Coupling Reactions Organic Chemistry|Stille|Negishi|Sonogashira|Suzuki| Hiyama|Heck Kumada Buchwald

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  • เผยแพร่เมื่อ 1 ก.พ. 2025

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  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +4

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  • @renukapgtps
    @renukapgtps 3 ปีที่แล้ว +5

    Short and sweetly explained all 10 reactions in 10 minutes excellent..

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Thank you madam,
      For more name reactions, please watch these video lectures of Venus Academy:
      1. Aldol Condensation: th-cam.com/video/6vw9xRDrPkQ/w-d-xo.html
      2. Baeyer - Villiger Oxidation Rearrangement: th-cam.com/video/bSIYN1TgNVg/w-d-xo.html
      3. Beckmann Rearrangement: th-cam.com/video/90sPi0E0fws/w-d-xo.html
      4. Benzil - Benzilic Acid Rearrangement: th-cam.com/video/uyYLpGUHe-s/w-d-xo.html
      5. #Birch #Reduction of Aromatic rings, Alkynes, Conjugated Dienes, alpha beta unsaturated Ketones : th-cam.com/video/qJoDhV4DX98/w-d-xo.html
      6. #Cannizzaro #Reaction: th-cam.com/video/uBCNEERmls8/w-d-xo.html
      7. #Claisen #Condensation, formation of Beta Keto Esters (Self Condensation vs Mixed Condensation) : th-cam.com/video/UY2y_2UUus4/w-d-xo.html
      8. #Claisen Rearrangement : th-cam.com/video/AZy5NgeTPpg/w-d-xo.html
      9. #Claisen - #Schmidt Reaction Differences between Aldol reaction, Cannizzaro Reaction and Claisen reaction: th-cam.com/video/YqCH8AEccSw/w-d-xo.html
      10. #Clemmensen Reduction Reaction (Part 13): th-cam.com/video/oIyUQBYEr44/w-d-xo.html
      11. #Curtius Rearrangement Reaction (Part 14): th-cam.com/video/c23ys2XHUoI/w-d-xo.html
      12. #Dieckmann Condensation Reaction Mechanism (Part 15): th-cam.com/video/OFQZLF95e4I/w-d-xo.html
      13. #Diels #Alder Reaction (Part 16): th-cam.com/video/eWnkxlUOPpg/w-d-xo.html
      14. #Dienone - #Phenol Rearrangement Reaction (Part 17): th-cam.com/video/65PG5VtGv24/w-d-xo.html
      15. #Favorskii Rearrangement Reaction (Part 18): th-cam.com/video/0uWqtCi21N4/w-d-xo.html
      16. #Friedel #Crafts #Alkylation and #Acylation Reaction (Part 19): th-cam.com/video/9KuYVo1sypg/w-d-xo.html #Fries Rearrangement Reaction: th-cam.com/video/Lat7VXgAJ8o/w-d-xo.html
      17. #Gabriel #Phthalimide Synthesis : th-cam.com/video/-OGKqOfHGQY/w-d-xo.html
      18. #Hell - #Volhard - #Zelinsky (#HVZ) Reaction: th-cam.com/video/NdhW0CBf8b4/w-d-xo.html
      19. #Hoffmann #Bromamide Reaction (Hoffmann Rearrangement / Hoffmann Bromamide degradation): th-cam.com/video/piZALtdU3rI/w-d-xo.html
      20. #Houben - #Hoesch #Acylation: th-cam.com/video/JJYLALhJ970/w-d-xo.html
      21. #Gattermann #Koch and #Gattermann #Formylation Reaction: th-cam.com/video/kPP4PEhhdHU/w-d-xo.html
      22. #Knoevenagel Reaction: th-cam.com/video/C_GKc7PXzgo/w-d-xo.html
      23. #Mannich reaction: th-cam.com/video/PKw5JOgiy8E/w-d-xo.html
      24. #Meervein-#ponndorf-#verley (#MPV) Reduction reaction mechanism th-cam.com/video/0dmKqDXqGbs/w-d-xo.html
      25. #Michael #Addition #Reaction: th-cam.com/video/Q0lZtG9R_es/w-d-xo.html
      26. #Oppenauer #Oxidation #Reaction || #Swern #Jones #Collins #Moffet #Sarett #Oxidation of #Alcohols: th-cam.com/video/O2Agjj5asgA/w-d-xo.html
      27. Palladium catalysed coupling reactions: th-cam.com/video/Zas_JlccBNQ/w-d-xo.html
      28. Perkin Reaction: th-cam.com/video/5KaYcNueuTI/w-d-xo.html
      29. Pinacol-Pinacolone Rearrangement: th-cam.com/video/YjbnDV26jd0/w-d-xo.html
      30. Reformatsky reaction : th-cam.com/video/r5qYVUF2A2E/w-d-xo.html
      31. Reimer-Tiemann Reaction: th-cam.com/video/lI2UBsNbZkE/w-d-xo.html
      32. #Ziegler #Natta Catalyst: th-cam.com/video/9ls6HZW4VrM/w-d-xo.html

    • @Dr.BhararhsaiPacchigolla
      @Dr.BhararhsaiPacchigolla 6 หลายเดือนก่อน

      Great work

  • @ashimadogra5832
    @ashimadogra5832 2 ปีที่แล้ว +2

    Sir, very detailed explanation. Really liked the way you gave insights about the practical aspects of the reactions. Thank you Sir.

    • @VenusAcademy
      @VenusAcademy  2 ปีที่แล้ว +1

      Thank you Dogra ji... wish you all the best.

  • @sabarishsubramani8593
    @sabarishsubramani8593 11 หลายเดือนก่อน +1

    The way you delivered the subject is very impressive.

    • @VenusAcademy
      @VenusAcademy  11 หลายเดือนก่อน +1

      Thank you for your compliments. Wish you all the best.

  • @korendalaxmi8985
    @korendalaxmi8985 2 ปีที่แล้ว +2

    Sir happy to see you sir. Nice explanation sir. I have seen in Sapala organics pvt Ltd.

    • @VenusAcademy
      @VenusAcademy  2 ปีที่แล้ว +1

      Thank you Laxmi madam...

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    Suzuki (Boron) Coupling Reaction - 6:38 (timeline of this video)

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    Stille (Sn - Tin) Coupling Reaction - 7:13 (timeline of this video)

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    Negishi (Zn - Zinc) Coupling Reaction - 8:11 (timeline of this video)

  • @susmitapandey3562
    @susmitapandey3562 4 หลายเดือนก่อน +1

    Very good 👍

    • @VenusAcademy
      @VenusAcademy  4 หลายเดือนก่อน +1

      @@susmitapandey3562 Thank you ji, wish you all the best 🙏

  • @anilkumarkarampoori2811
    @anilkumarkarampoori2811 2 ปีที่แล้ว +1

    The way of your explanation is so nice

    • @VenusAcademy
      @VenusAcademy  2 ปีที่แล้ว

      Thank you sir... Please watch other videos of Name reactions.
      th-cam.com/video/0uWqtCi21N4/w-d-xo.html

  • @kireetsangondi2200
    @kireetsangondi2200 6 หลายเดือนก่อน +1

    extraordinary explanation

    • @VenusAcademy
      @VenusAcademy  6 หลายเดือนก่อน +1

      Thank you sir, wish you all the best.

  • @kireetsangondi2200
    @kireetsangondi2200 2 ปีที่แล้ว +2

    nice sir ,i enjoyed

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    C-C Bond & C=C Bond Formation Reactions with Stereochemistry
    : th-cam.com/video/YqCH8AEccSw/w-d-xo.html
    Oxidation & Reduction Reactions with Stereochemistry: th-cam.com/video/qJoDhV4DX98/w-d-xo.html
    Rearrangement Reactions with Stereochemistry
    : th-cam.com/video/Lat7VXgAJ8o/w-d-xo.html

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    1. Aldol Condensation: th-cam.com/video/6vw9xRDrPkQ/w-d-xo.html
    2. Baeyer - Villiger Oxidation Rearrangement: th-cam.com/video/bSIYN1TgNVg/w-d-xo.html
    3. Beckmann Rearrangement: th-cam.com/video/90sPi0E0fws/w-d-xo.html
    4. Benzil - Benzilic Acid Rearrangement: th-cam.com/video/uyYLpGUHe-s/w-d-xo.html
    5. #Birch #Reduction of Aromatic rings, Alkynes, Conjugated Dienes, alpha beta unsaturated Ketones : th-cam.com/video/qJoDhV4DX98/w-d-xo.html
    6. #Cannizzaro #Reaction: th-cam.com/video/uBCNEERmls8/w-d-xo.html
    7. #Claisen #Condensation, formation of Beta Keto Esters (Self Condensation vs Mixed Condensation) : th-cam.com/video/UY2y_2UUus4/w-d-xo.html
    8. #Claisen Rearrangement : th-cam.com/video/AZy5NgeTPpg/w-d-xo.html
    9. #Claisen - #Schmidt Reaction Differences between Aldol reaction, Cannizzaro Reaction and Claisen reaction: th-cam.com/video/YqCH8AEccSw/w-d-xo.html
    10. #Clemmensen Reduction Reaction (Part 13): th-cam.com/video/oIyUQBYEr44/w-d-xo.html
    11. #Curtius Rearrangement Reaction (Part 14): th-cam.com/video/c23ys2XHUoI/w-d-xo.html
    12. #Dieckmann Condensation Reaction Mechanism (Part 15): th-cam.com/video/OFQZLF95e4I/w-d-xo.html
    13. #Diels #Alder Reaction (Part 16): th-cam.com/video/eWnkxlUOPpg/w-d-xo.html
    14. #Dienone - #Phenol Rearrangement Reaction (Part 17): th-cam.com/video/65PG5VtGv24/w-d-xo.html
    15. #Favorskii Rearrangement Reaction (Part 18): th-cam.com/video/0uWqtCi21N4/w-d-xo.html
    16. #Friedel #Crafts #Alkylation and #Acylation Reaction (Part 19): th-cam.com/video/9KuYVo1sypg/w-d-xo.html #Fries Rearrangement Reaction: th-cam.com/video/Lat7VXgAJ8o/w-d-xo.html
    17. #Gabriel #Phthalimide Synthesis : th-cam.com/video/-OGKqOfHGQY/w-d-xo.html
    18. #Hell - #Volhard - #Zelinsky (#HVZ) Reaction: th-cam.com/video/NdhW0CBf8b4/w-d-xo.html
    19. #Hoffmann #Bromamide Reaction (Hoffmann Rearrangement / Hoffmann Bromamide degradation): th-cam.com/video/piZALtdU3rI/w-d-xo.html
    20. #Houben - #Hoesch #Acylation: th-cam.com/video/JJYLALhJ970/w-d-xo.html
    21. #Gattermann #Koch and #Gattermann #Formylation Reaction: th-cam.com/video/kPP4PEhhdHU/w-d-xo.html
    22. #Knoevenagel Reaction: th-cam.com/video/C_GKc7PXzgo/w-d-xo.html
    23. #Mannich reaction: th-cam.com/video/PKw5JOgiy8E/w-d-xo.html
    24. #Meervein-#ponndorf-#verley (#MPV) Reduction reaction mechanism th-cam.com/video/0dmKqDXqGbs/w-d-xo.html
    25. #Michael #Addition #Reaction: th-cam.com/video/Q0lZtG9R_es/w-d-xo.html
    26. #Oppenauer #Oxidation #Reaction || #Swern #Jones #Collins #Moffet #Sarett #Oxidation of #Alcohols: th-cam.com/video/O2Agjj5asgA/w-d-xo.html
    27. Palladium catalysed coupling reactions: th-cam.com/video/Zas_JlccBNQ/w-d-xo.html
    28. Perkin Reaction: th-cam.com/video/5KaYcNueuTI/w-d-xo.html
    29. Pinacol-Pinacolone Rearrangement: th-cam.com/video/YjbnDV26jd0/w-d-xo.html
    30. Reformatsky reaction : th-cam.com/video/r5qYVUF2A2E/w-d-xo.html
    31. Reimer-Tiemann Reaction: th-cam.com/video/lI2UBsNbZkE/w-d-xo.html
    32. #Ziegler #Natta Catalyst: th-cam.com/video/9ls6HZW4VrM/w-d-xo.html

  • @ankit.lokesh1902
    @ankit.lokesh1902 9 หลายเดือนก่อน +1

    Great explanation

    • @VenusAcademy
      @VenusAcademy  9 หลายเดือนก่อน +2

      Thank you Sir.. wish you all the best.

  • @Ammaappa14-pm
    @Ammaappa14-pm 2 ปีที่แล้ว +2

    Good morning... Sir... Nice explanation what is the reference books for this topic please tell me sir...🙏🙏

    • @VenusAcademy
      @VenusAcademy  2 ปีที่แล้ว +1

      This topic is prepared from Palladium catalysis book by Prof. Tsuji wish you all the best.

    • @Ammaappa14-pm
      @Ammaappa14-pm 2 ปีที่แล้ว +1

      @@VenusAcademy thank you so much sir.... 🙏🙏

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    C-C Bond & C=C Bond Formation Reactions with Stereochemistry
    : th-cam.com/video/YqCH8AEccSw/w-d-xo.html

  • @muhammadaminbaig2994
    @muhammadaminbaig2994 2 ปีที่แล้ว +1

    Excellent

    • @VenusAcademy
      @VenusAcademy  2 ปีที่แล้ว

      Thank you Amin Baig ji,
      For more name reactions please watch these videos:
      1. Aldol Condensation: th-cam.com/video/6vw9xRDrPkQ/w-d-xo.html
      2. Baeyer - Villiger Oxidation Rearrangement: th-cam.com/video/bSIYN1TgNVg/w-d-xo.html
      3. Beckmann Rearrangement: th-cam.com/video/90sPi0E0fws/w-d-xo.html
      4. Benzil - Benzilic Acid Rearrangement: th-cam.com/video/uyYLpGUHe-s/w-d-xo.html
      5. #Birch #Reduction of Aromatic rings, Alkynes, Conjugated Dienes, alpha beta unsaturated Ketones : th-cam.com/video/qJoDhV4DX98/w-d-xo.html
      6. #Cannizzaro #Reaction: th-cam.com/video/uBCNEERmls8/w-d-xo.html
      7. #Claisen #Condensation, formation of Beta Keto Esters (Self Condensation vs Mixed Condensation) : th-cam.com/video/UY2y_2UUus4/w-d-xo.html
      8. #Claisen Rearrangement : th-cam.com/video/AZy5NgeTPpg/w-d-xo.html
      9. #Claisen - #Schmidt Reaction Differences between Aldol reaction, Cannizzaro Reaction and Claisen reaction: th-cam.com/video/YqCH8AEccSw/w-d-xo.html
      10. #Clemmensen Reduction Reaction (Part 13): th-cam.com/video/oIyUQBYEr44/w-d-xo.html
      11. #Curtius Rearrangement Reaction (Part 14): th-cam.com/video/c23ys2XHUoI/w-d-xo.html
      12. #Dieckmann Condensation Reaction Mechanism (Part 15): th-cam.com/video/OFQZLF95e4I/w-d-xo.html
      13. #Diels #Alder Reaction (Part 16): th-cam.com/video/eWnkxlUOPpg/w-d-xo.html
      14. #Dienone - #Phenol Rearrangement Reaction (Part 17): th-cam.com/video/65PG5VtGv24/w-d-xo.html
      15. #Favorskii Rearrangement Reaction (Part 18): th-cam.com/video/0uWqtCi21N4/w-d-xo.html
      16. #Friedel #Crafts #Alkylation and #Acylation Reaction (Part 19): th-cam.com/video/9KuYVo1sypg/w-d-xo.html #Fries Rearrangement Reaction: th-cam.com/video/Lat7VXgAJ8o/w-d-xo.html
      17. #Gabriel #Phthalimide Synthesis : th-cam.com/video/-OGKqOfHGQY/w-d-xo.html
      18. #Hell - #Volhard - #Zelinsky (#HVZ) Reaction: th-cam.com/video/NdhW0CBf8b4/w-d-xo.html
      19. #Hoffmann #Bromamide Reaction (Hoffmann Rearrangement / Hoffmann Bromamide degradation): th-cam.com/video/piZALtdU3rI/w-d-xo.html
      20. #Houben - #Hoesch #Acylation: th-cam.com/video/JJYLALhJ970/w-d-xo.html
      21. #Gattermann #Koch and #Gattermann #Formylation Reaction: th-cam.com/video/kPP4PEhhdHU/w-d-xo.html
      22. #Knoevenagel Reaction: th-cam.com/video/C_GKc7PXzgo/w-d-xo.html
      23. #Mannich reaction: th-cam.com/video/PKw5JOgiy8E/w-d-xo.html
      24. #Meervein-#ponndorf-#verley (#MPV) Reduction reaction mechanism th-cam.com/video/0dmKqDXqGbs/w-d-xo.html
      25. #Michael #Addition #Reaction: th-cam.com/video/Q0lZtG9R_es/w-d-xo.html
      26. #Oppenauer #Oxidation #Reaction || #Swern #Jones #Collins #Moffet #Sarett #Oxidation of #Alcohols: th-cam.com/video/O2Agjj5asgA/w-d-xo.html
      27. Palladium catalysed coupling reactions: th-cam.com/video/Zas_JlccBNQ/w-d-xo.html
      28. Perkin Reaction: th-cam.com/video/5KaYcNueuTI/w-d-xo.html
      29. Pinacol-Pinacolone Rearrangement: th-cam.com/video/YjbnDV26jd0/w-d-xo.html
      30. Reformatsky reaction : th-cam.com/video/r5qYVUF2A2E/w-d-xo.html
      31. Reimer-Tiemann Reaction: th-cam.com/video/lI2UBsNbZkE/w-d-xo.html
      32. #Ziegler #Natta Catalyst: th-cam.com/video/9ls6HZW4VrM/w-d-xo.html

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว +1

    Oxidation & Reduction Reactions with Stereochemistry: th-cam.com/video/qJoDhV4DX98/w-d-xo.html

  • @aravabrahmi6934
    @aravabrahmi6934 3 ปีที่แล้ว +1

    Tq sir

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Thank you Brahmi ji,
      Please follow these videos for more name reactions: th-cam.com/video/0uWqtCi21N4/w-d-xo.html
      Name Reactions alphabetical order: sites.google.com/site/venuschemistryacademy/home
      Wish you all the best.

  • @babacharykalvacharla3489
    @babacharykalvacharla3489 3 ปีที่แล้ว +1

    Palladium was water soluble and organic halide is soluble in organic solvent. How come reaction proceeds.

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Dear Babachary ji,
      Heck reaction is performed in organic solvents using organic bases such as Et3N etc.
      Suzuki reaction is performed in a mixture of organic solvents (dioxane, DMF etc) in water system.
      Palladium catalysts are soluble in organic solvents e.g. Palladium acetate: Solubility: sol organic solvents such as chloroform, methylene chloride, acetone, acetonitrile, diethyl ether. Dissolves with decomposition in aq HCl and aq KI solutions. Insol water and aqueous solutions of NaCl, NaOAc, NaNO3 as well as in alcohols and petroleum ether. Decomposes when heated with alcohols.
      However, when bases (inorganic bases like CsF, Cs2CO3, Na2CO3, K2CO3 are used then water also used).
      Typically in a Suzki reaction the solvent system will be : 1,4-dioxane/water (9/1 ratio) and the Pd catalysts such as Pd(dppf)Cl2 and CsF are used.

  • @VenusAcademy
    @VenusAcademy  3 ปีที่แล้ว

    Rearrangement Reactions with Stereochemistry
    : th-cam.com/video/Lat7VXgAJ8o/w-d-xo.html

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Palladium catalysed name reactions

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      10 Important Palladium catalyzed reactions are:
      Suzuki Miyaura
      Stille
      Negishi
      Kumada
      Hiyama
      Sonogashira
      Heck
      Buchwald Hartwig
      Carbonylation
      Cyanation

  • @yelamandaraopureti6219
    @yelamandaraopureti6219 3 ปีที่แล้ว +1

    Why R-F,Ar-F compounds doesn't participate in palladium catalyzed couplings reactions, please give sutable reason

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +2

      Dear Pureti ji,
      Palladium catalyzed reactions involves a step of oxidative addition and this step is facilitated by high electron density compounds like organic (C-X) halides /pseudo-halides of sp2 carbons, and the rate of the addition decreases in the following order; C-I > C-Br >>> C-Cl >>> F. Aryl fluorides are almost inert.
      It is clear from the above order that the R-Cl is less reactive and R-F is almost intact. However, recently, facile oxidative addition of sp2 C-Cl
      bonds can be used by using electron-rich ligands such as P(t-Bu)3 or N-heterocyclic carbene
      ligands, and electron-deficient
      aryl fluorides can be coupled when PMe3 or biphenylylphosphines ligands are used.
      In general, most of the halides/pseudo halides like Alkenyl, aryl halides, acyl halides, sulfonyl halides, Diazonium salts and triflates undergo facile oxidative addition.
      I hope your question is answered.
      wish you all the best.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +4

    Heck reaction

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Heck reaction is mediated by Pd to give new C C single bond.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Negishi Coupling

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Zinc mediated coupling reaction is known as Negishi coupling

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Buchwald Hartwig Amination

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Buchwald Hartwig amination reaction is an important reaction where aromatic amination is done mediated by Pd.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Suzuki Miyaura coupling

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Boronic acid or boronate esters are coupled using Pd catalyst.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Sonogashira coupling

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Sonogashira uses CuI as co catalyst.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Hiyama coupling

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +2

    Stille coupling

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Tin Sn mediated reactions are known as Stille coupling.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Kumada coupling

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Cyanation

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Cyanation is one of the reactions of Pd medium reactions to introduce CN group.

  • @drmvcharyphd5596
    @drmvcharyphd5596 3 ปีที่แล้ว +1

    Carbonylation

    • @VenusAcademy
      @VenusAcademy  3 ปีที่แล้ว +1

      Yes, carbonylation reactions can be done using palladium as catalyst.

  • @UxmalIKabah
    @UxmalIKabah 3 หลายเดือนก่อน +1

    Yo no entiendo por que la reaccion de heck esta a 180 grados de la de Stille. Ya estoy harta de que me vean la cara de estupila.