18.6 Nucleophilic Aromatic Substitution | Organic Chemistry

[@johnnytaylor9784]

Thanks Chad. Your videos have helped me a great deal throughout my pharmaceutical chemistry degree.

[@ChadsPrep]

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I have a quiz tomorrow for ochem (and an exam for another class too) so I'm binge watching your videos (: hope I do well

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[@local3128]

7:06 Isn't nitro group a better leaving group than cl? Then in the reaction, wouldn't NH2 substitute NO2 instead of Cl?

[@ChadsPrep]

If you look at the flow of electrons within the pi system, NO2 is withdrawing electron density towards itself and so the electron density at that point in the ring would be relatively higher making it less likely that substitution will occur there.

[@local3128]

Oh, true. Thanks for the reply. 😊

[@ChadsPrep]

You're welcome! happy studying :)

[@laurenpare1888]

for the elimination-addition reaction to form the benzyme intermediate, if the methyl were a pi donating EDG would regioselectivity be impacted for the final product? would the meta be favoured because EDGs add electron density to ortho and para positions? or would the reaction not happen?

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Thank you for helping me pass ochem II

[@ChadsPrep]

Good for you, Bridget!

[@miray7945]

is there supposed to be NO2 in the product @ 8:26 ?

[@ChadsPrep]

:( It absolutely was supposed to still have a nitro group para. ARRRRR! Thanks for the heads up and nice catch!

[@maxsingh1117]

@@ChadsPrepshould there also be a nitro at the ortho position, or did that one leave?

[@maxsingh1117]

@@ChadsPreplso great vids they do really help a lot 🙌🏾

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[@sajjadanjum2695]

very nice video

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Glad you like it, sajjad anjum!