I think I speak for thousands of people when I say that I'd pay major $$$ for a Pathoma/Boards/Osmosis/Physeo type service made by you. Blessings my guy
Hey thanks so much for the video! I am slightly confused how we will be able to distinguish between gilbert syn and CJ2. If they both have decreased UDP glucuronyl transferace?
The age of onset is one way. CJ2 will be during neonate/infant stages while Gilbert will be older child/adolescence (since its usually asymptomatic for the most part until jaundice is triggered). Also, Gilbert usually triggers jaundice during stressful situations like fasting and with alcohol consumption. And one last thing, indirect bilirubin in CJ2 is usually < 20mg while in gilbert, its usually < 3mg. Hope this helps!
The main difference is the severity, Gilbert syndrome is a very mild form that can be asymptomatic or occasionally cause jaundice during stress, fasting, etc but otherwise doesn't require treatment, and Crigler-Najjar type 1 is a more moderate form that can manifest with symptoms and be treated with phenobarbital
My UGTA1A is deficient according to my genetic test. But tests don’t show higher than normal indirect (unconjugated) bilirubin, but it’s the Conjugated that’s slightly high. My ultrasound shows nothing wrong with liver biliary ducts. I have beta thalassemia.
Is the black liver primarily due to conjugated bilirubin buildup in the liver? Cause if both Dubin johnson and Rotor have an increased buildup of conjugated bilirubin then why doesnt the increased buildup cause the liver to appear black in Rotor? Can anyone answer this please....
I know this question was asked a year ago but just in case anyone else is wondering: DJ is a defect in getting conjugated bilirubin out of the hepatocytes and into the bile canaliculi. Rotor syndrome is a defect in getting recycled bilirubin back into the liver. So Rotor syndrome has an elevation in bilirubin outside of the liver = no black liver!
I dont quite understand the difference between crigler najjar II and gilbert. is it just a different gene involved? Both decrease UDP Glucuronyl transferase and increase unconj bilirubin?
What would I have if presenting with isolated direct and indirect hyperbilirubinemia with 30% direct fraction? Total bilirubin level is 27 umol/L (normal range 0-20 umol/L)
I think I speak for thousands of people when I say that I'd pay major $$$ for a Pathoma/Boards/Osmosis/Physeo type service made by you. Blessings my guy
its cute how Dr. Dirty Medicine says he loves us at the end of each video
Honestly, I love it.
Awww
this video alone is worth $4.99. Thank you for making studying so much more enjoyable!
dirty.... simply love you. When I'm not a broke med student, I will make sure to donate any way I can!
This is Pure Gold, to me you DESERVE NOBEL PRIZE, thank you for helping us and beeing you👍🏻
Literally died laughing at the Rock has come back to dirty medicine 😂. Im friends with his first cousin haha we went to undergrad together
Another mnemonic about Dubin Johnson vs Rotor : in Dubin johnson liver is Dark, in Rotor it s Regular.
Your lectures are life savers for exams!!
Best video I've seen on the topic! 🙌 Thank you so much, you're great!
Excellent video as always. Would be great if you could do a video or two on Hepatitis if possible
Congrats on making the First Aid list again!
Waoooooooo amazing sir most of time I recommended your vid in diff step 1 preparation grp
Pay the man!!!!
Awesome vid. Thank-you.
Glad to see you back amazing work as always brother!
you are the best Doc!!
This was great, Dirty you are the people’s Champ!
You're too AWESOME, please be a professor and your students will love you.
For rotor syndrome, mneumonic is ROlled OATs, and oats are "not black" in colour, so is the liver in Rotor Syndrome
You explained this better than Pathoma! You rock!
If only I had money I would sponsor all these lectures
boards in 2 weeks and this is one of my weaker areas, thanks!!
i didn't expect to see the Rock in a video about bilirubin, i am pleasantly surprised
Hey thanks so much for the video! I am slightly confused how we will be able to distinguish between gilbert syn and CJ2. If they both have decreased UDP glucuronyl transferace?
The age of onset is one way. CJ2 will be during neonate/infant stages while Gilbert will be older child/adolescence (since its usually asymptomatic for the most part until jaundice is triggered).
Also, Gilbert usually triggers jaundice during stressful situations like fasting and with alcohol consumption.
And one last thing, indirect bilirubin in CJ2 is usually < 20mg while in gilbert, its usually < 3mg.
Hope this helps!
Great tie-in with Dubin Johnson and honestly one of the greatest WWE superstars.
the people elbow haha nice mimo about the rock :) you rocking bro
You've got a gift man, great video
Great way of explanation.. btw whats difference between Gilbert and criglar najjar type 1..
The main difference is the severity, Gilbert syndrome is a very mild form that can be asymptomatic or occasionally cause jaundice during stress, fasting, etc but otherwise doesn't require treatment, and Crigler-Najjar type 1 is a more moderate form that can manifest with symptoms and be treated with phenobarbital
This is GOLD! Thank you so much!
HI! Can we get a video on git embryology? Would really appreciate the help. THANK YOU. Love the videos.
can you make videos on the esophageal diseases and or various liver problems like steatosis and alcoholic and hepatitis changes
i just love this channel , awesome
Dubin Johnson ( Dwayne Johnson )
Black liver ( black Adam )
For Dubin-Johnson think of the MR(C)P in Dublin
I have always used the Rock to remember Dubin Johnson.. I was so happy to see this
My UGTA1A is deficient according to my genetic test. But tests don’t show higher than normal indirect (unconjugated) bilirubin, but it’s the Conjugated that’s slightly high. My ultrasound shows nothing wrong with liver biliary ducts. I have beta thalassemia.
appreciate the thing you do, thanks man
Thanks!
Made my day when the Rock was mentioned 😌🙏🏽
Thank you. Great video ❤
You are Simply Awesome Sir 👌
Is the black liver primarily due to conjugated bilirubin buildup in the liver? Cause if both Dubin johnson and Rotor have an increased buildup of conjugated bilirubin then why doesnt the increased buildup cause the liver to appear black in Rotor?
Can anyone answer this please....
I know this question was asked a year ago but just in case anyone else is wondering: DJ is a defect in getting conjugated bilirubin out of the hepatocytes and into the bile canaliculi. Rotor syndrome is a defect in getting recycled bilirubin back into the liver. So Rotor syndrome has an elevation in bilirubin outside of the liver = no black liver!
Great Lecture
Fantastic explanation
u r the best ! thank you
Thank you very much😊😊
Just 5 sec into your video and I click the Like button because I know I am gonna like it anyway Dr Dirty
Can they not be treated by introducing the needed enzyme?
Amazing work ... Antiretroviral drugs please
Very useful 👌
If there was udp-glucuronyl transferase deficiency does that mean there isn’t any conjugated bilirubin? Then how the body gets rid of the bilirubin?
Amazing 👏 ❤
Will definitely send in some help ....thank you
Bro ur the goat indeed
awesome!! more GI path please
U r great presenter
Great explanation 👍
My clue for Dubin-Johnson and the black liver is that Dubh means black in Irish and Gaelic, as in Dublin "Black Pool"
An excellent lecture wd good meumonic.... But i m getting too much adds while watching it..
U are awesome. Thanks bro
We love you back 💕
Thank you.
Its amazing ✨✨✨✨ and i guess you need to change the title to congenital hyperbilirubinemia
I dont quite understand the difference between crigler najjar II and gilbert. is it just a different gene involved? Both decrease UDP Glucuronyl transferase and increase unconj bilirubin?
Great man, great man!
Thankyou
dude you're so amazing . This was so helpful
What would I have if presenting with isolated direct and indirect hyperbilirubinemia with 30% direct fraction? Total bilirubin level is 27 umol/L (normal range 0-20 umol/L)
How to differentiate Gilbert fro criggler 1
Great video, thanks! 4 or 5 adverts is a bit excessive and rather annoying though 😒
Thank you sir💖
dirty how can i contribute without becoming a monthlo supportet?
may god bless u
Amazing
It really was an amazing lec
you are the best
Heyy are there other videos for git other than these 4??? Please help thanks!!!
Thanks man
Amazing thank you.
THANK YOUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU!!!!!!!!!
I have Gilbert. how my level bi,irybin go down or low.Somthing advice ,cure Can help with Calcium d clucarate
I can smellllllllllllllll, what the Rock, is cooking in this video.
Awesome
I love you too Dirty 😭❤️
love u too dad
❤🎉
thankuuuuuuuuuuuu
🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻
You're amazing
This>>>UW explanations
could high levels of bilirubin in the blood also be correlated with IBS issues? (body trying to increase/make more stercobilin)?
LOVE YOU MAN
Hilarious ending!
fire
LIFESAVERS should be branded based on you
😃😃😃😃
love u too
what about me?
Love you too, Dirty 🥺
D for dirty d for dubin d for Dark liver
I love you too ❤
Omg I just think about this topic few hours ago😳😳
love