading this effort. Thanks to Dr. O for having Dave on your channel. Many of us are following this inquiry with great interest that is personal as well as medical and academic. Kudos to all of you. :)
If LDL was bad for you why does the body make so much and why does every cell contain it. It's not the LDL but what we do to the LDL (via diet and lifestyle) that is the problem. Just my opinion.
Exactly my question!
LDL is not in every cell. Cholesterol is in every cell. LDL is a carrier of cholesterol.
So thankful for Dave and his work.
doctors are not scientists, they follow guidelines, problem is guidelines are owned by large companies
I still fit Dave's lean mass group. Now I am carnivore, waiting to see how my next levels are (btw, I will be 60 this year and my recent CAC was "0". I have been saying no statins for 40 years
Superb dialogue thank you gentlemen. Philip, you pushed it up against the wall!
Please discuss low carb and high ApoB.
Thank you! I have self diagnosed myself as a LMHR , but that is just thru listening and reading and trying to figure out how I can be so healthy on the one hand and have LDL in the thousands??? I am looking forward to the results of the study Dave has been conducting.
Same. I am lean, energetic, exercise daily, carnivore diet feel great and LDL is near 1k. Dr tells me I am going to have a stroke any moment 🤔
Ah. The mind of an engineer. How I love it so. Fantastic.
Thank you for the easy the understanding definition.
Time for an update with Dave! Great info coming out this past week from the Keto study / Lean Mass Hyper Responder Study.
Yes, thank you!
Context is always important.
Dave's and Nick's LMHR study
Which indicates that for that very limited specific LMHR group
Extremely high LDL does not cause ASCVD
Wonderful study
But
LMHR
Excludes
2/3 or more of Americans who are not lean but overweight or obese
A vast majority of Americans who are insulin resistant
A vast majority of Americans who are metabolically unhealthy
So does that mean non -LMHR people can
ignore high cholesterol
Ignore elevated ApoB
Ignore lipoprotein (a)
???
Dave mentioned that zero subjects in his experiment had calcification. Did the diagnostic tool to measure calcification get tested for accuracy?
But-I’m pretty sure I’m a LMHR 2 yr carnivore and suddenly had a diagnosed occlusion and subsequent stent (4 wks ago). Refusing statin therapy however!
Please respond where I fit into the findings of this novel study. BMI 20.5, TR 63, LDL 249, HDL 328. 65 YO and jogger. Love my low carb diet and it has changed my life. I can’t believe it caused the occlusion!!! Maybe 62 years on the SAD and COVID 4mos ago was the tipping point?? Thanks in advance!!!
What is your total cholesterol? Hdl 328?
People with HIGHER overall cholesterol live longer! Fact, look it up. Centenarians have high cholesterol.
Bernard Lappalo didn't have high cholesterol n live 115 yrs. Ate mostly plants n 3 cans sardines a week
So when would pharmacological intervention be indicated and what would that be?
Thank you for reaching out. We can not give individual medical advice via social media. Please feel free to book a call to discuss options for working with Dr.Ovadia and and his team. calendly.com/eliza-ifixhearts/15min ~ Eliza, on behalf of the Dr. Ovadia's I Fix Hearts team
Great video! ❤
Glad you liked it!!
awesome!!!!!
Same here, keto for 6 months, lost weight, fit, don't drink or smoke, very healthy stats except elevated ldl and dhl. Dr said just like other fad diets, keto affects cholesterol negatively. Told me to cut out all the fat/oil, and when I protested, he asked me if I wanted to have a heart attack 😢 Btw no familial cholesterol problems.
I'm sorry that happened. It's so sad these doctors just don't know better.
Same here except that as a physician myself, I won’t tolerate any condescension and dogmatic spew from my peers. No way am I going to take statins even though he’s been after me to do so for years.
I would love to participate in the forthcoming study. I am a LMHR with absolutely *perfect* numbers on everything other than LDL (my cRP is 0.9 for example). How would I get in line for consideration?
Also, I am a software engineer ;-)
How does Lp(a) factor into the LMHR population? Has Lp(a) been tested for and examined as part of the LMHR studies?
You just explained why we need protein: to move fats around the body.
Have you guys talked to Dr Ben Bickmam yet. I think him and Dave would have a great convo session!
I asked my Doc to stop Avortastaun a little over a month ago. I got my Lipid panels and as expected on a keto diet it jumped up over the thresholds for Total Cholesterol and LDL. My triglycerides were 94 and HDL at 74. Actually even in stating, panels rose as soon as I started Ketogenic diet in Jan 2021. My Dr is recommending Nexletol now. I asked to stop stating due to muscle pains and aches. Any thoughts? Thanks
Yes, Don't ask. Instead tell your doctor that you have decided to stop and why. You are the captain of the ship. It's your life, not his.
Antiinflammatory: photobiomodulation
I fall into a hyper responder. Now how to convince my doc I don’t need statins. My LDL has hit highest since start HIIT 8 months ago.
How high is ur LDL?
Thanks guys for the easy explanations on this topic. The best I have heard so far was by Dr Natasha Campbell-McBride. She nailed it in her book “Put Your Heart in Your Mouth”
engineer and scientists are needed to solve this, engineers have lost their power they need to be given authority over budgets and business so they can steer companies in the right direction.. this guy is proof.
Can anyone answer what a good triglyceride level would be? Gp wants to put us on statins due to high total cholesterol?
Trig under 100 is considered good but uner 80 is desirable. Also, trig/HDL ratio is one of the best markers for CAD. Under 2 is OK but try to target under 1. I am 61 years old. My trig/HDL is 0.7
Yes, if you divide trig by hdl, the goal is for it to be
@변창해 wow, thank you, I am 73 years old, and mine is .4 by that , definately saying no to my gp now!!
@@ritajaworski OMG you're doing amazing
With all due respect, but what’s Jack’s contribution in this debate?
He has also cut some of Dave’s interesting contributions to ask irrelevant questions
Does dave eat vegetables?
If you have a blood pressure of 111/70, then I suspect that my glycocalyx is working.
Lower blood pressure with the right amount of exercise.
Then does cholesterol enter the blood vessel walls?😊
This is interesting but also maddening. What about those of us who are losing weight, doing great on keto, but LDL goes up and doc freaks out? But we're not "lean mass" - we're no longer morbidly obese or obese, but we're still overweight. What are we? What's our issue?
Our metabolisms are so much better. Maybe not completely healed.
Why don't you all talk about the studies that Paul Mason mentions? I don't get it. There is a meta study of 19 LDL/longevity studies. 16 of them show that over age 45 or so, the higher your LDL, the LONGER you live. The lower your LDL, the quicker you die.
There are also studies showing that 50% to as little as 70% of heart attack sufferers have average or even low LDL, that only 50% to 30% have high LDL. Can't tell if you mentioned this one or not. If not, why not? Again, I think Dr. Paul Mason discusses this one. Maybe spend more time on his channel. Pls come up to speed.
I think you're missing the point somewhat. Those studies aren't irrelevant or anything. The point of Feldman's work is to hopefully show that high LDL levels in even metabolically healthy people, who should not have any other risk factors except for the LDL, isn't the demon it's made out to be. That conclusion is still applicable to the non so-called "lean mass hyper responders". The point is to make the argument for a more nuanced treatment of LDL as a whole, as Mason has also outlined.
@@MrKanti-yy5ux You're still missing the important point. You're so close, but you're not getting it.
Try harder. I'm not messing with you. Push a little more and see if you can get a breakthrough and see the thing I'm saying. You're failing to see it, and I don't feel like retyping it. It's up above, plain as day. Good luck!
Look, I like Feldman. But people like me are being left out (which is a separate point) - what about hyper responders who aren't lean? Why are we getting thrown under the bus? There may be more of us than lean-massers. And don't tell me we aren't being thrown under the bus, for crying out loud. I'm speaking figuratively.
@@johneubank8543 No, you're treating them as separate issues when they aren't. The reaction from doctors people like you and people like me (leaner) is exactly the same. We're both doing the right thing, but we're at different points in the process. Doesn't matter. The findings of Feldman's study covers both ends, the lean and not-so-lean with high LDL but low (or lowering) Triglycerides, and hopefully dispels the myth of LDL for BOTH OF US.
@@MrKanti-yy5ux You're not even trying. I'm done with you. Good luck.
@johneubank no one is saying you’re wrong.. but Feldman study is with people who’s ONLY red flag is extraordinarily high LDL. It rules out a lot of other things. His results in the end will still apply to overweight people (like yourself). To be in the study (I didnt qualify because of two things..
How about this hypothesis? All docs without an open mind are dummies.
If you ever wondered why you don’t go to engineers for medical advice, particularly when your life is on the line, this is a great example.
You need to elaborate.. his preliminary report confirms the lipid hypothesis may be invalid. his group with up to 4 years of LCHF diet showed almost no signs (many had zero signs) of plaque buildup. This clearly throws a wrench in the lipid hypothesis.
@@dsonyay no it doesn’t. 75% of the people age 55 and younger have a zero CAC score. He is doing a victory lap over something that 75% of the people have. But every study shows that over time these so-called LMHR folks will have a bad result. That is why you don’t listen to engineers for medical advice.
@@davidzip8841 Over 4 years their CAC would increase if your theory was true.
36:13 statin makers
Maybe it's not the ldl failing, but the cell is full of energy