🎯 Key points for quick navigation: 00:15 *📊 A study collected data on off-label rapamycin use, including both users and non-users.* 01:52 *🔬 The study was based on self-reported data from participants, not verified by medical records.* 04:52 *😮 Mouth sores were the only statistically significant side effect reported more frequently by rapamycin users.* 06:28 *🧠 Interestingly, anxiety and depression were reported less frequently in rapamycin users.* 07:52 *🦠 Continuous rapamycin use was associated with less severe COVID-19 infections and fewer long COVID symptoms.* 10:38 *💊 The most common rapamycin dose reported was 6 mg once a week orally.* 12:27 *⚠️ Rapamycin is not recommended for pregnant women, children, teenagers, or young adults.* 14:11 *🩸 Blood tests for sirolimus levels are recommended to ensure proper dosing and absorption.* 17:39 *🔄 Intermittent rapamycin use is preferred to avoid significant immune system suppression.* 21:28 *🍊 Grapefruit juice may slow down rapamycin metabolism, potentially increasing blood levels.* 23:16 *⏱️ Rapamycin dosing is typically once a week, with doses ranging from 1 to 6 mg.* 23:42 *🔄 Some users take rapamycin every other week with a doubled dose, alternating with metformin.* 24:26 *⏳ The concept of "five half-lives" is used to determine dosing frequency for rapamycin.* 25:18 *🛑 High doses of rapamycin interfere with mTOR2 assembly by competing for binding sites.* 25:45 *🔬 In transplant medicine, continuous rapamycin use suppresses mTOR2 to prevent organ rejection.* 27:10 *🐢 For anti-aging purposes, it's recommended to start with low doses (1-2 mg) and slowly increase over time.* 28:32 *💊 Personal experience: Starting at 1 mg every two weeks, gradually increased to 4 mg.* 29:09 *😖 Side effects experienced at 4 mg: hives and severe gum/tooth pain for several days.* 30:04 *🔬 Rapamycin affects mitochondrial function, iron, and copper metabolism, which could explain some side effects.* 30:46 *🐁 Mouse studies show about 10% improvement with rapamycin, but human results may vary due to different metabolic factors.* Made with HARPA AI
Hi Richard - very good videos here. I see in comment section you mention to try. I am about your age (I’m late 60s) and think too very healthy like you. Been for last 40 yrs running 20 miles a wk, exercise with heavy weights 4 days wk, BMI at 20, take no meds, eat no processed foods, all blood markers (~50 tested) in ideal range - so very thankful, lucky and fortunate. A few medical researchers i follow - mention if older and very healthy maybe no benefit by taking the once wk rapamycin and maybe some negative side effects. So just hard to determine if to start and not fully known maybe for another several yrs. Good if one was 30 could wait but in late 60s when all known could be too late. Think still I’ll wait another yr to decide as maybe little more info to help with decision. Thanks all efforts here with video updates you do each wk.
Hi Michael, thanks for sharing. Your protocol looks excellent! I have not started rapamycin yet, but am thinking about it. If we are doing the right things, does it help? According to the observational paper by Dr Kaeberlein there were few side effects and it seemed to improve general health. (www.ncbi.nlm.nih.gov/pmc/articles/PMC10187519/) . I think it is like Dr Cohen says, you need to think about what value it would give you and see if you see that.
It was very intresting to hear the guy from the trim trail explaining mtor is needed for thymus function.. being on rapa constantly will slow cell growth and also repair it seems like, even tho the studies show it increase repair thrue autophagy, yet people on it get slow healing from scars/get infections and so on. Wich would indicate a weaker body. Extended fast that on paper do the same as rapa, repair skin n stretch marks, kills off infections, cure cellulite n so on - so fasting really seems supperior
Hi Stefan, thanks for the comment. I would agree with Dr Fahy, it is about balance and cycling between growth and clean up modes. Fasting is good, but there does seem to be more people (Dr Peter Attia for example) coming out against it for older people because of the danger of lean tissue loss.
@@ModernHealthspan dident he find out that lifting weights during the fast helped with alot of the loss? I see alot of people look more musclar even post a fast, prob due to the hgh increase. I will try vibration therapy during the fast to activate autophagy alot more Btw you should read the book from the american health expert paul bragg i belive, the guy that sells the apple cider vinegar, his book on fasting is incredible
As noted, taking with grapefruit juice and a fatty meal can make the Rapa far more bioavailable. I like this efficiency and cost savings as you can't just buy rap at the corner store. But the question is does potentiating it with grapefruit juice extend the half life? I was taking 3mg weekly Rapamycin 4-12 hours after juicing a whole pomelo (which is basically a grapefruit) and after a few weeks suffered an infected anti-biotic resistant staff infected abscess. Coindidence? Maybe but hard to know. Wondering if the grapefruit crowd might be better off doing longer intervals to clear the system? Interested to know if anyone had tested levels over time with the grapefruit method. I'll also note that studies have shown that different variations of Pomelo have shown to produce different levels of the As noted, taking with grapefruit juice and a fatty meal can make the Rapa far more bioavailable. I like this efficiency and cost savings as you can't just buy rap at the corner store. But the question is does potentiating it with grapefruit juice extend the half life? I was taking 3mg weekly Rapamycin 4-12 hours after juicing a whole pomelo (which is basically a grapefruit) and after a few weeks suffered an infected anti-biotic resistant staff infected abscess. Coindidence? Maybe but hard to know. Wondering if the grapefruit crowd might be better off doing longer intervals to clear the system? I know that taking Pomelo/Grapefruit can be quite variable in effects both from variations in the fruits themselves, method of administration and individual responses to it
Grapefruit juice is metabolized by CYP3A4 which is why many medications advise you not to have grapefruit while on that medication. It's basically competing with the rapamycin as substrates of CYP3A4. The simple answer is that you're dramatically increasing your trough levels over time. Which also means you're pushing into the immunosuppression range. This would be a plausible explanation for your abscess. If you're going to try to economize by taking with grapefruit juice, you should definitely reduce your dose and get your trough checked to determine what levels you're achieving. I'm of the mind that a pulsing dose, with lower troughs, is going to be safer over time.
I would suggest you investigate the recent revelations regarding the new data regarding the irregular fatty acid C15:0. I suspect you will be interested.
I agree with Dr. Cohen. If you are already doing a lot of longevity interventions (even aspirin is an inhibitor of mTOR), maybe rapamycin does not add much value. I will also note that Dr. Blagosklonny, who first brought rapa as longevity medicine to the world's attention is now struggling with cancer despite his long-term rapa use.
Hi Tyler, thanks for sharing. I am also unsure, if you do the "right things" how much supplements can add. In principal we would all get a baseline of some sort, then take the supplement for 3 months and remeasure. But this is resource intensive. I did not know about Dr Blagosklonny having cancer. I wish him the best.
It is tasteless to disclose Dr B's medical condition in an argument against Rapamycin. If you were a physician such a move would be considered highly unethical. 😂
Hi Roger, thanks for the question. I don't think that Dr Pelton mentioned that name but I find a test here labtestsonline.org.uk/tests/sirolimus (in the UK) which is called sirolimus (the brand name for a rapamycin product).
Hi Smedley, thanks for pointing that out. That is a good point. I have just done some investigation and it is not soluble in water, but I see no mention of it being soluble in fat, rather there is some solubility in ethanol and propylene glycol.
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🎯 Key points for quick navigation:
00:15 *📊 A study collected data on off-label rapamycin use, including both users and non-users.*
01:52 *🔬 The study was based on self-reported data from participants, not verified by medical records.*
04:52 *😮 Mouth sores were the only statistically significant side effect reported more frequently by rapamycin users.*
06:28 *🧠 Interestingly, anxiety and depression were reported less frequently in rapamycin users.*
07:52 *🦠 Continuous rapamycin use was associated with less severe COVID-19 infections and fewer long COVID symptoms.*
10:38 *💊 The most common rapamycin dose reported was 6 mg once a week orally.*
12:27 *⚠️ Rapamycin is not recommended for pregnant women, children, teenagers, or young adults.*
14:11 *🩸 Blood tests for sirolimus levels are recommended to ensure proper dosing and absorption.*
17:39 *🔄 Intermittent rapamycin use is preferred to avoid significant immune system suppression.*
21:28 *🍊 Grapefruit juice may slow down rapamycin metabolism, potentially increasing blood levels.*
23:16 *⏱️ Rapamycin dosing is typically once a week, with doses ranging from 1 to 6 mg.*
23:42 *🔄 Some users take rapamycin every other week with a doubled dose, alternating with metformin.*
24:26 *⏳ The concept of "five half-lives" is used to determine dosing frequency for rapamycin.*
25:18 *🛑 High doses of rapamycin interfere with mTOR2 assembly by competing for binding sites.*
25:45 *🔬 In transplant medicine, continuous rapamycin use suppresses mTOR2 to prevent organ rejection.*
27:10 *🐢 For anti-aging purposes, it's recommended to start with low doses (1-2 mg) and slowly increase over time.*
28:32 *💊 Personal experience: Starting at 1 mg every two weeks, gradually increased to 4 mg.*
29:09 *😖 Side effects experienced at 4 mg: hives and severe gum/tooth pain for several days.*
30:04 *🔬 Rapamycin affects mitochondrial function, iron, and copper metabolism, which could explain some side effects.*
30:46 *🐁 Mouse studies show about 10% improvement with rapamycin, but human results may vary due to different metabolic factors.*
Made with HARPA AI
Hi Richard - very good videos here. I see in comment section you mention to try. I am about your age (I’m late 60s) and think too very healthy like you. Been for last 40 yrs running 20 miles a wk, exercise with heavy weights 4 days wk, BMI at 20, take no meds, eat no processed foods, all blood markers (~50 tested) in ideal range - so very thankful, lucky and fortunate. A few medical researchers i follow - mention if older and very healthy maybe no benefit by taking the once wk rapamycin and maybe some negative side effects. So just hard to determine if to start and not fully known maybe for another several yrs. Good if one was 30 could wait but in late 60s when all known could be too late. Think still I’ll wait another yr to decide as maybe little more info to help with decision. Thanks all efforts here with video updates you do each wk.
Hi Michael, thanks for sharing. Your protocol looks excellent! I have not started rapamycin yet, but am thinking about it. If we are doing the right things, does it help? According to the observational paper by Dr Kaeberlein there were few side effects and it seemed to improve general health. (www.ncbi.nlm.nih.gov/pmc/articles/PMC10187519/) . I think it is like Dr Cohen says, you need to think about what value it would give you and see if you see that.
Great interview.
Hi thanks Olya!
Good summary, tks Richard.
Hi Ray, thanks!
Can you take other supplements with rapamycin - and how long after the rapa dose, the others can be taken
It was very intresting to hear the guy from the trim trail explaining mtor is needed for thymus function.. being on rapa constantly will slow cell growth and also repair it seems like, even tho the studies show it increase repair thrue autophagy, yet people on it get slow healing from scars/get infections and so on. Wich would indicate a weaker body. Extended fast that on paper do the same as rapa, repair skin n stretch marks, kills off infections, cure cellulite n so on - so fasting really seems supperior
Hi Stefan, thanks for the comment. I would agree with Dr Fahy, it is about balance and cycling between growth and clean up modes. Fasting is good, but there does seem to be more people (Dr Peter Attia for example) coming out against it for older people because of the danger of lean tissue loss.
@@ModernHealthspan dident he find out that lifting weights during the fast helped with alot of the loss?
I see alot of people look more musclar even post a fast, prob due to the hgh increase. I will try vibration therapy during the fast to activate autophagy alot more
Btw you should read the book from the american health expert paul bragg i belive, the guy that sells the apple cider vinegar, his book on fasting is incredible
As noted, taking with grapefruit juice and a fatty meal can make the Rapa far more bioavailable. I like this efficiency and cost savings as you can't just buy rap at the corner store.
But the question is does potentiating it with grapefruit juice extend the half life? I was taking 3mg weekly Rapamycin 4-12 hours after juicing a whole pomelo (which is basically a grapefruit) and after a few weeks suffered an infected anti-biotic resistant staff infected abscess. Coindidence? Maybe but hard to know. Wondering if the grapefruit crowd might be better off doing longer intervals to clear the system? Interested to know if anyone had tested levels over time with the grapefruit method. I'll also note that studies have shown that different variations of Pomelo have shown to produce different levels of the
As noted, taking with grapefruit juice and a fatty meal can make the Rapa far more bioavailable. I like this efficiency and cost savings as you can't just buy rap at the corner store.
But the question is does potentiating it with grapefruit juice extend the half life? I was taking 3mg weekly Rapamycin 4-12 hours after juicing a whole pomelo (which is basically a grapefruit) and after a few weeks suffered an infected anti-biotic resistant staff infected abscess. Coindidence? Maybe but hard to know. Wondering if the grapefruit crowd might be better off doing longer intervals to clear the system? I know that taking Pomelo/Grapefruit can be quite variable in effects both from variations in the fruits themselves, method of administration and individual responses to it
Grapefruit juice is metabolized by CYP3A4 which is why many medications advise you not to have grapefruit while on that medication. It's basically competing with the rapamycin as substrates of CYP3A4. The simple answer is that you're dramatically increasing your trough levels over time. Which also means you're pushing into the immunosuppression range. This would be a plausible explanation for your abscess. If you're going to try to economize by taking with grapefruit juice, you should definitely reduce your dose and get your trough checked to determine what levels you're achieving. I'm of the mind that a pulsing dose, with lower troughs, is going to be safer over time.
I would suggest you investigate the recent revelations regarding the new data regarding the irregular fatty acid C15:0. I suspect you will be interested.
I agree with Dr. Cohen. If you are already doing a lot of longevity interventions (even aspirin is an inhibitor of mTOR), maybe rapamycin does not add much value. I will also note that Dr. Blagosklonny, who first brought rapa as longevity medicine to the world's attention is now struggling with cancer despite his long-term rapa use.
@@tylermoore4429 he took the clot shot, got cancer soon the after as many others
Hi Tyler, thanks for sharing. I am also unsure, if you do the "right things" how much supplements can add. In principal we would all get a baseline of some sort, then take the supplement for 3 months and remeasure. But this is resource intensive.
I did not know about Dr Blagosklonny having cancer. I wish him the best.
It is tasteless to disclose Dr B's medical condition in an argument against Rapamycin. If you were a physician such a move would be considered highly unethical. 😂
what was the name of the Blood test for Rapa??? Test Test Test....
Sirolimus
Hi Roger, thanks for the question. I don't think that Dr Pelton mentioned that name but I find a test here labtestsonline.org.uk/tests/sirolimus (in the UK) which is called sirolimus (the brand name for a rapamycin product).
Re: Dr Pelton: I didn't know that hay rapamycin was fat-soluble.
Hi Smedley, thanks for pointing that out. That is a good point. I have just done some investigation and it is not soluble in water, but I see no mention of it being soluble in fat, rather there is some solubility in ethanol and propylene glycol.
This stuff is way to expensive for how long it extends longevity.
Im not convinced this is worth my while.