Renin-Angiotensin-Aldosterone System (RAA System) | Made easy with a step-by-step explanation!

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In this video, explain how the RAA system regulates blood pressure, blood volume, and sodium homeostasis.
0:00 Introduction
0:53 Homeostasis
1:30 Stimuli
2:14 Sensors
4:58 Angiotensin II Synthesis
8:33 Effectors - Aldosterone
11:33 Effectors - All Other Effectors
15:17 - Regulating Glomerular Filtration Rate
16:50 - Recap of RAAS System
19:02 - Review!
19:34 - Endscreen Silliness
🦴 Other videos referenced:
Urinary System: • Urinary System | Struc...
Nephrons - Filtration and Reabsorption Basics: • Nephrons - Filtration ...
Homeostasis: • Homeostasis - BEST Way...
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Image used:
OpenStax Anatomy and PhysiologyOpenStax, CC BY 4.0
upload.wikimedia.org/wikipedi...
creativecommons.org/licenses/..., via Wikimedia Commons

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This guy actually knows how to teach... Thank you sir

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Thank you , better than lecture 2hrs in class

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Correct!

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Agree

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agree

[@user-lk4lm3wf1p]

20 minutes of this has saved me hours of studying. Thank you!

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OMG!!!! I only have a few more weeks of Human Anatomy and Physiology II and I am so MAD I just found you!!! You were here when I started Anatomy I and I didn't even know it. You have such a flow and easy way to follow each body system etc., Although I am just so mad I missed you for so long, thank you for being here now at least! THANK YOU!!!!

[@SiebertScience]

Hey Jenn! You're very welcome! Glad you're finding the videos helpful, and good luck with the last few weeks of your A&P class. Also, thanks for the support on Patreon!

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[@ST-gd4eq]

Thank you so much for this video! Your content makes these subjects very easy to understand and also very fun! Makes me enjoy learning these things.

[@claudiasantisteban478]

Such an amazing explanation of the RAAS!!!! Kudos and thank you!

[@lobofitness6997]

Your videos have made me understand concepts I have long ago struggled to comprehend. Thank you very much!

[@RWB_Yoga]

Thank you. This was the best explanation I've seen. Very clear & helpful.

[@user-jz2jq8wp8r]

Learning and retention are all about connection to the content. WOW.
For whatever reason, your visual outline w/ a concise explanation finally brought it home. Thanks...from the bottom of my kidneys !!

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Thank you so so much for drawing ALL the visuals 🫢AND explaining. They are very helpful!

[@maisa510]

Your explanations are top tier!! Just what I needed before an exam. Thank you!!!

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Thank you so much! You are an awesome teacher! I now understand somthing I've been reading about for a week. Thank you!

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Thank you very much. The way you explain things is really interesting and captivating.

[@such25]

Never understood better! Thanks a lot!!❤

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Such a good video! Love your diagrams

[@josephdivineande8085]

Wow!! Fantastic explanation. I can't still understand why I found this concept difficult back in Medical school. The stuffs keep getting easier. Thanks for the superb explanations

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Thank you for explaining it really well and for easier to understand you’re a really helpful to us students.❤

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[@ladycdp4u]

Thank you very much! This video explanation is extremely helpful.

[@paddyc93]

This review was excellent.

[@user-cp2bo9xi2r]

You make it so easy to understand the whole process of RAAS. Thanks a lot!!

[@SiebertScience]

You're so welcome!

[@mrsrestorationoftruthyahsc3057]

Never understood this until NOW, Thank u so much❤

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Wow this is good, well expanded

[@user-od5cj6ds3f]

You ARE THE MANN!!!!! I finally understand RAAS. Thank you :)

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[@32clairem]

The way you explain this is amazing, thanks 🎉

[@SiebertScience]

You're very welcome!

[@nancybarbour7710]

Amazing! I have hyperaldosteronism and this gave me a deeper understanding. Wish you were my dr.!!

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[@tranminh5396]

This lecture is very lively and interesting compared to this in school. Thank you so much

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[@SiebertScience]

You're welcome!

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[@louikaradsheh529]

Bril lecture.
Angiotensin II has an effect on both afferent and efferent arteriole but it mainly constricts the efferent to maintain the GFR.

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i’m just learning this in class! thank you!

[@SiebertScience]

Awesome! You're welcome!
I'm just curious, what level of class is it for? (high school, undergrad, med school, other?)

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@@SiebertScience undergrad

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[@SiebertScience]

Thanks! I'll add lymphatic system to my list of videos to make!

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[@SiebertScience]

You're welcome!

[@user-cu2wm6ep7b]

Thank you for your great video. Making a very difficult concept so easy. I checked the first aid, aldosterone only affects the ENAC and NA.K PUMP in collecting tubules not DCT .is it correct?

[@dr.chris8]

Struggling to say Juxtaglomerular had me laughing 😂😂😂

[@paulatewakatama8067]

Hello sir Siebert could you please cover Pharmacology 🙏

[@rameenfayyaz966]

Thank you!!- quick question, since you mention that this system is about low levels of Na+ if there was a high intake of sodium by the human, like eating salty meals- would this system cease? as in stop the stimulation of aldosterone to prevent reabsorption of Na+ into the blood stream and allow it for secrection into the urinary system.

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Btw love the way u teach

[@SiebertScience]

Thanks! I'll add genes and reproduction to my "videos to make" list.

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I WILL BE WAITING FOR IT

[@sarinakhan6946]

The macula densa are in the DCT? I thought the DCT was on the other side of the Loop of Henle?

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[@dankbudwoi871]

Does rehydration stabilise, reverse the activation of the ras system? I got really dehydrated few years back and have had high blood pressure ever since and Insomnia, palpitations...

[@lucywilliams1634]

Question: could this system explain why someone with renal agenesis would have POTS?

[@globalcitizen7]

Who regulate the macula densa and juxtraglomerular cess . I mean who makes them act???😢

[@SumayaAbdidahir]

I’ve almost fallen asleep on the video 😂❤it was soo clear, concise, and simple to understand, it doesn’t seem difficult anymore. Just wooow. Thank you for making these videos. ❤❤

[@josephdivineande8085]

Renin is an enzyme. Because it cstalyses the degredation of an hormone called angiotensinogen to angiotensine I, it is called Enzymatic hormone.

[@francesmayson9573]

❤

[@iGlimmyr]

Hmm I went looking for this topic because my blood pressure is too high, not too low. My renin levels are twice the normal level.

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[@juliaevanusa6631]

renin is an enzyme? my professor is calling it a hormone and my textbook is calling it an enzymatic hormone I'm so confused 😩

[@SiebertScience]

When renin converts angiotensinogen to angiotensin I, it's acting as an enzyme, not a hormone. Hormones bind with receptors on cells, whereas enzymes facilitate a chemical reaction, and the conversion of angiotensinogen to angiotensin I is a chemical reaction.
I think there are some renin receptors on some cells, which would technically make it a hormone as well, but that (renin binding to cell receptors) is beyond my expertise.

[@juliaevanusa6631]

@@SiebertScience ahhh okay!! amazing! I just want to let you know your videos help me so much! You explain things so well and I am such a visual learner so they are like a lightbulb for me 😁

[@SiebertScience]

@@juliaevanusa6631 ah yay! Glad you’ve found them helpful!

[@tasya7508]

Nowadays Sodium deficiency is a myth

[@gina4168]

Good explanation but why so many cuts on the video. Too much information too fast. It's not tik tok here.

[@SiebertScience]

For one, I'm not reading from a script, so I'm often unhappy with the way I say something at first, so I say it again differently and cut out the original. That leads to a lot of cuts.
Second, I just don't like long (or even short) pauses or hearing my breath. So I often cut those out. Mostly this is a stylistic choice, I guess. And I like that it shortens the video a bit.
Third, I don't really know. There's no way to make a video that works perfect for everyone. So I try to make videos I like, and I kind of like doing it that way.