In this 1-hour long conversation, we discuss.... • 00:00:52 - The concept of antagonistic pleiotropy, which is an important evolutionary biological explanation for aging whereby a gene may be understood to exhibit more than one trait where at least one of these traits is beneficial to the organism's fitness while yet another trait may be detrimental to that same organism's fitness. • 00:01:32 - What the fundamental molecular processes of aging are and some of the on-going research and general thought is surrounding these processes. • 00:04:05 - The essential differences that a pathologist would observe if they looked at and compared the tissues of a young person with a much older person... even beyond structural differences. • 00:05:00 - The qualities of the two major immune responses and how our innate immune response is both our best friend when it comes to keeping us alive -- but may be our worst enemy when it comes to keeping aging at bay. • 00:05:27 - The infiltration of immune cells into our tissues that occurs as a function of aging and the role of damaged or senescent cells in attracting these immune cells. • 00:07:16 - The changes in gut permeability that happen with age and how that may increase our susceptibility to chronic, low-level inflammation. • 00:08:36 - The evolutionary biology explanation for why we have the mechanism of cellular senescence in the first place. • 00:11:46 - The problem of senescent cells and the characteristics they possess that ultimately drive their ability to further their own accumulation. This is done through a feedback loop whereby the burden of senescent cells itself further increases their accumulation and, thus, associated pathologies. • 00:12:29 - The role of senescent cells in an "epithelial to mesenchymal transition," which facilitate loss of appropriate tissue function and even cancer metastasis and progression. • 00:13:36 - Why diseases of aging, despite occurring in vary diverse tissue types, all begin to crop up simultaneously after 50 or 60 years of life. • 00:16:30 - The clearance of senescent cells as a valid life extension strategy, where some animal research has shown a median lifespan increase by as much as nearly 25% in a mouse model of accelerated aging. • 00:17:50 - Why it might be a bad idea to kill off senescent cells just before surgery or when you might need acute tissue repair. • 00:18:55 - Why tackling cellular senescence may be a strategy that is best employed at strategic intervals rather than every single day. • 00:22:53 - Preservation of brain function and how supporting brain cells called astrocytes seem to be simultaneously the most likely type of brain cells to become senescent and also, perhaps unsurprisingly, to be the ones to give rise to brain cancer. • 00:26:04 - How mitochondrial dysfunction, even in the absence of DNA damage, can cause cells to undergo senescence. • 00:26:34 - The interesting observation that senescence from damage versus energy crisis (failed mitochondria) demonstrates a markedly different and uniquely identifiable phenotype of cellular senescence. • 00:28:41 - The change in immune strategies that occur as a result of aging and how that's reflected by a change in our number of lymphoid versus myeloid lineage cells. • 00:29:09 - Some of the current thought surrounding why we build up senescent cells as we age in spite of the fact that our immune system actually actively plays a role in clearing these cells. • 00:30:40 - The effects of prolonged fasting on the activation of hematopoietic stem cell self-renewal (Dr. Valter Longo's work) and the role this may play in rebalancing lymphoid and myeloid lineage cells. • 00:34:34 - The diverging approaches towards improving healthspan by taking action against senescent cells: use of senolytic drugs (which kill the cells) versus the use of drugs that dampen mTOR, such as rapamycin, which leave the cells alive but ultimately suppress the inflammatory aspects of their secretory phenotype. • 00:35:34 - How periodic prolonged fasts might mimic some of these effects associated with an mTOR dampening drug like rapamycin since fasting is itself a way to temporarily reduce mTOR activity and rodent research suggests it may clear these cells as well. • 00:37:33 - How the secretions of senescent cells can affect the regenerative capabilities of stem cells. • 00:38:14 - Some of the complexities behind scenarios in which cellular senescence may play a positive role in skin health, especially through the secretion of growth factors involved in repair as part of the senescence-associated secretory phenotype (SASP). • 00:41:29 - The open questions regarding the potentially differing origins of senescent cells between various tissue types (e.g. muscles vs. heart) and whether these cells are tied to the type of senescence associated with mitochondrial dysfunction... or... the other phenotype which is more commonly associated with various types of cellular damage. • 00:44:14 - The reason why telomeres are disproportionately the recipients of damage when nuclear DNA damage occurs. • 00:45:26 - The surprisingly large effect of exercise on lifespan that can occur in spite of (sustained) obesity. • 00:47:47 - The benefits of exercise in mitigating some of the side effects of chemotherapy. • 00:48:51 - The practicality of a consumer available clinical assays for DNA damage and the challenge of assessing tissue-specific senescence without the use of invasive biopsy. • 00:54:45 - Some of the interesting studies showing that nicotinamide riboside (a form of Vitamin B3) may improve tissue aging and mitochondrial function and whether this might be associated with reductions in cellular senescence or not. • 00:55:55 - The effect of so-called fasting mimetic compounds (e.g. hydroxycitrate, resveratrol & spermidine) on senescent cells. • 00:57:15 - The interesting capacity for cancer resistance in elephants, possibly conferred, in part, by extra copies of the tumor suppressor gene TP53. • 00:58:11 - The possible existence of cellular senescence as a conserved mechanism in some lower organisms. • 00:59:20 - How some rapidly dividing cells, such as keratinocytes in the basal layer of our skin, tend to undergo senescence more often whereas other rapidly dividing cells, such as those in the gut, tend to undergo programmed cell death as an alternative to senescence. Did you enjoy this podcast? Make sure to consider supporting future episodes for as little or as much as you like by creating a pay-what-you-can subscription here... www.foundmyfitness.com/crowdsponsor
FoundMyFitness these breakdowns of time are amazing. You have given me a priceless form of gaining knowledge that would otherwise be hard to search for. You bring these people who have studied for most of their professional lives in their respective fields and I can just absorb all of this wonderful research and information. What a time to be alive! Thank you! - Caliph
I'm already on a NATURAL senolytic product, formulated by a world renowned scientist and biochemist who also formulated a stem cell regeneration product that I took, to support my journey to completely eliminate my Fibromyalgia and MS! He also sits on the board of the world Stem Cell Congress. Feel free to get in touch
I find Dr. Patrick's work and her push to identify causes of aging so fascinating and interesting I just can't stop watching and learning. And always well-done in terms of clarity and integrity . . . No quasi-truths and unsupported ideas advanced just the facts as we now know. Wonderful!
Fascinating as always. Thank you so much for the work on your interview technique also (I know it's tempting to jump in as you often have amazing insights) but this interview where you allowed to her to speak fully was so much easier to watch. Best health show on TH-cam!
I listened closely to this video. Thank you for having Judy on from the Buck Inst. All morning while watering my front yard. Since I am 75, unlike Judy I stopped drinking that red stuff in 1986. I had really good memory function till 10 years ago and have had to alter my eating considerably to regain my memory functions back to a more usable state, and this was done through fasting and mct oil. The Adkins diet is not such a bad thing. God willing you too will reach 75 some day and hopefully through proper nutrition your body will not fail you. I will probably listen to this over again as it is energy dense. Thank you.
This is one of the best videos that I have ever watched. It would have remained completely engaging had it lasted for many more hours. Thank you so much - I plan to become a sponsor of your show now.
Great interview. Re: her comment that it might be best to rid of senescent cells *every once in a while,* (instead of constantly worrying about it), I've been doing a four to five day *fasting mimicking diet* once a month to get rid of senescent cells. It's nice to have confirmation that this is likely a helpful thing to do.
@@robynhope219 Dr. Valter Longo of Stanford University developed a medical fasting mimicking diet about ten years ago and tested it both on animals and on human beings. It had effects that went beyond those of taking metformin.
fascinating discussion - Dr. Campisi's work is impressive, as are her knowledge & communication skills. a 6 hr interview would have flown by. thanks for choosing her Rhonda - one of your best to date. now I feel obliged to give you some money. :-)
Judy's work has taught me a lot and it was a privilege to get to spend a little bit of time with her to record this... I'm so lucky to be able to have these conversations. Thank you for your support! :)
Superb! Focused, indepth, informative, Dr R, P style of targeting questions To extract easy explanation for the benefit of all viewers, Top of all admitting , "no one really knows exactly why that is actually happening " !
Probably the best podcast i ever watch in 20 years. There are few things (more specific) i learn today but ..there is another way if you understand ancient civilizations (it imply electricity and not chemistry communication of the cells, removing the "good bacteria" from the body, slower cell multiply ).
Fred H If you're interested in the information you can personally do all your own research. If you're interested in the experimental side that takes a lot of formal education.
• Great interview! Lots of good information, much appreciated. • Re: five-day fasts, I've done a couple of them, followed by re-feeds, since learning about them in the interview with Dr. Longo, and love how they leave me feeling. I'm planning on doing one fast a month for a while, and keeping an eye on the results. • I found the passing reference to spermidine supplements interesting. I haven't found a supplement, but have been eating foods high in spermidine (but very low in protein), like mushrooms and corn, during the fasts. • As a side note, I read recently that the supplement Quercetin also appears capable of targeting and killing senescent cells, and may make resveratrol more effective when they're taken together. PQQ, found in green tea, also appears to kill senescent cells. And caloric restriction (particularly a low calorie/high fat diet) appears to slow aging in both laboratory animals and, some evidence suggests, human beings. • Re: brain cells senescence, it is perhaps related to the accumulation of amyloid plaque, which can be removed by some nutrients, including folate and the sugar Trehalose. • Finally, a suggestion: It would be fun to see an interview with Dave Fisher, the man who's been living on 1600 calories a day for the past twenty years. Fisher was born in 1957, and looks maybe like he's in his mid-thirties. Unlikely I suppose, as he's not a scientist. But it would be interesting to learn more about his protocol, and the dramatic results.
Nils Osmar you say you have mushrooms and corn during your fasts? Do you eat during part of the fast or do you eat nothing for 5 days? I could perhaps fast for one full day but 5 days, no. Since you seem knowledgeable: I recently heard that eating animal protein makes it difficult for the body to get to the autophagy phase. I don’t quite know what I’m talking about but it made sense when I heard it:-)
Come to think of it, I was getting gray hairs last year and reversed them during a time I had a lot of money to spend on supplements. I was taking quercetin and resveratrol together among everything else, and living at a high elevation. I was fasting like crazy too. 48s twice a week. It was unsustainable but it probably really helped me out.
Wow, at 33:00 where she mentions mTOR and rapamycin it's almost as if Dr. Peter Attia presented this word for word in his video 'Peter Attia - Reverse engineered approach to human longevity'. In that video at 40:30 he literally writes out her words "yeast flies worms mice(mammals)" on the chalkboard and goes on to rave about rapamycin.
What I get from this is there is a need for a balance for the proper amount of senescent cells. Once there are too many of them, then we need to get rid of them. Easy to know, hard to do :-)
Cell senescence is a protective mechanism to remove damaged aged cells from the cycle in case they become cancerous. However as we age these cells escape the process and stop being removed by the immune system, they build up and the safety feature switches to a pro-aging one by driving chronic inflammation and inhibiting stem cells so they cannot repair and replenish damaged tissues. This is why removing the senescent cells back to a low level should boost tissue regeneration and improve health as it has in animal models and human cell lines.
She has a few videos on it on the channel but the main ones if i remember correctly are DHA & EPA omega 3's, Turmeric, Rasberries & Blueberries, really any whole fruit & green. She focuses on the Omegas a lot though.
Absolutely brilliant so clear about a very important modern health topic that eventuaĺy will become one of the most significant Universal Health topics ie diet exercise sleep and cellular sinescence ,but it will be a tradgedy if big money profiteering type of speudo medicine and those who endorse it start to use it we have very frightening scenario killing off the poor because they cannot afford and do not understand how to reverse or slow down sinescence but are encouraged to do the opposite!
Dear DR, which particular strain of Brocoli Seeds do recommed for sprouting. In your POdcast Dr said there are many varieties with very different levels of sulfor aphane and its precursors and precursor enzymes. thank you
Thanks Dr. Patrick, a fan, ... but this all sounds like Quorum Sensing, as a fan of Dr. Bonnie Bassler also. This is the mechanism that I have theorized for Metastasis - Once a quorum is formed we see Antagonistic Pleiotropic responses ... [Williams GC - 1957] and Dr. Campisi is describing the same Quorum Sensing function that we see for cancers (Metastasis) ... but following a different evolutionary path ... seems that all this can be regulated by blocking the "Cellular Communications" or more interesting ... "Redirect". ps ... the "unknowns" mentioned points right at your "Buddy" Dr. Ames' - Triage Theory .... 70 Going On 100 ... or maybe 70 Going On 128 ... the Hayflick Limit ... or if a fan of Ray Kurzweil ... then this is all a Moot Point ...
Very interesting! It had me wondering whether Hyperbaric Oxygen therapy could be effective in regenerating the Senescent cells...Interesting to me, as I am a technical diver, and can easily do dives in 20 to 30 feet of water breathing pure O2....and combine that with my ketogenic diet....If you think there is anything to this, I may start doing this a couple of times each month :-) Closest article I found almost on point with this follows: " Cell cycle synchronization of tumor cells by exposure to hyperbaric oxygenation (HBO) may increase the efficacy of chemotherapy or radiation by placing cells into a chemosensitive portion of the cycle. The purpose of the current study was to examine oxygen pressure-dependent relationships with respect to the cell cycle in prostate tumor cells in vitro. LNCaP cells were grown in an incubator at 21% O2 and then exposed to 100% oxygen at pressures up to 6 atmospheres (atm) for 1.5 h. Cells were then returned to the incubator and evaluated for DNA content by propidium iodide and new DNA synthesis with a pulse-chase experiment. Cell cycle effects were evaluated by flow cytometry. Exposure to HBO increased the percentage of cells synthesizing new DNA in a dose-dependent fashion: 0 atm, 44%; 6 atm, 65%. Cells that synthesize new DNA accumulate in G2/M as a function of partial pressure of oxygen. These results suggest that HBO induces cells to enter the cell cycle and accumulate in G2/M. Cell cycle synchronization and entry of senescent cells into the cell cycle suggest that HBO may be a useful adjuvant to chemotherapy or radiation in the treatment of prostate cancer. There are two potential mechanisms of action that may make HBO efficacious in the treatment of prostate cancer. HBO may potentiate cancer chemotherapeutic agents that cause damage to DNA during DNA synthesis or HBO may inhibit cell division causing accumulation in G2/M."
Ideally you want to kill the senescent cells, not keep them alive. The idea of a five day fast and re-feed is that the body kills them (cannibalizes them for amino acids) during the fast, then the body replaces them with brand new stem cells after the fast ends, which you resume eating normally again.
If elevated innate inflammation may drive aging, does this mean that inducing stress via hormesis (egcg, tumeric, sulforaphane, exercise etc) is activating acute inflammation rather than innate? So high levels of IGF1 in the brain is good, but ideally low everywhere else? Also, can anyone explain why for the non-super athlete, Peter Attia recommends exercises that work the fast type2 twitch fibers?! He also supplements with leucine during his workouts as a boost to mtor1. What's the mechanism?
Ben, acute simply refers to timing/duration. Here's a breakdown of innate vs. adaptive... en.wikipedia.org/wiki/Innate_immune_system en.wikipedia.org/wiki/Adaptive_immune_system There is some evidence that sulforaphane actually improves adaptive immune response. See this part of my video on sulforaphane: th-cam.com/video/zz4YVJ4aRfg/w-d-xo.htmlm14s| For a larger discussion of IGF-1, I suggest the video with Dr. Valter Longo. He has some interesting thoughts on the benefits of periodic deprivation (e.g. of IGF-1 via fasting) followed by periods of rejuvenation from re-feeding which inherently involves a restoration of growth signaling. Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis th-cam.com/video/d6PyyatqJSE/w-d-xo.html I'm of the opinion that vigorous exercise is also a very important factor in this discussion of IGF-1. Please listen to this podcast for an elaboration on my thoughts: Does Meat Consumption Cause Cancer? www.stitcher.com/podcast/foundmyfitness/e/48958267
(On Monday January 9, 2023). On The Matter of Cellular Senescence, Mitochondrial Dysfunction, Cancer (Neoplasia) and Chemical Processes in the Human Body in Aging (Ageing). Entropy, of Course, is the Most Significant Mechanism in All Cellular Processes, for the Amount of Disorder or Choas within the Biological Systems is just progressively greater within the Concept of Aging whether physical (Phenotype manifestation), epigenetically (The Methylome) or genotypically (Telomere attrition or DNA Destabilization) practically from inception (embryogenesis to birth) to The End of Physical Life (so-called Death). In fact, the physics of Health has often been neglected in favor of newfangled ideations of Molecular or Chemical basis of Pathology. As the latter Mechanisms of Disorder or Dysfunction are not irrelevant, they are not the only and most fundamental way to understand Pathology of Aging or the Catabolic-Anabolic Dysarray Within this downtrend in Biochemical Homeostasis. I concur with the Speaker, PhD Judith Campisi, in the Ignorance about most of what is Aging in a molecular basis, for even morphology (pyknosis, or necrosis) are somewhat very late-stage macroscopic ideations (frankly unfair professional declarations that have absolutely no ounce of therapy or curation value) of what is Pathology and because it is concomitant with advance age the stereotypical rationale is "it must be what Old Age or even Pathology must be". Certainly, Telomere mechanics, a grand and vast achievement and proteomics of, let's say TP53 (A most studied and most prevalent Transcription Factor in Neoplasia), and even Methylation Assessments Correlated to the Pathology (Animal or Human Studies) is advancement however minimal. Nevertheless, I must insist that up to this date, because the vast quantity of testing and so-called research has been using faulty or possibly even criminal species (Henrietta Lacks Anaplastic Cells is just one type of proliferation, specific to a Genotype and even specificity to that Genotype-Phenotype), there is little of any science or merit in the clarification of the Mechanism(s) of Aging or, much less more so in the Reversal Thereof. What Ph.D Judith Campisi and Ph.D Rhonda Patrick are really narrating herein is a vast array of Data Sets and Information Quarrels of the scientific professions (all vying for some intellectual property appropriation). Ph.D Rhonda Patrick, man mussen wiederlernen wass die Meinung des Lebens ist aber waehrend man haette die Wissenschaft und das Verständnis wir wuerden schon haetten den Reichtum und das Glueck wir muessen Haben....Heil!
47:00: Other than the hormetic effect exercise, aerobic exercise also moves the lymph, and nourishes the cells with fresh oxygenated blood. Can't just look at the sub-cellular level!
Nick Lane has a chapter in The Vital Question about the trade off in age and reproductive rate between, for example, rats and pigeons, and that the two are reciprocally related.
If these so-called experts from so-called esteemed educational institutions can be more humble instead of full of hubris, perhaps they will have a chance to glimpse at what caused senescent cells in the heart - because, as Tesla said, our body is " ... a priceless gift from one whom he loves above all, a marvelous work of art, of indescribable beauty, and mystery beyond human conception ....”
In terms of longevity America is number 40. Hong-Kong lives the longest period! There is a group of people live in the mountains of China who live off the land and drink the mountain water and they always live to be 125 years old!
Just because aging isn't well-understood so far doesn't mean it will remain this way in the immediate future. As long as the current anti-aging experimental treatments such as stem-cell and gene therapy keep working and improving, understanding everything isn't essential.
I wonder if it is possible that the immine system becomes cytokine resistant over time with years of signaling from an ever increasing number of senescent cells... And in doing so requires more and more pro-inflammatory molecules before it is targeted for death by the immune cells... Thereby increasing systemic inflammation and cancer risks?
But What if the telomere length is the cause of inflammation? People never seem to think the oter way around. They always go for inflammation, mitochondria etc, but they never consider the idea that telomeres are the reason we get inflammation, mitochondrial dysfunction etc. These things seemed to reverse in mice as well as brain size and cognitive function when they induced telomerase.
Telomeres are a BIGGIE. It is the underlying cause of all aging. Pls read The Telomere Effect, which talks about Telomerase. Liz Blackburn got the Nobel Prize for discovering Telomerase.
I'm already on a NATURAL senolytic product, formulated by a world renowned scientist and biochemist who also formulated a stem cell regeneration product that I took, to support my journey to completely eliminate my Fibromyalgia and MS! He also sits on the board of the world Stem Cell Congress. Feel free to get in touch
Next to lifestyle factors radiation (EMF) could play a big role that senescent cells accumulate in the body. EMF is a silent killer which is not directly visible but with lab tests could be a proven fact.
I couldn't think of anything worse than living to be a Super Senior. Imagine living without teeth and not being able to chew anything and pissing in your diapers 10 times a day! Good grief, NO thanks!
Notice that fasting works without scientists knowing how it works. If I had waited for permission from scientists to fast I would have either died or become a basketcase.
You see the design and still believe in evolution !?!? "Cells evolve" because they just thought so !!! Just go to Yahweh and ask to be saved. fasting eats senescent cells.
In this 1-hour long conversation, we discuss....
• 00:00:52 - The concept of antagonistic pleiotropy, which is an important evolutionary biological explanation for aging whereby a gene may be understood to exhibit more than one trait where at least one of these traits is beneficial to the organism's fitness while yet another trait may be detrimental to that same organism's fitness.
• 00:01:32 - What the fundamental molecular processes of aging are and some of the on-going research and general thought is surrounding these processes.
• 00:04:05 - The essential differences that a pathologist would observe if they looked at and compared the tissues of a young person with a much older person... even beyond structural differences.
• 00:05:00 - The qualities of the two major immune responses and how our innate immune response is both our best friend when it comes to keeping us alive -- but may be our worst enemy when it comes to keeping aging at bay.
• 00:05:27 - The infiltration of immune cells into our tissues that occurs as a function of aging and the role of damaged or senescent cells in attracting these immune cells.
• 00:07:16 - The changes in gut permeability that happen with age and how that may increase our susceptibility to chronic, low-level inflammation.
• 00:08:36 - The evolutionary biology explanation for why we have the mechanism of cellular senescence in the first place.
• 00:11:46 - The problem of senescent cells and the characteristics they possess that ultimately drive their ability to further their own accumulation. This is done through a feedback loop whereby the burden of senescent cells itself further increases their accumulation and, thus, associated pathologies.
• 00:12:29 - The role of senescent cells in an "epithelial to mesenchymal transition," which facilitate loss of appropriate tissue function and even cancer metastasis and progression.
• 00:13:36 - Why diseases of aging, despite occurring in vary diverse tissue types, all begin to crop up simultaneously after 50 or 60 years of life.
• 00:16:30 - The clearance of senescent cells as a valid life extension strategy, where some animal research has shown a median lifespan increase by as much as nearly 25% in a mouse model of accelerated aging.
• 00:17:50 - Why it might be a bad idea to kill off senescent cells just before surgery or when you might need acute tissue repair.
• 00:18:55 - Why tackling cellular senescence may be a strategy that is best employed at strategic intervals rather than every single day.
• 00:22:53 - Preservation of brain function and how supporting brain cells called astrocytes seem to be simultaneously the most likely type of brain cells to become senescent and also, perhaps unsurprisingly, to be the ones to give rise to brain cancer.
• 00:26:04 - How mitochondrial dysfunction, even in the absence of DNA damage, can cause cells to undergo senescence.
• 00:26:34 - The interesting observation that senescence from damage versus energy crisis (failed mitochondria) demonstrates a markedly different and uniquely identifiable phenotype of cellular senescence.
• 00:28:41 - The change in immune strategies that occur as a result of aging and how that's reflected by a change in our number of lymphoid versus myeloid lineage cells.
• 00:29:09 - Some of the current thought surrounding why we build up senescent cells as we age in spite of the fact that our immune system actually actively plays a role in clearing these cells.
• 00:30:40 - The effects of prolonged fasting on the activation of hematopoietic stem cell self-renewal (Dr. Valter Longo's work) and the role this may play in rebalancing lymphoid and myeloid lineage cells.
• 00:34:34 - The diverging approaches towards improving healthspan by taking action against senescent cells: use of senolytic drugs (which kill the cells) versus the use of drugs that dampen mTOR, such as rapamycin, which leave the cells alive but ultimately suppress the inflammatory aspects of their secretory phenotype.
• 00:35:34 - How periodic prolonged fasts might mimic some of these effects associated with an mTOR dampening drug like rapamycin since fasting is itself a way to temporarily reduce mTOR activity and rodent research suggests it may clear these cells as well.
• 00:37:33 - How the secretions of senescent cells can affect the regenerative capabilities of stem cells.
• 00:38:14 - Some of the complexities behind scenarios in which cellular senescence may play a positive role in skin health, especially through the secretion of growth factors involved in repair as part of the senescence-associated secretory phenotype (SASP).
• 00:41:29 - The open questions regarding the potentially differing origins of senescent cells between various tissue types (e.g. muscles vs. heart) and whether these cells are tied to the type of senescence associated with mitochondrial dysfunction... or... the other phenotype which is more commonly associated with various types of cellular damage.
• 00:44:14 - The reason why telomeres are disproportionately the recipients of damage when nuclear DNA damage occurs.
• 00:45:26 - The surprisingly large effect of exercise on lifespan that can occur in spite of (sustained) obesity.
• 00:47:47 - The benefits of exercise in mitigating some of the side effects of chemotherapy.
• 00:48:51 - The practicality of a consumer available clinical assays for DNA damage and the challenge of assessing tissue-specific senescence without the use of invasive biopsy.
• 00:54:45 - Some of the interesting studies showing that nicotinamide riboside (a form of Vitamin B3) may improve tissue aging and mitochondrial function and whether this might be associated with reductions in cellular senescence or not.
• 00:55:55 - The effect of so-called fasting mimetic compounds (e.g. hydroxycitrate, resveratrol & spermidine) on senescent cells.
• 00:57:15 - The interesting capacity for cancer resistance in elephants, possibly conferred, in part, by extra copies of the tumor suppressor gene TP53.
• 00:58:11 - The possible existence of cellular senescence as a conserved mechanism in some lower organisms.
• 00:59:20 - How some rapidly dividing cells, such as keratinocytes in the basal layer of our skin, tend to undergo senescence more often whereas other rapidly dividing cells, such as those in the gut, tend to undergo programmed cell death as an alternative to senescence.
Did you enjoy this podcast? Make sure to consider supporting future episodes for as little or as much as you like by creating a pay-what-you-can subscription here...
www.foundmyfitness.com/crowdsponsor
powerful show notes
Does nicotinic acid play a role in raising NAD levels ?
Yes Niacin does but dont use slow release or non flush as this can damage the liver.
No, never slow release.
FoundMyFitness these breakdowns of time are amazing. You have given me a priceless form of gaining knowledge that would otherwise be hard to search for. You bring these people who have studied for most of their professional lives in their respective fields and I can just absorb all of this wonderful research and information. What a time to be alive! Thank you! - Caliph
I want Rhonda Patrick to be Secretary of Health.
Wouldn't that be wonderful. Not under this administration, though.
Amen!
Roger Bird - Definitely, under a *_#YANG2020_* presidency.
I'm already on a NATURAL senolytic product, formulated by a world renowned scientist and biochemist who also formulated a stem cell regeneration product that I took, to support my journey to completely eliminate my Fibromyalgia and MS! He also sits on the board of the world Stem Cell Congress. Feel free to get in touch
The US only believes in unhealthy people for these positions
As a college student going into health science, I show your awesome videos to many of my peers for that extra dose of wonderful information.
That makes me very happy. Thank you! ❤️
She is biased for plant hormesis. I contrast her with Paul saladino.
I find Dr. Patrick's work and her push to identify causes of aging so fascinating and interesting I just can't stop watching and learning. And always well-done in terms of clarity and integrity . . . No quasi-truths and unsupported ideas advanced just the facts as we now know. Wonderful!
Fascinating as always. Thank you so much for the work on your interview technique also (I know it's tempting to jump in as you often have amazing insights) but this interview where you allowed to her to speak fully was so much easier to watch. Best health show on TH-cam!
I listened closely to this video. Thank you for having Judy on from the Buck Inst. All morning while watering my front yard. Since I am 75, unlike Judy I stopped drinking that red stuff in 1986. I had really good memory function till 10 years ago and have had to alter my eating considerably to regain my memory functions back to a more usable state, and this was done through fasting and mct oil. The Adkins diet is not such a bad thing. God willing you too will reach 75 some day and hopefully through proper nutrition your body will not fail you. I will probably listen to this over again as it is energy dense. Thank you.
This is one of the best videos that I have ever watched. It would have remained completely engaging had it lasted for many more hours. Thank you so much - I plan to become a sponsor of your show now.
Wow! That's high praise. Thank you for the comment & support. :)
Loved Judith Campisi's insight here! So interesting and she did a great job of conveying highly technical information simply enough for me to grasp.
You're the Champ Dr. Patrick!!!
Great interview. Re: her comment that it might be best to rid of senescent cells *every once in a while,* (instead of constantly worrying about it), I've been doing a four to five day *fasting mimicking diet* once a month to get rid of senescent cells. It's nice to have confirmation that this is likely a helpful thing to do.
What kind of fasting mimicking diet? Are you talking about Metformin? If you take it, it will mimick fasting and you don’t need to miss meals.
@@robynhope219 Dr. Valter Longo of Stanford University developed a medical fasting mimicking diet about ten years ago and tested it both on animals and on human beings. It had effects that went beyond those of taking metformin.
What a scientific, educating and lovely video!
Thank you, dr Rhonda!
The best of luck for your pregnancy!
Thank you, Anto!
Thank you friends for giving yours life to help the humanity! 🤩👍
Thank you so much Rhonda. You should win a nobel prize or something for distributing this information so readily. Taking your notes word for word.
OMG , gonna be the best Mom Dr Rhonda .
I like your honesty & enthusiasm, Dan! But really... I promise we'll stay on track over here. :)
fascinating discussion - Dr. Campisi's work is impressive, as are her knowledge & communication skills. a 6 hr interview would have flown by. thanks for choosing her Rhonda - one of your best to date. now I feel obliged to give you some money. :-)
Judy's work has taught me a lot and it was a privilege to get to spend a little bit of time with her to record this... I'm so lucky to be able to have these conversations. Thank you for your support! :)
Superb! Focused, indepth, informative,
Dr R, P style of targeting questions
To extract easy explanation for the benefit of all viewers, Top of all admitting , "no one really knows exactly why that is actually happening " !
Probably the best podcast i ever watch in 20 years. There are few things (more specific) i learn today but ..there is another way if you understand ancient civilizations (it imply electricity and not chemistry communication of the cells, removing the "good bacteria" from the body, slower cell multiply ).
So many information packed and inspiring interviews. I wish I worked in this field.
Fred H If you're interested in the information you can personally do all your own research. If you're interested in the experimental side that takes a lot of formal education.
Best interview ever, in all of history!
This was so fascinating thank you! She is so informative..!
This convo is the best - love from Irish medical student
Still hoping to see a video detailing how you grow broccoli sprouts.
• Great interview! Lots of good information, much appreciated.
• Re: five-day fasts, I've done a couple of them, followed by re-feeds, since learning about them in the interview with Dr. Longo, and love how they leave me feeling. I'm planning on doing one fast a month for a while, and keeping an eye on the results.
• I found the passing reference to spermidine supplements interesting. I haven't found a supplement, but have been eating foods high in spermidine (but very low in protein), like mushrooms and corn, during the fasts.
• As a side note, I read recently that the supplement Quercetin also appears capable of targeting and killing senescent cells, and may make resveratrol more effective when they're taken together. PQQ, found in green tea, also appears to kill senescent cells. And caloric restriction (particularly a low calorie/high fat diet) appears to slow aging in both laboratory animals and, some evidence suggests, human beings.
• Re: brain cells senescence, it is perhaps related to the accumulation of amyloid plaque, which can be removed by some nutrients, including folate and the sugar Trehalose.
• Finally, a suggestion: It would be fun to see an interview with Dave Fisher, the man who's been living on 1600 calories a day for the past twenty years. Fisher was born in 1957, and looks maybe like he's in his mid-thirties. Unlikely I suppose, as he's not a scientist. But it would be interesting to learn more about his protocol, and the dramatic results.
Nils Osmar you say you have mushrooms and corn during your fasts? Do you eat during part of the fast or do you eat nothing for 5 days? I could perhaps fast for one full day but 5 days, no. Since you seem knowledgeable: I recently heard that eating animal protein makes it difficult for the body to get to the autophagy phase. I don’t quite know what I’m talking about but it made sense when I heard it:-)
Come to think of it, I was getting gray hairs last year and reversed them during a time I had a lot of money to spend on supplements. I was taking quercetin and resveratrol together among everything else, and living at a high elevation. I was fasting like crazy too. 48s twice a week. It was unsustainable but it probably really helped me out.
Dr Campisi is just like my third grade teacher. Calm and great explanations. i love her! :)
Wow, at 33:00 where she mentions mTOR and rapamycin it's almost as if Dr. Peter Attia presented this word for word in his video 'Peter Attia - Reverse engineered approach to human longevity'. In that video at 40:30 he literally writes out her words "yeast flies worms mice(mammals)" on the chalkboard and goes on to rave about rapamycin.
This interview is amazing, keep up the good work!
Great interview, amazing work on both sides! Thank you!
Such a fan of both of you. Praise and blessings in abundance ✨🙏🏼💗🙏🏾🌱
What I get from this is there is a need for a balance for the proper amount of senescent cells.
Once there are too many of them, then we need to get rid of them.
Easy to know, hard to do :-)
Cell senescence is a protective mechanism to remove damaged aged cells from the cycle in case they become cancerous. However as we age these cells escape the process and stop being removed by the immune system, they build up and the safety feature switches to a pro-aging one by driving chronic inflammation and inhibiting stem cells so they cannot repair and replenish damaged tissues. This is why removing the senescent cells back to a low level should boost tissue regeneration and improve health as it has in animal models and human cell lines.
Thanks for all the content you do, its always very interesting and informative.
Thanks for your videos on such interesting topics and the way you make them comprehensible for the public! :-) I really enjoy your videos!
You are becoming one of the most influential scientist. Can you mention some of those supper anti-inflammatory substances ?????
She has a few videos on it on the channel but the main ones if i remember correctly are DHA & EPA omega 3's, Turmeric, Rasberries & Blueberries, really any whole fruit & green. She focuses on the Omegas a lot though.
Multi Day Fasting
you are simply the best. these videos seriously help me survive work some days. makes my brain so happy (:
Im really a big fan of Judith. Hugs from brazil
What a nice lady Judith is !
Best interview yet.
So incredible, thank you so much.
Don't name the kid "Sulforaphane Patrick"
Back to the drawing board...
Epigenetic Edgar?
Great discussion ladies 🙌
Fantastic discussion thanks
This doctor has such a pleasant voice 😁✌️
Another important discussion. So who all has a blood test showing low inflammation for their age group? I do but most don't have the test.
So good: deserves another viewing. Scientists keep going even though the popular creed seems belief over science.
Absolutely brilliant so clear about a very important modern health topic
that eventuaĺy will become one of the most significant Universal Health topics ie diet exercise sleep and cellular sinescence ,but it will be a tradgedy if big money profiteering type of speudo medicine and those who endorse it start to use it we have very frightening scenario killing off the poor because they cannot afford and do not understand how to reverse or slow down sinescence but are encouraged to do the opposite!
Highly interesting conversation. Great content as always Rhonda :)
Dear DR, which particular strain of Brocoli Seeds do recommed for sprouting. In your POdcast Dr said there are many varieties with very different levels of sulfor
aphane and its precursors and precursor enzymes. thank you
Thanks Dr. Patrick, a fan, ... but this all sounds like Quorum Sensing, as a fan of Dr. Bonnie Bassler also. This is the mechanism that I have theorized for Metastasis - Once a quorum is formed we see Antagonistic Pleiotropic responses ... [Williams GC - 1957] and Dr. Campisi is describing the same Quorum Sensing function that we see for cancers (Metastasis) ... but following a different evolutionary path ... seems that all this can be regulated by blocking the "Cellular Communications" or more interesting ... "Redirect".
ps ... the "unknowns" mentioned points right at your "Buddy" Dr. Ames' - Triage Theory ....
70 Going On 100 ... or maybe 70 Going On 128 ... the Hayflick Limit ... or if a fan of Ray Kurzweil ... then this is all a Moot Point ...
Very interesting! It had me wondering whether Hyperbaric Oxygen therapy could be effective in regenerating the Senescent cells...Interesting to me, as I am a technical diver, and can easily do dives in 20 to 30 feet of water breathing pure O2....and combine that with my ketogenic diet....If you think there is anything to this, I may start doing this a couple of times each month :-)
Closest article I found almost on point with this follows:
" Cell cycle synchronization of tumor cells by exposure to hyperbaric oxygenation (HBO) may increase the efficacy of chemotherapy or radiation by placing cells into a chemosensitive portion of the cycle. The purpose of the current study was to examine oxygen pressure-dependent relationships with respect to the cell cycle in prostate tumor cells in vitro. LNCaP cells were grown in an incubator at 21% O2 and then exposed to 100% oxygen at pressures up to 6 atmospheres (atm) for 1.5 h. Cells were then returned to the incubator and evaluated for DNA content by propidium iodide and new DNA synthesis with a pulse-chase experiment. Cell cycle effects were evaluated by flow cytometry. Exposure to HBO increased the percentage of cells synthesizing new DNA in a dose-dependent fashion: 0 atm, 44%; 6 atm, 65%. Cells that synthesize new DNA accumulate in G2/M as a function of partial pressure of oxygen. These results suggest that HBO induces cells to enter the cell cycle and accumulate in G2/M. Cell cycle synchronization and entry of senescent cells into the cell cycle suggest that HBO may be a useful adjuvant to chemotherapy or radiation in the treatment of prostate cancer. There are two potential mechanisms of action that may make HBO efficacious in the treatment of prostate cancer. HBO may potentiate cancer chemotherapeutic agents that cause damage to DNA during DNA synthesis or HBO may inhibit cell division causing accumulation in G2/M."
Ideally you want to kill the senescent cells, not keep them alive. The idea of a five day fast and re-feed is that the body kills them (cannibalizes them for amino acids) during the fast, then the body replaces them with brand new stem cells after the fast ends, which you resume eating normally again.
So interesting but I need to pause all the time to look up words. Even some of those used on the bottom for explaining :s
Super informative, equally interesting, thanks for posting!
Best look! Perfect hair, lipstick, makeup combo.
If elevated innate inflammation may drive aging, does this mean that inducing stress via hormesis (egcg, tumeric, sulforaphane, exercise etc) is activating acute inflammation rather than innate?
So high levels of IGF1 in the brain is good, but ideally low everywhere else?
Also, can anyone explain why for the non-super athlete, Peter Attia recommends exercises that work the fast type2 twitch fibers?! He also supplements with leucine during his workouts as a boost to mtor1. What's the mechanism?
Ben, acute simply refers to timing/duration.
Here's a breakdown of innate vs. adaptive...
en.wikipedia.org/wiki/Innate_immune_system
en.wikipedia.org/wiki/Adaptive_immune_system
There is some evidence that sulforaphane actually improves adaptive immune response. See this part of my video on sulforaphane:
th-cam.com/video/zz4YVJ4aRfg/w-d-xo.htmlm14s|
For a larger discussion of IGF-1, I suggest the video with Dr. Valter Longo. He has some interesting thoughts on the benefits of periodic deprivation (e.g. of IGF-1 via fasting) followed by periods of rejuvenation from re-feeding which inherently involves a restoration of growth signaling.
Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
th-cam.com/video/d6PyyatqJSE/w-d-xo.html
I'm of the opinion that vigorous exercise is also a very important factor in this discussion of IGF-1. Please listen to this podcast for an elaboration on my thoughts:
Does Meat Consumption Cause Cancer?
www.stitcher.com/podcast/foundmyfitness/e/48958267
(On Monday January 9, 2023). On The Matter of Cellular Senescence, Mitochondrial Dysfunction, Cancer (Neoplasia) and Chemical Processes in the Human Body in Aging (Ageing). Entropy, of Course, is the Most Significant Mechanism in All Cellular Processes, for the Amount of Disorder or Choas within the Biological Systems is just progressively greater within the Concept of Aging whether physical (Phenotype manifestation), epigenetically (The Methylome) or genotypically (Telomere attrition or DNA Destabilization) practically from inception (embryogenesis to birth) to The End of Physical Life (so-called Death). In fact, the physics of Health has often been neglected in favor of newfangled ideations of Molecular or Chemical basis of Pathology. As the latter Mechanisms of Disorder or Dysfunction are not irrelevant, they are not the only and most fundamental way to understand Pathology of Aging or the Catabolic-Anabolic Dysarray Within this downtrend in Biochemical Homeostasis. I concur with the Speaker, PhD Judith Campisi, in the Ignorance about most of what is Aging in a molecular basis, for even morphology (pyknosis, or necrosis) are somewhat very late-stage macroscopic ideations (frankly unfair professional declarations that have absolutely no ounce of therapy or curation value) of what is Pathology and because it is concomitant with advance age the stereotypical rationale is "it must be what Old Age or even Pathology must be". Certainly, Telomere mechanics, a grand and vast achievement and proteomics of, let's say TP53 (A most studied and most prevalent Transcription Factor in Neoplasia), and even Methylation Assessments Correlated to the Pathology (Animal or Human Studies) is advancement however minimal. Nevertheless, I must insist that up to this date, because the vast quantity of testing and so-called research has been using faulty or possibly even criminal species (Henrietta Lacks Anaplastic Cells is just one type of proliferation, specific to a Genotype and even specificity to that Genotype-Phenotype), there is little of any science or merit in the clarification of the Mechanism(s) of Aging or, much less more so in the Reversal Thereof. What Ph.D Judith Campisi and Ph.D Rhonda Patrick are really narrating herein is a vast array of Data Sets and Information Quarrels of the scientific professions (all vying for some intellectual property appropriation). Ph.D Rhonda Patrick, man mussen wiederlernen wass die Meinung des Lebens ist aber waehrend man haette die Wissenschaft und das Verständnis wir wuerden schon haetten den Reichtum und das Glueck wir muessen Haben....Heil!
47:00: Other than the hormetic effect exercise, aerobic exercise also moves the lymph, and nourishes the cells with fresh oxygenated blood. Can't just look at the sub-cellular level!
Nick Lane has a chapter in The Vital Question about the trade off in age and reproductive rate between, for example, rats and pigeons, and that the two are reciprocally related.
Dr Rhonda is such a cutie.
If these so-called experts from so-called esteemed educational institutions can be more humble instead of full of hubris, perhaps they will have a chance to glimpse at what caused senescent cells in the heart - because, as Tesla said, our body is " ... a priceless gift from one whom he loves above all, a marvelous work of art, of indescribable beauty, and mystery beyond human conception ....”
She looks very good for being in her 80's.
fantastic. thank you.
makes me sad more and more i get into the matter of reverse aging cancer the more i notice how far away we actually are.
Judy Campisi
Sure wish you would look into photobiomodulation 😊
So what good does resveratrol do if it doesn't counter senescent cell caused inflammation?
20:50. We can never control what happens to us. But we can always control how we react.
Ty for posting
At Yuvan we have extended both health-span and lifespan by serial rejuvenation.
awesome video!
Staggering that science can actually identify bowel disease in a fruit fly. Thats one delicate colonoscopy.
Chris Gonzales looool
In terms of longevity America is number 40. Hong-Kong lives the longest period! There is a group of people live in the mountains of China who live off the land and drink the mountain water and they always live to be 125 years old!
There is also a double edged sword with autophagy I saw in some studies. Just something that brought awareness.
Just because aging isn't well-understood so far doesn't mean it will remain this way in the immediate future. As long as the current anti-aging experimental treatments such as stem-cell and gene therapy keep working and improving, understanding everything isn't essential.
Awesome! Thanks.
Excellent
is there a role in the accumulation of titanium dioxide?
I wonder if it is possible that the immine system becomes cytokine resistant over time with years of signaling from an ever increasing number of senescent cells... And in doing so requires more and more pro-inflammatory molecules before it is targeted for death by the immune cells... Thereby increasing systemic inflammation and cancer risks?
Does Retin A get rid of senescent cells in skin?
But What if the telomere length is the cause of inflammation? People never seem to think the oter way around. They always go for inflammation, mitochondria etc, but they never consider the idea that telomeres are the reason we get inflammation, mitochondrial dysfunction etc. These things seemed to reverse in mice as well as brain size and cognitive function when they induced telomerase.
Telomeres are a BIGGIE. It is the underlying cause of all aging. Pls read The Telomere Effect, which talks about Telomerase. Liz Blackburn got the Nobel Prize for discovering Telomerase.
Excellent talk!
cool thanks
New pathways
Rhonda, she is almost perfect, except she is not vegan yet.
I would never make it through a Campisi lecture. Her sweet little voice lulls me to sleepyland.😏
I'm already on a NATURAL senolytic product, formulated by a world renowned scientist and biochemist who also formulated a stem cell regeneration product that I took, to support my journey to completely eliminate my Fibromyalgia and MS! He also sits on the board of the world Stem Cell Congress. Feel free to get in touch
Next to lifestyle factors radiation (EMF) could play a big role that senescent cells accumulate in the body. EMF is a silent killer which is not directly visible but with lab tests could be a proven fact.
Any food that man has touched cuts years off your life.
Mitochondria heteroplasmy rate. Check out Dr. Doug Wallace, the world's leading expert on Mitochondria.
💕💕💕
Cool, for the first time listening to DRP, I can't tell who has the biggest brain
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Medicare and Medicaid need to provide insurance for stem cell rejuvenation
End sugar subsidies!
I couldn't think of anything worse than living to be a Super Senior. Imagine living without teeth and not being able to chew anything and pissing in your diapers 10 times a day! Good grief, NO thanks!
👍🏻👍🏻👍🏻
Unity Biotechnology stock
Notice that fasting works without scientists knowing how it works. If I had waited for permission from scientists to fast I would have either died or become a basketcase.
Planaria and jellyfish are biological immortal.
This does not make the ribosomes happy
You see the design and still believe in evolution !?!? "Cells evolve" because they just thought so !!! Just go to Yahweh and ask to be saved.
fasting eats senescent cells.
Avoidance of IATROGENESIS most important for health span & life expectancy.
Rather than study elephants I’d like to see why sharks appear to be immortal