Gastrointestinal | Liver Circulation & Portal Hypertension
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- เผยแพร่เมื่อ 30 ก.ย. 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about liver circulation including the hepatic portal vein, common hepatic artery, hepatic artery proper, and many more important structures that are involved in the liver vasculature. We also talk about hepatic portal hypertension going into detail on pathologies such as Caput Medusae, and esophageal varices. We hope you enjoy this lecture and be sure to support us below!
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my comment maybe late but i think you are a little bit sick we really appreciate your hard work, these videos have helped alot
When he said trust me for this, I'm like I trust you with whole of my both atrium and ventricles 🥺
😃
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
both Atria* ☝🤓
You deserve a large portion of my tuition, thank you for recognizing your gift and sharing it with others.
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
Amazing ! Thanks a lot. Best explanation ever.
Thank you so much it's amazing how you make everything so much easier ❤️❤️❤️
you are great ..loved the way you explained in detail ... thank you
Thanks for clearing my doubts 👍.... Love from India
Thanks for your efforts it's helpful
Super-awesome!!!Thanks a ton,man!
Thank you so much 💕💕💕
thanks a lot dude..
Love from bottom of my ventricles with a lot of oxygenated blood😊
Excellent lecture! Thank you very much. Exactly what I was looking for. Any new developments on portal hypertension sure? Tips seem to be quite risky and almost like the last resort
Any one noted the lecture?
best channel in the world
It's incredible that you can talk for 45 minutes straight with few mistakes and little to no editing. Thanks for this video!
I wish this channel was available way back undergrad day☹️. Anyways, I am sitting for a professional exam and this video makes me cover a one week reading for instance, in just a few hours. I have never understood anatomy like I do now after watching your videos! I now enjoy studying anatomy. You were born with a rare gift, thank you so much for sharing with the world.
Conversion of Phytonadione into menaquinone-4:
1. Phytonadione into menadione
1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase.
1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units.
2. Menadione into menaquinone-4
2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1).
2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4.
Is this process incorrect or not?
Ninja nerd team out here saving med students' lives. God bless yall :"D
It would have made my life a lot easier if this videos had been available when I attended medical school. Always had doubts over certain subjects (I missed school time because of disease and for the death of my son). You explained everything better than anyone. So clearly... You are quite amazing.
The most amazing and clear vidoes I have come across yet. This is sth that i had not understood since med school and it all makes so much sense now. Thank you so much :) :) :) :)
Khushboo Singh you completed ..medical
Plz recommended some more channels for hepatology.
even tho this is a year ago. you sound sick. hope you feel better xD thanks for powering thru and teaching us under the weather
Best tutor ever. thank you so much for all this lectures!!!
Sooooo good…. Teaching is his calling/niché
As a medical student, this was super helpful, especially as we're discussing Schistosomiasis in our current case study. God bless you bro.
Aww while teaching hus expressions were so cute.. gosh I am in love with him :(
😆😆😆😆😆😆😆
I have a crush on him, too!!
Brilliant explanation! Thank you so much! 18/11/2018 😃😃
31:47 (Clinical Part)
You're the reason I passed my biochemistry exam. Thanks very much for sharing the informative videos💯💟
Superb as always. So impressed with your knowledge but also your ability to explain and articulate it all so well. This video was such a revelation to me. I had always assumed all returning blood from all organs was via the inferior vena cava but had no idea of this very clever portal to the liver. God or nature is so brilliant in its designs.
I wish you were my teacher!! You explain everything sooo well! Thank you!
You Sir, are bringing the swag into anatomy/physiology.
This is what happens when passion and competence are nicely blended.
If this is your way of studying/reviewing for yourself you are going to know your stuff!
Exams are a walk in the park for you, me thinks.
Also , way better source for me to recap GI-Liver basics before starting a PhD in this field.
Screw dull paper courses, this is the future!
Sir
Could you make a video on liver cirrhosis Vs CHF... Since it almost has similar signs and symptoms...
Thank you😊
Wonderful Work as always ,thanks to all the team :)
Thank you so much for everything 🤍
And yea at 27:43 when you said "Isn't that cool", our and your god Allah, the creator of all the humin beings and the whole universe and what it contains, told us to perceive ourselves, the creativity of our bodies and how does everything inside us cooperate together to make us live untill Allah takes our souls then we die even if we're completely healthy sometimes "the soul is something invisible, not understood because Allah refused to tell us about it".
He told us to perceive in Quran (Allah's talk) Surah Zarriat, Ayah 21:
{ وَفِيٓ أَنفُسِكُمۡۚ أَفَلَا تُبۡصِرُونَ }
and in your own selves! So, do you not perceive?
And his majesty refused to tell the humanity about the soul in Surah Esraa', Ayah 85:
{ وَيَسۡـَٔلُونَكَ عَنِ ٱلرُّوحِۖ قُلِ ٱلرُّوحُ مِنۡ أَمۡرِ رَبِّي وَمَآ أُوتِيتُم مِّنَ ٱلۡعِلۡمِ إِلَّا قَلِيلٗا }
And they ask you about the soul. Say, “The soul is something from the command of my Lord, and you are not given from the knowledge but a little.”
These are just 2 sentences of Allah's talk, there's much more.
I would loved it a lot more if the abdominal aorta was drawn on the middle,from where it actually supplies the organs
Love you man ❤ ur awesome you make everything easy make every concept clear now I know reason of Caput Medusa
Your videos are stunning, but I don't grasp where I should start learning this knowledge from; everything this so connected_ digestive system, circulatory system, endocrine system etc. that I get overwhelmed. And when I watch other TH-cam video, which have less information than this (but still have this masses of information), it feels like I am missing something... something crucial. Would you please walk me through?
Amazing explanation, you’re the best online teacher out there :). Thankyou for the effort!!
Had to mention this, shouldn’t the word be haematemesis at 43:52?
My 62 year old hubby has cirrhosis of the liver, a swollen spleen, a hernia, low blood platelets , low white blood cells and very high bilirubin and asceites (?). His hematologist doctor wants to put him on water pills or drain belly, do a bone marrow biopsy. She told him he needed a liver transplant. We asked her what role diet & nutrition plays in this. She said “NOTHING.” SO……We quit cold Turkey all alcohol, all processed foods, cut down drastically on sugar and salt. No pain meds, no prescriptions. He’s lost 33 lbs since diagnosed in August 22. I’ve only lost 9 ( Damnit). He says he feels so much better. We will - in the short term at least- continue to get blood tests and exam of belly ( CT Scan?) WE believe we can reverse this.
Super funny, I'm Watching your video and ironically I'm wearing the same shirt as you
They probably burnt some people during the old days because of caput Medusa. They were termed witches or wizard Haha 😂
Are all these organs kidney, spleen, intestines etc only have portal system veins or they have separate veins for IVC
Mind blowing. Plz make videos on rheumatic ds
The best channel in the world
It's awesome.. really very informative..thank u so much for u efforts...I highly appreciate ur simple diagrams...keep going
Thank you for the knowledge shared. As it gives me more understanding about my diagnoses. And how things work❤
My daughter passed away at 31 from Cirrhosis of the Liver. Thanks for helping me understand more about what happened.
We are sorry for your loss. We couldn't begin to understand your loss, but hopefully the understanding you've gained can bring you some closure.
May you have a long and healthy life
This is fabulous 😊 I recently got a job as a Research Nurse in Hepatology.. new field for me . Although I may not “need “ this understanding to do my job , technically speaking , I am feeling lost without this basic understanding of how the liver works .I so appreciate your help. You are an awesome teacher. Thank-you
I need to give you my entire tuition 🥺🥺🥺you know your stuff so well and you give it your all when teaching. Thank you so much 🙏🏾
Incredibly informative. The best tutoring video. I'm fortunate to have found his channel. Thank you so, so much.
Thank you. Now I'm more interested in medicine than before because of your lessons
I love your passion and how you simplify ! I am watching this because my BF has portal hypertension and kidney failure -Was total he has esophageal varices as well. Thank you!!!!!! I subscribed!
Thank you so much sir for your wonderful lecture, it is so useful and helpful to me.I couldn't understand this portion when I learnt from lecturers in our medical college, but once i listen to your lectures everything becomes crystal clear.You are really doing such a great service through these selfless efforts.I wish you good luck and all the courage to do more wonderful videos like this always in future.
I am a fan of Ninja Nerds, from Sri Lanka
I've been diagnosed with non-alcoholic fatty liver disease, high blood pressure, and high cholesterol I'm just here trying to learn as much as I can about my liver, I never gave it much thought before I always thought the heart, brain, or lungs where you're most important organ but now I know the liver is actually the most important organ thank you Doctor.
OMG IM SO GLAD I FOUND YOU... explained in a very well stepwise manner... Thank you so much...
Same here, studying for a professional exam, enjoying all aspects of medicine combining these lectures with papers...he is brilliant and sends so much energy and empathy through his eyes. I will be definitely taking some of the courses he offers. The universe loves you ninja 🤓!
Sensei you are amezing love from india 🇮🇳, just the way you teaching us is great...
Thanks for helping me understand how this works. My mom’s doctor is suggesting that speaking with a specialist about getting her TIPS procedure. This is scary stuff! 😔
Ninja nerd teach in urdu and so it gets easy for me to understand bro
I was diagnosed with portal hypertension of the liver. I've several nodules also but nothing more. This was very imformative and made me feel better about the outcome about the stunt placement.
My only worry now are the nodules.
Hope you get better soon
Mere papa ko cld h stage 4 portal hypertension h medicines chal rhi h...unki life ko danger to nhi h?
...I can never figure this guy out...is he a Physician...or Professor...or just some NInja ?....
its like watching my memory working in live action ....awesome job. I always used colored pens/pencils to draw similar thoughts
This is the best explanation I've ever gotten about this stuff, Im a RADIOGRAPHER by profession, this explanation makes sense
I feel Bad for the I reported on sonograms before knowing this
Hi, when we take a medicine or vitamin or mineral supplement sublingual what is the difference vs taking though the stomach>portal veins for the liver? Is it better for the liver or in the end is the same? (you are amazing)
best teacher Ive had so far
Excellent information & very well spoken. In Gastric bypass surgery most common to see Vitamin -A deficiency ( fat soluble Vitamin absorbed from stomach ) from Ophthalmology standpoint & patients have to take Vitamin -A regularly as a medicine. Thanks
Hi! I just discovered your channel and found it's truly very useful with your clear explanation and drawing! very much appreciated!
Thanks u made life easier on that topic 🙏🙏
Understand the hepatic portal Sys much better.
Sir, thank you for the thorough explanation...salute!
Thank you very Mach sir ..... stay happy and God bless you .....
You really know how deliver! Search for info on Portal Hypertention and stumbled upon your video. I can now review the medical write-up with greater understanding. Thank you!👏👏
Wow! so clear teaching, you are the best, thank you.
You are amazing. I always learn so much from you. 🙏🙏
It's like a talent for you 😂😂😂😂
perfect teacher, perfect video, perfect understanding & knowledge !!!
This is a great video for a patient like me. I have PBC. Your diagrams are really easy to understand thank you. I am waiting for the result on my portal Doppler scan.
By far you are the best I’ve seen! Thank you so much for your exceptional and detailed video! 🙏🏽👏🏽👍🏽😌God bless you!
Yesterday I can’t remember this topic when I studied with book suddenly I remember everything about liver after this miraculous video 📼 hats off bro u r hulk
Great demonstration this guy reminds me of my health teacher in high school, I learned more from him than any other teacher thanks so much.
Good information and making it understandable!
I have Lecture on Liver this saturday..Thanks for this..Now I can Say good bye to that lecture..
you are fantastic..... such a good teacher!!!
This is really really helpful!! Thank you very much!!!!!
how can i give 1000 likes in a video?
I actually came here came here not knowing the gross anatomy and now im leaving knowing the whole circulation thank you sooo much🙏🙏
you are a PHENOMENON bro!
Thanks Zack. Texting you straight from Punjab in India.
Can’t explain the effect your teaching had on me. So satisfying.
God bless you bro. ❤️
Hi from India, sir is great
A lot of thinks for great efforts .
I have pulmonary hypertension, and cirrhosis. How is that different to portal hypertension? I appreciate the knowledge your video presents but I’m confused because I thought my problem was with heart and lungs. Now I’m guessing my damaged liver is part of the equation.
10M baby, Chronic PVT suggested in Ultrasound, What should be the next action plan? Any guide for Radiology and treatment?
24:44 😂😂😂😂🤣🤣 why not make things more complicated 😂😂🤣🤣
Dude the way u simplified and made the concepts clear the whole history of medical school hasn’t done it
Thank you so much thank you so much thank you so much
24:40
Nice throw :)
Hahaha
Sir your amazing sir thank you for ur deep explanation
Excellent explanation...hat's off to the effort taken
so, the three consequences of portal hypertension are basically Varices which happen in different sites. (Anorectal hemorrhoids, Caput Medusa, and Esophageal varices).
Am I correct?
You are amazing zack , all love and respect ❤️
But if we put stunt between portal vein and IVC ... The liver will not get the hormones, nutrients, from the stomach, pancreas, spleen, intestines....
Then it's not harmful..?
Lots of love from india❤️❤️❤️🇮🇳🇮🇳
Missed ascites completely and a lot of other bits. Like how all the veins under pressure become varicose which means a stent may give opportunity for flow, but it may just keep goin the way its been goin.
Thank you so much sir for such a well explained video!