Dr. Benjamin Bikman - 'Ketones: The Metabolic Advantage'
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- เผยแพร่เมื่อ 26 ก.ย. 2024
- Dr. Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. He is currently a professor of pathophysiology and a biomedical scientist at Brigham Young University in Utah.
Dr. Bikman's professional focus as a scientist and professor is to better understand chronic modern-day diseases, with a special emphasis on the origins and consequences of obesity and diabetes, with an increasing scrutiny of the pathogenicity of insulin and insulin resistance. He frequently publishes his research in peer-reviewed journals and presents at international science meetings.
Dr. Bikman has long been an advocate of a ketogenic diet in light of the considerable evidence supporting its use as a therapy for reversing insulin resistance. His website InsulinIQ.com promotes dietary clarity, healing, and freedom through evidence-based science about insulin resistance. Employing cell-autonomous to whole-body systems, Dr. Bikman's recent efforts have focused on exploring the intimate associations between the metabolic and immune systems.
when Ben speaks.. the world should take note
Dr. Benjamin Bikman is such a highly skilled teacher. I wish when I was in university, years ago, that every science professor could have had the explanatory ability that he does. He is not only a great speaker, he makes it a point to always offer new insight in the area of metabolism. Far too often, after listening to hundreds of lectures from low carb doctors and researchers, you hear the same thing with a few variations and a few extra details. All three presentations that Dr. Bikman has given - the dynamics of brown fat, the role of glucagon in mitigating the insulinogenic effect of protein, and now the effects of ketones on the robustness of the cell/and ketones energy efficiency - always presents something novel. Thank you Dr. Bikman for always keeping these subjects fresh and interesting. I thank the producers of this channel for also bringing Dr. Bikman's presentations to the world.
Another one is Paul Mason, he brings some very complex information to the mix and new findings - and has co authored a few papers himself.
I lost 83 lbs in a year by eating keto /low carb. I am type 2 diabetic.My A1c has been at 5.2 for over a year.My cholesterol HDL is 60 ,triglycerides at 85 down from 198. I am at my healthiest since I was a teenager. Low carb works .Turns off appetite ,burns fat while eating fat! Love it!!
As a type 2 diabetic… i am glad you found your way
Get v
Ben Bikman is one of the best voices we have. Thanks for this.
He is the keto god
even if he lost our fine Canadian accent 🤣
It is obvious to me that Dr. Bikman has more knowledge in his brain on the subject of insulin and metabolic syndrome than his thought process can handle. The man is brilliant.
This is so much more informative than the generic “CICO” advice most people parrot endlessly.
It's brainless nonsense and they swear it's "science" lol 🤣
Prof Bikman, make your introduction as long as you like I can listen to this sort of information all day long.
This is brilliant stuff!
IF YOU WANT TO FEEL GREAT AND BANISH DEPRESSION,JOINT STIFFNESS, SKIN TAGS ,AND OTHER SKIN CONDITIONS, STAY AWAY FROM SUGARS COMPLETELY.
AMEN
Which means basically all carbohydrates regardless of their form
2 years later watching this and it’s amazing, I’ve learnt so much! Thank you.
I've seen this so many times. Bikman uses so much data and common sense in tandem and presents it all in a way that helped me change my life and take control of my health.
He literally is the Master!
Amazing information as always! I practice prolonged (48-72hr) fasting and am stunned by how much energy and mental focus I have when in a ketogenic state.
I love this man!!! He’s brilliant and has shed so much light on my issues, and given me so much peace about how I might see change in my insulin resistance. He’s So kind and so smart, I can’t say enough about the respect I have for you Dr. Bikman
And he has a great sense of humor.
Dr. Bikman, probably the greatest public speaker out there. Such a beautiful soul and truly captivating.
Bikman is always great.
Nephilimator total rock star
Thanks so much Dr Benjamin this was so amazing and encouraging. Tomorrow is my 24th week on the Carnivore diet and I got sick, massive pain and it took awhile for the drs to realise I had an ovarian cyst and I had such extreme negativity from most of the medical staff about me being in ketosis and of course for being on the Carnivore diet excepting one Doctor who knew of Dr Jason Fung and keto. So this has been uplifting. I've had CFS for a very long time and my muscles had wasted away and now even though I can faint from pain I definitely have so much more physical strength and have amazing muscle tone now. :))))))))
Dr. Ben Bulman: most eloquent speaker in the lchf sphere.
This is poetic and sheets a true pleasure to listen to you speak.
who the hell is Ben Bulman?
Sheets?
@@David_Brinkerhoff93 I think it’s a typo error Bikman
Ahhh, disappointed you didn’t cover ketones and the brain, I MUST find a podcast where you cover this issue as promised!! I had to listen to this a few times, lots of info, deep, thank you so much for posting this!
Fantastic presentation. I hear so often people call keto the "starvation" diet from those of a particular militant diet/lifestyle choice and Ben puts this into crystal clear focus
Found him recently wish I had known about this gentleman sooner in life.
I am 75. Wish I had know of keto years ago.
Love, Love, Love Dr Bikman. His research is so important. I really hope more people hear what he is saying. Listen to this guy. He has so many important answers to many important questions regarding diseases of modern man.
Very well explained. English is my second language and I understand this . Great work!
The word “ waste” has negative connotations when in fact it is a good thing in this context.
Dr Atkins should be credited too. He brought the idea of low carbing for health to the mainstream.
A man before his time a visionary
Emerald Jam and Mikey Webb, ❤️You are BOTH SO RIGHT! 😋. It was Dr Atkins who first brought low carbing
BACK into the limelight and I owe him my healthy T2 Diabetic life, now FREE of diabetes. I grieve the hateful accusations against him by THE FOOD FACTORY INDUSTRY and the dishonest and/or jealous and ignorant doctors supporting the Killer SAD PYRAMID! Also I never believe recommendations coming the ADA and the AHA. which are both generously supported by companies like Kellogg and Quaker Oats and all the giant major high-carb food makers who are happy to ruin our health and kill us just so they keep on making billions of $$$ in profits.
Truth.
Atkins identified what Ben is calling the uncoupled use of energy as metabolic advantage but he could not explain it. Atkins was right and Ben is a genious.
That is a spot on observation. Dr. Atkins was a pioneer, and like most pioneers, they stumble upon a truth by being a keen observer. However, as a pioneer, they lack the tools or know how to explain the the mechanisms behind a phenomenon. That is where brilliant men like Dr. Bikman come in. He can fill in the details, further establishing the legitimacy of Dr. Atkins assertions. The only tragedy is that he is not around to see how much he is being vindicated.
@@alphacause you are totally right! 👍Dr Atkins ❤️. and his message saved my life. when i was a newly-diagnosed fourth generation (young,) T2D and found his simple, common sense approach to weight loss through carb control. I’m nearly 88 now ( to my astonishment ! 😁) and in amazingly good health. Dr Bikman’ brilliance has filled in a lot of scientific WHYS for me. 🥳🥰and has convinced me how wise I am to follow the Keto life-style even though no one else I know locally is doing that!
This was amazing. I cannot wait for the "incredible data" on effects of ketones on brain tissue. :)
I was fascinated to learn that raised insulin levels, as in insulin resistance / pre diabetes, lowers the metabolic rate. It partly accounts for the extra time that it takes for the person with pre diabetes to start to develop ketones when they start to fast.
Exercising and maintaining a degree of ketosis by low carb / HF eating should I hope lead to lower insulin levels, glucose levels and HbA1c, and increased metabolic rate. I look forward to the work on the brain and from his opening remarks, it would also appear to be likely that it will be extremely important.
One of my favorite people ever.
Dr. Bikman rocks. Thanks man, learning so much from you. I wish I had time to come take every class you teach at BYU. :)
Lord Atkins was the real trailblazer. ⭐ All hail the ATKINS DIET!! When people ask me what diet I'm doing, I always say "The Atkins Diet" vs. "Keto". 😉 Although, all the bodybuilders from Gold's/ Muscle Beach CA in the 70s, like Arnold Schwarzenegger, we're doing the the very Low Carb Diet six days a week, with one day on Sunday as a cheat day. All those classic bodybuilders knew the secret to a lean muscular physique all the way back then: The Atkins Advantage. 👍
When I was in my early 20’s, my baseline metabolic rate was 8,500 calories a day. Bodybuilder, 147 lbs 6’2”. Probably prediabetic then because I’m diabetic now. 45 days on keto and feel great!
Please keep up these talks. Your family needs to come with for travel. Take them on a hike in the mountains. The world needs more talks like yours on what the science says about carbs, protein and fats. And what we need and when and how much.
Your talk on insulin/glucagon was very enlightening. I'm trying to go 95% keto/carnivore. It feels so good. I feel dirty doing it. But it is definitely what I need to do. I feel so much better. Mixing in veg/startch, various ones do not work. Find the ones that do. Kale works for me very well. Spinach peas or potatoes not so much. White or brown rice is ok in small quantities. Maybe i'll try a high dose of those to see what can work as an alternative. Going out to eat is nightmare. Seed oils wreck me fast and put weight on and cause me to snack and not feel full. But YMMV
I can't moderate. Good for you that you can. Four years carnivore.
Interesting to hear about uncoupling in white fat with ketogenesis. For myself, when I fast, many areas of my body feel considerably warmer -- it "feels" like ALL my fat is actually creating heat.
On my way to and from my gym I drive with all the windows down. Hoping this practice will create beige and brown fat because it's still winter
I truly enjoy intelligent speakers
Brilliant and engaging--as usual.
I love listening to Dr. Benjamin!
Thanks Dr. Bikman for illuminating the world.
One of my favourite fellow Canadians!!
This professor is giving precious information, he is the man
It would be interesting repeating metabolic comparison between "standard" keto diet vs carnivore diet
A great presentation! Thank you, Dr. Bikman!
Dr. Bikman "s humour us quite dry, but I love it for it's illustrative effect. "I'm sure most of you know exactly what I'm talking about." Ha, I feel spoken to not spoken at I really enjoy the reinforcing nature of his talks!
Clear and straight talk, I like this aspect of Ben. Thank you for sharing!
It's pretty simple, imo. We evolved eating meat and fat, not Cheerios.
🤔🤔🤔🤔🤔🤔🤔 yes
@M Crumb I've found through trial and error that I'm much better off without that stuff.
Genesis 1:1 and Revelation 4:11 We did not evolve; Genesis 9:2,3 We were given permission by our Heavenly Father, Jehovah God, to eat meat.... We should eat real food, not processed junk.
What is the diff between monkeys and us... Meat! Ye... imagine Darvin putting out this one too? Sugar would’ve been banned!
Day 11 of Keto. The thought of Cheerios or weetabix and cold milk hmmmm...I have cream in my coffee now but I loved a pint of milk, I miss milk so much 😐
I’m a type 1 diabetic that used to be a sugar burner. I inject all my insulin. The thing that bothers me about “Keto doctors” is that they all tell us we need to avoid insulin. But NONE of them give values for this. Since I inject all my insulin, I know EXACTLY how much insulin I receive each day. But despite this, I’m clueless as to whether that value is good or not. I found one page on the Internet called “understanding type 1 diabetes” saying the daily requirement of insulin for people is their weight in pounds, divided by 4. So I’m 5’ 11” and weigh 180lbs. So it says I should be at 45 units of insulin daily.
But it doesn’t say how much insulin daily allows me to be in ketosis. And none of the “Keto teachers” actually give values for insulin. Or ACTUAL ways to determine how much insulin a person should receive each day, based on their age/height/weight to be in ketosis.
If you told me values I should be striving for, I’d be very motivated to hit these values. An example would be...If you needed to be 1/8th of your body weight in insulin each day (so for me 180/8 is 22.5 units of insulin daily). Then I’d actually have a goal in mind that I’d need to hit. Currently on a good day my daily insulin is around 36 units. And I’m slowly improving. But I have no idea what I’m supposed to be striving for.
I’d be very thankful if you gave values for how much insulin a person can receive each day and still be in ketosis. Because everyone still gets insulin each day, even if they don’t eat food. So how much insulin does a fasting person receive each day.
I’d be soooooo happy if you (or anyone else knows the answer).
Also I take 12 units lantus (slow acting insulin) before bed, and 12 units when I wake up. Then I just correct my blood sugar with novolog (fast acting insulin) when it rises above 120. So usually another 12 units of insulin to correct high blood sugars. These numbers all vary by a ton daily.
Or if anyone could even just tell me their age/height/weight/how much insulin they take each day/and whether they’re in ketosis or not based on those numbers, that would be immensely helpful!!!
how much insulin you need will be based on how much you eat how you spike your sugar level. Insulin is to help regulate blood sugar.
Not sure if you will see this but for what its worth.... I'm approximately your weight and height and on a very low carb diet. I take about 8 units of lantus twice a day and around 2 to 4 units of humalog a day total. I spend at least some part of each day in ketosis.
Can you not get an insulin pump so you don't have to calculate it, and it does it for you?
@@mikp8519 Hey, may I ask how do you know you are in Ketosis? Do you have a measuring device that measures ketones? If not, do you just not eat for a couple of hours? If so, how many hours? Sorry, so many questions, but my dear mother has type 2 diabetes and 2 months ago i decided that i must take it upon myself to help reverse it or possibly help her heal from it. I wish I would of known this years ago, but its never to late. Hopefully you see my comment, and able to respond. God bless.
@@KaRiNa-pj9sb your mother ( with TYPE 2 diabetes) and the original poster of this comment ( who has TYPE 1 Diabetes ) have two completely different diseases so unfortunately his figures or advice will not actually apply to you. So for help with YOUR question pay attention very closely to Professor Bikman!
Amazing video, always enjoy listening to Benjamin Bikman
WOW Dr B, you blow me away! Insulin and metabolism, so the whole plethora of high carb snacks wouldnt be helping the obesity epidemic!
Dr nadir ali as well
It seems the Glucose and the A1C may rise with Keto.
It happened to me.
Following a 4 months keto diet, my fasting Glucose went up 70 to 77 mg/dl, and my HB A1C (%) went up 5.3 to 5.7.
I'd appreciate your comments.
I know this comment is late, but he has a video from two months ago called "Surprising symptoms related to metabolism+why glucose may rise on keto". I'm getting ready to check it out myself.
Dr Cywes has talked extensively about this phenomenon. It generally happens in patients that have been under ketosis for a long time and have become so good at burning fats that their pancreas stops temporarily producing insulin and the blood glucose starts creeping up. Basically, the body starts acting like a Type 1 diabetic that has almost no insulin. What he says has been helpful to his patients is for them to have a few meals a week that are very low in fat but high in protein. With the reduction of fat, the body has to turn on the glucose burning machinery. So he recommends for people to have a few meals a week with leaner proteins like white fish and chicken breast and cook them using methods where you don't add fats like poaching them in broth. Also don't use oil to season and use seasonings like lemon juice and mustard. Basically it's saying that veteran ketovores have to do a few meals doing something like the Protein Sparing Modified Fast for one or 2 days per week. If you don't have carb addiction issues you can also encourage a mild insulin response by eating a few low glycemic fruits like berries once a week. Check your blood glucose to adapt the protocol to your body
I thought it was because the red blood cells got healthier
beautifull and effecient ability to express the topic to be understood regardless of the complexity
this is of course relevant to the treatment of cachexia that helps treat catastrophic muscle wasting due to cancer metabolism inflammation. Keeping muscle metabolism 'coupled' as stated protect it. So this theory goes to explaining why ketosis is beneficial in dealing with cachexia.
I bet doc Bikman is an excellent professor.
Fantastic lecture - great relevance to all. Thanks so much.
"Endocrine theory encompasses caloric theory" :-)
Love Dr.Bikman talks!
Thank you so much.
ketones rock - 4 months omad on keto diet 19 kg down.
love the ketones!
Thanks for the science, mate.
From an evolutionary perspective, this makes sense. When you only have meat to eat and your body is relying on back-up reserves, you need to be as efficient as possible to make sure to get more. When you have plenty of carbs to eat, you can be lazy and don't need to be efficient. Whey you have HUGE amounts of carbs to eat.... well, you're beyond evolutionary conditions at that point.
Today, many of us have as much of whatever as we want to eat, so the 'lazy' metabolism can become ridiculously lazy. We need to become more efficient, not to avoid starvation, but to avoid the side-effects of lazy metabolism.
Dr. Ben, please teach me how to drive your cool car
That was informative, but very hard to follow and I'm a med student....
He speaks so detailed that we can all understand 👍👏
Looking forward to the rebuttal that calories from a steak are the same as calories from a Pop Tart....
To be fair, they are. Its the HORMONES that are different and that is what really matters.
Calories are calories, no matter how you slice it. It’s the nutrient density of a food that should be considered. Steak of course blows a pop tart to smithereens!
"my long winded introduction"...true words
Interestingly, the "clutch" of a manual transmission is called in the German language "Kupplung".
Excellent podcast 🙂👍
Dr Bikman is absolutely enlightening 🤓
Great presentation, what is not clear to me is how can (initial slides: Insulin Slows metabolic rate) a T1 diabetic (Group 1-3) with 23.1mmol of glucose also has 4.5mmol ketones? I thought if one is in ketosis there would be no insulin circulating?
Insulin is always present because there’s always glucose running in your bloodstream. Even if you don’t take it any food. The liver will produce glucose through gluconeogenesis. And it’s not a constant some people will produce more than others. So insulin is always there as a baseline.
I'm still curious what ketones do with brain cell...I hope Dr. Ben will publish/talk his research soon...
Same
IT DEFINITELY DOES AWAY WITH BRAIN FOG AND MENTAL CLARITY. I KNOW FROM 25 YEARS EXPERIENCE OF DOING KETO.
Well, there is a study on mcts and alzheimers even without keto amd improved cognition was found with 45g a day. Gotta work your way up though or youll be stuck on a toilet..
How can this be explained in evolutionary terms? High insulin signifies a fed state, low insulin a fasting state. You would expect low insulin to correlate to tight coupling in both fat and muscle to preserve stored energy supplies and maximize survival in times of famine. Instead the opposite seems to be the case. Really interesting stuff but a real conundrum, for me at least. I’m a big ketosis diet advocate btw. At 62 I’m returning to the physique I had at 32-magical!
What makes you think being satiated, full, will always mean a high amount of insulin?
My psoriatic arthritis definitely gets better when I get off the carbs.... I know this but still have a hard time keeping it up.
Try carnivore, it’s even better
You should put the when and where in the description.
I love you, it makes me love myself even more bec ketosis makes me feel better ❤️
Thank you for this! Great information!
I don't understand this ( 35.24 ) in the evolutionary context. The data says that ketosis makes white fat "browner" which means that it throws more energy away as heat. And ketosis is characteristic of the fasting state, which is what animals go into when there's a famine. But why would an animal throw more energy away during a famine? Surely it makes more sense to conserve energy?
I think it's to do with hibernation/sleeping at night, i.e conking out when it's cold. It makes sense that there'd be some sort of mechanism to save muscle and generate excess heat to maintain a minimum temperature
@@UncleRoykus First reason, fat is stored to be burned. So the body learns how to burn it. The second reason is the longer the fast the more energetic you get because you MUST MOVE, EXPLORE, KILL, EAT and survive. All require an enormous amount of energy and the body, especially in case of famine, really wants to use as much energy as possible without waste, so it learns how to use it most efficient.
Love to watch Dr. Bickman! Intelligent and awesome speaker! But can someone tell me how to battle contraption with extended fasts?
Interesting!!!!
What I understood:
Coupled mitochondria = direct correlation between oxygen utilization and ATP production… saves energy. Holds onto calories and fat.
Uncoupled mitochondria = much more oxygen utilized than ATP produced. Wastes energy. Burns calories and fat.
ABSOLUTELY LOVE THIS!
A brilliant explanation.
Nobel Peace Prize candidate along with Dr Jason Fung... that’s what I’m saying.
Yes! Absolutely!
Yay! Another feather in the Canadian hat! Beaver fur hat of course!
Excellent information, even for a newbie! I miss my old Subaru ;)
31:00 It occurs to me around this point that this data is very relevant for the exact techniques practices in the WHM.
I wonder if this explains why I feel cold during fasting. Less energy is used for heat.
Watching in Nov 2021
Thank you
Resting energy old vs younger. Twinkie diet reigns suprim for the teens. Vs me old man self. I'm keto mostly and need to be. I was obease. It was creeping in for years. I could exercise it away but lock down said nope.
Is a high metabolism better for longevity
I trust this information.
Ive never heard of Ben but I’m impressed
great news: ketones couple muscle mitochondria and uncouple adipose mitochondria 😃
It is believed that using energy just for heat is a very clean way for our body to burn calories. And having less calories and adipose tissue in your system is correlated with better health and longevity. You might want to check out the Calorie Restriction Society forums, especially post about cold exposure (which also uncouples mitochondria, as a means to produce heat). @You Tube
Yep. Goodbye fat stores. Yay!
Watching this again in 2021 and reacting to the coughing differently than I did the first time I watched it in the pre-covid era.
Agreed. But the relationship with appetite, as far as weight control, is what matters in the end.
Do you have any data on the body composition of the groups? I would imagine the overall REE is even in the young because the muscle tissue mitochondria become slightly more tightly coupled and the fat tissue becomes less coupled, but it evens out. In the older people the smaller amount of muscle tissue, and perhaps overabundance of fat tissue to boot, means the REE is skewed in favour of the higher burn rate thanks to a larger relative proportion of tissue with a higher uncoupling rate.
I'm waiting for him to tackle lectins.
Dr. Paul Mason is doing that right now. Lectins look look pretty bad.
YEAH, THOSE WHO SAY THEY DON'T EAT DEAD ANIMALS LIKE TO EAT DEAD PLANTS THAT CARRY KILLER LECTINS THAT GOD CREATED AS A PROTECTION FOR THE PLANTS. GOD GAVE EVERY LIVING THING A FIGHTING CHANCE.
@@robinluich5576 beware that lectins are also found in dairy and meat from animals raised conventionally.
it was very helpful, thanks
Ojalá puedan subtitularlo en español 😢
You are great.
Maybe this is correct I don’t know, but it seems like you could compare burning carbohydrates to kindling on the fire and burning a fat to burning large logs.
In summary?
Great talk thank you.
In reference to 5:15.. I thought that ketones in the urine or breath are acitate which only a small part of the ketone. The other parts are not wasted but used or repackaged. Help me understand how that is calories wasted?
Over my head
For those of us whom are hyperinsulinemic then we can't dismiss the effects of protein, ask diabetics how much insulin they inject for protein consumption!. I wish you'd made this clearer at the beginning rather than the end as often your research is used to beat us up as protein deniers as people DON'T fully listen to your talks and miss the comments re HYPERINSULINEMIA !
I've seen the effects excess protein has on my A1c, my idea of a cheat on KETO is a ribeye steak! Controlling protein as well broke my first KETO stall then adding in ADF [Dr FUng] finally pushed my insulin even lower to break another 1yr KETO stall - ADF allows me to eat a little more protein too!
I think you missed important parts of his lecture. Diabetics following the standard diabetic diet in the USA are getting too many carbs.
Ketogenic state for me feels like the fountain of youth I feel like I’m a teenager again and I’m 46!