Parkinson's and Alzheimer's: The solution in sight | Dr. Alberto Espay | TEDxWrigleyville
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- เผยแพร่เมื่อ 27 ต.ค. 2022
- In his groundbreaking talk, Dr. Alberto Espay questions traditional hypotheses regarding the causes, and therefore the treatments, of neurodegeneration, diseases such as Huntington's, Alzheimer's, and Parkinson's, discussing what we can do to bring about meaningful change for the sake of patients today and tomorrow.
Dr. Espay is the Endowed Chair of the James J. and Joan A. Gardner Center for Parkinson’s disease at the University of Cincinnati. He has published over 300 peer-reviewed research articles and 8 books, including Common Movement Disorders Pitfalls, which received the Highly Commended BMA Medical Book Award in 2013 and Brain Fables, the Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer them, coauthored with Parkinson patient and advocate Benjamin Stecher, selected by the Association of American Publishers for the PROSE Award honoring the best scholarly work in Neuroscience published in 2020. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
Hoping that this leads soon to a feasible treatment for patients with neurodegenerative diseases. My dad has PD.
So they thought the clumped proteins in the brain were the problem, which led to them using methods to remove them but this generally resulted in making patients worse (brain shrinkage). Now they are adding more of the loose flexible proteins to the brain to bring back to normal levels and this seems to be working to stop the diseases. Ongoing they are still looking to remedy for the invisible cause that causes the protein clumping in the first place and the presumably the reduction/ loss of loose proteins .
Thank you , I had a hard time following him , thank you for summing it up
Thank you for this Dr. Espay and all of the great work you are doing at University of Cincinnati.
This is so incredibly encouraging! Thank you for your service!
I'm almost finished with my graphic memoir of how I used my health and fitness knowledge to stop my mother with mild dementia from forgetting me, and it worked. I tricked her off caffeine, then no prescription meds, forced her/tricked her/incentivized her to drink water, kept her away from high fructose corn syrup and other poison, because they made her mean and delusional, and kept her away from gluten. I had a lot of crazy things happen to me that was not my mother’s fault. First I had to fight a nursing home in probate court for 2 months who illegally held my mother for the insurance money. The police put her in handcuffs, and that wasn’t needed or her fault, an Emergency Room doctor gave her an anti-psychotic because that is “just what they do”, and that caused more problems, and in the end, hospice listed her death certificate wrong for a reason, I can only guess was for financial. The dept. of public health told me that nobody verifies and monitors death certificates either..
This is so exciting. Thank you for the great talk and work being done!
Wow! Dr.Espay your presentation is immensely inspiring, not to mention exciting!
Very interesting. Thanks for telling dr Alberto Espay and also thanks for your investigation.
I am so happy to hear this. I have given up ! How long until we will have your treatment ? I am 46 and been suffering 12 years. Thank you for your dose of sunshine!!!!
My tremors are as a result of 2 brain opperation th remove only part of a tumor that grew back to it's original size. The operations damaged my nerves vastly, leaving myself paralyzed. This paralysis I overcame to a large extent but I was left with tremors and other issues that have increased over the years. No magic bullet for me but please please PLEASE help that can be helped - I beg you 🙏.
Very informative! Thank you 🙏
God willing that will happen.. I have two relatives with PD and its seriously horrible, as is Alzheimers wouldnt wish it anyone😞
Amazing.
Very exciting news!!
That seems hilariously obvious after thinking about it. You need the regular proteins in order for the brain to be functional - unless you're replacing the curled-up proteins with working proteins or in some way increasing the amount of regular proteins, ,all you are doing is removing brain tissue without helping the regular proteins.
That is really similar to the history of research on lactate in muscles during exercise: for decades the indicator, a byproduct, of the process was specifically targeted without actual understanding of the process. And now it is treated from another way round at the level of initial materials and fuel. Still not caring about the machinery.
Oh, and there was a relatevely recent paper on serotonin and depression - another "correlation not causation" example.
I was thinking about that too: how wrong the thinking was in both cases. A huge amount of damage and death has resulted from the Medical Model theory of depression; I imagine many have died as well from the wrongheaded thinking about these proteins. I haven't seen much coverage of these two long-term mistakes in the mainstream press. Hmm. Why would that be?
A great speaker. Thank u so much. But I wonder about mechanisms of prion-like. If we put more monomer, whether they will interact with abnormal protein, then it makes more aggregation?
Does fasting induced autophagy in any way help in treating these diseases
Can't hurt but getting the mercury ☿ out works better
I heard that part of the issue could be the brain having issues with getting glucose.
My mom has died from Alzheimers at the age of 77. Not a very nice way of dying.
great
Yes
So what should we be doing to prevent us and our loved ones from getting these diseases?
Exercise. The more steps you get on your Fitbit the lower your risk for dementia. Eat to lower inflammation. Socialize, and lower your stress levels, both of which also lower inflammation. Eat less simple carbohydrates so you won't get glucose intolerance. Don't delay on getting hearing aids if you need them. Poor hearing is highly associated with dementia. Probably because it interferes with your social interactions and your interactions with the world in general. Try to lose excess weight (causes inflammation). By excess I mean approaching the obesity cut off or beyond. A little extra weight is actually protective for older people. Learn a new hobby especially one which taxes your brain a little bit so it will form many new connections. An art class like pottery, sculpture, drawing etc. Or learn a new musical instrument. Or a new language. A lot of Spanish people Spanish speaking people come to where I work so I decided to learn Spanish. I'm using an app called Duolingo, which I find very, very motivating. I'm 65 years old and absolutely determined and almost hooked LOL. And here's one that goes entirely against conventional wisdom: if you're an older person, don't lower your LDL cholesterol. High LDL in older people is protective against cancer, infection, dementia and atherosclerosis. Older people with high LDL live longer. If you don't believe me, Google this: 'LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature'. One of the most astonishing - and infuriating - articles I've ever read, and I'm a big reader of research articles. The way evidence has been distorted and articles cherry picked for earlier 'reviews' of the literature. I'm delighted now to have high LDL. If you are on statins, or someone is trying to put you on statins, you especially need to read this!
@@leeleeturn thank you so much for that 🙏 I read your whole comment and saved it onto my notes
@@ArkansasGamer you're very welcome. I've read tons about it because dementia is probably my greatest fear in life. I watched my grandmother die of Alzheimer's. I can't bear the thought of being completely helpless like that. If you have your mind, at least you have options.
Nice
Nice speaking
the answer at minute 12.30
duke will use this :)
👏👏👏
ok but what causes proteins in the brain to clump up in the first place? i mean, we eat normal protein from food, and it clumps up in the brain. why?
The speaker said in the beginning that an abnormality in the brain causes them to clump up into defensive balls and be rendered useless .
Viruses can also be the cause
💙💚
Completely makes sense:. Seems now the goal is to figure out the tools to delivering the strengthening particles to the brain:. My first thought is using blood as a delivery device as it is in constant circulatory flow into and out of the brain. Hmmm how do we get past the screening device? Hmm some kind of iv injection.... It is really about balance, right? Ok my brain is now thinking about how proper gastro digestion depends on balance:. One cannot remove an element without replacing, almost like an algebraic formula.......thinking on this, thank you for the progressive push!
2 decades going down the wrong path :(
☺️☺️🥰
there are thousands and thousands of single parent across the countries , districts, states, and they are well administered by their group leaders or team leaders who can protect the siblings ....through joint ventures ,....... many religious communities had many such single parents who claimed compensation from respective republic government , so ...... how did the structure of community classification arrive as BC, obc , SC , forward community so on ........who is collecting the fees of such students who are under such community ........... chidambaram ......has entire list of such community based fees provided by the institutions .......madam jyothi .... Lakshmi ......
Toujours le même problème avec la traduction en français tout le monde ne parle pas anglais merci
Prevention is the real solution.
I suspect in the future amniotic fluid will be discovered to have remarkable healing properties for Dementia, Alzheimer's & Brain Damage.💝
I suspect not
@@micbear9334 I am really not sure if you are familiar with any process. But we may have to agree to disagree.
@@dalelerette206 if you can show me the pubmed article which shows benefit relative to placebo, I may be able to change my mind.
@@micbear9334 When someone answers with a request for information, it usually indicates an incredulous response. You should just let your yes mean YES and you no mean NO. And if you do not believe me, just say NO. When someone answers a yes or no question with surreptitious request for information, it may actually be an indication of general apathy. So I will answer to the caliber of your request with a request for you to Google it. Have a good day.
I have Parkinson's and Alzheimer's. Hey wait a minute. Who the heck just spilled my drink?
Jesus loves you ❤️✝️
The rapid increase of the digital environment and EMF pollution is contributing to the problem.. smart meters and security cameras and health alarms in elderly homes are literally frying them. Vitamin b1 deficiency is a precussors to these diseases
BEST SCIENCE DOES NOT CONFUSE CONSEQUENCES FOR CAUSES?!…
This guy, this talk, this 'breakthrough', I am extremely skeptical. Especially on TED, home of the self-publicist. And TEDX isn't even TED really.
We all want the wonder cure, but too many woolly words, maybe sorta kinda: No miracle today.
A cure will not come about through a "miracle".
It will come about through applied science... that takes people, words, work.
It may be disappointing for you not to find a "miracle" in a TH-cam video, but I think you need to look at the bigger picture.
No aluminum - no alzheimer's. Tale silica or bamboo silica, lots of water to flush out aluminum from your body.
Please don't peddle pseudoscience, thanks.
That's not pseudoscience. That's using natural remedies to our advantage.
Also, they aren't peddling. This is free advice.
@@thomasselby3912 Are you a scientist? Do you have evidence-backed science for your claims?
If not, shut up. Nobody needs to hear about another wonder cure/cause on the web.
Where is the aluminium coming from to get into the body?
@@addictedfoolgamer1970 Food additives, cosmetics, vaccines, certain meds.
This video is so caught with a lot of technical jargon while many people are dying of these diseases. Totally ridiculous! 😢
It's an extremely technical subject. Of course a neurologist is going to have jargon and technical terms of art.
If YOU can do better, then do it, instead of whining about a free video.
It seemed pretty understandable to me. I'm just a layperson
So by removing the technical jargon it should reduce the number of people dying? I’m not sure I understand your point.
@@addictedfoolgamer1970 I should have said this in a different way. I don't quite understand all the technical stuff, but I really want solutions. Too many people are dying. It's been long overdue. I mean how many people does it take to die, before a cure happens? I think it's great that there are videos like this.
@@lancelotkamaka2563 Ah yes! i see your point now. Very true. Thanks
To late for creepy joe
Don't be pathetic. We are talking about people's lives, not your petty politics.
F.U.
Toujours le même problème avec la traduction en français tout le monde ne parle pas anglais merci