Specific (Adaptive) Immunity | Humoral and Cell-Mediated Responses
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- เผยแพร่เมื่อ 15 มิ.ย. 2024
- CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram.
This is how our bodies learn to identify a new pathogen and develop immunity to that pathogen in the future.
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0:00 Introduction
0:48 A Wild Pathogen Appears!
2:11 Phagocytosis and Presenting the Antigen
3:27 T-Helper Cells
4:29 Humoral Response (B-Cells and Antibodies!)
7:07 Cell-Mediated Response (Killer T-Cells!)
9:18 Recap
11:13 More bad acting...
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Image used:
“6VSB spike protein SARS-CoV-2 monomer in homotrimer” commons.wikimedia.org/wiki/Fi..., 5-HT2AR, CC0, via Wikimedia Commons
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Can't begin to express how excited I am to have come across your channel! 60 slides all explained in one amazing video, and everything just clicked in my head. Thanks Siebert!!
To add a bit to the cell-mediated response for people reading the comments, the infected cell presents the antigen via the MHC-I (instead of the MHC-II of the APC cells) and the T-killer lymphocyte uses the CD8 receptor for that antigen
Thank you it was actually helpful
Fantastic lecture and comments.
But T8 lymphocytes need T4 lymphocytes so how did T4 lymphocytes get activated if they don't recognize CMH1
I've been trying to get my head around this topic for months now and I stumbled across this video, ive never heard it explained so well and so precisely yet in a way so easy to understand. You're an extraordinary teacher, THANKS!
This was insanely precise. I love that you follow such a linear path for something involving a lot of steps at once. Seriously thank you thank you thank you. I've watched a lot of good videos on immunity but yours was the only one to truly make it fully understandable.
Thanks so much for the kind words! Glad you found it helpful.
Yes, this is so true thank you😊
Thank you so much. I have spent hours looking for videos to help me on this topic and now you have made it crystal clear in my head. Please continue to make more videos they help so much
Aw, thank you for the comment! Glad it was helpful!
EXACTLY. This was by far the best video I've found on this topic, presented in such a CLEAR and organized way! This man truly has a gift for teaching.
Thank you for the "clear as glass" explanation!
You're welcome!
I have been researching this topic over the past week for an assignment, struggling to find anything as clear and helpful as this video by a mile. This video literally feels like the best video on the whole internet for explaining B cell and T cell functions and specific immune responses in general. The detail is perfect, the whole video flows. Thank you so much, I really appreciate your work!
Thank you so much for doing this! I was having a hard time reading about this topic on my own. It made so much sense :D
The best and clearest presentation !
Thank you so much! Adding the etymology of the cell and biochem names is super helpful
This is the most helpful video I have seen on the interaction within the adaptive immune system. Thank you for such a clear explanation
I got frustrated learning about immune system, but your video is truly a big help for me to understand it better. Hopefully u will continue making new videos cause I gonna be a big fan of your
Glad it helped! I plan to keep making more videos!
Thank you so much for such amazing explanation. Definitely gonna nail this topic tomorrow
awesome explanation. you connected the processes of cell-mediated and humoral immunity really well
Super cool video. Thank you so much. You make it straight forward, interesting and deep at the same time. Best doctor here!
Reviewing my Physiology notes to take my TEAS exam. I looked through so many videos that were either too complex or too simple. This was perfect! Loved the artwork and the clean separation of processes. Thank you!!!
You're welcome! I'm glad you found it helpful.
Yeah, it's hard to find resources at the right level for a lot of this stuff.
This is so amazing, you explain what my 3 hours lectures couldn't in 10 minutes.
What an attractive and genius way of presenting!! Please continue doing it for other parts of pathology and physiology. You made the subject matter very edible 😀😀😀
Thanks! I plan to keep making videos 👍🏼
I wish you were making videos 4 years ago, my goodness man you are a life saver
Great video, and such beautiful visuals
thorough and helpful, im an NP student and this was SUPER helpful !
Thank you so much! Very helpful video. Love the pictures made it much more clear :)
You're welcome!
This is so concise, Thank a lot Prof. !!!
This was super helpful! Thank you!
You have definitely help and educate me so so much with your videos. You are the best with the You analyses and make it look very simple to understand. Thank u so much.
Oh thanku so much for that wonderful class helped me to understand the topic very much... plz keep going and post more videos..
Bless you! Please continue doing what you're doing! You're an angel
You are wonderful ... clear and crisp ... wish youtube present u to the needful learners in the manner how our cells present the antigens for betterment of body :)
Thanks! I hope TH-cam listens to your advice, haha! :)
Really awesome big picture video. Thank you🙏🧬
Please continue making these videos. Once I learned about your channel, I can't stop watching them to learn more! Very concise and easy to digest diagrams (they are also very cute) Thank you so much
You're welcome! I plan to keep making them!
Brother one of the finest video on this topic.....you got my respect 👍🏻🤝🏻
I
Spent a week trying to figure this out and u explained it in a few minutes. You are truly a teacher indeed. Can you couple this with the Mac 1 and two? Omg you are good. I have hope now of passing this section of the exam tomorrow!
When you're taking a 6 week online accelerated A&P 2 class before nursing school starts-- you're freaking out and then you find Siebert Science. I may pass now. THANK YOU. lol
This man needs a medal for this breakdown! I’m passing this exam! Talk about confidence he just gave me
Extremely beautiful and beneficial. I love that so much.. please continue
Fantastic lecture and comments
Love your videos! I'm doing biomed and some concepts I just cant' understand until you explain it. Also, omg I love Cells at Work too!!
thank you sooooooooo much this clicks so well now
You're welcome! Glad it helped!
Nursing student here! Thank you so much for these videos!! You are a hero!
so far your videos have been very helpful:) thank you for making it easier for us. although I didn't believe you were sick :x
Big help 🎉 thank you!
This was the bomb. Thank you
I have a class test in 4 hours and now I am fully confident that I'll ace that! Thank you.
Thank you so much for this amazing video
I'm a very visual learner and the way you drew it all out and separated the different processes! thank you for finally helping my brain understand this topic :) If I get an A on my exam today I can thank you!!
Glad the videos were helpful. Let me know how you did on your exam!
Your videos have single handedly taught me all of the systems that we need to know for the MCAT! I never took anatomy as its not required for us and when I started studying I had regrets on not taking it, but man your videos on the immune system, digestive, respiratory, circulatory and kidneys have literally taught me everything!!! Your videos are so well put together and so easy to follow I hope TH-cam pays you a million dollars a year for your services :)
Question about the immune system: So what is the difference between MHC-II and MHC-I? Are MHC-II's only present on macrophages?
Seriously thank you x 1000 and I hope to use your videos throughout medical school once I make it there :)
I found it more helpful and easy to understand
This is a great video thanks so much for making it
best guide ever!
i didnt had a problem with focusing on your lecture. That's rare for me thank you for the video
Very helpful ! Thank you so much :)
You're welcome!
THANK YOU! 🎉🎉
Took me so long to understand until this short video , so clear :) thanks
Thank you so much
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thanks heaps for this video!
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I always watch your videos before reading a textbook bc most of the time textbook seems very complicated, then I do my quizz assignment with ease
Thank you
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Many thanks very good video
I'm not a Bio major but this is probably the best video explaining anything ever. Helps me understand research I'll have to read for my extra-credit assignment. Thanks!
Best video explaining anything ever???
What a great compliment! I appreciate it!
I thank God for helping me find this channel 🙏🙏 immunology best explanation ❤
I watched the lymphatic system video and now this … and I want to watch the blood one next. For the very first time I’m finding human body systems fascinating. Never had such a great teacher before. I might have gone into medicine if I had had videos like this in my younger life!
Now I’m going to use them to teach my kids!
Aw, thanks for the kind words! Best of luck with homeschooling anatomy this year!
I've been watching a couple of videos on the Immune System and I could easily admit that you're the Phil Jackson of Immunology.
Well, Phil Jackson with a touch of DiCaprio (nice fake acting lol). You've mastered the act of transferring knowledge.
Thank you!!!
Hey, my students tell me my acting is improving! But they’re probably just being nice...
Thanks for the comment!
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very clear and specific video, just hoped you would take about the types of interferones and the "component system" too. This would have helped to be even more complete. Maybe talking about the NK-cells too but overall very very good video
NK cells are part of the innate immune system, that's why they are not being discussed here
thank you so much
Thank you,
I dont think ive ever commented on a youtube video in my life, but this was so helpful i almost did a backflip out of joy, thanks !!!!!
thank you
Thank you!!!!
100% perfect🤞👏👏clear and understandable ♥️
Thanks so much!
Not so convincing coughing, but the lecture was amazinggggg. Thanks!
So you’re saying I shouldn’t quit TH-cam to become an actor??? ;)
wonderful and help tutorial, I like it
Thanks for the comment!
thanks you for this AMAZING explanation, and you should definitely be an actor😂
You’re literally the best!!! I don’t know why you don’t do biochemistry😭
I’d love to do biochemistry someday. But this isn’t my job…I do all this stuff in my spare time, so I’m pretty limited in how much content I can make.
oh my god, thank you so much for this video, immunology is driving me crazy
Just Excellent💯💯
Thank you 🙌
Can you make vd about the non-specific?
This is good ✨
Thanks!
Do you have a video on Hypersensitivity Reactions?
hataraku saibou in the background! It's a good show focusing on body immunology ! 😄
I was hoping some people would notice that! Great show!
Thank uuuuuuuuu❤❤❤❤❤❤❤❤
the best video to explain this. I really wanted a clear cut, step by step demonstration and this is incredibly helpful. thankyou!
What about MHC 1 that present the antigen for T cytotoxic?
The intelligence of our body
I like the Cells at Work easter egg.
Yeah, I just discovered the show last week! So good!
I have a question regarding the B cell maturing in the bone marrow i read in multiple sources that it start’s developing in the bone marrow but continues in the spleen to final maturation but i also read it matures in the bone marrow so can you tell me which is true?
can you just clear a doubt ? How can cells retain specific memory of any pathogen in spite of having average life span?
they keep dividing into new cells and passing on the information.
this guy made my life a lot easier
The problem is, everybody start to modify the truth at the moment of the cross between innate and adaptive immunity so I can’t know what is real or not real ...
- The T helper cell learn the shape of the antigen presented by the APC and goes on ?
OR
- The T helper cell have already learn a antigen specificity at the birth and goes on only if himself and the APC match ?
Goat
Cells At Work!! i love that anime!
This is for class 12??
goated
very helpful, especially when you have a teacher that doesnt do her job
Thanks! Glad you found it helpful. Yeah, a bad teacher makes it tough, but as a student you have to find what works for you! (such as finding TH-cam videos)
APC: the body’s way of wearing the blood of our enemies 😂
Those cells literally decapitate the invader and WEAR it’s body to alert other cells!! How cool is that!!!
would Humoral mediated immunity be how we build immunity through vaccines???????///
There are several different mechanisms for different types of vaccines, but understand this type of immunity is kind of the first step in understanding how those work.
I would be very careful if you listen to this and use it to learn immunology. It is oversimplified. For example, CD4 does not define specificity nor does it recognize antigenic proteins. This is mis-leading. Be careful.
Thanks for pointing this out! I added a correction in the description:
"CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram."